HUP0202733A2 - Intermedierek kinolonkarbonsav-származékok előállítására - Google Patents

Intermedierek kinolonkarbonsav-származékok előállítására

Info

Publication number
HUP0202733A2
HUP0202733A2 HU0202733A HUP0202733A HUP0202733A2 HU P0202733 A2 HUP0202733 A2 HU P0202733A2 HU 0202733 A HU0202733 A HU 0202733A HU P0202733 A HUP0202733 A HU P0202733A HU P0202733 A2 HUP0202733 A2 HU P0202733A2
Authority
HU
Hungary
Prior art keywords
production
general formula
carboxylic acid
acid derivatives
naphthyridine
Prior art date
Application number
HU0202733A
Other languages
English (en)
Inventor
Trevor John Grinter
Simon Howie
Original Assignee
Sb Pharmco Puerto Rico Inc.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sb Pharmco Puerto Rico Inc., filed Critical Sb Pharmco Puerto Rico Inc.,
Publication of HUP0202733A2 publication Critical patent/HUP0202733A2/hu
Publication of HUP0202733A3 publication Critical patent/HUP0202733A3/hu
Publication of HU229391B1 publication Critical patent/HU229391B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány gyógyszerészeti hatóanyagok, például antibakteriálishatású kinolonkarbonsavszármazékok előállítására felhasználható új (I)általános képletű vegyületekre - amelyek képletében R jelentése 1-4szénatomos alkilcsoport vagy 1-4 szénatomos halogén-alkil-csoport -vonatkozik. A találmány kiterjed az (I) általános képletű vegyületekelőállítására is, amelynek során egy (II) általános képletű vegyületet- amelynek képletében R jelentése az (I) általános képletnélmeghatározott, valamint P1 és P2 azonos vagy egymástól eltérőjelentése amino-védőcsoport - metánszulfonsavval reagáltatnak. Ó
HU0202733A 1999-09-03 2000-09-01 Intermedierek kinolonkarbonsav-származékok elõállítására HU229391B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9920919.9A GB9920919D0 (en) 1999-09-03 1999-09-03 Novel compound
PCT/GB2000/003358 WO2001017961A2 (en) 1999-09-03 2000-09-01 Intermediates for the production of naphthyridine-3-carboxylic acid derivatives

Publications (3)

Publication Number Publication Date
HUP0202733A2 true HUP0202733A2 (hu) 2003-01-28
HUP0202733A3 HUP0202733A3 (en) 2005-12-28
HU229391B1 HU229391B1 (hu) 2013-11-28

Family

ID=10860355

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202733A HU229391B1 (hu) 1999-09-03 2000-09-01 Intermedierek kinolonkarbonsav-származékok elõállítására

Country Status (30)

Country Link
US (3) US6703512B1 (hu)
EP (1) EP1212321B1 (hu)
JP (1) JP4208463B2 (hu)
KR (1) KR100705363B1 (hu)
CN (1) CN1255402C (hu)
AR (1) AR029452A1 (hu)
AT (1) ATE270671T1 (hu)
AU (1) AU773698B2 (hu)
BR (1) BRPI0013750B8 (hu)
CA (1) CA2383751C (hu)
CO (1) CO5180620A1 (hu)
CZ (1) CZ2002759A3 (hu)
DE (1) DE60012028T2 (hu)
DK (1) DK1212321T3 (hu)
ES (1) ES2223570T3 (hu)
GB (1) GB9920919D0 (hu)
HK (1) HK1046908B (hu)
HU (1) HU229391B1 (hu)
IL (2) IL148441A0 (hu)
MX (1) MXPA02002356A (hu)
MY (1) MY126789A (hu)
NO (1) NO322501B1 (hu)
NZ (1) NZ517601A (hu)
PL (1) PL206491B1 (hu)
PT (1) PT1212321E (hu)
SI (1) SI1212321T1 (hu)
TR (1) TR200200548T2 (hu)
TW (1) TWI264435B (hu)
WO (1) WO2001017961A2 (hu)
ZA (1) ZA200201779B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2281817C (en) * 1999-06-29 2008-07-29 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against maxillary sinus pathogenic bacteria
GB9920919D0 (en) * 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
PT1412078E (pt) 2001-08-02 2009-01-08 Lg Life Sciences Ltd Processos para a produção de derivados amino-protegidos da 4- aminometileno-pirrolidin-3-ona, gemifloxacina ou um seu sal
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
KR101061456B1 (ko) * 2002-07-17 2011-09-02 시바 홀딩 인크 퀴나크리돈 안료를 제조하기 위한 산화방법
KR100653334B1 (ko) * 2003-03-07 2006-12-04 주식회사 엘지생명과학 4-아미노메틸-3-알콕시이미노피롤리딘 메탄설폰산염의 신규한 제조 방법
US8822934B2 (en) * 2006-11-03 2014-09-02 Accuray Incorporated Collimator changer
CN104693088B (zh) * 2013-12-06 2018-01-05 常州市勇毅生物药业有限公司 一种吉米沙星侧链的制备方法

Family Cites Families (27)

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JPS57134482A (en) 1981-02-13 1982-08-19 Dainippon Pharmaceut Co Ltd 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
IN162769B (hu) 1984-11-13 1988-07-09 Kyorin Seiyaku Kk
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH01100165A (ja) 1987-10-13 1989-04-18 Shionogi & Co Ltd オキシムまたはヒドロキシアミン誘導体系抗菌剤
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
JPH0356479A (ja) 1989-07-24 1991-03-12 Takeshi Yokota 水溶性キノロン誘導体のｐ‐トルエンスルホン酸塩
PL166381B1 (pl) 1989-08-16 1995-05-31 Pfizer Sposób wytwarzania nowych podstawionych kwasów 7-azabicyklochinolonokarboksylowych PL PL PL PL
US5137892A (en) 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
EP0541086A1 (en) 1991-11-08 1993-05-12 Kaken Pharmaceutical Co., Ltd. Antibacterial 6-fluoro-quinolones having an oxime group on the substituent in position 7
JPH0673056A (ja) 1992-08-26 1994-03-15 Kaken Pharmaceut Co Ltd キノリンカルボン酸誘導体およびその塩
DE69509442T2 (de) * 1994-06-16 1999-09-02 Lg Chemical Ltd. Chinolincarbonsäurederivate mit 7-(4-Amino-methyl-3-oxim)-pyrrolidin-Substituenten und Verfahren zu ihrer Herstellung
US5776944A (en) 1994-06-16 1998-07-07 Lg Chemical Ltd. 7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
JP3449658B2 (ja) 1994-12-21 2003-09-22 杏林製薬株式会社 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
ES2117426T3 (es) 1995-06-06 1998-08-01 Pfizer Forma cristalina de la sal anhidra compuesta de los acidos 7-((1a,5a,6a)-6-amino-3-azabiciclo(3.1.0.)hex-3-il)-6-fluoro-1-(2,4-difluorofenil)-1,4-dihidro-4-oxo-1,8-naftiridina-3-carboxilico y metanosulfonico.
UA59341C2 (uk) 1995-08-11 2003-09-15 Пфайзер, Інк. (1s,2s)-1-(4-гідроксифеніл)-2-(4-гідрокси-4-фенілпіперидин-1-іл)-1-пропанолметансульфонат тригідрат
JP4316013B2 (ja) 1996-03-29 2009-08-19 スミスクライン・ビーチャム・コーポレイション エプロサルタン二水和物ならびにその製法および処方
MA24500A1 (fr) 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
KR100286874B1 (ko) 1998-03-04 2001-04-16 성재갑 보호된 4-아미노메틸-피롤리딘-3-온의 제조방법
PT1082300E (pt) 1998-05-29 2004-02-27 Upjohn Co Monometanossulfonato de 3-¬(1'-n-metilamino)etil-n-benzil|pirrolidina
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
PT1223935E (pt) 1999-06-29 2008-04-03 Lg Life Sciences Ltd Utilização de compostos de gemifloxacina contra bactérias
AU6947900A (en) 1999-09-01 2001-03-26 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against bacteria
GB9920917D0 (en) * 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) * 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
EP1242079A4 (en) 1999-09-22 2003-01-22 Smithkline Beecham Methods of anti-bacterial use of fluoroquinolonic compounds
KR20010091379A (ko) 2000-03-15 2001-10-23 성재갑 7-(4-아미노메틸-3-옥심)피롤리딘 치환체를 갖는 퀴놀린카르복실산 유도체의 신규 제조방법
KR20020018560A (ko) 2000-09-01 2002-03-08 성재갑 3-아미노메틸-4-ｚ-메톡시이미노피롤리딘의 신규 제조방법

Also Published As

Publication number Publication date
DE60012028T2 (de) 2005-08-18
ATE270671T1 (de) 2004-07-15
JP4208463B2 (ja) 2009-01-14
HUP0202733A3 (en) 2005-12-28
ZA200201779B (en) 2003-08-27
WO2001017961A3 (en) 2001-09-20
CA2383751A1 (en) 2001-03-15
ES2223570T3 (es) 2005-03-01
TWI264435B (en) 2006-10-21
BRPI0013750B8 (pt) 2021-05-25
EP1212321B1 (en) 2004-07-07
CN1255402C (zh) 2006-05-10
US20050033064A1 (en) 2005-02-10
PL354725A1 (en) 2004-02-09
TR200200548T2 (tr) 2002-09-23
CN1372558A (zh) 2002-10-02
MXPA02002356A (es) 2002-07-30
PL206491B1 (pl) 2010-08-31
EP1212321A2 (en) 2002-06-12
NZ517601A (en) 2003-08-29
GB9920919D0 (en) 1999-11-10
NO20021043D0 (no) 2002-03-01
BR0013750B1 (pt) 2014-06-17
DK1212321T3 (da) 2004-10-25
US6803467B2 (en) 2004-10-12
IL148441A0 (en) 2002-09-12
BR0013750A (pt) 2002-05-21
CA2383751C (en) 2010-06-29
KR20020041423A (ko) 2002-06-01
MY126789A (en) 2006-10-31
HU229391B1 (hu) 2013-11-28
AU6857300A (en) 2001-04-10
NO20021043L (no) 2002-03-01
HK1046908A1 (en) 2003-01-30
DE60012028D1 (de) 2004-08-12
HK1046908B (en) 2005-05-27
AR029452A1 (es) 2003-07-02
US20040138292A1 (en) 2004-07-15
PT1212321E (pt) 2004-10-29
CO5180620A1 (es) 2002-07-30
AU773698B2 (en) 2004-06-03
IL148441A (en) 2007-03-08
NO322501B1 (no) 2006-10-16
WO2001017961A2 (en) 2001-03-15
SI1212321T1 (en) 2004-12-31
JP2003508517A (ja) 2003-03-04
US6703512B1 (en) 2004-03-09
CZ2002759A3 (cs) 2002-06-12
KR100705363B1 (ko) 2007-04-10

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: LG LIFE SCIENCES LTD., KR

Free format text: FORMER OWNER(S): SB PHARMCO PUERTO RICO INC.,, US

MM4A Lapse of definitive patent protection due to non-payment of fees