BRPI0013750B8 - intermediários para a produção de derivados de ácido naftiridina-3-carboxílico - Google Patents

intermediários para a produção de derivados de ácido naftiridina-3-carboxílico

Info

Publication number
BRPI0013750B8
BRPI0013750B8 BRPI0013750A BR0013750A BRPI0013750B8 BR PI0013750 B8 BRPI0013750 B8 BR PI0013750B8 BR PI0013750 A BRPI0013750 A BR PI0013750A BR 0013750 A BR0013750 A BR 0013750A BR PI0013750 B8 BRPI0013750 B8 BR PI0013750B8
Authority
BR
Brazil
Prior art keywords
naphthyridine
production
carboxylic acid
intermediates
acid derivatives
Prior art date
Application number
BRPI0013750A
Other languages
English (en)
Other versions
BR0013750B1 (pt
BR0013750A (pt
Inventor
Howie Simon
John Grinter Trevor
Original Assignee
Sb Pharmco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sb Pharmco Inc filed Critical Sb Pharmco Inc
Publication of BR0013750A publication Critical patent/BR0013750A/pt
Publication of BR0013750B1 publication Critical patent/BR0013750B1/pt
Publication of BRPI0013750B8 publication Critical patent/BRPI0013750B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"intermediários para a produção de derivados de ácido naftiridina-3-carboxílico". intermediários químicos de fórmula ( i ) e sua preparação, os quais são de uso na produção de derivados de ácido naftiridina carboxílico possuindo atividade antibacteriana.
BRPI0013750A 1999-09-03 2000-09-01 intermediários para a produção de derivados de ácido naftiridina-3-carboxílico BRPI0013750B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9920919.9 1999-09-03
GBGB9920919.9A GB9920919D0 (en) 1999-09-03 1999-09-03 Novel compound
PCT/GB2000/003358 WO2001017961A2 (en) 1999-09-03 2000-09-01 Intermediates for the production of naphthyridine-3-carboxylic acid derivatives

Publications (3)

Publication Number Publication Date
BR0013750A BR0013750A (pt) 2002-05-21
BR0013750B1 BR0013750B1 (pt) 2014-06-17
BRPI0013750B8 true BRPI0013750B8 (pt) 2021-05-25

Family

ID=10860355

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0013750A BRPI0013750B8 (pt) 1999-09-03 2000-09-01 intermediários para a produção de derivados de ácido naftiridina-3-carboxílico

Country Status (30)

Country Link
US (3) US6703512B1 (pt)
EP (1) EP1212321B1 (pt)
JP (1) JP4208463B2 (pt)
KR (1) KR100705363B1 (pt)
CN (1) CN1255402C (pt)
AR (1) AR029452A1 (pt)
AT (1) ATE270671T1 (pt)
AU (1) AU773698B2 (pt)
BR (1) BRPI0013750B8 (pt)
CA (1) CA2383751C (pt)
CO (1) CO5180620A1 (pt)
CZ (1) CZ2002759A3 (pt)
DE (1) DE60012028T2 (pt)
DK (1) DK1212321T3 (pt)
ES (1) ES2223570T3 (pt)
GB (1) GB9920919D0 (pt)
HK (1) HK1046908B (pt)
HU (1) HU229391B1 (pt)
IL (2) IL148441A0 (pt)
MX (1) MXPA02002356A (pt)
MY (1) MY126789A (pt)
NO (1) NO322501B1 (pt)
NZ (1) NZ517601A (pt)
PL (1) PL206491B1 (pt)
PT (1) PT1212321E (pt)
SI (1) SI1212321T1 (pt)
TR (1) TR200200548T2 (pt)
TW (1) TWI264435B (pt)
WO (1) WO2001017961A2 (pt)
ZA (1) ZA200201779B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2281817C (en) * 1999-06-29 2008-07-29 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against maxillary sinus pathogenic bacteria
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
US7199242B2 (en) 2001-08-02 2007-04-03 Lg Life Sciences Limited Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and/or 4-aminomethylene-pyrrolidin-3-alkoxyimino derivatives and/or gemifloxacin or a salt thereof
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
KR101061456B1 (ko) * 2002-07-17 2011-09-02 시바 홀딩 인크 퀴나크리돈 안료를 제조하기 위한 산화방법
KR100653334B1 (ko) * 2003-03-07 2006-12-04 주식회사 엘지생명과학 4-아미노메틸-3-알콕시이미노피롤리딘 메탄설폰산염의 신규한 제조 방법
US8822934B2 (en) * 2006-11-03 2014-09-02 Accuray Incorporated Collimator changer
CN104693088B (zh) * 2013-12-06 2018-01-05 常州市勇毅生物药业有限公司 一种吉米沙星侧链的制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57134482A (en) 1981-02-13 1982-08-19 Dainippon Pharmaceut Co Ltd 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
IN162769B (pt) 1984-11-13 1988-07-09 Kyorin Seiyaku Kk
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH01100165A (ja) 1987-10-13 1989-04-18 Shionogi & Co Ltd オキシムまたはヒドロキシアミン誘導体系抗菌剤
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
JPH0356479A (ja) 1989-07-24 1991-03-12 Takeshi Yokota 水溶性キノロン誘導体のｐ‐トルエンスルホン酸塩
IE66202B1 (en) 1989-08-16 1995-12-13 Pfizer Azabicyclo quinolone carboxylic acids
US5137892A (en) 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
EP0541086A1 (en) 1991-11-08 1993-05-12 Kaken Pharmaceutical Co., Ltd. Antibacterial 6-fluoro-quinolones having an oxime group on the substituent in position 7
JPH0673056A (ja) 1992-08-26 1994-03-15 Kaken Pharmaceut Co Ltd キノリンカルボン酸誘導体およびその塩
US5776944A (en) 1994-06-16 1998-07-07 Lg Chemical Ltd. 7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
DE69509442T2 (de) 1994-06-16 1999-09-02 Lg Chemical Ltd Chinolincarbonsäurederivate mit 7-(4-Amino-methyl-3-oxim)-pyrrolidin-Substituenten und Verfahren zu ihrer Herstellung
JP3449658B2 (ja) 1994-12-21 2003-09-22 杏林製薬株式会社 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
ES2117426T3 (es) 1995-06-06 1998-08-01 Pfizer Forma cristalina de la sal anhidra compuesta de los acidos 7-((1a,5a,6a)-6-amino-3-azabiciclo(3.1.0.)hex-3-il)-6-fluoro-1-(2,4-difluorofenil)-1,4-dihidro-4-oxo-1,8-naftiridina-3-carboxilico y metanosulfonico.
WO1997007098A1 (en) 1995-08-11 1997-02-27 Pfizer Inc. (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanolmethanesulfonate trihydrate
PL188816B1 (pl) 1996-03-29 2005-04-29 Smithkline Beecham Corp Nowy związek, dwuwodzian monometanosulfonianu kwasu (E)-alfa-[2-n-butylo-1-[(4-karboksyfenylo) metylo]-1H-imidazol-5-ilo] metyleno-2-tiofenopropionowego, sposób jego wytwarzania, kompozycja farmaceutyczna i sposób wytwarzania stałej postaci farmaceutycznej do dawkowania
MA24500A1 (fr) * 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
KR100286874B1 (ko) 1998-03-04 2001-04-16 성재갑 보호된 4-아미노메틸-피롤리딘-3-온의 제조방법
DK1082300T3 (da) 1998-05-29 2003-12-15 Upjohn Co 3-[1'-N-Methylamino)ethyl-N-benzyl]pyrrolidin-monomethansulfonat
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
JP2003531101A (ja) 1999-06-29 2003-10-21 スミスクライン・ビーチャム・コーポレイション 細菌に対するフルオロキノロン化合物の使用法
AU6947900A (en) 1999-09-01 2001-03-26 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against bacteria
GB9920919D0 (en) * 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
AU7709400A (en) 1999-09-22 2001-04-24 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against bacteria
KR20010091379A (ko) 2000-03-15 2001-10-23 성재갑 7-(4-아미노메틸-3-옥심)피롤리딘 치환체를 갖는 퀴놀린카르복실산 유도체의 신규 제조방법
KR20020018560A (ko) 2000-09-01 2002-03-08 성재갑 3-아미노메틸-4-ｚ-메톡시이미노피롤리딘의 신규 제조방법

Also Published As

Publication number Publication date
US20040138292A1 (en) 2004-07-15
CZ2002759A3 (cs) 2002-06-12
CA2383751C (en) 2010-06-29
NO322501B1 (no) 2006-10-16
WO2001017961A2 (en) 2001-03-15
GB9920919D0 (en) 1999-11-10
TR200200548T2 (tr) 2002-09-23
AU773698B2 (en) 2004-06-03
US6703512B1 (en) 2004-03-09
PT1212321E (pt) 2004-10-29
US6803467B2 (en) 2004-10-12
DK1212321T3 (da) 2004-10-25
PL354725A1 (en) 2004-02-09
NZ517601A (en) 2003-08-29
HUP0202733A3 (en) 2005-12-28
KR20020041423A (ko) 2002-06-01
MXPA02002356A (es) 2002-07-30
PL206491B1 (pl) 2010-08-31
AU6857300A (en) 2001-04-10
ES2223570T3 (es) 2005-03-01
DE60012028D1 (de) 2004-08-12
ZA200201779B (en) 2003-08-27
HU229391B1 (hu) 2013-11-28
SI1212321T1 (en) 2004-12-31
BR0013750B1 (pt) 2014-06-17
IL148441A (en) 2007-03-08
MY126789A (en) 2006-10-31
IL148441A0 (en) 2002-09-12
CO5180620A1 (es) 2002-07-30
HK1046908B (zh) 2005-05-27
CN1255402C (zh) 2006-05-10
NO20021043D0 (no) 2002-03-01
TWI264435B (en) 2006-10-21
ATE270671T1 (de) 2004-07-15
HUP0202733A2 (hu) 2003-01-28
KR100705363B1 (ko) 2007-04-10
EP1212321B1 (en) 2004-07-07
EP1212321A2 (en) 2002-06-12
BR0013750A (pt) 2002-05-21
CA2383751A1 (en) 2001-03-15
NO20021043L (no) 2002-03-01
JP4208463B2 (ja) 2009-01-14
US20050033064A1 (en) 2005-02-10
JP2003508517A (ja) 2003-03-04
DE60012028T2 (de) 2005-08-18
HK1046908A1 (en) 2003-01-30
WO2001017961A3 (en) 2001-09-20
CN1372558A (zh) 2002-10-02
AR029452A1 (es) 2003-07-02

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: LG LIFE SCIENCES LTD. (KR)

Free format text: TRANSFERIDO DE : SB PHARMCO PUERTO RICO, INC.

B25L Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled

Owner name: SB PHARMCO PUERTO RICO INC. (PR)

Free format text: REFERENTE A RPI 1816 DE 25/10/05, COD. 25.1, POR TER SIDO INDEVIDO.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 24 E 25 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/06/2014, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/09/2000 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 01/09/2020