SK284777B6 - Kryštalická polymorfná forma guajacyl esteru kyseliny 1-metyl-5-p-toluoylpyrol-2-acetaminooctovej a spôsob jej prípravy - Google Patents

Kryštalická polymorfná forma guajacyl esteru kyseliny 1-metyl-5-p-toluoylpyrol-2-acetaminooctovej a spôsob jej prípravy Download PDF

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Publication number
SK284777B6
SK284777B6 SK895-2000A SK8952000A SK284777B6 SK 284777 B6 SK284777 B6 SK 284777B6 SK 8952000 A SK8952000 A SK 8952000A SK 284777 B6 SK284777 B6 SK 284777B6
Authority
SK
Slovakia
Prior art keywords
methyl
toluoylpyrrole
ester
acetamidoacetic acid
mixture
Prior art date
Application number
SK895-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK8952000A3 (en
Inventor
Sergio Anzalone
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Medosan Industrie Biochimiche Riunite S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A., Medosan Industrie Biochimiche Riunite S.R.L. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of SK8952000A3 publication Critical patent/SK8952000A3/sk
Publication of SK284777B6 publication Critical patent/SK284777B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
SK895-2000A 1997-12-24 1998-12-16 Kryštalická polymorfná forma guajacyl esteru kyseliny 1-metyl-5-p-toluoylpyrol-2-acetaminooctovej a spôsob jej prípravy SK284777B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97RM000811A IT1297140B1 (it) 1997-12-24 1997-12-24 Forma cristallina del guaiacil estere dell'acido l-metil-5-p-toluoil- pirrol-2-acetammidoacetico, procedimento per la sua preparazione e
PCT/IT1998/000363 WO1999033797A1 (en) 1997-12-24 1998-12-16 NEW CRYSTALLINE POLYMORPHIC FORM OF 1-METHYL-5-p-TOLUOYLPYRROLE-2-ACETAMIDOACETIC ACID GUAIACYL ESTER (MED 15)

Publications (2)

Publication Number Publication Date
SK8952000A3 SK8952000A3 (en) 2000-12-11
SK284777B6 true SK284777B6 (sk) 2005-11-03

Family

ID=11405418

Family Applications (1)

Application Number Title Priority Date Filing Date
SK895-2000A SK284777B6 (sk) 1997-12-24 1998-12-16 Kryštalická polymorfná forma guajacyl esteru kyseliny 1-metyl-5-p-toluoylpyrol-2-acetaminooctovej a spôsob jej prípravy

Country Status (22)

Country Link
US (1) US6288241B1 (hu)
EP (1) EP1082304B1 (hu)
JP (1) JP4693236B2 (hu)
KR (1) KR100554704B1 (hu)
CN (1) CN1200930C (hu)
AT (1) ATE255562T1 (hu)
AU (1) AU781283B2 (hu)
BR (1) BR9814476A (hu)
CA (1) CA2315835C (hu)
CZ (1) CZ297132B6 (hu)
DE (1) DE69820301T2 (hu)
DK (1) DK1082304T3 (hu)
ES (1) ES2210853T3 (hu)
HK (1) HK1035717A1 (hu)
HU (1) HU228112B1 (hu)
IL (1) IL136828A (hu)
IT (1) IT1297140B1 (hu)
PL (1) PL197768B1 (hu)
PT (1) PT1082304E (hu)
SK (1) SK284777B6 (hu)
TR (1) TR200001867T2 (hu)
WO (1) WO1999033797A1 (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2020175023A1 (ja) * 2019-02-28 2021-12-16 国立大学法人東京工業大学 アミドの製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1210673B (it) * 1982-02-26 1989-09-20 Medosan Ind Biochimi Antinfiammatoria amidi pirrolacetiche ad attivita'
IT1148117B (it) * 1982-03-05 1986-11-26 Medosan Ind Biochimi Attivita'antiflogistica,analgesica,antipiretica,mucolitica e seda tiva della tosse dell'1 metil-5-p-tolilpirrol-2-acetato di 2'metossi-fenile
IT1197688B (it) * 1983-07-29 1988-12-06 Medosan Ind Biochimi Attivita' antiflogistica,analgesica,antipiretica ed antiaggregante piastrinica di 1-metil-5-metilbenzoilpirrol-2-acetamido acetanilidi
IT1278144B1 (it) * 1995-07-14 1997-11-17 Medosan Ricerca Srl Impiego dell'amtolmetineguacil (med 15) come farmaco antisecretivo sulla secrezione gastrica e quindi gastroprotettivo.
ATE237326T1 (de) * 1997-08-08 2003-05-15 Medosan Ricerca Srl Verwendung von 2-methoxyphenyl-1-methyl-5p-methyl-benzoylpyrro -2-acetamido-acetat zur herstellung eines antientzündungsmittels mit vorbeugung von magenhypersekretion und nierenfunktionsstörung

Also Published As

Publication number Publication date
ATE255562T1 (de) 2003-12-15
DE69820301T2 (de) 2004-10-14
WO1999033797A1 (en) 1999-07-08
DE69820301D1 (de) 2004-01-15
CN1200930C (zh) 2005-05-11
JP4693236B2 (ja) 2011-06-01
CA2315835A1 (en) 1999-07-08
JP2001527064A (ja) 2001-12-25
ES2210853T3 (es) 2004-07-01
HUP0101025A1 (hu) 2001-08-28
PL197768B1 (pl) 2008-04-30
PL341424A1 (en) 2001-04-09
KR20010033497A (ko) 2001-04-25
SK8952000A3 (en) 2000-12-11
PT1082304E (pt) 2004-04-30
CZ297132B6 (cs) 2006-09-13
IL136828A (en) 2005-08-31
AU781283B2 (en) 2005-05-12
IT1297140B1 (it) 1999-08-03
KR100554704B1 (ko) 2006-02-24
EP1082304B1 (en) 2003-12-03
EP1082304A1 (en) 2001-03-14
BR9814476A (pt) 2000-10-10
AU1782899A (en) 1999-07-19
IL136828A0 (en) 2001-06-14
TR200001867T2 (tr) 2000-12-21
CZ20002336A3 (cs) 2000-12-13
HU228112B1 (en) 2012-11-28
DK1082304T3 (da) 2004-04-05
US6288241B1 (en) 2001-09-11
HK1035717A1 (en) 2001-12-07
CA2315835C (en) 2008-03-25
CN1283185A (zh) 2001-02-07
HUP0101025A3 (en) 2001-09-28
ITRM970811A1 (it) 1999-06-24

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Legal Events

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MK4A Expiry of patent

Expiry date: 20181216