ATE547514T1 - Protein-demethylasen mit einer jmjc-domäne - Google Patents

Protein-demethylasen mit einer jmjc-domäne

Info

Publication number
ATE547514T1
ATE547514T1 AT06836609T AT06836609T ATE547514T1 AT E547514 T1 ATE547514 T1 AT E547514T1 AT 06836609 T AT06836609 T AT 06836609T AT 06836609 T AT06836609 T AT 06836609T AT E547514 T1 ATE547514 T1 AT E547514T1
Authority
AT
Austria
Prior art keywords
protein
demethylases
jmjc domain
novel
demethylase
Prior art date
Application number
AT06836609T
Other languages
English (en)
Inventor
Yi Zhang
Yuichi Tsukada
Kenichi Yamane
Robert John Klose
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38006404&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE547514(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ North Carolina filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE547514T1 publication Critical patent/ATE547514T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT06836609T 2005-10-28 2006-10-27 Protein-demethylasen mit einer jmjc-domäne ATE547514T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73105305P 2005-10-28 2005-10-28
US78943706P 2006-04-05 2006-04-05
PCT/US2006/042126 WO2007053480A2 (en) 2005-10-28 2006-10-27 Protein demethylases comprising a jmjc domain

Publications (1)

Publication Number Publication Date
ATE547514T1 true ATE547514T1 (de) 2012-03-15

Family

ID=38006404

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06836609T ATE547514T1 (de) 2005-10-28 2006-10-27 Protein-demethylasen mit einer jmjc-domäne

Country Status (7)

Country Link
US (2) US20090203057A1 (de)
EP (1) EP1941060B1 (de)
JP (1) JP5078901B2 (de)
AT (1) ATE547514T1 (de)
AU (1) AU2006308957B2 (de)
CA (1) CA2622615A1 (de)
WO (1) WO2007053480A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006506991A (ja) 2002-11-25 2006-03-02 デン・コンゲリエ・ヴェテリネー−オ・ランボホイスコレ ブタ多型およびその検出のための方法
WO2007104314A2 (en) * 2006-03-14 2007-09-20 Københavns Universitet INHIBITION OF GASCl
EP1950286B1 (de) * 2007-01-26 2015-08-12 Universitätsklinikum Freiburg Proteinkomplex mit Tri-demethylierungsaktivität und Verfahren zu seiner Herstellung und Verwendung
WO2009075811A1 (en) * 2007-12-07 2009-06-18 Tufts Medical Center, Inc. Compositions and methods for immortalizing cells and screening for anti-cancer agents
WO2010008463A1 (en) * 2008-06-25 2010-01-21 The University Of North Carolina At Chapel Hill Deficiency in the histone demethylase jhdm2a results in impaired energy expenditure and obesity
WO2011011366A2 (en) * 2009-07-20 2011-01-27 Constellation Pharmaceuticals Agents for stimulating activity of methyl modifying enzymes and methods of use thereof
US20130102477A1 (en) 2010-06-23 2013-04-25 Ryan D. Morin Biomarkers for non-hodgkin lymphomas and uses thereof
CN101886130B (zh) * 2010-06-25 2012-02-08 中国环境科学研究院 一种污染物致dna去甲基化能力定量检测方法
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
RU2765155C2 (ru) 2010-09-10 2022-01-26 Эпизайм, Инк. Ингибиторы ezh2 человека и способы их применения
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
TW201733984A (zh) 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
EP3461896B1 (de) 2011-07-15 2023-11-29 The General Hospital Corporation Verfahren zur transkription einer aktivatorähnlichen effektoranordnung
CN102417894B (zh) * 2011-10-21 2013-06-05 中国科学院广州生物医药与健康研究院 一种提高诱导生成多能性干细胞效率的方法
WO2013123411A1 (en) * 2012-02-17 2013-08-22 Board Of Regents, The University Of Texas System Methods for diagnosing and treating cancer
ES2745016T3 (es) 2012-04-13 2020-02-27 Epizyme Inc Bromhidrato de N-((4,6-dimetil-2-oxo-L,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2H-piran-4-il)amino)-4-metil-4'-(morfolinometil)-[L,1'-bifenil]-3-carboxamida para su uso en el tratamiento de un trastorno proliferativo celular del sistema hematológico
US9890364B2 (en) 2012-05-29 2018-02-13 The General Hospital Corporation TAL-Tet1 fusion proteins and methods of use thereof
WO2014055634A1 (en) * 2012-10-02 2014-04-10 Yale University Identification of small molecule inhibitors of jumonji at-rich interactive domain 1a (jarid1a) and 1b (jarid1b) histone demethylase
US20150267176A1 (en) 2012-10-12 2015-09-24 The General Hospital Corporation Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins
BR112015008487B1 (pt) 2012-10-15 2022-05-31 Epizyme, Inc Compostos de benzeno substituído, composição farmacêutica compreendendo os ditos compostos e uso terapêutico dos mesmos para tratar um distúrbio mediado por ezh2
EP3623463B1 (de) 2013-02-07 2021-10-20 The General Hospital Corporation Tale-transkriptionsaktivatoren
HUE063984T2 (hu) 2013-10-16 2024-02-28 Epizyme Inc Hidroklorid só forma az EZH2 gátlásához
WO2016019266A1 (en) * 2014-08-01 2016-02-04 The Research Foundation For The State University Of New York Detection of protein arginine demethylase activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7098012B1 (en) * 1997-11-12 2006-08-29 Mcgill University DNA demethylase, therapeutic and diagnostic uses thereof
US20040097440A1 (en) * 2002-11-11 2004-05-20 Isis Pharmaceuticals Inc. Modulation of jumonji expression
US20050003378A1 (en) * 2002-12-19 2005-01-06 Moshe Szyf Inhibitor of demethylase, antitumorigenic agent, and an in vitro assay for demethylase inhibitors
WO2007104314A2 (en) * 2006-03-14 2007-09-20 Københavns Universitet INHIBITION OF GASCl

Also Published As

Publication number Publication date
AU2006308957A1 (en) 2007-05-10
WO2007053480A2 (en) 2007-05-10
JP5078901B2 (ja) 2012-11-21
US20160244802A1 (en) 2016-08-25
JP2009513138A (ja) 2009-04-02
EP1941060A4 (de) 2009-11-18
AU2006308957B2 (en) 2012-04-12
CA2622615A1 (en) 2007-05-10
EP1941060B1 (de) 2012-02-29
US20090203057A1 (en) 2009-08-13
EP1941060A2 (de) 2008-07-09
WO2007053480A3 (en) 2009-04-23

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