DK3184523T3 - N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4' -(morphofinomethyl)-[1,1'-biphenyl]-3-carboxamidhydrobromid til anvendelse i behandlingen af en sygdom med celleproliferation i det hæmatologiske system. - Google Patents
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4' -(morphofinomethyl)-[1,1'-biphenyl]-3-carboxamidhydrobromid til anvendelse i behandlingen af en sygdom med celleproliferation i det hæmatologiske system. Download PDFInfo
- Publication number
- DK3184523T3 DK3184523T3 DK16191716.6T DK16191716T DK3184523T3 DK 3184523 T3 DK3184523 T3 DK 3184523T3 DK 16191716 T DK16191716 T DK 16191716T DK 3184523 T3 DK3184523 T3 DK 3184523T3
- Authority
- DK
- Denmark
- Prior art keywords
- methyl
- morphophinomethyl
- dihydropyridin
- pyran
- tetrahydro
- Prior art date
Links
- -1 (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl) methyl Chemical group 0.000 title 2
- 230000004663 cell proliferation Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 210000005096 hematological system Anatomy 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261624215P | 2012-04-13 | 2012-04-13 | |
| EP13774979.2A EP2836491B1 (en) | 2012-04-13 | 2013-04-11 | Salt form of a human histone methyltransferase ezh2 inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3184523T3 true DK3184523T3 (da) | 2019-08-19 |
Family
ID=49328166
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16191716.6T DK3184523T3 (da) | 2012-04-13 | 2013-04-11 | N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4' -(morphofinomethyl)-[1,1'-biphenyl]-3-carboxamidhydrobromid til anvendelse i behandlingen af en sygdom med celleproliferation i det hæmatologiske system. |
| DK13774979.2T DK2836491T3 (da) | 2012-04-13 | 2013-04-11 | Saltform af en human histonmethyltransferase ezh2-inhibitor |
| DK19180479.8T DK3628670T3 (da) | 2012-04-13 | 2013-04-11 | Saltform til ezh2-hæmning |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13774979.2T DK2836491T3 (da) | 2012-04-13 | 2013-04-11 | Saltform af en human histonmethyltransferase ezh2-inhibitor |
| DK19180479.8T DK3628670T3 (da) | 2012-04-13 | 2013-04-11 | Saltform til ezh2-hæmning |
Country Status (25)
| Country | Link |
|---|---|
| US (6) | US9394283B2 (da) |
| EP (4) | EP3628670B1 (da) |
| JP (3) | JP6255382B2 (da) |
| KR (3) | KR20220123339A (da) |
| CN (2) | CN104603130B (da) |
| AU (2) | AU2013245878B2 (da) |
| BR (1) | BR112014025508B1 (da) |
| CA (1) | CA2870005C (da) |
| CY (2) | CY1119383T1 (da) |
| DK (3) | DK3184523T3 (da) |
| ES (3) | ES2617379T3 (da) |
| HR (2) | HRP20170295T1 (da) |
| HU (3) | HUE045353T2 (da) |
| IL (4) | IL296199B1 (da) |
| IN (1) | IN2014DN09068A (da) |
| LT (2) | LT2836491T (da) |
| MX (1) | MX362339B (da) |
| NZ (1) | NZ700761A (da) |
| PL (3) | PL3184523T3 (da) |
| PT (3) | PT3628670T (da) |
| RS (2) | RS55690B1 (da) |
| RU (1) | RU2658911C2 (da) |
| SG (3) | SG10201912109QA (da) |
| SI (2) | SI2836491T1 (da) |
| WO (1) | WO2013155317A1 (da) |
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| RU2658919C2 (ru) | 2012-10-15 | 2018-06-26 | Эпизайм, Инк. | Замещенные бензольные соединения |
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| EA030196B1 (ru) | 2013-04-30 | 2018-07-31 | Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед | Ингибиторы энхансера zeste гомолога 2 |
| RU2016104044A (ru) | 2013-07-10 | 2017-08-15 | Глэксосмитклайн Интеллекчуал Проперти (Nо.2) Лимитед | Ингибиторы усилителя zeste гомолога 2 |
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| WO2013173441A2 (en) | 2012-05-16 | 2013-11-21 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
| NZ746054A (en) | 2012-10-15 | 2020-07-31 | Epizyme Inc | Methods of treating cancer |
| FI3057962T3 (fi) | 2013-10-16 | 2023-11-03 | Epizyme Inc | Hydrokloridisuolamuoto ezh2-estoon |
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