HUP0000777A2 - Ritalinsav só rezolválása - Google Patents

Ritalinsav só rezolválása

Info

Publication number
HUP0000777A2
HUP0000777A2 HU0000777A HUP0000777A HUP0000777A2 HU P0000777 A2 HUP0000777 A2 HU P0000777A2 HU 0000777 A HU0000777 A HU 0000777A HU P0000777 A HUP0000777 A HU P0000777A HU P0000777 A2 HUP0000777 A2 HU P0000777A2
Authority
HU
Hungary
Prior art keywords
resolution
acid salt
acid
ritalinic acid
treo
Prior art date
Application number
HU0000777A
Other languages
English (en)
Inventor
Gerard Andrew Potter
Hooshang Shahriari Zavareh
Original Assignee
Medeva Europe Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medeva Europe Limited filed Critical Medeva Europe Limited
Publication of HUP0000777A2 publication Critical patent/HUP0000777A2/hu
Publication of HUP0000777A3 publication Critical patent/HUP0000777A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Gyroscopes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány tárgya eljárás treő-ritalinsav enantiőmer-dúsítőttfőrmájának előállítására. A találmány értelmében úgy járnak el, hőgy asav egy akirális vagy királis savval, vagy bázissal képzett sójaenantiőmereinek keverékét egy királis rezőlválószer alkalmazásávalrezőlválják. A találmány kiterjed d-treő-metil-fenidát előállítására,valamint a treő-ritalinsav új kettős sójára is. ŕ
HU0000777A 1997-01-17 1998-01-14 Resolution of ritalinic acid salt HUP0000777A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9700912.0A GB9700912D0 (en) 1997-01-17 1997-01-17 Resolution
PCT/GB1998/000112 WO1998031668A1 (en) 1997-01-17 1998-01-14 Resolution of ritalinic acid salt

Publications (2)

Publication Number Publication Date
HUP0000777A2 true HUP0000777A2 (hu) 2000-09-28
HUP0000777A3 HUP0000777A3 (en) 2000-10-30

Family

ID=10806137

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000777A HUP0000777A3 (en) 1997-01-17 1998-01-14 Resolution of ritalinic acid salt

Country Status (17)

Country Link
US (1) US6441178B2 (hu)
EP (1) EP0958281B1 (hu)
JP (1) JP2001508791A (hu)
AT (1) ATE262510T1 (hu)
AU (1) AU5569198A (hu)
CA (1) CA2272716C (hu)
CZ (1) CZ293045B6 (hu)
DE (1) DE69822606T2 (hu)
DK (1) DK0958281T3 (hu)
ES (1) ES2218799T3 (hu)
GB (1) GB9700912D0 (hu)
HU (1) HUP0000777A3 (hu)
NO (1) NO993517L (hu)
PL (1) PL189745B1 (hu)
PT (1) PT958281E (hu)
WO (1) WO1998031668A1 (hu)
ZA (1) ZA98374B (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837284A (en) 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US6486177B2 (en) 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5922736A (en) * 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
US6962997B1 (en) 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
US7247730B2 (en) * 2003-03-07 2007-07-24 Isp Investments Inc. Process for the preparation of dexmethylphenidate hydrochloride
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
AU2005313887B2 (en) * 2004-12-09 2011-10-27 Celgene Corporation Treatment using D-threo methylphenidate
WO2010128517A1 (en) * 2009-05-07 2010-11-11 Malladi Drugs & Pharmaceuticals Ltd. Improved process for the preparation of d-threo-ritalinic acid hydrochloride by resolution of dl-threo-ritalinic acid using chiral carboxylic acid
JP5886869B2 (ja) * 2010-12-17 2016-03-16 ローズ テクノロジーズ メチルフェニデート塩酸塩の低温合成
US9283214B2 (en) 2011-03-23 2016-03-15 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9119809B2 (en) 2011-03-23 2015-09-01 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9603809B2 (en) 2011-03-23 2017-03-28 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
US9498447B2 (en) 2011-03-23 2016-11-22 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US8916588B2 (en) 2011-03-23 2014-12-23 Ironshore Pharmaceuticals & Development, Inc. Methods for treatment of attention deficit hyperactivity disorder
US10292937B2 (en) 2011-03-23 2019-05-21 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
US10905652B2 (en) 2011-03-23 2021-02-02 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US11241391B2 (en) 2011-03-23 2022-02-08 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
CN103608004A (zh) 2011-03-23 2014-02-26 艾伦索尔医药发展股份有限公司 用于治疗注意力缺陷障碍的方法和组合物
US8927010B2 (en) 2011-03-23 2015-01-06 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9278928B2 (en) * 2012-11-29 2016-03-08 Zcl Chemicals Limited Process for the preparation of d-threo-ritalinic acid salts via novel salts of intermediate thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2957880A (en) * 1953-12-23 1960-10-25 Ciba Pharm Prod Inc Process for the conversion of stereoisomers
SU466229A1 (ru) * 1973-01-23 1975-04-05 Всесоюзный научно-исследовательский химико-фармацевтический институт им. С.Орджоникидзе Способ получени гидрохлорида метилового эфира трео- -фенил- (пиперидил-2)-уксусной кислоты
US4285964A (en) 1979-08-30 1981-08-25 Continental Pharma Salts of (+)-catechine, their preparation and use, and compositions containing these salts
US5162344A (en) 1987-05-04 1992-11-10 Robert Koch Procaine double salt complexes
DE69716713T2 (de) * 1996-02-02 2003-07-03 Medeva Europ Ltd Verfahren zur herstellung von d-threo-(r,r)-methylphenidat und recycling nicht erwünschter enantiomere durch epimerisierung
ATE212336T1 (de) * 1996-03-08 2002-02-15 Medeva Europ Ltd Auflösungsverfahren von threo-methylphenidate

Also Published As

Publication number Publication date
EP0958281B1 (en) 2004-03-24
NO993517D0 (no) 1999-07-16
HUP0000777A3 (en) 2000-10-30
CZ293045B6 (cs) 2004-01-14
PL334838A1 (en) 2000-03-27
DE69822606D1 (de) 2004-04-29
GB9700912D0 (en) 1997-03-05
US6441178B2 (en) 2002-08-27
ATE262510T1 (de) 2004-04-15
EP0958281A1 (en) 1999-11-24
ES2218799T3 (es) 2004-11-16
JP2001508791A (ja) 2001-07-03
CZ230299A3 (cs) 1999-11-17
US20020019535A1 (en) 2002-02-14
DE69822606T2 (de) 2004-08-05
CA2272716A1 (en) 1998-07-23
NO993517L (no) 1999-07-16
PL189745B1 (pl) 2005-09-30
DK0958281T3 (da) 2004-06-14
AU5569198A (en) 1998-08-07
ZA98374B (en) 1999-01-22
WO1998031668A1 (en) 1998-07-23
CA2272716C (en) 2007-09-18
PT958281E (pt) 2004-07-30

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