HUP0101025A1 - 1-Metil-5-p-toluoilpirrol-2-acetamidoecetsav-gvajakonil-észter új kristályos polimorf formája - Google Patents

1-Metil-5-p-toluoilpirrol-2-acetamidoecetsav-gvajakonil-észter új kristályos polimorf formája

Info

Publication number
HUP0101025A1
HUP0101025A1 HU0101025A HUP0101025A HUP0101025A1 HU P0101025 A1 HUP0101025 A1 HU P0101025A1 HU 0101025 A HU0101025 A HU 0101025A HU P0101025 A HUP0101025 A HU P0101025A HU P0101025 A1 HUP0101025 A1 HU P0101025A1
Authority
HU
Hungary
Prior art keywords
toluoylpyrrole
methyl
polymorphic form
new crystalline
crystalline polymorphic
Prior art date
Application number
HU0101025A
Other languages
English (en)
Inventor
Sergio Anzalone
Original Assignee
Medosan Industrie Biochimiche Riunite S.R.L.
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medosan Industrie Biochimiche Riunite S.R.L., Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Medosan Industrie Biochimiche Riunite S.R.L.
Publication of HUP0101025A1 publication Critical patent/HUP0101025A1/hu
Publication of HUP0101025A3 publication Critical patent/HUP0101025A3/hu
Publication of HU228112B1 publication Critical patent/HU228112B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány az (I) képletű 1-metil-5-p-toluoilpirrol-2-acet-amidoecetsav-gvajakonil-észter új, polimorf kristályos módosulatáravonatkozik, e vegyületet MED 15, 2 formaként jelöljük. A találmányoltalmi körébe tartozik továbbá a MED 15, 2 forma vegyület előállításieljárása is. A fenti vegyület gyulladásgátló, analgetikus éslázcsillapító hatású. Ó
HU0101025A 1997-12-24 1998-12-16 New crystalline polymorphic form of 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid guaiacyl ester HU228112B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97RM000811A IT1297140B1 (it) 1997-12-24 1997-12-24 Forma cristallina del guaiacil estere dell'acido l-metil-5-p-toluoil- pirrol-2-acetammidoacetico, procedimento per la sua preparazione e
PCT/IT1998/000363 WO1999033797A1 (en) 1997-12-24 1998-12-16 NEW CRYSTALLINE POLYMORPHIC FORM OF 1-METHYL-5-p-TOLUOYLPYRROLE-2-ACETAMIDOACETIC ACID GUAIACYL ESTER (MED 15)

Publications (3)

Publication Number Publication Date
HUP0101025A1 true HUP0101025A1 (hu) 2001-08-28
HUP0101025A3 HUP0101025A3 (en) 2001-09-28
HU228112B1 HU228112B1 (en) 2012-11-28

Family

ID=11405418

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101025A HU228112B1 (en) 1997-12-24 1998-12-16 New crystalline polymorphic form of 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid guaiacyl ester

Country Status (22)

Country Link
US (1) US6288241B1 (hu)
EP (1) EP1082304B1 (hu)
JP (1) JP4693236B2 (hu)
KR (1) KR100554704B1 (hu)
CN (1) CN1200930C (hu)
AT (1) ATE255562T1 (hu)
AU (1) AU781283B2 (hu)
BR (1) BR9814476A (hu)
CA (1) CA2315835C (hu)
CZ (1) CZ297132B6 (hu)
DE (1) DE69820301T2 (hu)
DK (1) DK1082304T3 (hu)
ES (1) ES2210853T3 (hu)
HK (1) HK1035717A1 (hu)
HU (1) HU228112B1 (hu)
IL (1) IL136828A (hu)
IT (1) IT1297140B1 (hu)
PL (1) PL197768B1 (hu)
PT (1) PT1082304E (hu)
SK (1) SK284777B6 (hu)
TR (1) TR200001867T2 (hu)
WO (1) WO1999033797A1 (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020229118A1 (en) * 2019-02-28 2021-09-23 Tokyo Institute Of Technology Method for producing amide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1210673B (it) 1982-02-26 1989-09-20 Medosan Ind Biochimi Antinfiammatoria amidi pirrolacetiche ad attivita'
IT1148117B (it) * 1982-03-05 1986-11-26 Medosan Ind Biochimi Attivita'antiflogistica,analgesica,antipiretica,mucolitica e seda tiva della tosse dell'1 metil-5-p-tolilpirrol-2-acetato di 2'metossi-fenile
IT1197688B (it) * 1983-07-29 1988-12-06 Medosan Ind Biochimi Attivita' antiflogistica,analgesica,antipiretica ed antiaggregante piastrinica di 1-metil-5-metilbenzoilpirrol-2-acetamido acetanilidi
IT1278144B1 (it) * 1995-07-14 1997-11-17 Medosan Ricerca Srl Impiego dell'amtolmetineguacil (med 15) come farmaco antisecretivo sulla secrezione gastrica e quindi gastroprotettivo.
ATE237326T1 (de) * 1997-08-08 2003-05-15 Medosan Ricerca Srl Verwendung von 2-methoxyphenyl-1-methyl-5p-methyl-benzoylpyrro -2-acetamido-acetat zur herstellung eines antientzündungsmittels mit vorbeugung von magenhypersekretion und nierenfunktionsstörung

Also Published As

Publication number Publication date
KR100554704B1 (ko) 2006-02-24
IL136828A (en) 2005-08-31
DK1082304T3 (da) 2004-04-05
CN1200930C (zh) 2005-05-11
PL341424A1 (en) 2001-04-09
AU781283B2 (en) 2005-05-12
SK8952000A3 (en) 2000-12-11
DE69820301D1 (de) 2004-01-15
HUP0101025A3 (en) 2001-09-28
ATE255562T1 (de) 2003-12-15
HK1035717A1 (en) 2001-12-07
PL197768B1 (pl) 2008-04-30
CZ20002336A3 (cs) 2000-12-13
CA2315835C (en) 2008-03-25
SK284777B6 (sk) 2005-11-03
AU1782899A (en) 1999-07-19
EP1082304B1 (en) 2003-12-03
TR200001867T2 (tr) 2000-12-21
JP4693236B2 (ja) 2011-06-01
PT1082304E (pt) 2004-04-30
BR9814476A (pt) 2000-10-10
IT1297140B1 (it) 1999-08-03
IL136828A0 (en) 2001-06-14
EP1082304A1 (en) 2001-03-14
WO1999033797A1 (en) 1999-07-08
DE69820301T2 (de) 2004-10-14
US6288241B1 (en) 2001-09-11
ITRM970811A1 (it) 1999-06-24
CA2315835A1 (en) 1999-07-08
CN1283185A (zh) 2001-02-07
KR20010033497A (ko) 2001-04-25
CZ297132B6 (cs) 2006-09-13
HU228112B1 (en) 2012-11-28
JP2001527064A (ja) 2001-12-25
ES2210853T3 (es) 2004-07-01

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