EA201600166A1 - Производные пиперидина и азепина как модуляторы рецептора прокинетицина - Google Patents

Производные пиперидина и азепина как модуляторы рецептора прокинетицина

Info

Publication number
EA201600166A1
EA201600166A1 EA201600166A EA201600166A EA201600166A1 EA 201600166 A1 EA201600166 A1 EA 201600166A1 EA 201600166 A EA201600166 A EA 201600166A EA 201600166 A EA201600166 A EA 201600166A EA 201600166 A1 EA201600166 A1 EA 201600166A1
Authority
EA
Eurasian Patent Office
Prior art keywords
azepina
modulators
piperidine
derivatives
prokineticin receptor
Prior art date
Application number
EA201600166A
Other languages
English (en)
Other versions
EA031310B1 (ru
Inventor
Сара Бусьба
Анне Голдби
Керри Дженкинс
Наташа Кинзелла
Мартин Тилл
Original Assignee
Такеда Фармасьютикл Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Такеда Фармасьютикл Компани Лимитед filed Critical Такеда Фармасьютикл Компани Лимитед
Publication of EA201600166A1 publication Critical patent/EA201600166A1/ru
Publication of EA031310B1 publication Critical patent/EA031310B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Данное изобретение предлагает соединения формулы (I) и их фармацевтически приемлемые солив которой m, X, R, R, Rи Rявляются такими, как определено в описании, способы их получения, фармацевтические композиции, содержащие их, и их применение в терапии.
EA201600166A 2013-08-08 2014-08-07 Производные пиперидина и азепина как модуляторы рецептора прокинетицина EA031310B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1314286.4A GB201314286D0 (en) 2013-08-08 2013-08-08 Therapeutic Compounds
PCT/GB2014/052428 WO2015019103A1 (en) 2013-08-08 2014-08-07 Piperidine and azepine derivatives as prokineticin receptor modulators

Publications (2)

Publication Number Publication Date
EA201600166A1 true EA201600166A1 (ru) 2016-10-31
EA031310B1 EA031310B1 (ru) 2018-12-28

Family

ID=49261949

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201600166A EA031310B1 (ru) 2013-08-08 2014-08-07 Производные пиперидина и азепина как модуляторы рецептора прокинетицина

Country Status (12)

Country Link
US (2) US9790201B2 (ru)
EP (1) EP3030553B1 (ru)
JP (1) JP6423877B2 (ru)
CN (1) CN105452233B (ru)
AU (1) AU2014304308B2 (ru)
BR (1) BR112016002724B1 (ru)
CA (1) CA2919297C (ru)
EA (1) EA031310B1 (ru)
ES (1) ES2665675T3 (ru)
GB (1) GB201314286D0 (ru)
HK (1) HK1219723A1 (ru)
WO (1) WO2015019103A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11246860B2 (en) 2019-11-07 2022-02-15 Lophora ApS 5-HT2A agonists for use in treatment of depression

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT77352A (hu) 1994-08-24 1998-03-30 Astra Aktiebolag Spiro[aza-bicikloalkán-oxazolidin]-2'-on-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9600683D0 (sv) 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
AR013184A1 (es) 1997-07-18 2000-12-13 Astrazeneca Ab Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
SE9702799D0 (sv) 1997-07-25 1997-07-25 Astra Ab New compounds
SE9900100D0 (sv) 1999-01-15 1999-01-15 Astra Ab New compounds
SE9903760D0 (sv) 1999-10-18 1999-10-18 Astra Ab New compounds
SE9904176D0 (sv) 1999-11-18 1999-11-18 Astra Ab New use
SE0000540D0 (sv) 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
SE0002729D0 (sv) 2000-07-20 2000-07-20 Astrazeneca Ab Novel compound form
WO2002094794A1 (en) 2001-05-18 2002-11-28 Astrazeneca Ab 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders
CN1294136C (zh) 2001-06-01 2007-01-10 阿斯特拉曾尼卡有限公司 用于治疗的烟碱乙酰胆碱受体新型配体
CA2482311C (en) 2002-04-18 2009-12-08 Astrazeneca Ab Furyl compounds
DE60328010D1 (de) 2002-04-18 2009-07-30 Astrazeneca Ab Heterocyclische verbindungen
JP4511196B2 (ja) 2002-04-18 2010-07-28 アストラゼネカ・アクチエボラーグ チエニル化合物
SE0202430D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab New Compounds
SE0202465D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab New compounds
SE0202598D0 (sv) 2002-09-02 2002-09-02 Astrazeneca Ab Alpha-7 Nicotinic receptor agonists and statins in combination
PL378268A1 (pl) 2002-11-26 2006-03-20 Pfizer Products Inc. Aktywatory PPAR
CA2567398A1 (en) 2004-05-25 2005-12-08 Pfizer Products Inc. New use
CA2635845A1 (en) 2005-12-29 2007-07-12 Janssen Pharmaceutica N.V. Prokineticin 2 receptor antagonists
CL2006003736A1 (es) * 2005-12-29 2008-05-16 Janssen Pharmaceutica Nv Compuestos derivados de triazina o pirimidina sustituida, antagonistas del receptor de prokineticina 1, composicion farmaceutica; y uso en el tratamiento de trastornos gastrointestinales.
WO2009098576A1 (en) 2008-02-05 2009-08-13 Pfizer Inc. Pyridinyl amides for the treatment of cns and metabolic disorders
WO2010077976A2 (en) * 2008-12-17 2010-07-08 The Regents Of The University Of California Prokineticin receptor antagonists and uses thereof
WO2012006004A1 (en) * 2010-06-28 2012-01-12 Janssen Pharmaceutica Nv Prokineticin 1 receptor antagonists for the treatment of pain
WO2014160668A1 (en) * 2013-03-25 2014-10-02 Bristol-Myers Squibb Company Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors
US9359330B2 (en) * 2013-08-26 2016-06-07 Purdue Pharma L.P. Substituted piperidines as sodium channel blockers

Also Published As

Publication number Publication date
JP6423877B2 (ja) 2018-11-14
CN105452233B (zh) 2017-12-08
EP3030553B1 (en) 2018-01-03
CA2919297A1 (en) 2015-02-12
EP3030553A1 (en) 2016-06-15
BR112016002724B1 (pt) 2022-02-15
US20160185752A1 (en) 2016-06-30
HK1219723A1 (zh) 2017-04-13
CN105452233A (zh) 2016-03-30
US9790201B2 (en) 2017-10-17
ES2665675T3 (es) 2018-04-26
GB201314286D0 (en) 2013-09-25
JP2016527300A (ja) 2016-09-08
AU2014304308A1 (en) 2016-01-07
WO2015019103A1 (en) 2015-02-12
BR112016002724A2 (pt) 2017-08-01
BR112016002724A8 (pt) 2020-02-04
CA2919297C (en) 2021-09-14
US20180009780A1 (en) 2018-01-11
US10160745B2 (en) 2018-12-25
AU2014304308B2 (en) 2018-07-05
EA031310B1 (ru) 2018-12-28

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