BR9814476A - "forma polimórfica cristalina de guaiacil éster de ácido 1-metil-5-p-toluoilpirrol-2 acetamido acético (med 15)" - Google Patents

"forma polimórfica cristalina de guaiacil éster de ácido 1-metil-5-p-toluoilpirrol-2 acetamido acético (med 15)"

Info

Publication number
BR9814476A
BR9814476A BR9814476-6A BR9814476A BR9814476A BR 9814476 A BR9814476 A BR 9814476A BR 9814476 A BR9814476 A BR 9814476A BR 9814476 A BR9814476 A BR 9814476A
Authority
BR
Brazil
Prior art keywords
methyl
toluoylpyrrole
med
ester
polymorphic form
Prior art date
Application number
BR9814476-6A
Other languages
English (en)
Inventor
Sergio Anzalone
Original Assignee
Sigma Tau Ind Farmaceuti
Medosan Ind Biochimi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Medosan Ind Biochimi filed Critical Sigma Tau Ind Farmaceuti
Publication of BR9814476A publication Critical patent/BR9814476A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção:<B>"FORMA POLIMóRFICA CRISTALINA DE GUAIACIL éSTER DE áCIDO 1-METIL-5-p-TOLUOILPIRROL-2-ACETAMIDO ACéTICO (MED 15)". São descritos uma nova forma cristalina de guaiacil éster ácido de 1-metil-5-p-toluoilpirrol-2-acetamidoacético, um processo para sua preparação e composição farmacêuticas contempladas com atividade antiinflamatória, analgésica a antipirética contendo a mesma.
BR9814476-6A 1997-12-24 1998-12-16 "forma polimórfica cristalina de guaiacil éster de ácido 1-metil-5-p-toluoilpirrol-2 acetamido acético (med 15)" BR9814476A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97RM000811A IT1297140B1 (it) 1997-12-24 1997-12-24 Forma cristallina del guaiacil estere dell'acido l-metil-5-p-toluoil- pirrol-2-acetammidoacetico, procedimento per la sua preparazione e
PCT/IT1998/000363 WO1999033797A1 (en) 1997-12-24 1998-12-16 NEW CRYSTALLINE POLYMORPHIC FORM OF 1-METHYL-5-p-TOLUOYLPYRROLE-2-ACETAMIDOACETIC ACID GUAIACYL ESTER (MED 15)

Publications (1)

Publication Number Publication Date
BR9814476A true BR9814476A (pt) 2000-10-10

Family

ID=11405418

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814476-6A BR9814476A (pt) 1997-12-24 1998-12-16 "forma polimórfica cristalina de guaiacil éster de ácido 1-metil-5-p-toluoilpirrol-2 acetamido acético (med 15)"

Country Status (22)

Country Link
US (1) US6288241B1 (pt)
EP (1) EP1082304B1 (pt)
JP (1) JP4693236B2 (pt)
KR (1) KR100554704B1 (pt)
CN (1) CN1200930C (pt)
AT (1) ATE255562T1 (pt)
AU (1) AU781283B2 (pt)
BR (1) BR9814476A (pt)
CA (1) CA2315835C (pt)
CZ (1) CZ297132B6 (pt)
DE (1) DE69820301T2 (pt)
DK (1) DK1082304T3 (pt)
ES (1) ES2210853T3 (pt)
HK (1) HK1035717A1 (pt)
HU (1) HU228112B1 (pt)
IL (1) IL136828A (pt)
IT (1) IT1297140B1 (pt)
PL (1) PL197768B1 (pt)
PT (1) PT1082304E (pt)
SK (1) SK284777B6 (pt)
TR (1) TR200001867T2 (pt)
WO (1) WO1999033797A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020175023A1 (ja) * 2019-02-28 2020-09-03 国立大学法人東京工業大学 アミドの製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1210673B (it) * 1982-02-26 1989-09-20 Medosan Ind Biochimi Antinfiammatoria amidi pirrolacetiche ad attivita'
IT1148117B (it) 1982-03-05 1986-11-26 Medosan Ind Biochimi Attivita'antiflogistica,analgesica,antipiretica,mucolitica e seda tiva della tosse dell'1 metil-5-p-tolilpirrol-2-acetato di 2'metossi-fenile
IT1197688B (it) 1983-07-29 1988-12-06 Medosan Ind Biochimi Attivita' antiflogistica,analgesica,antipiretica ed antiaggregante piastrinica di 1-metil-5-metilbenzoilpirrol-2-acetamido acetanilidi
IT1278144B1 (it) 1995-07-14 1997-11-17 Medosan Ricerca Srl Impiego dell'amtolmetineguacil (med 15) come farmaco antisecretivo sulla secrezione gastrica e quindi gastroprotettivo.
DK1024807T3 (da) 1997-08-08 2003-08-04 Medosan Ricerca Srl Anvendelse af forbindelsen 2-methoxyphenyl-1-methyl-5p-methylbenzoyl-pyrrol-2-acetamidoacetat for fremstilling af et anti-inflammatorisk medikament med forhindring af gastrisk hypersecernering og forstyrrelse af nyrefunktionen

Also Published As

Publication number Publication date
CN1200930C (zh) 2005-05-11
DE69820301D1 (de) 2004-01-15
EP1082304A1 (en) 2001-03-14
WO1999033797A1 (en) 1999-07-08
AU1782899A (en) 1999-07-19
PT1082304E (pt) 2004-04-30
DE69820301T2 (de) 2004-10-14
DK1082304T3 (da) 2004-04-05
HU228112B1 (en) 2012-11-28
CZ297132B6 (cs) 2006-09-13
IT1297140B1 (it) 1999-08-03
EP1082304B1 (en) 2003-12-03
KR100554704B1 (ko) 2006-02-24
SK8952000A3 (en) 2000-12-11
JP2001527064A (ja) 2001-12-25
HUP0101025A3 (en) 2001-09-28
PL341424A1 (en) 2001-04-09
AU781283B2 (en) 2005-05-12
ES2210853T3 (es) 2004-07-01
HUP0101025A1 (hu) 2001-08-28
JP4693236B2 (ja) 2011-06-01
TR200001867T2 (tr) 2000-12-21
KR20010033497A (ko) 2001-04-25
PL197768B1 (pl) 2008-04-30
CN1283185A (zh) 2001-02-07
IL136828A0 (en) 2001-06-14
ATE255562T1 (de) 2003-12-15
HK1035717A1 (en) 2001-12-07
CZ20002336A3 (cs) 2000-12-13
CA2315835C (en) 2008-03-25
SK284777B6 (sk) 2005-11-03
CA2315835A1 (en) 1999-07-08
US6288241B1 (en) 2001-09-11
ITRM970811A1 (it) 1999-06-24
IL136828A (en) 2005-08-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08G Application fees: restoration [chapter 8.7 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL: C07D 207/323, A61K 31/40, A61P 29/00

Ipc: C07D 207/323 (2009.01), A61K 31/40 (2009.01), A61P

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AO ESTABELECIDO NOS ART. 8O, 11 E24 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]