IL136828A - CRYSTALLINE POLYMORPHIC FORM OF 1-METHYL-5-p-TOLUOYLPYRROLE-2-ACETAMIDOACETIC ACID GUAIACYL ESTER (MED 15) - Google Patents

CRYSTALLINE POLYMORPHIC FORM OF 1-METHYL-5-p-TOLUOYLPYRROLE-2-ACETAMIDOACETIC ACID GUAIACYL ESTER (MED 15)

Info

Publication number
IL136828A
IL136828A IL13682898A IL13682898A IL136828A IL 136828 A IL136828 A IL 136828A IL 13682898 A IL13682898 A IL 13682898A IL 13682898 A IL13682898 A IL 13682898A IL 136828 A IL136828 A IL 136828A
Authority
IL
Israel
Prior art keywords
toluoylpyrrole
methyl
med
polymorphic form
crystalline polymorphic
Prior art date
Application number
IL13682898A
Other languages
English (en)
Other versions
IL136828A0 (en
Original Assignee
Sigma Tau Ind Farmaceuti
Medosan Ind Biochimi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Medosan Ind Biochimi filed Critical Sigma Tau Ind Farmaceuti
Publication of IL136828A0 publication Critical patent/IL136828A0/xx
Publication of IL136828A publication Critical patent/IL136828A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
IL13682898A 1997-12-24 1998-12-16 CRYSTALLINE POLYMORPHIC FORM OF 1-METHYL-5-p-TOLUOYLPYRROLE-2-ACETAMIDOACETIC ACID GUAIACYL ESTER (MED 15) IL136828A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97RM000811A IT1297140B1 (it) 1997-12-24 1997-12-24 Forma cristallina del guaiacil estere dell'acido l-metil-5-p-toluoil- pirrol-2-acetammidoacetico, procedimento per la sua preparazione e
PCT/IT1998/000363 WO1999033797A1 (en) 1997-12-24 1998-12-16 NEW CRYSTALLINE POLYMORPHIC FORM OF 1-METHYL-5-p-TOLUOYLPYRROLE-2-ACETAMIDOACETIC ACID GUAIACYL ESTER (MED 15)

Publications (2)

Publication Number Publication Date
IL136828A0 IL136828A0 (en) 2001-06-14
IL136828A true IL136828A (en) 2005-08-31

Family

ID=11405418

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13682898A IL136828A (en) 1997-12-24 1998-12-16 CRYSTALLINE POLYMORPHIC FORM OF 1-METHYL-5-p-TOLUOYLPYRROLE-2-ACETAMIDOACETIC ACID GUAIACYL ESTER (MED 15)

Country Status (22)

Country Link
US (1) US6288241B1 (xx)
EP (1) EP1082304B1 (xx)
JP (1) JP4693236B2 (xx)
KR (1) KR100554704B1 (xx)
CN (1) CN1200930C (xx)
AT (1) ATE255562T1 (xx)
AU (1) AU781283B2 (xx)
BR (1) BR9814476A (xx)
CA (1) CA2315835C (xx)
CZ (1) CZ297132B6 (xx)
DE (1) DE69820301T2 (xx)
DK (1) DK1082304T3 (xx)
ES (1) ES2210853T3 (xx)
HK (1) HK1035717A1 (xx)
HU (1) HU228112B1 (xx)
IL (1) IL136828A (xx)
IT (1) IT1297140B1 (xx)
PL (1) PL197768B1 (xx)
PT (1) PT1082304E (xx)
SK (1) SK284777B6 (xx)
TR (1) TR200001867T2 (xx)
WO (1) WO1999033797A1 (xx)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2020175023A1 (ja) * 2019-02-28 2021-12-16 国立大学法人東京工業大学 アミドの製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1210673B (it) * 1982-02-26 1989-09-20 Medosan Ind Biochimi Antinfiammatoria amidi pirrolacetiche ad attivita'
IT1148117B (it) * 1982-03-05 1986-11-26 Medosan Ind Biochimi Attivita'antiflogistica,analgesica,antipiretica,mucolitica e seda tiva della tosse dell'1 metil-5-p-tolilpirrol-2-acetato di 2'metossi-fenile
IT1197688B (it) * 1983-07-29 1988-12-06 Medosan Ind Biochimi Attivita' antiflogistica,analgesica,antipiretica ed antiaggregante piastrinica di 1-metil-5-metilbenzoilpirrol-2-acetamido acetanilidi
IT1278144B1 (it) * 1995-07-14 1997-11-17 Medosan Ricerca Srl Impiego dell'amtolmetineguacil (med 15) come farmaco antisecretivo sulla secrezione gastrica e quindi gastroprotettivo.
ATE237326T1 (de) * 1997-08-08 2003-05-15 Medosan Ricerca Srl Verwendung von 2-methoxyphenyl-1-methyl-5p-methyl-benzoylpyrro -2-acetamido-acetat zur herstellung eines antientzündungsmittels mit vorbeugung von magenhypersekretion und nierenfunktionsstörung

Also Published As

Publication number Publication date
ATE255562T1 (de) 2003-12-15
DE69820301T2 (de) 2004-10-14
WO1999033797A1 (en) 1999-07-08
DE69820301D1 (de) 2004-01-15
CN1200930C (zh) 2005-05-11
JP4693236B2 (ja) 2011-06-01
CA2315835A1 (en) 1999-07-08
JP2001527064A (ja) 2001-12-25
ES2210853T3 (es) 2004-07-01
HUP0101025A1 (hu) 2001-08-28
PL197768B1 (pl) 2008-04-30
PL341424A1 (en) 2001-04-09
KR20010033497A (ko) 2001-04-25
SK8952000A3 (en) 2000-12-11
PT1082304E (pt) 2004-04-30
CZ297132B6 (cs) 2006-09-13
AU781283B2 (en) 2005-05-12
IT1297140B1 (it) 1999-08-03
KR100554704B1 (ko) 2006-02-24
EP1082304B1 (en) 2003-12-03
EP1082304A1 (en) 2001-03-14
BR9814476A (pt) 2000-10-10
AU1782899A (en) 1999-07-19
SK284777B6 (sk) 2005-11-03
IL136828A0 (en) 2001-06-14
TR200001867T2 (tr) 2000-12-21
CZ20002336A3 (cs) 2000-12-13
HU228112B1 (en) 2012-11-28
DK1082304T3 (da) 2004-04-05
US6288241B1 (en) 2001-09-11
HK1035717A1 (en) 2001-12-07
CA2315835C (en) 2008-03-25
CN1283185A (zh) 2001-02-07
HUP0101025A3 (en) 2001-09-28
ITRM970811A1 (it) 1999-06-24

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