AU659738B2 - New pyrrolothienopyrazine compounds, processes for the preparation thereof, and pharmaceutical compositions containing them - Google Patents

New pyrrolothienopyrazine compounds, processes for the preparation thereof, and pharmaceutical compositions containing them

Info

Publication number
AU659738B2
AU659738B2 AU40059/93A AU4005993A AU659738B2 AU 659738 B2 AU659738 B2 AU 659738B2 AU 40059/93 A AU40059/93 A AU 40059/93A AU 4005993 A AU4005993 A AU 4005993A AU 659738 B2 AU659738 B2 AU 659738B2
Authority
AU
Australia
Prior art keywords
compounds
pyrrolothienopyrazine
processes
preparation
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU40059/93A
Other versions
AU4005993A (en
Inventor
Gerhard Adam
Beatrice Guardiola-Lemaitre
Jean-Charles Lancelot
Sylvain Rault
Pierre Renard
Max Robba
Juan-Carlos Pilo Vicente
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of AU4005993A publication Critical patent/AU4005993A/en
Application granted granted Critical
Publication of AU659738B2 publication Critical patent/AU659738B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to the compounds of general formula (I): <IMAGE> in which R1, R2, R3 and A are as defined in the description, to their optical isomers and to their addition salts with a pharmaceutically acceptable acid or base. Medicaments.
AU40059/93A 1992-06-05 1993-06-04 New pyrrolothienopyrazine compounds, processes for the preparation thereof, and pharmaceutical compositions containing them Ceased AU659738B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9206800 1992-06-05
FR9206800A FR2691967B1 (en) 1992-06-05 1992-06-05 NOVEL PYRROLOTHIENOPYRAZINIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Publications (2)

Publication Number Publication Date
AU4005993A AU4005993A (en) 1993-12-09
AU659738B2 true AU659738B2 (en) 1995-05-25

Family

ID=9430449

Family Applications (1)

Application Number Title Priority Date Filing Date
AU40059/93A Ceased AU659738B2 (en) 1992-06-05 1993-06-04 New pyrrolothienopyrazine compounds, processes for the preparation thereof, and pharmaceutical compositions containing them

Country Status (11)

Country Link
EP (1) EP0573360B1 (en)
JP (1) JPH0794460B2 (en)
AT (1) ATE170187T1 (en)
AU (1) AU659738B2 (en)
CA (1) CA2097779A1 (en)
DE (1) DE69320542T2 (en)
DK (1) DK0573360T3 (en)
ES (1) ES2123038T3 (en)
FR (1) FR2691967B1 (en)
NZ (1) NZ247791A (en)
ZA (1) ZA933942B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10040802B2 (en) 2015-03-12 2018-08-07 Merck Sharp & Dohme Corp. Thienopyrazine inhibitors of IRAK4 activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0449728A1 (en) * 1990-03-27 1991-10-02 Adir Et Compagnie 4H-pyrrolo (1,2-a)thieno(2,3-f)(1,4)diazepine derivatives, process for their preparation and pharmaceutical compositions containing them
EP0496140A1 (en) * 1990-01-16 1992-07-29 E. Marlowe Goble Endosteal fixation stud and system

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2659332B1 (en) * 1990-03-08 1994-04-29 Adit Et Cie NOVEL PYRROLO [1,2-A] THIENO [3,2-F] DIAZEPINES [1,4], THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0496140A1 (en) * 1990-01-16 1992-07-29 E. Marlowe Goble Endosteal fixation stud and system
EP0449728A1 (en) * 1990-03-27 1991-10-02 Adir Et Compagnie 4H-pyrrolo (1,2-a)thieno(2,3-f)(1,4)diazepine derivatives, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0573360B1 (en) 1998-08-26
ATE170187T1 (en) 1998-09-15
FR2691967B1 (en) 1995-06-09
DE69320542T2 (en) 1999-04-29
JPH0794460B2 (en) 1995-10-11
AU4005993A (en) 1993-12-09
CA2097779A1 (en) 1993-12-06
FR2691967A1 (en) 1993-12-10
ES2123038T3 (en) 1999-01-01
DE69320542D1 (en) 1998-10-01
EP0573360A1 (en) 1993-12-08
NZ247791A (en) 1994-12-22
DK0573360T3 (en) 1999-05-25
JPH06172363A (en) 1994-06-21
ZA933942B (en) 1993-12-30

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired