HUP9802146A2 - Eljárás optikailag aktív 2-amino-omega-oxoalkánsav-származékok előállítására és a vegyületek - Google Patents

Eljárás optikailag aktív 2-amino-omega-oxoalkánsav-származékok előállítására és a vegyületek

Info

Publication number
HUP9802146A2
HUP9802146A2 HU9802146A HUP9802146A HUP9802146A2 HU P9802146 A2 HUP9802146 A2 HU P9802146A2 HU 9802146 A HU9802146 A HU 9802146A HU P9802146 A HUP9802146 A HU P9802146A HU P9802146 A2 HUP9802146 A2 HU P9802146A2
Authority
HU
Hungary
Prior art keywords
amino acid
amino
compounds
acid derivatives
omega
Prior art date
Application number
HU9802146A
Other languages
English (en)
Inventor
Wilhelmus Hubertus Joseph Boesten
Quirinus Bernardus Broxterman
Marcus Joseph Maria Plaum
Original Assignee
Dsm N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19765731&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9802146(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dsm N.V. filed Critical Dsm N.V.
Publication of HU9802146D0 publication Critical patent/HU9802146D0/hu
Publication of HUP9802146A2 publication Critical patent/HUP9802146A2/hu
Publication of HUP9802146A3 publication Critical patent/HUP9802146A3/hu
Publication of HU220580B1 publication Critical patent/HU220580B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/06—Preparation of carboxylic acid amides from nitriles by transformation of cyano groups into carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgya eljárás (S)-2-aminő-w-őxőalkánsav-származékők -amelyek (I) általánős képletében n 0-4, R1 és R2 alkilcsőpőrt vagy ahőzzájűk kapcsőlódó őxigénatőmőkkal és az azőkhőz kapcsőlódószénatőmmal együtt egy gyűrűt képeznek - előállítására ésfelhasználására, valamint a közbenső termékként kapőtt új vegyületek. Az eljárást az jellemzi, hőgy a megfelelő aldehidet a megfelelőacetátvédett aldehiddé alakítják, abből előállítják a megfelelő aminő-nitrilt, az aminő-nitrilt a megfelelő aminősavamiddá alakítják át, azaminősavamidőn enzimatikűs, enantiőszelektív hidrőlízist hajtanakvégre, amelyben az (R) enantiőmer váltőzatlan marad, az (S) enantiőmerpedig (S)-aminősavvá alakűl át, és az (S)-aminősavat izőláljál, Azaminő-nitrilnek aminősavamiddá való átalakítása űtán kapőttreakcióelegyet előnyösen benzaldehiddel kezelik, az így kapőtt Schiff-bázist elválasztják, és az aminősavamidőt felszabadítják belőle. Az (I) általánős képletű vegyületek gyógyszerek előállításárahasználhatók. ŕ
HU9802146A 1997-09-25 1998-09-24 Eljárás optikailag aktív 2-amino-omega-oxoalkánsav-származékok előállítására és a vegyületek HU220580B1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL1007113A NL1007113C2 (nl) 1997-09-25 1997-09-25 Werkwijze voor de bereiding van optisch actieve 2-amino-omega- oxoalkaanzuurderivaten.

Publications (4)

Publication Number Publication Date
HU9802146D0 HU9802146D0 (en) 1998-12-28
HUP9802146A2 true HUP9802146A2 (hu) 1999-04-28
HUP9802146A3 HUP9802146A3 (en) 1999-09-28
HU220580B1 HU220580B1 (hu) 2002-03-28

Family

ID=19765731

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802146A HU220580B1 (hu) 1997-09-25 1998-09-24 Eljárás optikailag aktív 2-amino-omega-oxoalkánsav-származékok előállítására és a vegyületek

Country Status (15)

Country Link
EP (1) EP0905257B2 (hu)
JP (1) JPH11236361A (hu)
KR (1) KR19990030181A (hu)
CN (1) CN1218797A (hu)
AT (1) ATE267265T1 (hu)
CA (1) CA2247952A1 (hu)
CZ (1) CZ308698A3 (hu)
DE (1) DE69823941T3 (hu)
ES (1) ES2221974T5 (hu)
HU (1) HU220580B1 (hu)
IL (1) IL126313A (hu)
NL (1) NL1007113C2 (hu)
NO (1) NO984447L (hu)
SG (1) SG74077A1 (hu)
TW (1) TW430641B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999041249A1 (fr) * 1998-02-17 1999-08-19 Daicel Chemical Industries, Ltd. Procedes de production de monoacetals de dialdehyde
US6174711B1 (en) 1998-07-05 2001-01-16 Mitsubishi Gas Chemical Company Method for producing L-allysine acetal
HUP0105151A3 (en) 1998-07-15 2004-11-29 Bristol Myers Squibb Co Preparation of (s)-2-amino-6,6-dimethoxyhexanoic acid methyl ester via novel dioxolanes
US6620600B2 (en) 2000-09-15 2003-09-16 Bristol-Myers Squibb Co. Enzymatic resolution of aryl and thio-substituted acids
JP4851668B2 (ja) * 2001-09-13 2012-01-11 株式会社日本ファインケム ジアルデヒドモノエチレンアセタールアミノニトリルの製造方法
JP2003081964A (ja) * 2001-09-13 2003-03-19 Japan Hydrazine Co Inc α−アミノ酸アミドの製造方法
DE10155065A1 (de) * 2001-11-09 2003-05-22 Degussa Verfahren zur Kristallisation von Oxonorleucinacetal
WO2004089878A1 (ja) * 2003-04-02 2004-10-21 Tanabe Seiyaku Co., Ltd. 光学活性α－アミノニトリル化合物の製法
CN114988989A (zh) * 2021-03-02 2022-09-02 汉淇生医科技有限公司 戊二醛与1,6-己二醇之加成物、包含其之医药组合物及应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5142111B2 (hu) * 1971-10-02 1976-11-13
DE3043159C2 (de) * 1980-11-15 1982-12-09 Degussa Ag, 6000 Frankfurt Cyclische Acetale des Glutaminsäure-γ-semialdehyds, Verfahren zu deren Herstellung und ihre Verwendung
DE3043252C2 (de) * 1980-11-15 1982-12-02 Degussa Ag, 6000 Frankfurt Cyclische Acetale von N-Acylglutaminsäure -γ- semialdehyden, Verfahren zu deren Herstellung und ihre Verwendung
WO1989001525A1 (en) * 1987-08-17 1989-02-23 Novo Industri A/S Process for preparation of organic chemicals
EP0383403A1 (en) * 1989-02-16 1990-08-22 Stamicarbon B.V. Process for preparation of organic chemicals
US5332826A (en) * 1993-10-13 1994-07-26 Eastman Kodak Company Process for preparing aminoacetonitriles in one vessel
JPH10295392A (ja) † 1997-04-22 1998-11-10 Kanegafuchi Chem Ind Co Ltd Ｌ−アルリジンアセタールの製造方法

Also Published As

Publication number Publication date
NO984447L (no) 1999-03-26
EP0905257B2 (en) 2007-02-21
HUP9802146A3 (en) 1999-09-28
CZ308698A3 (cs) 1999-05-12
DE69823941D1 (de) 2004-06-24
DE69823941T2 (de) 2005-08-11
HU9802146D0 (en) 1998-12-28
NL1007113C2 (nl) 1999-03-26
KR19990030181A (ko) 1999-04-26
CA2247952A1 (en) 1999-03-25
ATE267265T1 (de) 2004-06-15
CN1218797A (zh) 1999-06-09
HU220580B1 (hu) 2002-03-28
ES2221974T3 (es) 2005-01-16
DE69823941T3 (de) 2007-10-18
IL126313A0 (en) 1999-05-09
IL126313A (en) 2001-04-30
SG74077A1 (en) 2000-07-18
EP0905257B1 (en) 2004-05-19
TW430641B (en) 2001-04-21
EP0905257A1 (en) 1999-03-31
JPH11236361A (ja) 1999-08-31
NO984447D0 (no) 1998-09-24
ES2221974T5 (es) 2007-10-16

Similar Documents

Publication Publication Date Title
HUP0203785A2 (hu) Eljárás Casodex enantiomereinek, származékainak és intermediereinek előállítására
DE69942140D1 (de) Verfahren zur Herstellung von L-Aminosäuren
BG105655A (en) Method for the preparation of 5-cyanophthalide
HUP9802146A2 (hu) Eljárás optikailag aktív 2-amino-omega-oxoalkánsav-származékok előállítására és a vegyületek
ATE37861T1 (de) Verfahren zur herstellung einer freien alpha-laminos|ure.
DE3875953D1 (de) Verfahren zur herstellung von organischen chemischen verbindungen.
DE3767993D1 (de) Verfahren zur herstellung von thienylaethylaminen, und mittels des verfahrens hergestellte dithienylaethylamine.
ATE66465T1 (de) Verfahren zur herstellung von iminodiacetonitril.
HUP0103428A2 (hu) Új eljárás optikailag aktív alfa-amino-nitrilek előállítására
ATE225329T1 (de) Verfahren zur herstellung von r-(-)-carnitin
Lee et al. Enzymatic introduction of cyanide into imine for constructing optically active compound by (R)-oxy-nitrilase in almond meal
WO2004021981A3 (en) METHODS FOR THE PREPARATION OF β-AMINO ACIDS
HUP0003857A2 (hu) Eljárás alkoxi-furanon-amin-származékok előállítására, az eljárással kapott vegyületek és a vegyületek alkalmazása
DE60040592D1 (de) Verfahren zur herstellung von alpha-aminoketonen
EA199901059A1 (ru) Способ получения энантиомерно обогащенных n-производных лактамов
Lebedev Preparation of chiral 4-substituted γ-lactams and the corresponding γ-aminobutyric acids.
HUP0001852A2 (hu) Új eljárás 3-(N,N-diciklobutil-amino)-8-fluor-3,4-dihidro-2H-1-benzopirán-5-karboxamid racém és enantiomer formáinak előállítására, és az eljárás intermedierei
DE69127960D1 (de) Verfahren zur Herstellung von (S)-vinyl- und (S)-allenyl-Gaba
WO2002057227A3 (en) Process of enantiomerically enriched flavor and fragrance components
ATE143415T1 (de) D-2,4-dihydroxy-3,3-dimethylbutansäurenitril, seine herstellung und verwendung sowie verfahren zur herstellung von d-pantolacton, d-2,4- dihydroxy-3,3-dimethylbutansäureamid und d- pantothensäure
ATE161822T1 (de) Verfahren zur herstellung von (s)-4-aminohepta- 5,6-diencarbon-säure und intermediate
ATE260883T1 (de) Verfahren zur herstellung von atropasäureethylester
HUP9601362A2 (hu) Eljárás optikailag aktív vegyületek előállítására
DE69519864T2 (de) Verfahren zur herstellung von chiralen tetrazyklischen dopaminergischen verbindungen
ATE370182T1 (de) Polyaminosäuren und verfahren zu deren herstellung

Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee