AR056875A1 - Ligandos del receptor vaniloide y su aplicacion para la fabricacion de medicamentos - Google Patents

Ligandos del receptor vaniloide y su aplicacion para la fabricacion de medicamentos

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Publication number
AR056875A1
AR056875A1 ARP060104575A ARP060104575A AR056875A1 AR 056875 A1 AR056875 A1 AR 056875A1 AR P060104575 A ARP060104575 A AR P060104575A AR P060104575 A ARP060104575 A AR P060104575A AR 056875 A1 AR056875 A1 AR 056875A1
Authority
AR
Argentina
Prior art keywords
unsubstituted
monosubstituted
saturated
radical
unsaturated
Prior art date
Application number
ARP060104575A
Other languages
English (en)
Inventor
Jeewoo Lee
Gregor Bahrenberg
Vry Jean De
Klaus Schiene
Robert Frank
Derek John Saunders
Hyung Chul Ryu
Thomas Christoph
Bernd Sundermann
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE200510050408 external-priority patent/DE102005050408A1/de
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of AR056875A1 publication Critical patent/AR056875A1/es

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    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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Abstract

Reivindicacion 1: Compuestos sustituidos de la formula general (1), en la que X representa O, S o N-CsN; Y representa -NH2, -NHR30, -NR31R32 o representa un radical alifático C1-10 lineal o ramificado, saturado o insaturado, no sustituido o al menos monosustituido; n representa 0, 1, 2, 3 o 4; R1, R2, R3 y R4, independientemente entre sí, cada uno representa H; F; CI; Br; I; -SF5; -NO2; -CF3; -CN; -NH2; -OH; -SH; -C(=O)-NH2; -S(=O)2-NH2; C(=O)-NH-OH;-C(=O)-OH; -C(=O)-H; -S(=O)2-OH; -NHR11; - NR12R13; -OR14; -SR15; -C(=O)-NHR16; -C(=O)-NR17R18; -S(=O)2NHR19; -S(=O)2-NR20R21; - C(=O)-OR22; -C(=O)-R23; -S(=O)-R24; -S(=O)2R24 o representan un radical alifático C1-10 lineal o ramificado, saturado o insaturado, no sustituido o al menos monosustituido; R5 representa H; F; CI; Br; I; -SF5; -NO2; -CF3; -CF2CI; -CN; -NH2; -OH; -SH; -C(=O)-NH2; -S(=O)2-NH2; -C(=O)-NH-OH; -C(=O)-OH; -C(=O)-H; -S(=O)2-OH; -NHR11; -NR12R13; -OR14; -SR15; -C(=O)-NHR16; -C(=O)NR17R18; -S(=O)2-NHR19; -S(=O)2- NR20R21; -C(=O)-OR22; C(=O)R23, -S(=O)2-R24; -S(=O)-R24; representa un radical alifático C1-10 lineal o ramificado, saturado o insaturado, no sustituido o al menos monosustituido; o representa un radical cicloalifático de 3, 4, 5, 6, 7, 8, o 9 miembros insaturado o saturado, no sustituido o al menos monosustituido opcionalmente comprendiendo al menos un heteroátomo como miembro del anillo, en lo cual el radical se enlaza en cada caso a la estructura original mediante un átomo de carbono en el anillo del radical cicloalifático; T representa C-R6 y U representa C-R7 y V representa N y W representa C-R8 o T representa C-R6 y U representa N y V representa C-R9 y W representa C-R8 o T representa N y U representa C-R7 y V representa C-R9 y W representa C-R8 o T representa N y U representa N y V representa C-R9 y W representa C-R8 o T representa N y U representa C-R7 y V representa N y W representa C-R8 o T representa C-R6 y U representa N y V representa N y W representa C-R8 o T representa C-R6 y U representa C-R7 y V representa C-R9 y W representa C-R10; R6 y R7, independientemente entre sí, cada uno representa H; F; CI; Br; I; -SF5; -NO2; -CF3; -CF2CI; -CN; -NH2; -OH; -SH; -C(=O)-NH2; -S(=O)2-NH2; -C(=O)-NH-OH; -C(=O)-OH; -C(=O)-H; -S(=O)2-OH; -NHR11; -NR12R13; -OR14; -SR15; -C(=O)-NHR16; -C(=O)-NR17R18; -S(=O)2-NHR19; -S(=O)2-NR20R21; -C(=O)-OR22; -C(=O)-R23, -S(=O)-R24; -S(=O)2-R24; representan un radical alifático C1-10 lineal o ramificado, saturado o insaturado, no sustituido o al menos monosustituido; o representan un radical arilo de 6 o 10 miembros no sustituido o al menos monosustituido, la cual se puede enlazar por un grupo alquileno C1-6 o un grupo alquenileno C2-6 o un grupo alquinileno C2-6 lineal o ramificado, no sustituido o al menos monosustituido; R8 representa H; F; CI; Br; I; -SF5; -NO2; -CF3; -CF2CI; -CN; -NH2; -OH; -SH; -C(=O)-NH2; -S(=O)2-NH2; -C(=O)-NH-OH; -C(=O)-OH; -C(=O)-H; -S(=O)2-OH; -NHR11; -NR12R13; -OR14; -SR15; -C(=O)-NHR16; - C(=O)-NR17R18; -S(=O)2-NHR19; -S(=O)2-NR20R21; -C(=O)-OR22; -C(=O)-R23; -S(=O)-R24 -S(=O)2-R24; -C(=NH)-NH2; -C(=NH)-NH-R27; -N=C(NH2)2; -N=C(NHR28)(NHR29); representa un radical alifático C1-10 lineal o ramificado, saturado o insaturado, no sustituido o al menos monosustituido; representa un radical cicloalifático de 3, 4, 5, 6, 7, 8, o 9 miembros insaturado o saturado, no sustituido o al menos monosustituido, que presenta opcionalmente al menos un heteroátomo como miembro del anillo, en lo cual el radical se enlaza en cada caso a la estructura original mediante un átomo de carbono en el anillo del radical cicloalifático y que puede estar fusionado con un sistema cíclico mono- o policíclico saturado o insaturado, no sustituido o al menos monosustituido y/o se puede enlazar por un grupo alquileno C1-6- o grupo alquenileno C2-6- o un grupo alquinileno C2-6- lineal o ramificado, no sustituido o al menos monosustituido; o representa un radical arilo o heteroarilo de 5 a 14 miembros no sustituido o al menos monosustituido, que puede estar fusionado con un sistema cíclico mono- o policíclico saturado o insaturado, no sustituido o al menos monosustituido y/o se puede enlazar por un grupo alquileno C1-6- o un grupo alquenileno C2-6- o un grupo alquinileno C2-6- lineal o ramificado, no sustituido o al menos monosustituido; R9 representa H; F; CI; Br; I; -SF5; -NO2; -CF3; -CF2CI; -CN; -NH2; -OH; - SH; -C(=O)-NH2; -S(=O)2-NH2; -C(=O)-NH-OH; -C(=O)-OH; -C(=O)-H; - S(=O)2-OH; -NHR11; -NR12R13; -OR14; -SR15; -C(=O)-NHR16; -C(=O)NR17R18; -S(=O)rNHR19; -S(=O)2-NR20R21; -C(=O)-OR22; -C(=O)-R23; -S(=O)-R24; -S(=O)2-R24 o representa un radical alifático C1-10 lineal o ramificado, saturado o insaturado, no sustituido o al menos monosustituido; R10 representa -SF5; -NO2; -CF3; -CF2CI; -CN; -NH2; -OH; -SH; -C(=O)-NH2; -S(=O)2-NH2; -C(=O)-NH-OH; -C(=O)-OH; -C(=O)-H; -S(=O)2-OH; -NHR11; -NR12R13; -OR14; -SR15; -C(=O)-NHR16; -C(=O)-NR17R18; -S(=O)2-NHR19; -S(=O)2- NR20R21; -C(=O)-OR22; -C(=O)-R23; -S(=O)-R24; -S(=O)2-R24; -C(=NH)-NH2; -C(=NH)-NH-R27; -N=C(NH2)2; -N=C(NHR28)(NHR29); representa un radical alifático C1-10 lineal o ramificado, saturado o insaturado, que está en cada caso sustituido con opcionalmente 1, 2, 3, 4, 5, 6, 7, 8 o 9 sustituyentes mutuamente independientemente seleccionados del grupo que consiste en -CN, -NO2, -OH, -NH2, -SH, -O(alquilo C1-5), -S(alquilo C1-5), -NH(alquilo C1-5), -N(alquilo C1-5)(alquilo C1-5),-OCF3 y - SCF3; representa un radical no sustituido alquenilo C2-10 o un radical no sustituido alquinilo C2-10; representa un radical cicloalifático de 3-, 4-, 5-, 6-, 7-, 8- o 9 miembros insaturado o saturado, no sustituido o al menos monosustituido, opcionalmente comprendiendo al menos un heteroátomo como miembro del anillo, en lo cual el radical se enlaza en cada caso a la estructura original mediante un átomo de carbono en el anillo del radical cicloalifático y que puede estar fusionado con un sistema cíclico mono o policíclico saturado o insaturado, no sustituido o al menos monosustituido y/o puede enlazarse por un grupo alquileno C1-6 lineal o ramificado, no sustituido o al menos monosustituido; o representa un radical arilo o heteroarilo de 5 a 14 miembros no sustituido o al menos monosustituido que puede estar fusionado con un sistema cíclico mono- o policíclico saturado o insaturado, no sustituido o al menos monosustituido y/o se puede enlazar por un grupo alquileno C1- 6- lineal o ramificado, no sustituido o al menos monosustituido; R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R27, R28 y R29, independientemente entre sí, cada uno representa un radical alifático C1-10 lineal o ramificado, saturado o insaturado, no sustituido o al menos monosustituido; representa un radical cicloalifático de 3, 4, 5, 6, 7, 8, o 9 miembros insaturado o saturado, no sustituido o al menos monosustituido, opcionalmente comprendiendo al menos un heteroátomo como miembro del anillo, en lo cual el radical puede fusionarse con un sistema cíclico mono o policíclico saturado o insaturado, no sustituido o al menos monosustituido y/o se puede enlazar por un grupo alquileno C1-6- o un grupo heteroalquileno de 2 a 6 miembros lineal o ramificado, no sustituido o al menos monosustituido; o representa un radical arilo o heteroarilo de 5 hasta 14 miembros no sustituido o al menos monosustituido que puede estar fusionado con un sistema cíclico mono o policíclico saturado o insaturado, no sustituido o al menos monosustituido y/o se puede enlazar por un grupo alquileno .C1-6- o un grupo heteroalquileno de 2 a 6 miembros lineal o ramificado. no sustituido o al menos monosustituido; o R12 y R13 cada uno juntos forman, con el átomo de nitrogeno como miembro del anillo que los enlaza, un radical heterocicloalifático de 4, 5, 6, 7, 8 o 9 miembros saturado o insaturado, no sustituido o al menos monosustituido, que comprende opcionalmente al menos otro heteroátomo como miembro del anillo, que puede estar fusionado con un sistema cíclico mono o policíclico saturado o insaturado, no sustituido o al menos monosustituido; y R25 y R26, independientemente entre sí, cada uno representa un radical hidrogeno; representa un radical alifático C1-10 lineal o ramificado, saturado o insaturado, no sustituido o al menos monosustituido; representa un radical arilo o heteroarilo de 5 a 14 miembros no sustituido o al menos monosustituido, que puede estar fusionado con un sistema cíclico mono o policíclico saturado o insaturado, no sustituido o al menos monosustituido y/o se puede enlazar por un grupo alquileno C1-6 o un grupo alquenileno C2-6 o un grupo alquinileno C2- 6- lineal o ramificado, no sustituido o al menos monosustituido; o representa un radical cicloalifático de 3, 4, 5, 6, 7, 8, o 9 miembros insaturado o saturado, no sustituido o al menos monosustituido, que presenta opcionalmente al menos un heteroátomo como miembro del anillo; con la condicion que R25 y R26 no representan cada uno un radical hidrogeno; o R25 y R26 cada uno juntos forman, con el átomo de carbono como miembro del anillo que los enlaza, un radical cicloalifático de 3, 4, 5 o 6 miembros saturado o insaturado, no sustituido o al menos monosustituido; y R30, R31 y R32, independientemente entre sí, cada uno representa un radical alifático C1-10 lineal o ramificado, saturado o insaturado, no sustituido o al menos monosustituido; cada uno opcionalmente en forma de uno de sus estereoisomeros puros, en particular enantiomeros o diaestereoisomeros, de sus racematos o en forma de una mezcla de estereoisomeros, en particular de los enantiomeros y/o diaestereomeros en cualquier proporcion de mezcla, o cada uno en forma de sales correspondientes o cada uno en forma de solvatos correspondientes.
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US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
WO2008110351A2 (en) * 2007-03-15 2008-09-18 Dompe' Pha.R.Ma S.P.A. Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents
WO2008125295A2 (de) * 2007-04-13 2008-10-23 Grünenthal GmbH Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln
DE102007017884A1 (de) 2007-04-13 2008-10-16 Grünethal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
DE102007018151A1 (de) * 2007-04-16 2008-10-23 Günenthal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
CA2686838C (en) 2007-05-09 2017-03-14 Vertex Pharmaceuticals Incorporated Modulators of cftr
UA102534C2 (en) 2007-12-07 2013-07-25 Вертекс Фармасьютикалз Инкорпорейтед Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]-dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
PL2231606T3 (pl) 2007-12-07 2013-07-31 Vertex Pharma Sposoby wytwarzania kwasów cykloalkilokarboksyamidopirydynobenzoesowych
CN101925575B (zh) 2008-01-28 2014-06-18 株式会社爱茉莉太平洋 作为香草酸受体拮抗剂的化合物、其异构体或其药物学可接受的盐、及包含这些化合物的药物组合物
CA2716109C (en) 2008-02-28 2016-07-19 Vertex Pharmaceuticals Incorporated Heteroaryl derivatives as cftr modulators
LT2273983T (lt) 2008-05-09 2016-10-25 Grünenthal GmbH Tarpinės miltelių kompozicijos gamybos būdas ir galutinė kieta dozavimo forma naudojant purškalo kietinimo stadija
CN102137851B (zh) * 2008-07-02 2014-08-27 株式会社爱茉莉太平洋 作为香草素受体拮抗剂的化合物、其异构体或其药学可接受的盐以及包含它们的药物组合物
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
US8946204B2 (en) 2009-05-07 2015-02-03 Gruenenthal Gmbh Substituted phenylureas and phenylamides as vanilloid receptor ligands
ES2640257T3 (es) * 2009-05-07 2017-11-02 Medifron Dbt Inc. Fenilureas y fenilamidas sustituidas como ligandos del receptor vanilloide
JP2012529535A (ja) 2009-06-12 2012-11-22 ブリストル−マイヤーズ スクイブ カンパニー キナーゼモジュレーターとして有用なニコチンアミド化合物
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
JP2013518085A (ja) 2010-02-01 2013-05-20 ノバルティス アーゲー ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体
WO2011095450A1 (en) 2010-02-02 2011-08-11 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
CN106943403A (zh) 2010-04-07 2017-07-14 弗特克斯药品有限公司 药物组合物和其给药方法
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
WO2011160206A1 (en) 2010-06-23 2011-12-29 Morin Ryan D Biomarkers for non-hodgkin lymphomas and uses thereof
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
CA3176977A1 (en) 2010-09-10 2012-03-15 Epizyme, Inc. Inhibitors of human ezh2, and methods of use thereof
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
TW201733984A (zh) 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
WO2013013817A1 (en) 2011-07-26 2013-01-31 Grünenthal GmbH Substituted heterocyclic aza derivatives
CA2842976A1 (en) 2011-07-26 2013-01-31 Grunenthal Gmbh Substituted bicyclic aromatic carboxamide and urea derivatives as vanilloid receptor ligands
SI2736495T1 (sl) 2011-07-29 2017-12-29 Gruenenthal Gmbh Tableta, odporna proti zlorabi, ki zagotavlja takojšnje sproščanje zdravila
BR112014006675A2 (pt) * 2011-09-26 2017-04-04 Gruenenthal Gmbh derivados de metanossulfonamida substituídos como ligantes de receptor vaniloide
CA2849960A1 (en) * 2011-09-26 2013-04-04 Grunenthal Gmbh Aryl or n-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands
CA2849350A1 (en) * 2011-09-26 2013-04-04 Grunenthal Gmbh Amine substituted methanesulfonamide derivatives as vanilloid receptor ligands
WO2013068462A1 (en) * 2011-11-09 2013-05-16 Grünenthal GmbH Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an n-containing group as vanilloid receptor ligands
TW201326133A (zh) * 2011-11-09 2013-07-01 Gruenenthal Gmbh 以被取代吡唑基甲醯胺及被以一含氧基團取代之含有一苯基基元之尿素衍生物做為類香草素受體之配位體
IL282732B2 (en) 2012-04-13 2023-04-01 Eisai R&D Man Co Ltd Salt form of human histone methyltransferase inhibitor 2ezh
WO2014028829A1 (en) 2012-08-16 2014-02-20 The Scripps Research Institute Novel kappa opioid ligands
CN110041250A (zh) 2012-10-15 2019-07-23 Epizyme股份有限公司 经取代的苯化合物
MA38949A1 (fr) 2013-10-16 2017-07-31 Eisai R&D Man Co Ltd Forme saline d'hydrochlorure pour inhibition d'ezh2
CN105848657B (zh) 2013-11-12 2020-05-22 沃泰克斯药物股份有限公司 制备用于治疗cftr介导的疾病的药物组合物的方法
EP3221692B1 (en) 2014-11-18 2021-06-23 Vertex Pharmaceuticals Inc. Process of conducting high throughput testing high performance liquid chromatography
MY193423A (en) 2015-11-16 2022-10-12 Esteve Labor Dr Oxadiazaspiro compounds for the treatment of drug abuse and addiction
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
PL3464272T3 (pl) 2016-06-07 2022-03-28 Jacobio Pharmaceuticals Co., Ltd. Nowe pochodne heterocykliczne użyteczne jako inhibitory SHP2
WO2018112843A1 (en) * 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
TWI664175B (zh) 2017-03-23 2019-07-01 大陸商北京加科思新藥研發有限公司 用於作為shp2抑制劑之新穎雜環衍生物
MA53002A (fr) 2018-06-27 2021-05-05 Eth Zuerich Nouveaux composés de pyridine et de pyrazine en tant qu'inhibiteurs du récepteur cannabinoïde 2
WO2020002314A1 (en) 2018-06-27 2020-01-02 F. Hoffmann-La Roche Ag Radiolabeled cannabinoid receptor 2 ligand
AU2019344899A1 (en) 2018-09-18 2021-04-15 Nikang Therapeutics, Inc. Fused tricyclic ring derivatives as Src homology-2 phosphatase inhibitors
RU2755206C1 (ru) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Средство пролонгированного анальгетического действия и лекарственный препарат на его основе
TW202214574A (zh) * 2020-06-08 2022-04-16 加拿大商愛彼特生物製藥公司 經取代之(呔-1-基甲基)脲類、經取代之n-(呔-1-基甲基)醯胺類及其類似物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1209016C (zh) * 1999-08-18 2005-07-06 阿方蒂农科有限公司 杀真菌剂
ATE240284T1 (de) * 2000-03-06 2003-05-15 Solvias Ag Organische verbindungen durch kopplung von nukleophilen, vinylverbindungen oder co mit wasser, alkohole oder aminen
CN100439332C (zh) * 2000-08-21 2008-12-03 株式会社太平洋 硫脲衍生物以及包含该衍生物的药物组合物
WO2002016319A1 (en) * 2000-08-21 2002-02-28 Pacific Corporation Novel thiourea compounds and the pharmaceutical compositions containing the same
US7915264B2 (en) * 2001-03-26 2011-03-29 Novartis Ag Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain
KR100707123B1 (ko) 2003-07-02 2007-04-16 그뤼넨탈 게엠베하 바닐로이드 수용체의 길항제로서 강력한 진통효과를나타내는 4-(메틸설포닐아미노)페닐 동족체 및 이를함유하는 약학적 조성물
JP5197016B2 (ja) 2004-12-23 2013-05-15 デシファラ ファーマスーティカルズ， エルエルシー 酵素モジュレータ及び治療
US7888374B2 (en) 2005-01-28 2011-02-15 Abbott Laboratories Inhibitors of c-jun N-terminal kinases
US7572808B2 (en) * 2005-06-17 2009-08-11 Bristol-Myers Squibb Company Triazolopyridine cannabinoid receptor 1 antagonists
PT1940821E (pt) 2005-10-19 2013-05-29 Gruenenthal Gmbh Novos ligandos do receptor de vanilóide e seu uso para a produção de medicamentos

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