LT2836491T - Žmogaus histono metiltransferazės ezh2 slopiklio druskos forma - Google Patents

Žmogaus histono metiltransferazės ezh2 slopiklio druskos forma

Info

Publication number
LT2836491T
LT2836491T LTEP13774979.2T LT13774979T LT2836491T LT 2836491 T LT2836491 T LT 2836491T LT 13774979 T LT13774979 T LT 13774979T LT 2836491 T LT2836491 T LT 2836491T
Authority
LT
Lithuania
Prior art keywords
salt form
histone methyltransferase
ezh2 inhibitor
human histone
methyltransferase ezh2
Prior art date
Application number
LTEP13774979.2T
Other languages
English (en)
Inventor
Kevin Wayne Kuntz
Kuan-Chun Huang
Hyeong Wook CHOI
Kristen SANDERS
Steven Mathieu
Arani CHANDA
Frank Fang
Original Assignee
Epizyme, Inc.
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme, Inc., Eisai R&D Management Co., Ltd. filed Critical Epizyme, Inc.
Publication of LT2836491T publication Critical patent/LT2836491T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
LTEP13774979.2T 2012-04-13 2013-04-11 Žmogaus histono metiltransferazės ezh2 slopiklio druskos forma LT2836491T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261624215P 2012-04-13 2012-04-13
PCT/US2013/036193 WO2013155317A1 (en) 2012-04-13 2013-04-11 Salt form of a human hi stone methyltransf erase ezh2 inhibitor

Publications (1)

Publication Number Publication Date
LT2836491T true LT2836491T (lt) 2017-03-27

Family

ID=49328166

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP13774979.2T LT2836491T (lt) 2012-04-13 2013-04-11 Žmogaus histono metiltransferazės ezh2 slopiklio druskos forma
LTEP16191716.6T LT3184523T (lt) 2012-04-13 2013-04-11 N-((4,6-dimetil-2-okso-1,2-dihidropiridin-3-il)metil)-5-(etil (tetrahidro-2h-piran-4-il)amino)-4-metil-4'-(morfolinometil)-[1,1'-bifenil]-3-karboksamido hidrobromidas, skirtas naudoti hematologinės sistemos proliferacinio sutrikimo gydymui

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTEP16191716.6T LT3184523T (lt) 2012-04-13 2013-04-11 N-((4,6-dimetil-2-okso-1,2-dihidropiridin-3-il)metil)-5-(etil (tetrahidro-2h-piran-4-il)amino)-4-metil-4'-(morfolinometil)-[1,1'-bifenil]-3-karboksamido hidrobromidas, skirtas naudoti hematologinės sistemos proliferacinio sutrikimo gydymui

Country Status (25)

Country Link
US (6) US9394283B2 (lt)
EP (4) EP4190777A1 (lt)
JP (3) JP6255382B2 (lt)
KR (3) KR102438340B1 (lt)
CN (2) CN104603130B (lt)
AU (2) AU2013245878B2 (lt)
BR (1) BR112014025508B1 (lt)
CA (1) CA2870005C (lt)
CY (2) CY1119383T1 (lt)
DK (3) DK2836491T3 (lt)
ES (3) ES2745016T3 (lt)
HR (2) HRP20170295T1 (lt)
HU (3) HUE031976T2 (lt)
IL (4) IL282732B2 (lt)
IN (1) IN2014DN09068A (lt)
LT (2) LT2836491T (lt)
MX (1) MX362339B (lt)
NZ (1) NZ700761A (lt)
PL (3) PL3184523T3 (lt)
PT (3) PT3184523T (lt)
RS (2) RS55690B1 (lt)
RU (1) RU2658911C2 (lt)
SG (3) SG10201912109QA (lt)
SI (2) SI3184523T1 (lt)
WO (1) WO2013155317A1 (lt)

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Also Published As

Publication number Publication date
IL282732A (en) 2021-06-30
SG11201406468YA (en) 2015-01-29
CN104603130B (zh) 2018-04-27
EP2836491B1 (en) 2016-12-07
SI3184523T1 (sl) 2020-04-30
EP2836491A4 (en) 2015-09-16
JP2018002742A (ja) 2018-01-11
CY1119383T1 (el) 2018-02-14
KR20220123339A (ko) 2022-09-06
RU2014145544A (ru) 2016-06-10
HUE031976T2 (en) 2017-08-28
US20210137936A1 (en) 2021-05-13
HRP20191653T1 (hr) 2020-02-21
RS55690B1 (sr) 2017-07-31
CN108358899B (zh) 2021-07-27
IN2014DN09068A (lt) 2015-05-22
SG10201912109QA (en) 2020-02-27
HUE045353T2 (hu) 2019-12-30
JP2015512942A (ja) 2015-04-30
DK2836491T3 (en) 2017-03-06
EP4190777A1 (en) 2023-06-07
CN108358899A (zh) 2018-08-03
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