HUP0301010A2 - A koleszteril-észter és a viaszészter szintézisét egyaránt gátló vegyületek faggyúmirigy-betegségek kezeléséhez és ezeket tartalmazó gyógyszerkészítmények - Google Patents

A koleszteril-észter és a viaszészter szintézisét egyaránt gátló vegyületek faggyúmirigy-betegségek kezeléséhez és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0301010A2
HUP0301010A2 HU0301010A HUP0301010A HUP0301010A2 HU P0301010 A2 HUP0301010 A2 HU P0301010A2 HU 0301010 A HU0301010 A HU 0301010A HU P0301010 A HUP0301010 A HU P0301010A HU P0301010 A2 HUP0301010 A2 HU P0301010A2
Authority
HU
Hungary
Prior art keywords
sebaceous gland
pharmaceutical compositions
compositions containing
dual inhibitors
ester
Prior art date
Application number
HU0301010A
Other languages
English (en)
Inventor
Reynold Homan
Original Assignee
Warner-Lambert Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Co. filed Critical Warner-Lambert Co.
Publication of HUP0301010A2 publication Critical patent/HUP0301010A2/hu
Publication of HUP0301010A3 publication Critical patent/HUP0301010A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány (II) képletű 5[(2,4,6-triizopropil-fenil)-acetil]-szulfaminsav-2,6-diizopropil-fenil-észter vagy gyógyszerészetilegelfogadható sóinak használatát magában foglaló eljárásra vonatkozik,amely vegyületek a faggyúmirigy betegségeinek kezelésére szolgálnak. Atalálmány kiterjed a vegyületet tartalmazó gyógyszerkészítményre is. Ó
HU0301010A 2000-02-02 2001-01-23 Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders and pharmaceutical compositions containing them HUP0301010A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17977800P 2000-02-02 2000-02-02
PCT/US2001/002190 WO2001056556A2 (en) 2000-02-02 2001-01-23 Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders

Publications (2)

Publication Number Publication Date
HUP0301010A2 true HUP0301010A2 (hu) 2003-08-28
HUP0301010A3 HUP0301010A3 (en) 2005-03-29

Family

ID=22657957

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301010A HUP0301010A3 (en) 2000-02-02 2001-01-23 Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders and pharmaceutical compositions containing them

Country Status (34)

Country Link
US (2) US6730703B2 (hu)
EP (1) EP1263421B1 (hu)
JP (1) JP2003531113A (hu)
KR (1) KR20020073574A (hu)
CN (1) CN1398182A (hu)
AP (1) AP2002002612A0 (hu)
AT (1) ATE295724T1 (hu)
AU (1) AU781563B2 (hu)
BG (1) BG107042A (hu)
BR (1) BR0107954A (hu)
CA (1) CA2398219A1 (hu)
CR (1) CR6712A (hu)
DE (1) DE60110897T2 (hu)
DZ (1) DZ3288A1 (hu)
EA (1) EA004255B1 (hu)
EE (1) EE200200429A (hu)
ES (1) ES2239145T3 (hu)
GE (1) GEP20043286B (hu)
HR (1) HRP20020717A2 (hu)
HU (1) HUP0301010A3 (hu)
IL (1) IL150865A0 (hu)
IS (1) IS6478A (hu)
MA (1) MA26872A1 (hu)
MX (1) MXPA02007309A (hu)
NO (1) NO20023659L (hu)
NZ (1) NZ520330A (hu)
OA (1) OA12173A (hu)
PL (1) PL357041A1 (hu)
PT (1) PT1263421E (hu)
SK (1) SK10972002A3 (hu)
UA (1) UA75345C2 (hu)
WO (1) WO2001056556A2 (hu)
YU (1) YU57502A (hu)
ZA (1) ZA200206075B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1281399A3 (en) * 2001-08-01 2004-02-11 Warner-Lambert Company Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production
US20050031699A1 (en) 2003-06-26 2005-02-10 L'oreal Porous particles loaded with cosmetically or pharmaceutically active compounds
CA2541814C (en) 2003-10-09 2010-02-23 Warner-Lambert Company Llc Pharmaceutical compositions comprising malonamide derivatives for decreasing sebum production
KR100906288B1 (ko) 2005-02-24 2009-07-06 워너-램버트 캄파니 엘엘씨 결정질 ａｃａｔ 억제제
FR2903999B1 (fr) * 2006-07-19 2008-09-05 Galderma Res & Dev S N C Snc Modulateurs de sc4mol dans le traitement de l'acne ou de l'hyperseborrhee
FR2904002A1 (fr) * 2006-07-19 2008-01-25 Galderma Res & Dev S N C Snc Modulateurs de la lanosterol synthetase dans le traitement de l'acne ou de l'hyperseborrhee
FR2938342A1 (fr) * 2008-11-13 2010-05-14 Galderma Res & Dev Ciblage de modulateurs de ces1 et/ou ces3 dans le traitement de l'acne, d'une dermatite seborrheique ou de l'hyperseborrhee
EP2391342A2 (en) 2009-01-28 2011-12-07 Nanobio Corporation Compositions for treatment and prevention of acne, methods of making the compositions, and methods of use thereof
WO2019246558A1 (en) * 2018-06-21 2019-12-26 Dermavant Sciences GmbH Topical formulations of dgat1 inhibitors and their methods of use

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4545977A (en) * 1985-01-11 1985-10-08 G. D. Searle & Co. Compositions and methods for treating severe acne with isotretinoin
US4751026A (en) 1986-03-24 1988-06-14 Warner-Lambert Company Substituted anilides of oleic, linoleic, or linolenic acid as inhibitors of acyl-coa:cholesterol acyltransferase
US4722927A (en) 1986-04-28 1988-02-02 Warner-Lambert Company Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase
JPS6323848A (ja) 1986-07-11 1988-02-01 ワ−ナ−−ランバ−ト・コンパニ− Ω−（置換フエニルオキシ）−アルカン酸のアリ−ル−およびアラルキルアミド
US4716175A (en) 1987-02-24 1987-12-29 Warner-Lambert Company Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase
IE61716B1 (en) 1987-06-02 1994-11-30 Warner Lambert Co Antihyperlipidemic and antiatherosclerotic urea compounds
US5015644A (en) 1987-06-02 1991-05-14 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds
JPH0193569A (ja) 1987-07-02 1989-04-12 Warner Lambert Co アシル‐ＣｏＡ：コレステロールアシルトランスフエラーゼのＮ‐〔（２，６‐ジ置換）フエニル〕尿素およびカルバメート阻害剤
US5116848A (en) 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
US5030653A (en) 1988-03-30 1991-07-09 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US4948806A (en) 1988-03-30 1990-08-14 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US4999373A (en) 1988-03-30 1991-03-12 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US4868210A (en) 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US5155127A (en) 1989-02-09 1992-10-13 Warner-Lambert Company N-(substituted aryl)-n'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents
US4923896A (en) 1989-02-09 1990-05-08 Warner-Lambert Company N-(substituted aryl)-N'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents
US4994465A (en) 1989-02-17 1991-02-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds
AU632809B2 (en) 1989-05-25 1993-01-14 Takeda Chemical Industries Ltd. Benzocycloalkane benzopyran and benzothiopyran urea derivatives and production thereof
AU629376B2 (en) 1989-08-04 1992-10-01 Mitsubishi Chemical Corporation 1-phenylalkyl-3-phenylurea derivatives
WO1991004027A1 (en) 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
TW205037B (hu) 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd
JPH05310678A (ja) 1990-01-22 1993-11-22 Mitsubishi Kasei Corp １−フェニルアルキル−３−フェニル尿素誘導体
US5362878A (en) 1991-03-21 1994-11-08 Pfizer Inc. Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
CA2128093C (en) 1992-01-23 1998-02-03 Ernest S. Hamanaka 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxoquinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
WO1993024458A1 (en) 1992-05-28 1993-12-09 Pfizer Inc. New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase (acat)
US5565472A (en) 1992-12-21 1996-10-15 Pfizer Inc. 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
US5491172A (en) * 1993-05-14 1996-02-13 Warner-Lambert Company N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents
US5596001A (en) 1993-10-25 1997-01-21 Pfizer Inc. 4-aryl-3-(heteroarylureido)quinoline derivatves
US5494172A (en) * 1994-05-12 1996-02-27 Miller Compressing Company Magnetic pulley assembly
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
AU763687B2 (en) * 1998-06-25 2003-07-31 Tularik Inc. Arylsulfonanilide phosphates
EP1324995A2 (en) * 2000-09-27 2003-07-09 Merck & Co., Inc. Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders

Also Published As

Publication number Publication date
EA004255B1 (ru) 2004-02-26
ZA200206075B (en) 2003-10-30
AU781563B2 (en) 2005-06-02
NZ520330A (en) 2004-02-27
PT1263421E (pt) 2005-08-31
AP2002002612A0 (en) 2002-09-30
BG107042A (bg) 2003-04-30
DE60110897D1 (de) 2005-06-23
DE60110897T2 (de) 2006-03-23
DZ3288A1 (en) 2001-08-09
MA26872A1 (fr) 2004-12-20
MXPA02007309A (es) 2002-11-29
CA2398219A1 (en) 2001-08-09
EP1263421B1 (en) 2005-05-18
KR20020073574A (ko) 2002-09-27
OA12173A (en) 2006-05-08
YU57502A (sh) 2006-01-16
CR6712A (es) 2004-01-14
EP1263421A2 (en) 2002-12-11
HUP0301010A3 (en) 2005-03-29
SK10972002A3 (sk) 2003-07-01
IS6478A (is) 2002-07-19
ATE295724T1 (de) 2005-06-15
JP2003531113A (ja) 2003-10-21
NO20023659D0 (no) 2002-08-01
EE200200429A (et) 2003-12-15
NO20023659L (no) 2002-09-25
US6730703B2 (en) 2004-05-04
BR0107954A (pt) 2002-10-22
PL357041A1 (en) 2004-07-12
EA200200764A1 (ru) 2002-12-26
US20030060507A1 (en) 2003-03-27
WO2001056556A3 (en) 2002-03-07
ES2239145T3 (es) 2005-09-16
UA75345C2 (en) 2006-04-17
GEP20043286B (en) 2004-07-26
CN1398182A (zh) 2003-02-19
US20040161393A1 (en) 2004-08-19
IL150865A0 (en) 2003-02-12
WO2001056556A2 (en) 2001-08-09
HRP20020717A2 (en) 2003-12-31
AU2971801A (en) 2001-08-14

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees