AU7035194A - 11-benzaldoxime-17beta-methoxy-17alpha- methoxymethylestradiene-derivatives, methods for their production and pharmaceuticals containing these substances - Google Patents

11-benzaldoxime-17beta-methoxy-17alpha- methoxymethylestradiene-derivatives, methods for their production and pharmaceuticals containing these substances

Info

Publication number
AU7035194A
AU7035194A AU70351/94A AU7035194A AU7035194A AU 7035194 A AU7035194 A AU 7035194A AU 70351/94 A AU70351/94 A AU 70351/94A AU 7035194 A AU7035194 A AU 7035194A AU 7035194 A AU7035194 A AU 7035194A
Authority
AU
Australia
Prior art keywords
benzaldoxime
derivatives
methoxymethylestradiene
17alpha
17beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU70351/94A
Other versions
AU682373B2 (en
Inventor
Walter Dr. Elger
Gunther Dr. Kaufmann
Anatoli Dr. Kurischko
Michael Prof. Dr. Oettel
Gerd Dr. Schubert
Lothar Dr. Sobeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU7035194A publication Critical patent/AU7035194A/en
Application granted granted Critical
Publication of AU682373B2 publication Critical patent/AU682373B2/en
Assigned to SCHERING AKTIENGESELLSCHAFT reassignment SCHERING AKTIENGESELLSCHAFT Alteration of Name(s) in Register under S187 Assignors: JENAPHARM GMBH
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

Abstract

11-Benzaldoxime-oestradiene derivatives of the general formula I <IMAGE> and their pharmaceutically acceptable salts, a process for their preparation and pharmaceutical compositions containing them are described. The described compounds display potent antigestagenic effects with lower glucocorticoid activity.
AU70351/94A 1993-09-20 1994-08-18 11-benzaldoxime-17beta-methoxy-17alpha- methoxymethylestradiene-derivatives, methods for their production and pharmaceuticals containing these substances Ceased AU682373B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4332284 1993-09-20
DE4332284A DE4332284C2 (en) 1993-09-20 1993-09-20 11-Benzaldoxime-17beta-methoxy-17alpha-methoxymethyl-estradiene derivatives, process for their preparation and medicaments containing these compounds

Publications (2)

Publication Number Publication Date
AU7035194A true AU7035194A (en) 1995-03-30
AU682373B2 AU682373B2 (en) 1997-10-02

Family

ID=6498354

Family Applications (1)

Application Number Title Priority Date Filing Date
AU70351/94A Ceased AU682373B2 (en) 1993-09-20 1994-08-18 11-benzaldoxime-17beta-methoxy-17alpha- methoxymethylestradiene-derivatives, methods for their production and pharmaceuticals containing these substances

Country Status (19)

Country Link
EP (1) EP0648779B1 (en)
JP (1) JP2696672B2 (en)
KR (1) KR100190775B1 (en)
AT (1) ATE149513T1 (en)
AU (1) AU682373B2 (en)
CA (1) CA2130515C (en)
CZ (1) CZ289801B6 (en)
DE (2) DE4332284C2 (en)
DK (1) DK0648779T3 (en)
ES (1) ES2102144T3 (en)
FI (1) FI112948B (en)
GR (1) GR3023644T3 (en)
HU (1) HU219399B (en)
NO (1) NO304988B1 (en)
NZ (1) NZ264228A (en)
PL (1) PL179460B1 (en)
RU (1) RU2130944C1 (en)
SK (1) SK280315B6 (en)
UA (1) UA39101C2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332283A1 (en) * 1993-09-20 1995-04-13 Jenapharm Gmbh Novel 11-benzaldoximestradiene derivatives, processes for their preparation and medicaments containing these compounds
US5576310A (en) * 1994-09-20 1996-11-19 Jenapharm Gmbh 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
DE19745085A1 (en) * 1997-10-11 1999-04-15 Jenapharm Gmbh 11β-Benzaldoxim-9alpha, 10alpha-epoxy-estr-4-ene derivatives, processes for their preparation and pharmaceutical preparations containing these compounds
DE19809845A1 (en) * 1998-03-03 1999-09-09 Jenapharm Gmbh S-substituted 11beta-benzaldoxime-estra-4,9-diene-carbonic acid thiol esters, processes for their preparation and pharmaceutical preparations containing these compounds
DE19906152B4 (en) 1999-02-10 2005-02-10 Jenapharm Gmbh & Co. Kg Active substance-containing laminates for transdermal systems
KR100755109B1 (en) 1999-08-31 2007-09-04 바이엘 쉐링 파마 악티엔게젤샤프트 Mesoprogestins Progesterone Receptor Modulators for the Treatment and Prevention of Benign Hormone Dependent Gynecological Disorders
WO2001026603A2 (en) 1999-08-31 2001-04-19 Jenapharm Gmbh & Co. Kg Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives
US7629334B1 (en) * 1999-08-31 2009-12-08 Bayer Schering Pharma Aktiengesellschaft Mesoprogrestins (progesterone receptor modulations) as a component of compositions for hormone replacement therapy (HRT)
HUP0202460A3 (en) 1999-08-31 2004-04-28 Schering Ag Mesoprogestins (progesterone receptor modulators) as a component of compositions for hormone replacement therapy (hrt)
DE19961219A1 (en) * 1999-12-15 2001-07-19 Jenapharm Gmbh 11beta-phenyltratriene derivatives with fluoroalkyl groups in the aromatic side chain, their preparation and pharmaceutical compositions containing these compounds
DE10056677A1 (en) * 2000-11-10 2002-05-16 Jenapharm Gmbh Preparation of estradienyl-benzaldoxime urethane or carbonate derivative, for use e.g. in treating endometriosis, involves reacting corresponding oxime with trichloromethyl chloroformate then alcohol, thiol or amine
DE10056676A1 (en) * 2000-11-10 2002-05-16 Jenapharm Gmbh Preparation of estradienyl-benzaldoxime derivative preparation in high yield, for use e.g. in treating endometriosis, from epoxy-estrenone by multi-stage process including selective Grignard reaction
EP1285927A3 (en) * 2001-08-16 2005-06-29 Schering Aktiengesellschaft Use of glucocorticoid antagonists for the prevention and treatment of diseases of the male reproductive system
DE10221034A1 (en) * 2002-05-03 2003-11-20 Schering Ag New 17-alpha-fluoroalkyl-11-beta-benzaldoxime-estradiene derivatives, useful as antigestagens in post-menopausal hormone replacement therapy or for treating e.g. gynecological disorders
DK1525215T3 (en) * 2002-08-02 2007-01-15 Schering Ag Modulators for the progesterone receptor with elevated anti-gonadotropic activity for women's fertility control and hormone replacement therapy
DE10236405A1 (en) 2002-08-02 2004-02-19 Schering Ag New 4-(3-oxo-estra-4,9-dien-11 beta-yl)-benzaldehyde oximes, are progesterone receptor modulators useful in female contraception, hormone replacement therapy and treatment of gynecological disorders
DE102005059222B4 (en) * 2005-12-08 2007-10-11 Bayer Schering Pharma Ag 11β-Benzaldoxime derivatives of D-homoestra-4,9-dien-3-ones
LT2078032T (en) 2006-10-24 2017-11-10 Repros Therapeutics Inc. Compositions and methods for suppressing endometrial proliferation
TWI539953B (en) 2008-04-28 2016-07-01 瑞波若斯治療學公司 Compositions and methods for treating breast cancer
MX2012010327A (en) 2010-03-22 2012-11-16 Repros Therapeutics Inc Compositions and methods for non-toxic delivery of antiprogestins.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3504421A1 (en) * 1985-02-07 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen 11 beta -Phenylgonanes, the preparation thereof and pharmaceutical products containing these
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
DK0411733T3 (en) * 1989-08-04 1999-06-28 Schering Ag 11-beta-aryl-gona-4,9-dien-3-ones
DE4332283A1 (en) * 1993-09-20 1995-04-13 Jenapharm Gmbh Novel 11-benzaldoximestradiene derivatives, processes for their preparation and medicaments containing these compounds

Also Published As

Publication number Publication date
EP0648779A3 (en) 1995-08-09
DE59401919D1 (en) 1997-04-10
NO942952D0 (en) 1994-08-09
ES2102144T3 (en) 1997-07-16
HU9402695D0 (en) 1994-11-28
EP0648779B1 (en) 1997-03-05
HU219399B (en) 2001-04-28
CA2130515C (en) 2001-07-17
HUT68315A (en) 1995-06-28
SK95894A3 (en) 1995-04-12
CZ196994A3 (en) 1995-04-12
FI112948B (en) 2004-02-13
PL305091A1 (en) 1995-04-03
PL179460B1 (en) 2000-09-29
DE4332284A1 (en) 1995-03-23
GR3023644T3 (en) 1997-08-29
ATE149513T1 (en) 1997-03-15
SK280315B6 (en) 1999-11-08
KR100190775B1 (en) 1999-06-01
FI943688A (en) 1995-03-21
CA2130515A1 (en) 1995-03-21
AU682373B2 (en) 1997-10-02
RU94029667A (en) 1996-06-27
NZ264228A (en) 1995-04-27
DK0648779T3 (en) 1997-09-15
NO942952L (en) 1995-03-21
NO304988B1 (en) 1999-03-15
CZ289801B6 (en) 2002-04-17
FI943688A0 (en) 1994-08-09
EP0648779A2 (en) 1995-04-19
RU2130944C1 (en) 1999-05-27
DE4332284C2 (en) 1997-05-28
UA39101C2 (en) 2001-06-15
JPH07149790A (en) 1995-06-13
JP2696672B2 (en) 1998-01-14
KR950008531A (en) 1995-04-19

Similar Documents

Publication Publication Date Title
AU7035094A (en) New 11-benzaldoxime-estradiene-derivatives, methods for their production and pharmaceuticals containing these substances
AU7035194A (en) 11-benzaldoxime-17beta-methoxy-17alpha- methoxymethylestradiene-derivatives, methods for their production and pharmaceuticals containing these substances
AU3544593A (en) New naphthylalkylamines, process for preparing them and pharmaceutical compositions containing them
EP0361273A3 (en) 7-substituted derivatives of 3,5-dihydroxyhept-6-inoic acid, process for their preparation, their use as medicaments, and intermediates
AU6594790A (en) Benzoxazine derivatives, pharmaceutical compositions containing them and processes for their production
HUT70150A (en) Substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridines, pharmaceutical compositions containing them and method for its preparation
AU656466B2 (en) New benzimidazole compounds, a process for their preparation and pharmaceutical compositions containing them
AU4616893A (en) New benzopyran compounds, process for their preparation and the pharmaceutical compositions which contain them
AU6602394A (en) New alpha-amino acid compounds, a process for the preparation thereof and pharmaceutical compositions containing them
AU3559793A (en) New 3-aminochroman spiro compounds, processes for their preparation and pharmaceutical compositions containing them
AU656674B2 (en) New thiochroman compounds, processes for the preparation thereof, and pharmaceutical compositions containing them
CA2103825A1 (en) 17-hydroxyiminomethyl-5.beta., 14.beta.-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
AU668398B2 (en) New aminoalkylchromones, processes for the preparation thereof, and pharmaceutical compositions containing them
AU5522794A (en) New angiopeptin cyclopeptide compounds, process for the preparation thereof, and pharmaceutical compositios containing them
AU659738B2 (en) New pyrrolothienopyrazine compounds, processes for the preparation thereof, and pharmaceutical compositions containing them
AU5658694A (en) Cyclohexylsulfonyl-acrylic acid and its derivatives, pharmaceutical compositions containing them and process for preparing same

Legal Events

Date Code Title Description
PC Assignment registered

Owner name: SCHERING AKTIENGESELLSCHAFT

Free format text: FORMER OWNER WAS: JENAPHARM GMBH