CY1119383T1 - Αναστολεας ανθρωπινης ιστονικης μεθυλοτρανσφερασης εζη2 σε μορφη αλατος - Google Patents

Αναστολεας ανθρωπινης ιστονικης μεθυλοτρανσφερασης εζη2 σε μορφη αλατος

Info

Publication number
CY1119383T1
CY1119383T1 CY20171100290T CY171100290T CY1119383T1 CY 1119383 T1 CY1119383 T1 CY 1119383T1 CY 20171100290 T CY20171100290 T CY 20171100290T CY 171100290 T CY171100290 T CY 171100290T CY 1119383 T1 CY1119383 T1 CY 1119383T1
Authority
CY
Cyprus
Prior art keywords
methylother
anasteleas
histonic
salt
human
Prior art date
Application number
CY20171100290T
Other languages
English (en)
Inventor
Kevin Wayne Kuntz
Kuan-Chun Huang
Hyeong Wook Choi
Kristen Sanders
Steven Mathieu
Arani Chanda
Frank Fang
Original Assignee
Epizyme, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme, Inc. filed Critical Epizyme, Inc.
Publication of CY1119383T1 publication Critical patent/CY1119383T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Περιγράφεται ενταύθα το υδροβρωμικό Ν-((4,6-διμεθυλο-2-οξο-1,2-διυδροπυριδιν-3-υλ)μεθυλ)-5-(αιθυλο(τετραϋδρο-2Η-πυραν-4-υλ)αμινο)-4-μεθυλ-4'-(μορφολινομεθυλ)-[1,1’-διφαινυλ]-3-καρβοξαμίδιο. Επίσης περιγράφεται ενταύθα μια ειδική πολύμορφη μορφή της ένωσης.
CY20171100290T 2012-04-13 2017-03-06 Αναστολεας ανθρωπινης ιστονικης μεθυλοτρανσφερασης εζη2 σε μορφη αλατος CY1119383T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261624215P 2012-04-13 2012-04-13
PCT/US2013/036193 WO2013155317A1 (en) 2012-04-13 2013-04-11 Salt form of a human hi stone methyltransf erase ezh2 inhibitor

Publications (1)

Publication Number Publication Date
CY1119383T1 true CY1119383T1 (el) 2018-02-14

Family

ID=49328166

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20171100290T CY1119383T1 (el) 2012-04-13 2017-03-06 Αναστολεας ανθρωπινης ιστονικης μεθυλοτρανσφερασης εζη2 σε μορφη αλατος
CY20191100981T CY1122883T1 (el) 2012-04-13 2019-09-18 Ν-((4,6-διμεθυλ-2-οξο-l,2-διυδροπυριδιν-3-υλ)μεθυλ)-5-(αιθυλ (τετραϋδρο-2η-πυραν-4-υλ)αμινο)-4-μεθυλ-4'-(μορφολινομεθυλ)-[l,1'-διφαινυλ]-3-καρβοξαμιδιο υδροβρωμικο για χρηση στη θεραπεια μιας κυτταροπολλαπλασιαστικης διαταραχης του αιματολογικου συστηματος

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20191100981T CY1122883T1 (el) 2012-04-13 2019-09-18 Ν-((4,6-διμεθυλ-2-οξο-l,2-διυδροπυριδιν-3-υλ)μεθυλ)-5-(αιθυλ (τετραϋδρο-2η-πυραν-4-υλ)αμινο)-4-μεθυλ-4'-(μορφολινομεθυλ)-[l,1'-διφαινυλ]-3-καρβοξαμιδιο υδροβρωμικο για χρηση στη θεραπεια μιας κυτταροπολλαπλασιαστικης διαταραχης του αιματολογικου συστηματος

Country Status (25)

Country Link
US (6) US9394283B2 (el)
EP (4) EP2836491B1 (el)
JP (3) JP6255382B2 (el)
KR (3) KR102438340B1 (el)
CN (2) CN104603130B (el)
AU (2) AU2013245878B2 (el)
BR (1) BR112014025508B1 (el)
CA (1) CA2870005C (el)
CY (2) CY1119383T1 (el)
DK (3) DK3628670T3 (el)
ES (3) ES2745016T3 (el)
HR (2) HRP20170295T1 (el)
HU (3) HUE031976T2 (el)
IL (4) IL296199A (el)
IN (1) IN2014DN09068A (el)
LT (2) LT2836491T (el)
MX (1) MX362339B (el)
NZ (1) NZ700761A (el)
PL (3) PL3184523T3 (el)
PT (3) PT3184523T (el)
RS (2) RS55690B1 (el)
RU (1) RU2658911C2 (el)
SG (3) SG11201406468YA (el)
SI (2) SI3184523T1 (el)
WO (1) WO2013155317A1 (el)

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Also Published As

Publication number Publication date
HRP20191653T1 (hr) 2020-02-21
US20230140327A1 (en) 2023-05-04
JP2018199740A (ja) 2018-12-20
EP2836491A4 (en) 2015-09-16
KR102438340B1 (ko) 2022-08-30
HUE045353T2 (hu) 2019-12-30
PT3184523T (pt) 2019-09-26
US20210137936A1 (en) 2021-05-13
CN104603130B (zh) 2018-04-27
AU2018200168B2 (en) 2019-08-29
JP2015512942A (ja) 2015-04-30
SG11201406468YA (en) 2015-01-29
US11491163B2 (en) 2022-11-08
DK2836491T3 (en) 2017-03-06
PL3628670T3 (pl) 2023-02-20
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