DE69820301D1 - Neue krystalline polymorphe form von 1-methyl-5-p-toluoylpyrrol-2-acetamidoessigsäure guaiacyl ester (med 15) - Google Patents
Neue krystalline polymorphe form von 1-methyl-5-p-toluoylpyrrol-2-acetamidoessigsäure guaiacyl ester (med 15)Info
- Publication number
- DE69820301D1 DE69820301D1 DE69820301T DE69820301T DE69820301D1 DE 69820301 D1 DE69820301 D1 DE 69820301D1 DE 69820301 T DE69820301 T DE 69820301T DE 69820301 T DE69820301 T DE 69820301T DE 69820301 D1 DE69820301 D1 DE 69820301D1
- Authority
- DE
- Germany
- Prior art keywords
- methyl
- new
- toluoylpyrrol
- krystalline
- med
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97RM000811A IT1297140B1 (it) | 1997-12-24 | 1997-12-24 | Forma cristallina del guaiacil estere dell'acido l-metil-5-p-toluoil- pirrol-2-acetammidoacetico, procedimento per la sua preparazione e |
ITRM970811 | 1997-12-24 | ||
PCT/IT1998/000363 WO1999033797A1 (en) | 1997-12-24 | 1998-12-16 | NEW CRYSTALLINE POLYMORPHIC FORM OF 1-METHYL-5-p-TOLUOYLPYRROLE-2-ACETAMIDOACETIC ACID GUAIACYL ESTER (MED 15) |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69820301D1 true DE69820301D1 (de) | 2004-01-15 |
DE69820301T2 DE69820301T2 (de) | 2004-10-14 |
Family
ID=11405418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69820301T Expired - Lifetime DE69820301T2 (de) | 1997-12-24 | 1998-12-16 | Neue krystalline polymorphe form von 1-methyl-5-p-toluoylpyrrol-2-acetamidoessigsäure guaiacyl ester (med 15) |
Country Status (22)
Country | Link |
---|---|
US (1) | US6288241B1 (de) |
EP (1) | EP1082304B1 (de) |
JP (1) | JP4693236B2 (de) |
KR (1) | KR100554704B1 (de) |
CN (1) | CN1200930C (de) |
AT (1) | ATE255562T1 (de) |
AU (1) | AU781283B2 (de) |
BR (1) | BR9814476A (de) |
CA (1) | CA2315835C (de) |
CZ (1) | CZ297132B6 (de) |
DE (1) | DE69820301T2 (de) |
DK (1) | DK1082304T3 (de) |
ES (1) | ES2210853T3 (de) |
HK (1) | HK1035717A1 (de) |
HU (1) | HU228112B1 (de) |
IL (1) | IL136828A (de) |
IT (1) | IT1297140B1 (de) |
PL (1) | PL197768B1 (de) |
PT (1) | PT1082304E (de) |
SK (1) | SK284777B6 (de) |
TR (1) | TR200001867T2 (de) |
WO (1) | WO1999033797A1 (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220144884A1 (en) * | 2019-02-28 | 2022-05-12 | Tokyo Institute Of Technology | Method for producing amide |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1210673B (it) * | 1982-02-26 | 1989-09-20 | Medosan Ind Biochimi | Antinfiammatoria amidi pirrolacetiche ad attivita' |
IT1148117B (it) * | 1982-03-05 | 1986-11-26 | Medosan Ind Biochimi | Attivita'antiflogistica,analgesica,antipiretica,mucolitica e seda tiva della tosse dell'1 metil-5-p-tolilpirrol-2-acetato di 2'metossi-fenile |
IT1197688B (it) * | 1983-07-29 | 1988-12-06 | Medosan Ind Biochimi | Attivita' antiflogistica,analgesica,antipiretica ed antiaggregante piastrinica di 1-metil-5-metilbenzoilpirrol-2-acetamido acetanilidi |
IT1278144B1 (it) * | 1995-07-14 | 1997-11-17 | Medosan Ricerca Srl | Impiego dell'amtolmetineguacil (med 15) come farmaco antisecretivo sulla secrezione gastrica e quindi gastroprotettivo. |
JP2001513497A (ja) * | 1997-08-08 | 2001-09-04 | メドサン、リセルカ エス.アール.エル. | 胃分泌過多および腎損傷の予防作用を有する抗炎症剤の製造のための化合物2−メトキシフェニル−1−メチル−5p−メチルベンゾイル−ピロール−2−アセトアミドアセテートの使用 |
-
1997
- 1997-12-24 IT IT97RM000811A patent/IT1297140B1/it active IP Right Grant
-
1998
- 1998-12-16 JP JP2000526481A patent/JP4693236B2/ja not_active Expired - Lifetime
- 1998-12-16 TR TR2000/01867T patent/TR200001867T2/xx unknown
- 1998-12-16 SK SK895-2000A patent/SK284777B6/sk not_active IP Right Cessation
- 1998-12-16 EP EP98962664A patent/EP1082304B1/de not_active Expired - Lifetime
- 1998-12-16 IL IL13682898A patent/IL136828A/xx not_active IP Right Cessation
- 1998-12-16 DK DK98962664T patent/DK1082304T3/da active
- 1998-12-16 AT AT98962664T patent/ATE255562T1/de active
- 1998-12-16 PL PL341424A patent/PL197768B1/pl unknown
- 1998-12-16 DE DE69820301T patent/DE69820301T2/de not_active Expired - Lifetime
- 1998-12-16 HU HU0101025A patent/HU228112B1/hu unknown
- 1998-12-16 CN CNB988126567A patent/CN1200930C/zh not_active Expired - Lifetime
- 1998-12-16 AU AU17828/99A patent/AU781283B2/en not_active Expired
- 1998-12-16 CA CA002315835A patent/CA2315835C/en not_active Expired - Lifetime
- 1998-12-16 KR KR1020007006998A patent/KR100554704B1/ko not_active IP Right Cessation
- 1998-12-16 CZ CZ20002336A patent/CZ297132B6/cs not_active IP Right Cessation
- 1998-12-16 BR BR9814476-6A patent/BR9814476A/pt not_active Application Discontinuation
- 1998-12-16 US US09/581,289 patent/US6288241B1/en not_active Expired - Lifetime
- 1998-12-16 WO PCT/IT1998/000363 patent/WO1999033797A1/en active IP Right Grant
- 1998-12-16 PT PT98962664T patent/PT1082304E/pt unknown
- 1998-12-16 ES ES98962664T patent/ES2210853T3/es not_active Expired - Lifetime
-
2001
- 2001-07-10 HK HK01104771A patent/HK1035717A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |