WO2001092251A3 - Aryloxy ester and acid compounds - Google Patents

Aryloxy ester and acid compounds Download PDF

Info

Publication number
WO2001092251A3
WO2001092251A3 PCT/EP2001/006015 EP0106015W WO0192251A3 WO 2001092251 A3 WO2001092251 A3 WO 2001092251A3 EP 0106015 W EP0106015 W EP 0106015W WO 0192251 A3 WO0192251 A3 WO 0192251A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid compounds
aryloxy ester
aryloxy
ester
coor
Prior art date
Application number
PCT/EP2001/006015
Other languages
French (fr)
Other versions
WO2001092251A2 (en
Inventor
Joseph M Kapinsky
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Priority to IL15297001A priority Critical patent/IL152970A0/en
Priority to EP01945195A priority patent/EP1322633A2/en
Priority to JP2002500865A priority patent/JP2003535086A/en
Priority to CA002410633A priority patent/CA2410633A1/en
Priority to AU2001267483A priority patent/AU2001267483A1/en
Priority to MXPA02010875A priority patent/MXPA02010875A/en
Publication of WO2001092251A2 publication Critical patent/WO2001092251A2/en
Publication of WO2001092251A3 publication Critical patent/WO2001092251A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

This invention is directed to aryloxy ester and acid compounds of the formula (1): Ar-O-(CH2)n-COOR which can be utilized as intermediates in the synthesis of Factor Xa inhibitors to increase their potency and oral activity, and to a method for their production.
PCT/EP2001/006015 2000-05-31 2001-05-25 Aryloxy ester and acid compounds WO2001092251A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IL15297001A IL152970A0 (en) 2000-05-31 2001-05-25 Aryloxy ester and acid compounds
EP01945195A EP1322633A2 (en) 2000-05-31 2001-05-25 Aryloxy ester and acid compounds
JP2002500865A JP2003535086A (en) 2000-05-31 2001-05-25 Aryloxy esters and acid compounds
CA002410633A CA2410633A1 (en) 2000-05-31 2001-05-25 Aryloxy ester and acid compounds
AU2001267483A AU2001267483A1 (en) 2000-05-31 2001-05-25 Aryloxy ester and acid compounds
MXPA02010875A MXPA02010875A (en) 2000-05-31 2001-05-25 Aryloxy ester and acid compounds.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20818900P 2000-05-31 2000-05-31
US60/208,189 2000-05-31

Publications (2)

Publication Number Publication Date
WO2001092251A2 WO2001092251A2 (en) 2001-12-06
WO2001092251A3 true WO2001092251A3 (en) 2003-04-17

Family

ID=22773578

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/006015 WO2001092251A2 (en) 2000-05-31 2001-05-25 Aryloxy ester and acid compounds

Country Status (7)

Country Link
EP (1) EP1322633A2 (en)
JP (1) JP2003535086A (en)
AU (1) AU2001267483A1 (en)
CA (1) CA2410633A1 (en)
IL (1) IL152970A0 (en)
MX (1) MXPA02010875A (en)
WO (1) WO2001092251A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050065178A1 (en) 2003-09-19 2005-03-24 Anwer Basha Substituted diazabicycloakane derivatives

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
A.J. SAGGIOMO ET AL.: "Alcoholation of the Trifluoromethyl Group. I. Ortho Esters Derived from 1- and 3-Trifluoromethylphenolthiazines (1).", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 6, 1969, PROVO US, pages 631 - 634, XP002188913 *
GUTHRIE, J. PETER: "Thermodynamics of ester and orthoester formation from trifluoroacetic acid", CAN. J. CHEM. (1976), 54(2), 202-9, XP001063910 *
J.F. KING ET AL.: "Alkyl 2,2,2-Trifluoroethanesulfonates (Tresylates): Elimination-Additions vs Bimolecular Nucelophilic Substitution in Reactions with Nucleophiles in Aqueous Media", JOURNAL OF ORGANIC CHEMISTRY, vol. 61, 1996, EASTON US, pages 7250 - 7255, XP002188911 *
M.P. CAVA ET AL.: "Pyridine Derivatives. II. Some Halogen Substituted 2-Pyridoxyacetic Acids", JOURNAL OF ORGANIC CHEMISTRY, vol. 23, 1958, EASTON US, pages 1614 - 1616, XP002188915 *
P. TARRANT ET AL.: "Some Reactions of Fluoroethanes with Sodium Ethoxide", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 75, 1953, DC US, pages 932 - 934, XP002188912 *
PEDERSEN, E. B. ET AL: "Thiophene chemistry. XXI. Alkylation of ambident ions from potential hydroxythiophenes", TETRAHEDRON (1972), 28(9), 2479-88, XP002188914 *

Also Published As

Publication number Publication date
AU2001267483A1 (en) 2001-12-11
JP2003535086A (en) 2003-11-25
MXPA02010875A (en) 2003-04-22
CA2410633A1 (en) 2001-12-06
EP1322633A2 (en) 2003-07-02
WO2001092251A2 (en) 2001-12-06
IL152970A0 (en) 2003-06-24

Similar Documents

Publication Publication Date Title
GEP20074135B (en) Process for the synthesis of (is)-4,5-dimethoxy-1-(methylaminomethyl)- benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
RS50140B (en) Percyquinnin, a process for its production, and its use as a pharmaceutical
DE69931393D1 (en) ANTITHROMBOTIC AMIDE
AP2002002637A0 (en) Novel piperazine
IL133623A0 (en) Antithrombotic agents
EP0999834A4 (en) Antithrombotic agents
AU2001280438A1 (en) Substituted heterocyclic amides
MY136269A (en) Novel diphenylazetidinone, process for its preparation, medicaments comprising this compound and their use
HK1078857A1 (en) Intermediates for the production of beraprost and its salts
MXPA03011954A (en) Novel sulfonic acid derivatives.
IL153561A0 (en) 4-alkoxy cyclohexane-1-amino carboxylic acid esters and method for the production thereof
MXPA03012045A (en) Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives.
ATE280767T1 (en) ANTIDIABETIC THIAZOLIDINDIONES AND THEIR PRODUCTION
ATE457972T1 (en) METHOD FOR PRODUCING 7-AMINO-SYN-3,5-DIHYDROXYHEPTANIC ACID DERIVATIVES AND INTERMEDIATE COMPOUNDS OF THIS METHOD AND THEIR PRODUCTION
DE60114640D1 (en) Antithrombosemittel
AU2003242592A1 (en) Amide derivatives as inhibitors of the enzymatic activity of renin
WO2001092251A3 (en) Aryloxy ester and acid compounds
MXPA03002493A (en) Efficient process for the preparation of a factor xa inhibitor.
WO2004065360A3 (en) Piperazine derivatives and their use as synthesis intermediates
AU7851201A (en) Method for the production of imidazo-(1,2-c)(2,3)-benzodiazepines and intermediates in the production thereof
AU6152796A (en) Syntheses of optically pure compounds useful as garft inhibi tors and their intermediates
HUP0103088A2 (en) Production of beraprost ester by selective reduction
AU7919700A (en) Method for the production of cyanoacetic acid esters
HUP0101025A1 (en) New crystalline polymorphic form of 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid guaiacyl ester
NO20024999D0 (en) Synthesis of intermediates for the preparation of vitamin D derivatives

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: PA/a/2002/010875

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2001945195

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 152970

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2410633

Country of ref document: CA

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2002 500865

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2001267483

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2001945195

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2001945195

Country of ref document: EP