HK1035717A1 - New crystalline polymorphic form of 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid guaiacyl ester (med 15) - Google Patents

New crystalline polymorphic form of 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid guaiacyl ester (med 15)

Info

Publication number
HK1035717A1
HK1035717A1 HK01104771A HK01104771A HK1035717A1 HK 1035717 A1 HK1035717 A1 HK 1035717A1 HK 01104771 A HK01104771 A HK 01104771A HK 01104771 A HK01104771 A HK 01104771A HK 1035717 A1 HK1035717 A1 HK 1035717A1
Authority
HK
Hong Kong
Prior art keywords
toluoylpyrrole
methyl
med
new crystalline
polymorphic form
Prior art date
Application number
HK01104771A
Other languages
English (en)
Inventor
Sergio Anzalone
Original Assignee
Sigma Tau Ind Farmaceuti
Medosan Ind Biochimi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Medosan Ind Biochimi filed Critical Sigma Tau Ind Farmaceuti
Publication of HK1035717A1 publication Critical patent/HK1035717A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
HK01104771A 1997-12-24 2001-07-10 New crystalline polymorphic form of 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid guaiacyl ester (med 15) HK1035717A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97RM000811A IT1297140B1 (it) 1997-12-24 1997-12-24 Forma cristallina del guaiacil estere dell'acido l-metil-5-p-toluoil- pirrol-2-acetammidoacetico, procedimento per la sua preparazione e
PCT/IT1998/000363 WO1999033797A1 (en) 1997-12-24 1998-12-16 NEW CRYSTALLINE POLYMORPHIC FORM OF 1-METHYL-5-p-TOLUOYLPYRROLE-2-ACETAMIDOACETIC ACID GUAIACYL ESTER (MED 15)

Publications (1)

Publication Number Publication Date
HK1035717A1 true HK1035717A1 (en) 2001-12-07

Family

ID=11405418

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01104771A HK1035717A1 (en) 1997-12-24 2001-07-10 New crystalline polymorphic form of 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid guaiacyl ester (med 15)

Country Status (22)

Country Link
US (1) US6288241B1 (xx)
EP (1) EP1082304B1 (xx)
JP (1) JP4693236B2 (xx)
KR (1) KR100554704B1 (xx)
CN (1) CN1200930C (xx)
AT (1) ATE255562T1 (xx)
AU (1) AU781283B2 (xx)
BR (1) BR9814476A (xx)
CA (1) CA2315835C (xx)
CZ (1) CZ297132B6 (xx)
DE (1) DE69820301T2 (xx)
DK (1) DK1082304T3 (xx)
ES (1) ES2210853T3 (xx)
HK (1) HK1035717A1 (xx)
HU (1) HU228112B1 (xx)
IL (1) IL136828A (xx)
IT (1) IT1297140B1 (xx)
PL (1) PL197768B1 (xx)
PT (1) PT1082304E (xx)
SK (1) SK284777B6 (xx)
TR (1) TR200001867T2 (xx)
WO (1) WO1999033797A1 (xx)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020229118A1 (en) * 2019-02-28 2021-09-23 Tokyo Institute Of Technology Method for producing amide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1210673B (it) * 1982-02-26 1989-09-20 Medosan Ind Biochimi Antinfiammatoria amidi pirrolacetiche ad attivita'
IT1148117B (it) * 1982-03-05 1986-11-26 Medosan Ind Biochimi Attivita'antiflogistica,analgesica,antipiretica,mucolitica e seda tiva della tosse dell'1 metil-5-p-tolilpirrol-2-acetato di 2'metossi-fenile
IT1197688B (it) * 1983-07-29 1988-12-06 Medosan Ind Biochimi Attivita' antiflogistica,analgesica,antipiretica ed antiaggregante piastrinica di 1-metil-5-metilbenzoilpirrol-2-acetamido acetanilidi
IT1278144B1 (it) * 1995-07-14 1997-11-17 Medosan Ricerca Srl Impiego dell'amtolmetineguacil (med 15) come farmaco antisecretivo sulla secrezione gastrica e quindi gastroprotettivo.
WO1999007363A1 (en) 1997-08-08 1999-02-18 Medosan, Ricerca S.R.L. Use of the compound 2-methoxyphenyl-1-methyl-5p-methylbenzoyl-pyrrol-2-acetamido acetate for the production of an anti-inflammatory drug with prevention of gastric hypersecretion and renal impairment

Also Published As

Publication number Publication date
CN1200930C (zh) 2005-05-11
PL197768B1 (pl) 2008-04-30
SK284777B6 (sk) 2005-11-03
DE69820301T2 (de) 2004-10-14
PL341424A1 (en) 2001-04-09
CN1283185A (zh) 2001-02-07
ITRM970811A1 (it) 1999-06-24
JP2001527064A (ja) 2001-12-25
DK1082304T3 (da) 2004-04-05
BR9814476A (pt) 2000-10-10
ATE255562T1 (de) 2003-12-15
DE69820301D1 (de) 2004-01-15
WO1999033797A1 (en) 1999-07-08
JP4693236B2 (ja) 2011-06-01
AU781283B2 (en) 2005-05-12
PT1082304E (pt) 2004-04-30
ES2210853T3 (es) 2004-07-01
TR200001867T2 (tr) 2000-12-21
CA2315835C (en) 2008-03-25
HU228112B1 (en) 2012-11-28
AU1782899A (en) 1999-07-19
IT1297140B1 (it) 1999-08-03
EP1082304B1 (en) 2003-12-03
KR100554704B1 (ko) 2006-02-24
SK8952000A3 (en) 2000-12-11
HUP0101025A3 (en) 2001-09-28
IL136828A (en) 2005-08-31
EP1082304A1 (en) 2001-03-14
CA2315835A1 (en) 1999-07-08
CZ297132B6 (cs) 2006-09-13
CZ20002336A3 (cs) 2000-12-13
IL136828A0 (en) 2001-06-14
HUP0101025A1 (hu) 2001-08-28
KR20010033497A (ko) 2001-04-25
US6288241B1 (en) 2001-09-11

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Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20181215