AR033984A1 - Derivados de pirrolidina, procedimiento para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la fabricacion de medicamentos - Google Patents
Derivados de pirrolidina, procedimiento para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la fabricacion de medicamentosInfo
- Publication number
- AR033984A1 AR033984A1 ARP010103416A ARP010103416A AR033984A1 AR 033984 A1 AR033984 A1 AR 033984A1 AR P010103416 A ARP010103416 A AR P010103416A AR P010103416 A ARP010103416 A AR P010103416A AR 033984 A1 AR033984 A1 AR 033984A1
- Authority
- AR
- Argentina
- Prior art keywords
- arylcarbonyl
- alkyl
- arylalkyl
- aryl
- arylcarbonylalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Pregnancy & Childbirth (AREA)
- Biochemistry (AREA)
Abstract
Derivados de pirrolidina, que comprenden un compuesto de fórmula general (1) en donde R1 es hidrógeno, alquilcarbonilo o arilcarbonilo; R2 es alquilo, alquilcicloalquilo, alquilcicloalquilalquilo, cicloalquilo, halógenoalquilo, carboxialquilo, aminoalquilo, dialquilaminoalquilo, alcoxialquilo, alcoxicarbonilalquilo, alquinilo, arilo, arilalquilo, arilalquil(alcoxicarbonil)alquilo, arilcarbonilalquilo, ariloxialquilo, arilalquenilo, aril(alcoxicarbonil)alquilo, heteroarilo, heteroarilalquilo, heterociclilo o heterociclilalquilo; A es -C(O)-R3, -CH(OH)-R4, ó -C(O)-NR5R6, en donde R3 y R4 son independientemente del grupo formado por alquilo, arilo, arilalquinilo, arilalquilo y arilalquenilo; R5 es hidrógeno, alquilo, cicloalquilo, cicloalquilalquilo, carboxialquilo, o arilalquilo; R6 es alquilo, alquilcarbonilalquilo, cianoalquilo, hidroxialquilo, hidroxialquil-(hidroxialquilo), alcoxicarbonilalquilo, arilcarbonilalquilo, arilaminocarbonilalquilo, aril(alquil)aminocarbonil-alquilo, aminocarbonillaquilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, heterociclilo, cicloalquilo, cicloalquilalquilo, o carboxialquilo, o R6 se selecciona del grupo consistente en las fórmulas (2), (3) y (4) o -NR5R6 en -C(O)NR5R6 para A representa un anillo saturado de 5 o 6 miembros, sustituido opcionalmente con carboxi, alquiloxicarbonilo, hidroxi, alcoxicarbonilalcoxi, fenilalquilo o fenilalcoxicarbonilo, R7 es hidrógeno, alquilo, alquenilo, alquiltioalquilo, arilo, heteroarilo, carboxialquilo, carboxi, alcoxicarbonilalquilo, arilalquilo, o heteroarilalquilo; o un compuesto de fórmula 5, R7a es hidrógeno o alquilo; R8 es -OR9 o -NR10R11, en donde R9 es hidrógeno, alquilo, arilalquilo; R10 es hidrógeno o alquilo; y R11 es alquilo, arilo, heteroarilo, arilalquilo, o el grupo -NR10R11 representa un anillo de 5 ó 6 miembros opcionalmente sustituido con carboxi, alquiloxicarbonilo, hidroxi, alcoxicarbonilalcoxi, fenialaquilo o fenilalcoxicarbonilo; R12 es alquilo, arilo, o arilalquilo; Y es -O-, -O-S(O2)-, -O-C(O)- o -O-(C)-NH; m es 0, 1 o 2; X es -SO2, -CO-, -C(O)O-, -SO2NH-, o -C(O)NR13- en donde R13 es hidrógeno, alquilo, arilo o carboxialquilo; y formas diméricas, y/o ésteres farmacéuticamente aceptables, y/o sales farmacéuticamente aceptables, y/o sales farmacéuticamente aceptables de los mismos. Los compuestos son útiles como inhibidores de metaloproteasas, por ej. zinc proteasas, en particular zinc hidrolasas, y son efectivos en el tratamiento de enfermedades asociadas con la vasoconstricción de incidencia creciente. Se describen también un proceso para su preparación, composiciones farmacéuticas y el uso de dichos derivados para la fabricación de medicamentos para la profilaxis y tratamiento de trastornos que están causados por la actividad de la enzima conversora de endotelina (ECE), especialmente isquemia de miocardio, insuficiencia cardíaca congestiva, arritmia, hipertensión, hipertensión pulmonar, asma, vasoespasmo cerebral, hemorragia subaracnoidal, pre-eclampsia, enfermedades del rinón, aterosclerosis, enfermedad de Bueger, artritis de Takayasu, complicaciones diabéticas, cáncer de pulmón, cáncer prostático, trastornos gastroinstestinales, shock endotóxico y septicemia, y para la curación de heridas y control de la menstruación, glaucoma, rechazo de injertos, enfermedades asociadas con indicaciones citostáticas, oftalmológicas y cerebroprotectoras, y protección de órganos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00114947 | 2000-07-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR033984A1 true AR033984A1 (es) | 2004-01-21 |
Family
ID=8169224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010103416A AR033984A1 (es) | 2000-07-19 | 2001-07-17 | Derivados de pirrolidina, procedimiento para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la fabricacion de medicamentos |
Country Status (16)
Country | Link |
---|---|
US (1) | US6541638B2 (es) |
EP (1) | EP1303485A1 (es) |
JP (1) | JP4068452B2 (es) |
KR (1) | KR100568841B1 (es) |
CN (1) | CN1620433A (es) |
AR (1) | AR033984A1 (es) |
AU (1) | AU2001270627A1 (es) |
BR (1) | BR0112580A (es) |
CA (1) | CA2414311C (es) |
GT (1) | GT200100145A (es) |
MX (1) | MXPA03000223A (es) |
PA (1) | PA8522501A1 (es) |
PE (1) | PE20020294A1 (es) |
UY (1) | UY26847A1 (es) |
WO (1) | WO2002006222A1 (es) |
ZA (1) | ZA200300167B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100406439C (zh) * | 2000-07-19 | 2008-07-30 | 霍夫曼-拉罗奇有限公司 | 作为金属蛋白酶抑制剂的吡咯烷衍生物 |
RU2290403C2 (ru) | 2000-12-28 | 2006-12-27 | Дайити Фармасьютикал Ко., Лтд. | Ингибиторы vla-4 |
DE60336986D1 (de) | 2002-03-05 | 2011-06-16 | Sumitomo Chemical Co | Verfahren zur herstellung von biarylverbindungen |
EP1613269B1 (en) | 2003-04-04 | 2015-02-25 | Incyte Corporation | Compositions, methods and kits relating to her-2 cleavage |
WO2004092164A1 (en) | 2003-04-10 | 2004-10-28 | Amgen, Inc. | Cyclic amine derivatives and their use in the treatment of inflammation-related disorders mediated by bradykinin |
EP1631542A1 (en) | 2003-04-10 | 2006-03-08 | Amgen, Inc. | Bicyclic compounds having bradykinin receptors affinity and pharmaceutical compositions thereof |
ATE388708T1 (de) | 2003-06-20 | 2008-03-15 | Amgen Inc | Piperazinderivate und anwendungsverfahren |
CN1826336B (zh) | 2003-07-24 | 2010-06-02 | 第一制药株式会社 | 环己烷羧酸类 |
CN1294120C (zh) * | 2003-10-21 | 2007-01-10 | 山东大学 | 吡咯烷类基质金属蛋白酶抑制剂及其应用 |
RU2435585C2 (ru) * | 2006-04-13 | 2011-12-10 | Актелион Фармасьютиклз Лтд | Антагонисты рецептора эндотелина, предназначенные для ранней стадии идиопатического фиброза легких |
ES2350548B1 (es) * | 2009-06-25 | 2011-09-29 | Institut Univ. De Ciència I Tecnologia, S.A. | N-fenil-1-sulfonil-2-pirrolidinacarboxamidas para la identificacion de actividad biologica y farmacologica. |
EP2730571A1 (en) * | 2012-11-12 | 2014-05-14 | Universitat De Barcelona | 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
JP7163916B2 (ja) * | 2017-07-05 | 2022-11-01 | 日産化学株式会社 | ベンジル化合物 |
CN110078593A (zh) * | 2018-11-15 | 2019-08-02 | 南通正达农化有限公司 | 一种苹果蠹蛾性信息素的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
AU644008B2 (en) * | 1990-08-10 | 1993-12-02 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production and use |
JP3091297B2 (ja) * | 1992-01-10 | 2000-09-25 | 住友製薬株式会社 | ピロリジン誘導体およびその製造方法 |
BR9712792A (pt) * | 1996-08-28 | 1999-12-14 | Procter & Gamble | Inibidores de metaloprotease bidentada. |
IL128666A (en) * | 1996-08-28 | 2005-09-25 | Procter & Gamble | Substituted cyclic amine metalloprotease inhibitors |
EP0998457A4 (en) * | 1997-07-10 | 2010-03-10 | CRYSTALLINE FORMS OF INTERMEDIATES OF ANTIBIOTICASE CHAINS | |
BR9910098A (pt) * | 1998-05-01 | 2000-12-26 | Kyoto Pharma Ind | Derivados de carbapenem, utilização dos mesmos e compostos intermediários dos mesmos |
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2001
- 2001-07-10 MX MXPA03000223A patent/MXPA03000223A/es not_active Application Discontinuation
- 2001-07-10 WO PCT/EP2001/007950 patent/WO2002006222A1/en not_active Application Discontinuation
- 2001-07-10 BR BR0112580-0A patent/BR0112580A/pt not_active IP Right Cessation
- 2001-07-10 JP JP2002512128A patent/JP4068452B2/ja not_active Expired - Fee Related
- 2001-07-10 KR KR1020037000781A patent/KR100568841B1/ko not_active IP Right Cessation
- 2001-07-10 AU AU2001270627A patent/AU2001270627A1/en not_active Abandoned
- 2001-07-10 CA CA002414311A patent/CA2414311C/en not_active Expired - Fee Related
- 2001-07-10 CN CNA018130232A patent/CN1620433A/zh active Pending
- 2001-07-10 EP EP01949485A patent/EP1303485A1/en not_active Withdrawn
- 2001-07-16 PA PA20018522501A patent/PA8522501A1/es unknown
- 2001-07-16 PE PE2001000711A patent/PE20020294A1/es not_active Application Discontinuation
- 2001-07-17 UY UY26847A patent/UY26847A1/es not_active Application Discontinuation
- 2001-07-17 AR ARP010103416A patent/AR033984A1/es unknown
- 2001-07-17 US US09/907,135 patent/US6541638B2/en not_active Expired - Fee Related
- 2001-07-18 GT GT200100145A patent/GT200100145A/es unknown
-
2003
- 2003-01-07 ZA ZA200300167A patent/ZA200300167B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2001270627A1 (en) | 2002-01-30 |
BR0112580A (pt) | 2003-06-17 |
GT200100145A (es) | 2002-05-16 |
CA2414311C (en) | 2008-01-08 |
EP1303485A1 (en) | 2003-04-23 |
PE20020294A1 (es) | 2002-04-17 |
JP4068452B2 (ja) | 2008-03-26 |
US20020049243A1 (en) | 2002-04-25 |
KR100568841B1 (ko) | 2006-04-10 |
CN1620433A (zh) | 2005-05-25 |
UY26847A1 (es) | 2002-01-31 |
ZA200300167B (en) | 2004-04-07 |
PA8522501A1 (es) | 2002-09-17 |
US6541638B2 (en) | 2003-04-01 |
JP2004504297A (ja) | 2004-02-12 |
CA2414311A1 (en) | 2002-01-24 |
MXPA03000223A (es) | 2003-06-06 |
WO2002006222A1 (en) | 2002-01-24 |
KR20030016416A (ko) | 2003-02-26 |
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