SE466202B - Nya karbapenemderivat och foerfarande foer framstaellning daerav - Google Patents

Nya karbapenemderivat och foerfarande foer framstaellning daerav

Info

Publication number
SE466202B
SE466202B SE8504538A SE8504538A SE466202B SE 466202 B SE466202 B SE 466202B SE 8504538 A SE8504538 A SE 8504538A SE 8504538 A SE8504538 A SE 8504538A SE 466202 B SE466202 B SE 466202B
Authority
SE
Sweden
Prior art keywords
formula
group
given above
protecting group
meanings given
Prior art date
Application number
SE8504538A
Other languages
English (en)
Swedish (sv)
Other versions
SE8504538L (sv
SE8504538D0 (sv
Inventor
C U Kim
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SE8504538D0 publication Critical patent/SE8504538D0/xx
Publication of SE8504538L publication Critical patent/SE8504538L/xx
Publication of SE466202B publication Critical patent/SE466202B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SE8504538A 1984-10-02 1985-10-01 Nya karbapenemderivat och foerfarande foer framstaellning daerav SE466202B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/656,838 US4683301A (en) 1982-04-08 1984-10-02 Carbapenem antibiotics

Publications (3)

Publication Number Publication Date
SE8504538D0 SE8504538D0 (sv) 1985-10-01
SE8504538L SE8504538L (sv) 1986-04-03
SE466202B true SE466202B (sv) 1992-01-13

Family

ID=24634788

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8504538A SE466202B (sv) 1984-10-02 1985-10-01 Nya karbapenemderivat och foerfarande foer framstaellning daerav

Country Status (24)

Country Link
US (1) US4683301A (de)
JP (1) JPS6187682A (de)
KR (1) KR910009270B1 (de)
AT (1) AT395151B (de)
AU (1) AU575432B2 (de)
BE (1) BE903353A (de)
CA (1) CA1260945A (de)
CH (1) CH665640A5 (de)
DE (1) DE3535196A1 (de)
DK (1) DK446685A (de)
ES (2) ES8703880A1 (de)
FI (1) FI79317C (de)
FR (1) FR2571054B1 (de)
GB (1) GB2165247B (de)
GR (1) GR852336B (de)
HU (1) HU194240B (de)
IL (1) IL76539A0 (de)
IT (1) IT1190396B (de)
LU (1) LU86105A1 (de)
NL (1) NL8502681A (de)
OA (1) OA08113A (de)
PT (1) PT81236B (de)
SE (1) SE466202B (de)
ZA (1) ZA857581B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732977A (en) * 1982-09-28 1988-03-22 Bristol Myers Company Carbapenem antibiotics
US5116833A (en) * 1990-10-19 1992-05-26 Bristol-Myers Squibb Company Antibiotic c-3 dithioacetal-substituted carbapenem compounds, compositions, and methods of use thereof
AR002507A1 (es) * 1995-06-28 1998-03-25 Merck & Co Inc Proceso mejorado para sintetizar intermediarios de carbapenem
US5823718A (en) * 1996-07-25 1998-10-20 Alnet (Proprietary) Limited Pillar bag

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
US4235920A (en) * 1975-11-21 1980-11-25 Merck & Co., Inc. N-Alkylated derivatives of thienamycin
AU4061378A (en) * 1977-10-19 1980-04-17 Merck & Co., Inc. 1-azabicyclo (3.2.0) hept-2-enes
AU531084B2 (en) * 1977-10-19 1983-08-11 Merck & Co., Inc. Azetidine derivatives
US4218463A (en) * 1977-12-28 1980-08-19 Merck & Co., Inc. 3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4174316A (en) * 1978-08-14 1979-11-13 Merck & Co., Inc. 4-Iodomethylazetidin-2-one
US4232036A (en) * 1978-10-24 1980-11-04 Merck & Co., Inc. 6-, 1- and 2-Substituted-1-carbadethiapen-2-em-3-carboxylic acids
DE2966497D1 (en) * 1978-10-24 1984-01-26 Merck & Co Inc 6-, 1- and 2-substituted-1-carbapen-2-em-3-carboxylic acids, processes for the preparation of such compounds and pharmaceutical composition comprising such compounds
US4208422A (en) * 1978-10-24 1980-06-17 Merck & Co., Inc. 1-Substituted-pen-2-em-3-carboxylic acids
US4318912A (en) * 1979-01-02 1982-03-09 Merck & Co., Inc. 6-(1-Hydroxyethyl)-3-substituted-1-azabicyclo(3.2.0)-hept-2-en-7-one-2-carboxylic acid
DK165280A (da) * 1979-04-19 1980-10-20 Merck & Co Inc Fremgangsmaade til fremstilling af 2- og 6-substituerede 1-carbadethiapen-2-em-3-carboxylsyrer og mellemprodukter til brug ved udoevelse af fremgangsmaaden
US4376774A (en) * 1979-05-29 1983-03-15 Merck & Co., Inc. Antibiotic N-heterocyclyl thienamycin
EP0055990B1 (de) * 1979-08-10 1986-06-11 Beecham Group Plc Beta-Lactam-Antibiotika, ihre Herstellung und Verwendung
EP0037082B1 (de) * 1980-03-27 1985-03-20 Merck & Co. Inc. Verfahren zur Herstellung von 1-Carbapenem-Derivaten und von Zwischenprodukten via silyl-substituierter Dithioacetale
IE52147B1 (en) * 1980-03-27 1987-07-08 Merck & Co Inc 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation
US4309346A (en) * 1980-03-27 1982-01-05 Merck & Co., Inc. Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates
EP0038869A1 (de) * 1980-04-30 1981-11-04 Merck & Co. Inc. Verfahren zur Herstellung von 1-Carbapenemen und Zwischenprodukte für ihre Herstellung
JPS56161393A (en) * 1980-05-16 1981-12-11 Sanraku Inc Beta-lactam compound
US4378315A (en) * 1980-05-29 1983-03-29 Merck & Co., Inc. Process for the preparation of thienamycin and intermediates
US4350631A (en) * 1980-12-18 1982-09-21 Merck & Co., Inc. 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates
ES8404184A1 (es) * 1981-08-03 1984-04-16 Merck & Co Inc Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
EP0074599A1 (de) * 1981-09-09 1983-03-23 Takeda Chemical Industries, Ltd. 5,6-Cis-Carbapenem-Derivate, ihre Herstellung und Verwendung
US4640915A (en) * 1982-03-29 1987-02-03 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives
CA1198440A (en) * 1982-04-08 1985-12-24 Choung U. Kim Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
EP0113101A1 (de) * 1982-12-30 1984-07-11 Merck & Co. Inc. 6-(1-Hydroxyäthyl)-2-SR8-1-methyl-1-carbadethiapen-2-em-3-carbonsäureester
DK140584A (da) * 1983-03-08 1984-09-09 Bristol Myers Co Fremgangsmaade til fremstilling af carbapenemderivater

Also Published As

Publication number Publication date
HU194240B (en) 1988-01-28
GB2165247B (en) 1988-08-10
ES8703880A1 (es) 1987-03-01
DK446685D0 (da) 1985-10-01
FI853748A0 (fi) 1985-09-27
ES8800223A1 (es) 1987-11-01
KR860003257A (ko) 1986-05-21
FI79317C (fi) 1989-12-11
LU86105A1 (fr) 1986-06-11
PT81236A (en) 1985-11-01
ES547438A0 (es) 1987-03-01
DE3535196A1 (de) 1986-04-10
CA1260945A (en) 1989-09-26
NL8502681A (nl) 1986-05-01
BE903353A (fr) 1986-04-01
SE8504538L (sv) 1986-04-03
GB2165247A (en) 1986-04-09
CH665640A5 (de) 1988-05-31
AT395151B (de) 1992-10-12
FI853748L (fi) 1986-04-03
FR2571054B1 (fr) 1988-09-30
FI79317B (fi) 1989-08-31
AU4810285A (en) 1986-04-10
IT8522317A0 (it) 1985-10-01
ZA857581B (en) 1986-05-28
JPS6187682A (ja) 1986-05-06
AU575432B2 (en) 1988-07-28
ATA284985A (de) 1992-02-15
DK446685A (da) 1986-04-03
ES553605A0 (es) 1987-11-01
HUT38641A (en) 1986-06-30
FR2571054A1 (fr) 1986-04-04
GB8524125D0 (en) 1985-11-06
OA08113A (fr) 1987-03-31
US4683301A (en) 1987-07-28
GR852336B (de) 1986-02-04
KR910009270B1 (ko) 1991-11-08
IL76539A0 (en) 1986-02-28
SE8504538D0 (sv) 1985-10-01
IT1190396B (it) 1988-02-16
PT81236B (pt) 1988-02-17

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