HUP0004250A2 - Hidroxi-ecetsav-észter származékok, előállítási eljárásuk és alkalmazásuk szintézis intermedierekként - Google Patents

Hidroxi-ecetsav-észter származékok, előállítási eljárásuk és alkalmazásuk szintézis intermedierekként

Info

Publication number
HUP0004250A2
HUP0004250A2 HU0004250A HUP0004250A HUP0004250A2 HU P0004250 A2 HUP0004250 A2 HU P0004250A2 HU 0004250 A HU0004250 A HU 0004250A HU P0004250 A HUP0004250 A HU P0004250A HU P0004250 A2 HUP0004250 A2 HU P0004250A2
Authority
HU
Hungary
Prior art keywords
preparation
ester derivatives
synthesis intermediates
group
hydroxyacetic
Prior art date
Application number
HU0004250A
Other languages
English (en)
Inventor
André Bousquet
Andrée Musolino
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of HUP0004250A2 publication Critical patent/HUP0004250A2/hu
Publication of HUP0004250A3 publication Critical patent/HUP0004250A3/hu
Publication of HU226771B1 publication Critical patent/HU226771B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

A jelen találmány az (I) általános képletű (R)-szulfoniloxi-ecetsavészterekre vonatkozik ahol R1 benzil-csoportot, 1-4 szénatomosalkilcsoportot - mely adott egy vagy több halogénatommal szubsztituáltlehet - vagy fenil-csoportot jelent, mely adott esetben szubsztituálvalehet egy vagy több halogénatommal egy vagy több egyenes vagy elágazóC1-4 alkilcsoporttal vagy egy nitrocsoporttal. A fenti vegyületekclopidogrel szintézis intermedierjei. Ó
HU0004250A 1997-10-06 1998-09-29 2-sulfonyloxy-2-(2-chlorophenyl)-acetic acid methyl ester derivatives, process for their preparation and process for the praparation of clopidogrel using the same HU226771B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9712441A FR2769313B1 (fr) 1997-10-06 1997-10-06 Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
PCT/FR1998/002082 WO1999018110A1 (fr) 1997-10-06 1998-09-29 Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese

Publications (3)

Publication Number Publication Date
HUP0004250A2 true HUP0004250A2 (hu) 2001-10-28
HUP0004250A3 HUP0004250A3 (en) 2001-12-28
HU226771B1 HU226771B1 (en) 2009-09-28

Family

ID=9511879

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004250A HU226771B1 (en) 1997-10-06 1998-09-29 2-sulfonyloxy-2-(2-chlorophenyl)-acetic acid methyl ester derivatives, process for their preparation and process for the praparation of clopidogrel using the same

Country Status (15)

Country Link
US (3) US6573381B1 (hu)
EP (1) EP1021449B1 (hu)
JP (3) JP3827946B2 (hu)
AT (1) ATE211476T1 (hu)
AU (1) AU9354498A (hu)
BR (1) BR9813022B1 (hu)
CA (1) CA2306409C (hu)
DE (1) DE69803397T2 (hu)
DK (1) DK1021449T3 (hu)
ES (1) ES2171040T3 (hu)
FR (1) FR2769313B1 (hu)
HU (1) HU226771B1 (hu)
NO (1) NO325150B1 (hu)
PT (1) PT1021449E (hu)
WO (1) WO1999018110A1 (hu)

Families Citing this family (32)

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WO2002018357A1 (en) * 2000-08-29 2002-03-07 Rpg Life Sciences Limited A ONE-POT PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS OF 4, 5, 6, 7 - TETRAHYDROTHIENO (3,2-c) PYRIDINE DERIVATIVES HAVING ANTITHROMBOTIC ACTIVITY
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
MXPA04006088A (es) * 2001-12-18 2004-09-27 Teva Pharma Polimorfo de sulfato de hidrogeno de clopidogrel.
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
ITMI20020933A1 (it) * 2002-05-03 2003-11-03 Danimite Dipharma S P A Procedimento per la sintesi di clopidogrel
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
ITMI20022228A1 (it) * 2002-10-21 2004-04-22 Dinamite Dipharma S P A Sali di clopidogrel con acidi alchil-solforici.
EP1603920A1 (en) 2003-03-12 2005-12-14 Cadila Healthcare Ltd. Polymorph and amorphous form of (s)-(+)-clopidogrel bisulfate
WO2004098593A1 (en) * 2003-05-05 2004-11-18 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate composition
US8907090B2 (en) 2003-11-03 2014-12-09 Cadila Healthcare Limited Processes for preparing different forms of (S)-(+)-Clopidogrel bisulfate
EP1589019B1 (de) 2004-04-20 2008-08-13 Ratiopharm GmbH Stereoselektives Verfahren zur Herstellung von Clopidogrel
CZ20041048A3 (cs) * 2004-10-18 2005-11-16 Zentiva, A. S Způsob výroby klopidogrelu
CN100406568C (zh) * 2005-02-18 2008-07-30 淮北市辉克药业有限公司 氯吡格雷新生产工艺
WO2007032023A2 (en) * 2005-07-12 2007-03-22 Rpg Life Sciences Limited A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
US20080311636A1 (en) * 2005-09-02 2008-12-18 Daiichi Fine Chemical Co., Ltd. Method for Producing Optically Active Alpha-Hydroxycarboxylic Acid
KR101235117B1 (ko) 2005-12-26 2013-02-20 에스케이케미칼주식회사 광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
WO2007144729A1 (en) * 2006-06-13 2007-12-21 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of clopidogrel
WO2008004249A2 (en) * 2006-07-04 2008-01-10 Msn Laboratories Limited An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts
ATE488520T1 (de) * 2006-08-04 2010-12-15 Merz Pharma Gmbh & Co Kgaa Pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin
KR100834967B1 (ko) * 2006-08-11 2008-06-03 에스케이케미칼주식회사 여액의 라세미화 반응에 의한 ｓ-(＋)-클로피도그렐의고수율 제조방법
EP1980563A1 (en) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
KR20090086903A (ko) * 2007-04-18 2009-08-14 테바 파마슈티컬 인더스트리즈 리미티드 개선된 클로피도그렐의 제조 방법
KR20150041173A (ko) 2007-04-27 2015-04-15 사이덱스 파마슈티칼스, 인크. 클로피도그렐 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 및 사용 방법
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
KR100990949B1 (ko) 2008-06-09 2010-10-29 엔자이텍 주식회사 클로피도그렐 및 그의 유도체의 제조방법
KR101743591B1 (ko) 2009-05-13 2017-06-20 사이덱스 파마슈티칼스, 인크. 프라수그렐 및 사이클로덱스트린 유도체를 포함하는 약학 조성물 및 그의 제조 및 사용 방법
CN102120744B (zh) * 2010-02-02 2013-01-09 江苏威凯尔医药科技有限公司 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途
CN102558138A (zh) * 2010-12-08 2012-07-11 湖北成田制药股份有限公司 2-卤代苯基-2-(2-噻吩乙氨基)乙酸酯类及其盐的制备方法
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
CN102351877B (zh) * 2011-08-12 2014-07-09 天津药物研究院 噻吩衍生物、其制备方法和用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
US5189170A (en) 1989-09-29 1993-02-23 Sanofi Process for the preparation of phenylacetic derivatives of thieno-pyridines
FR2652575B1 (fr) * 1989-09-29 1992-01-24 Sanofi Sa Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664276B1 (fr) * 1990-07-04 1992-10-23 Sanofi Sa Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese.
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
JPH06293729A (ja) * 1993-04-06 1994-10-21 Sankyo Co Ltd 光学活性カルボン酸誘導体
US5583147A (en) * 1994-03-23 1996-12-10 The Dupont Merck Pharmaceutical Company Amides for the treatment of atherosclerosis
FR2751540B1 (fr) * 1996-07-26 1998-10-16 Sanofi Sa Composition pharmaceutique antithrombotique
HU222283B1 (hu) * 1997-05-13 2003-05-28 Sanofi-Synthelabo Eljárás tieno[3,2-c]piridin-származékok előállítására

Also Published As

Publication number Publication date
HUP0004250A3 (en) 2001-12-28
BR9813022B1 (pt) 2010-07-13
US7153969B2 (en) 2006-12-26
US6573381B1 (en) 2003-06-03
JP4903819B2 (ja) 2012-03-28
DK1021449T3 (da) 2002-04-22
JP2009137989A (ja) 2009-06-25
EP1021449A1 (fr) 2000-07-26
WO1999018110A1 (fr) 1999-04-15
AU9354498A (en) 1999-04-27
BR9813022A (pt) 2000-08-15
ES2171040T3 (es) 2002-08-16
JP2006124398A (ja) 2006-05-18
FR2769313B1 (fr) 2000-04-21
NO20001736L (no) 2000-06-06
US20030208077A1 (en) 2003-11-06
JP3827946B2 (ja) 2006-09-27
DE69803397T2 (de) 2002-08-29
PT1021449E (pt) 2002-06-28
NO325150B1 (no) 2008-02-11
JP4264437B2 (ja) 2009-05-20
US20040260110A1 (en) 2004-12-23
US6894186B2 (en) 2005-05-17
HU226771B1 (en) 2009-09-28
NO20001736D0 (no) 2000-04-04
FR2769313A1 (fr) 1999-04-09
CA2306409C (fr) 2010-06-29
CA2306409A1 (fr) 1999-04-15
DE69803397D1 (de) 2002-02-28
EP1021449B1 (fr) 2002-01-02
JP2001519353A (ja) 2001-10-23
ATE211476T1 (de) 2002-01-15

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