SG10201912109QA - Salt form of a human hi stone methyltransf erase ezh2 inhibitor - Google Patents
Salt form of a human hi stone methyltransf erase ezh2 inhibitorInfo
- Publication number
- SG10201912109QA SG10201912109QA SG10201912109QA SG10201912109QA SG10201912109QA SG 10201912109Q A SG10201912109Q A SG 10201912109QA SG 10201912109Q A SG10201912109Q A SG 10201912109QA SG 10201912109Q A SG10201912109Q A SG 10201912109QA SG 10201912109Q A SG10201912109Q A SG 10201912109QA
- Authority
- SG
- Singapore
- Prior art keywords
- stone
- human
- salt form
- ezh2 inhibitor
- methyltransf erase
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261624215P | 2012-04-13 | 2012-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201912109QA true SG10201912109QA (en) | 2020-02-27 |
Family
ID=49328166
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201406468YA SG11201406468YA (en) | 2012-04-13 | 2013-04-11 | Salt form of a human hi stone methyltransf erase ezh2 inhibitor |
| SG10201608577RA SG10201608577RA (en) | 2012-04-13 | 2013-04-11 | Salt form of a human hi stone methyltransf erase ezh2 inhibitor |
| SG10201912109QA SG10201912109QA (en) | 2012-04-13 | 2013-04-11 | Salt form of a human hi stone methyltransf erase ezh2 inhibitor |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201406468YA SG11201406468YA (en) | 2012-04-13 | 2013-04-11 | Salt form of a human hi stone methyltransf erase ezh2 inhibitor |
| SG10201608577RA SG10201608577RA (en) | 2012-04-13 | 2013-04-11 | Salt form of a human hi stone methyltransf erase ezh2 inhibitor |
Country Status (25)
| Country | Link |
|---|---|
| US (6) | US9394283B2 (en) |
| EP (4) | EP3628670B1 (en) |
| JP (3) | JP6255382B2 (en) |
| KR (3) | KR102120883B1 (en) |
| CN (2) | CN104603130B (en) |
| AU (2) | AU2013245878B2 (en) |
| BR (1) | BR112014025508B1 (en) |
| CA (1) | CA2870005C (en) |
| CY (2) | CY1119383T1 (en) |
| DK (3) | DK2836491T3 (en) |
| ES (3) | ES2931316T3 (en) |
| HR (2) | HRP20170295T1 (en) |
| HU (3) | HUE031976T2 (en) |
| IL (4) | IL282732B2 (en) |
| IN (1) | IN2014DN09068A (en) |
| LT (2) | LT2836491T (en) |
| MX (1) | MX362339B (en) |
| NZ (1) | NZ700761A (en) |
| PL (3) | PL3628670T3 (en) |
| PT (3) | PT2836491T (en) |
| RS (2) | RS55690B1 (en) |
| RU (1) | RU2658911C2 (en) |
| SG (3) | SG11201406468YA (en) |
| SI (2) | SI3184523T1 (en) |
| WO (1) | WO2013155317A1 (en) |
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| CA2862289C (en) | 2012-02-10 | 2019-11-26 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| KR20230004871A (en) | 2012-04-13 | 2023-01-06 | 에피자임, 인코포레이티드 | Combination therapy for treating cancer |
| SG11201406468YA (en) * | 2012-04-13 | 2015-01-29 | Epizyme Inc | Salt form of a human hi stone methyltransf erase ezh2 inhibitor |
| WO2013173441A2 (en) | 2012-05-16 | 2013-11-21 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
| PE20150887A1 (en) | 2012-10-15 | 2015-06-04 | Epizyme Inc | SUBSTITUTE BENZENE COMPOUNDS |
| NZ706836A (en) | 2012-10-15 | 2019-02-22 | Epizyme Inc | Methods of treating cancer |
| EP2970305B1 (en) | 2013-03-15 | 2017-02-22 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| EP2991980B1 (en) | 2013-04-30 | 2019-01-02 | Glaxosmithkline Intellectual Property (No. 2) Limited | Enhancer of zeste homolog 2 inhibitors |
| US9556157B2 (en) | 2013-07-10 | 2017-01-31 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
| EP3033334A1 (en) | 2013-08-15 | 2016-06-22 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
| AU2014337300B2 (en) | 2013-10-16 | 2019-01-03 | Eisai R&D Management Co., Ltd. | Hydrochloride salt form for EZH2 inhibition |
| JP2016533364A (en) * | 2013-10-18 | 2016-10-27 | エピザイム，インコーポレイティド | How to treat cancer |
| US9738630B2 (en) | 2013-11-19 | 2017-08-22 | Bristol-Myers Squibb Company | Inhibitors of lysine methyl transferase |
| ES2863996T3 (en) | 2013-12-06 | 2021-10-13 | Epizyme Inc | Combination therapy for cancer treatment |
| CN106999498B (en) | 2014-06-17 | 2021-06-08 | Epizyme股份有限公司 | EZH2 inhibitors for the treatment of lymphoma |
| ES2725928T3 (en) | 2014-06-20 | 2019-09-30 | Constellation Pharmaceuticals Inc | Crystal forms of 2 - ((4S) -6- (4-chlorophenyl) -1-methyl-4H-benzo [c] isoxazolo [4,5-e] azepin-4-yl) acetamide |
| MX2017004969A (en) | 2014-10-16 | 2017-07-19 | Epizyme Inc | Method for treating cancer. |
| BR112017010166A2 (en) * | 2014-11-17 | 2018-02-14 | Eisai R&D Man Co Ltd | solid tumor treatment method, activity inhibition method, oral dosage form for treating a solid tumor, solid pharmaceutical formulation, process for preparing a pharmaceutical formulation, and solid pharmaceutical composition |
| TW201636344A (en) | 2014-12-05 | 2016-10-16 | 美國禮來大藥廠 | Inhibitors of EZH2 |
| EP3285773A4 (en) | 2015-04-20 | 2019-04-10 | Epizyme, Inc. | Combination therapy for treating cancer |
| EP3307713A4 (en) | 2015-06-10 | 2019-01-23 | Epizyme, Inc. | Ezh2 inhibitors for treating lymphoma |
| WO2017035234A1 (en) | 2015-08-24 | 2017-03-02 | Epizyme, Inc. | Method for treating cancer |
| TW201718598A (en) | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Inhibitors of EZH2 |
| WO2017040190A1 (en) | 2015-08-28 | 2017-03-09 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (r)-n-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1h-indole-3-carboxamide |
| CA3011186A1 (en) | 2016-01-29 | 2017-08-03 | Epizyme, Inc. | Combination therapy for treating cancer |
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| EP3529242A1 (en) | 2016-10-19 | 2019-08-28 | Constellation Pharmaceuticals, Inc. | Synthesis of inhibitors of ezh2 |
| WO2018137639A1 (en) * | 2017-01-25 | 2018-08-02 | 恩瑞生物医药科技（上海）有限公司 | Histone methyltransferase ezh2 inhibitor, preparation method and pharmaceutical use thereof |
| US11642346B2 (en) | 2017-03-31 | 2023-05-09 | Epizyme, Inc. | Combination therapy for treating cancer |
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| JP2021531340A (en) | 2018-07-09 | 2021-11-18 | フォンダシヨン、アジール、デ、アブグルスFondation Asile Des Aveugles | Inhibition of the PRC2 subunit to treat eye disorders |
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2013
- 2013-04-11 SG SG11201406468YA patent/SG11201406468YA/en unknown
- 2013-04-11 PL PL19180479.8T patent/PL3628670T3/en unknown
- 2013-04-11 SG SG10201608577RA patent/SG10201608577RA/en unknown
- 2013-04-11 RU RU2014145544A patent/RU2658911C2/en not_active Application Discontinuation
- 2013-04-11 PL PL16191716T patent/PL3184523T3/en unknown
- 2013-04-11 ES ES19180479T patent/ES2931316T3/en active Active
- 2013-04-11 MX MX2014012380A patent/MX362339B/en active IP Right Grant
- 2013-04-11 EP EP19180479.8A patent/EP3628670B1/en active Active
- 2013-04-11 SI SI201331566T patent/SI3184523T1/en unknown
- 2013-04-11 IL IL282732A patent/IL282732B2/en unknown
- 2013-04-11 DK DK13774979.2T patent/DK2836491T3/en active
- 2013-04-11 HU HUE13774979A patent/HUE031976T2/en unknown
- 2013-04-11 EP EP13774979.2A patent/EP2836491B1/en active Active
- 2013-04-11 HU HUE19180479A patent/HUE060881T2/en unknown
- 2013-04-11 PL PL13774979T patent/PL2836491T3/en unknown
- 2013-04-11 AU AU2013245878A patent/AU2013245878B2/en active Active
- 2013-04-11 EP EP22200677.7A patent/EP4190777A1/en active Pending
- 2013-04-11 WO PCT/US2013/036193 patent/WO2013155317A1/en active Application Filing
- 2013-04-11 KR KR1020147030684A patent/KR102120883B1/en active IP Right Grant
- 2013-04-11 KR KR1020207015664A patent/KR102438340B1/en active IP Right Grant
- 2013-04-11 LT LTEP13774979.2T patent/LT2836491T/en unknown
- 2013-04-11 SI SI201330551A patent/SI2836491T1/en unknown
- 2013-04-11 RS RS20170198A patent/RS55690B1/en unknown
- 2013-04-11 KR KR1020227029511A patent/KR20220123339A/en not_active Application Discontinuation
- 2013-04-11 SG SG10201912109QA patent/SG10201912109QA/en unknown
- 2013-04-11 CN CN201380030902.3A patent/CN104603130B/en active Active
- 2013-04-11 IN IN9068DEN2014 patent/IN2014DN09068A/en unknown
- 2013-04-11 HU HUE16191716A patent/HUE045353T2/en unknown
- 2013-04-11 PT PT137749792T patent/PT2836491T/en unknown
- 2013-04-11 LT LTEP16191716.6T patent/LT3184523T/en unknown
- 2013-04-11 US US14/394,431 patent/US9394283B2/en active Active
- 2013-04-11 BR BR112014025508-3A patent/BR112014025508B1/en active IP Right Grant
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