MA38949A1 - Forme saline d'hydrochlorure pour inhibition d'ezh2 - Google Patents
Forme saline d'hydrochlorure pour inhibition d'ezh2Info
- Publication number
- MA38949A1 MA38949A1 MA38949A MA38949A MA38949A1 MA 38949 A1 MA38949 A1 MA 38949A1 MA 38949 A MA38949 A MA 38949A MA 38949 A MA38949 A MA 38949A MA 38949 A1 MA38949 A1 MA 38949A1
- Authority
- MA
- Morocco
- Prior art keywords
- dgat1
- ezh2
- hydrochloride
- inhibition
- saline form
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne de nouveaux composés qui sont des inhibiteurs d'acyl-coenzyme a: diacylglycérol transférase 1 (dgat1), des compositions pharmaceutiques les contenant, des procédés pour leur préparation, ainsi que leur utilisation en thérapie, seuls ou en combinaison avec des thérapies de gestion du poids ou autre thérapie de diminution des triglycérides pour la prévention ou le traitement de maladies liées à un dysfonctionnement de dgat1 ou dans lesquelles une modulation de l'activité de dgat1 peut avoir un bénéfice thérapeutique.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361891786P | 2013-10-16 | 2013-10-16 | |
PCT/US2014/060724 WO2015057859A1 (fr) | 2013-10-16 | 2014-10-15 | Forme saline d'hydrochlorure pour inhibition d'ezh2 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA38949A1 true MA38949A1 (fr) | 2017-07-31 |
Family
ID=52828660
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA38949A MA38949A1 (fr) | 2013-10-16 | 2014-10-15 | Forme saline d'hydrochlorure pour inhibition d'ezh2 |
Country Status (24)
Country | Link |
---|---|
US (3) | US10040782B2 (fr) |
EP (2) | EP4324525A2 (fr) |
JP (2) | JP6608812B2 (fr) |
KR (1) | KR102142177B1 (fr) |
CN (1) | CN105829302B (fr) |
AU (2) | AU2014337300B2 (fr) |
CA (1) | CA2925889C (fr) |
CL (1) | CL2016000866A1 (fr) |
DK (1) | DK3057962T3 (fr) |
EA (1) | EA038869B1 (fr) |
ES (1) | ES2960953T3 (fr) |
FI (1) | FI3057962T3 (fr) |
HU (1) | HUE063984T2 (fr) |
IL (1) | IL244787B (fr) |
LT (1) | LT3057962T (fr) |
MA (1) | MA38949A1 (fr) |
MX (1) | MX2016004703A (fr) |
MY (1) | MY179802A (fr) |
PE (1) | PE20161273A1 (fr) |
PL (1) | PL3057962T3 (fr) |
PT (1) | PT3057962T (fr) |
SG (2) | SG10201901977XA (fr) |
SI (1) | SI3057962T1 (fr) |
WO (1) | WO2015057859A1 (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2836491T (pt) | 2012-04-13 | 2017-02-08 | Eisai R&D Man Co Ltd | Forma salina de um inibidor da histona metiltransferase humana ezh2 |
KR102142177B1 (ko) | 2013-10-16 | 2020-08-07 | 에피자임, 인코포레이티드 | Ezh2 억제용 하이드로클로라이드 염 형태 |
US20160303135A1 (en) | 2013-12-06 | 2016-10-20 | Epizyme, Inc. | Combination therapy for treating cancer |
US10166238B2 (en) | 2014-06-17 | 2019-01-01 | Epizyme, Inc. | EZH2 inhibitors for treating lymphoma |
EP3206688A4 (fr) | 2014-10-16 | 2018-06-13 | Epizyme, Inc. | Méthode de traitement du cancer |
US10786511B2 (en) * | 2014-11-17 | 2020-09-29 | Epizyme, Inc. | Method for treating cancer |
CA2983265A1 (fr) | 2015-04-20 | 2016-10-27 | Health Research, Inc. | Polytherapie pour le traitement du cancer |
JP6890097B2 (ja) | 2015-06-10 | 2021-06-18 | エピザイム,インコーポレイティド | リンパ腫を処置するためのezh2阻害剤 |
AU2016312514A1 (en) | 2015-08-24 | 2018-03-15 | Epizyme, Inc. | Method for treating cancer |
WO2017132518A1 (fr) | 2016-01-29 | 2017-08-03 | Epizyme, Inc. | Polythérapie pour le traitement du cancer |
EP3464643A4 (fr) | 2016-06-01 | 2020-04-01 | Epizyme Inc | Utilisation d'inhibiteurs de ezh2 pour le traitement du cancer |
WO2017218953A1 (fr) | 2016-06-17 | 2017-12-21 | Epizyme, Inc. | Inhibiteurs d'ezh2 pour traiter le cancer |
CN110191722B (zh) | 2017-01-19 | 2022-03-01 | 第一三共株式会社 | 用于治疗htlv-1相关性脊髓病的药物组合物 |
WO2018183885A1 (fr) | 2017-03-31 | 2018-10-04 | Epizyme, Inc. | Multithérapie pour le traitement du cancer |
AU2018275123A1 (en) | 2017-06-02 | 2020-01-30 | Epizyme, Inc. | Use of EZH2 inhibitors for treating cancer |
CA3074720A1 (fr) | 2017-09-05 | 2019-03-14 | Epizyme, Inc. | Polytherapie pour le traitement du cancer |
JP2021531340A (ja) | 2018-07-09 | 2021-11-18 | フォンダシヨン、アジール、デ、アブグルスFondation Asile Des Aveugles | 眼障害を治療するためのprc2サブユニットの阻害 |
US20220298222A1 (en) | 2019-08-22 | 2022-09-22 | Juno Therapeutics, Inc. | Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods |
TW202400140A (zh) | 2022-04-27 | 2024-01-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物與ezh1及/或ezh2抑制劑之組合 |
Family Cites Families (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0733729A (ja) | 1993-07-26 | 1995-02-03 | Kirin Brewery Co Ltd | N−シアノ−n′−置換−アリールカルボキシイミダミド化合物の製造法 |
US5716993A (en) | 1993-12-27 | 1998-02-10 | Eisai Co., Ltd. | Anthranilic acid derivatives |
DE19516776A1 (de) | 1995-05-10 | 1996-11-14 | Boehringer Ingelheim Int | Chromatin-Regulatorgene |
US5741819A (en) | 1995-06-07 | 1998-04-21 | 3-Dimensional Pharmaceuticals, Inc. | Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors |
JP3906935B2 (ja) | 1995-12-18 | 2007-04-18 | 杏林製薬株式会社 | N−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
WO2000018725A1 (fr) | 1998-09-30 | 2000-04-06 | The Procter & Gamble Company | Cetoamides 2-substitues |
UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
ES2330719T3 (es) | 2000-12-28 | 2009-12-15 | SHIONOGI & CO., LTD. | Derivados de 2-piridona con afinidad para el receptor cannabinoide de tipo 2. |
US7700293B2 (en) | 2001-08-02 | 2010-04-20 | The Regents Of The University Of Michigan | Expression profile of prostate cancer |
EP2130820A1 (fr) | 2002-02-19 | 2009-12-09 | Shionogi & Co., Ltd. | Antiprurigineux |
TW200306155A (en) | 2002-03-19 | 2003-11-16 | Du Pont | Benzamides and advantageous compositions thereof for use as fungicides |
US7442685B2 (en) | 2003-06-13 | 2008-10-28 | The University Of North Carolina At Chapel Hill | DOT1 histone methyltransferases as a target for identifying therapeutic agents for leukemia |
US7563589B2 (en) | 2004-06-01 | 2009-07-21 | The University Of North Carolina At Chapel Hill | Reconstituted histone methyltransferase complex and methods of identifying modulators thereof |
JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
US7923219B2 (en) | 2005-06-02 | 2011-04-12 | The University Of North Carolina At Chapel Hill | Ubiquitin E3 ligase |
FR2889526B1 (fr) | 2005-08-04 | 2012-02-17 | Aventis Pharma Sa | 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
BRPI0618417A2 (pt) | 2005-10-19 | 2012-07-31 | Gruenenthal Chemie | novos ligandos de receptores de vanilàide e seu uso para produzir medicamentos |
EP1951672B1 (fr) | 2005-10-21 | 2011-05-25 | Merck Sharp & Dohme Corp. | Inhibiteurs du canal potassique |
JP5078901B2 (ja) | 2005-10-28 | 2012-11-21 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | JmjCドメインを含むタンパク質デメチラーゼ |
WO2007070818A1 (fr) | 2005-12-14 | 2007-06-21 | Bristol-Myers Squibb Company | Heterocycles a six elements utiles en tant qu’inhibiteurs de serine protease |
US8524467B2 (en) | 2006-01-20 | 2013-09-03 | The University Of North Carolina At Chapel Hill | Diagnostic and therapeutic targets for leukemia |
EP2018166A2 (fr) | 2006-05-15 | 2009-01-28 | Irm Llc | Composés et compositions de téréphtalamate, et leur utilisation en tant qu'inhibiteurs de l'intégrase du vih |
CA2652634A1 (fr) | 2006-05-18 | 2007-11-29 | Amphora Discovery Corporation | Certaines quinolones substituees, compositions et utilisations |
CA2666461A1 (fr) | 2006-10-10 | 2008-09-12 | Burnham Institute For Medical Research | Compositions neuroprotectrices et procedes correspondants |
US8314087B2 (en) | 2007-02-16 | 2012-11-20 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and methods of use |
US8338437B2 (en) | 2007-02-28 | 2012-12-25 | Methylgene Inc. | Amines as small molecule inhibitors |
WO2008113006A1 (fr) | 2007-03-14 | 2008-09-18 | Xenon Pharmaceuticals Inc. | Procédés d'utilisation de composés à base de quinolinone dans le traitement des maladies ou des affections associées aux canaux sodiques |
DE102007017884A1 (de) | 2007-04-13 | 2008-10-16 | Grünethal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
WO2009006577A2 (fr) | 2007-07-03 | 2009-01-08 | The Regents Of The University Of Michigan | Compositions et méthodes pour inhiber la protéine ezh2 |
AU2008319308B2 (en) | 2007-10-31 | 2013-01-31 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
CA2709257C (fr) | 2007-12-19 | 2016-12-13 | Cancer Research Technology Limited | Composes pyrido[2,3-b]pyrazine substitues en position 8 et leur utilisation |
WO2009124137A2 (fr) | 2008-04-01 | 2009-10-08 | Mount Sinai School Of Medicine Of New York University | Procédé de suppression d’une transcription de gène par méthylation d’histone lysine |
US20100113415A1 (en) | 2008-05-29 | 2010-05-06 | Rajapakse Hemaka A | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
JP5548197B2 (ja) | 2008-08-08 | 2014-07-16 | ニューヨーク ブラッド センター, インコーポレイテッド | レトロウイルスの集合及び成熟の小分子阻害剤 |
FR2934995B1 (fr) | 2008-08-14 | 2010-08-27 | Sanofi Aventis | Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique |
US20120065247A1 (en) | 2009-03-27 | 2012-03-15 | Discoverybiomed, Inc. | Modulating ires-mediated translation |
US20110021362A1 (en) | 2009-07-20 | 2011-01-27 | Constellation Pharmaceuticals | Agents for stimulating activity of methyl modifying enzymes and methods of use thereof |
CA2784899A1 (fr) | 2009-12-30 | 2011-07-07 | Avon Products, Inc. | Composition eclaircissante topique et utilisations de celle-ci |
EA023788B1 (ru) | 2010-05-07 | 2016-07-29 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Производные индола и фармацевтические композиции на их основе |
ES2528269T3 (es) | 2010-05-07 | 2015-02-06 | Glaxosmithkline Llc | Azaindazoles |
WO2011140325A1 (fr) | 2010-05-07 | 2011-11-10 | Glaxosmithkline Llc | Indazoles |
CN103261890B (zh) | 2010-09-10 | 2016-04-06 | Epizyme股份有限公司 | 人ezh2抑制剂及其应用方法 |
US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
US20130310379A1 (en) | 2010-11-19 | 2013-11-21 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
ES2607064T3 (es) | 2010-12-01 | 2017-03-29 | Glaxosmithkline Llc | Indoles |
WO2012075500A2 (fr) | 2010-12-03 | 2012-06-07 | Epizyme, Inc. | Modulateurs à base de 7-déazapurine de l'histone méthyltransférase et procédés d'utilisation de ceux-ci |
EP2681216B1 (fr) | 2011-02-28 | 2017-09-27 | Epizyme, Inc. | Composés hétéroaryles bicycliques substitués condensés en 6,5 |
JO3438B1 (ar) * | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
TWI598336B (zh) | 2011-04-13 | 2017-09-11 | 雅酶股份有限公司 | 經取代之苯化合物 |
CN110420327B (zh) | 2012-03-12 | 2022-05-03 | Epizyme股份有限公司 | 人ezh2抑制剂及其应用方法 |
PT2836491T (pt) | 2012-04-13 | 2017-02-08 | Eisai R&D Man Co Ltd | Forma salina de um inibidor da histona metiltransferase humana ezh2 |
ES2925312T3 (es) | 2012-04-13 | 2022-10-14 | Epizyme Inc | Terapia combinada para el tratamiento del cáncer |
WO2013173441A2 (fr) | 2012-05-16 | 2013-11-21 | Glaxosmithkline Llc | Inhibiteurs d'homologue d'activateur de zeste 2 |
CA3177498A1 (fr) | 2012-10-15 | 2014-04-24 | Epizyme, Inc. | Methodes de traitement du cancer |
SG11201502803VA (en) | 2012-10-15 | 2015-05-28 | Epizyme Inc | Substituted benzene compounds |
AU2013361060B2 (en) | 2012-12-21 | 2018-04-19 | Epizyme, Inc. | 1,4-pyridone compounds |
EP2935264B1 (fr) | 2012-12-21 | 2017-10-18 | Epizyme, Inc. | Composés hétéroaryles bicycliques 1,4-pyridone |
WO2014144747A1 (fr) | 2013-03-15 | 2014-09-18 | Epizyme, Inc. | Composés hétéroaryles bicycliques substitués condensés en 6,5 |
WO2014172044A1 (fr) | 2013-03-15 | 2014-10-23 | Epizyme, Inc. | Composés de benzène substitués |
US9624205B2 (en) | 2013-07-19 | 2017-04-18 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
EP3022184B1 (fr) | 2013-07-19 | 2017-09-27 | Epizyme, Inc. | Composés de benzène substitués |
KR102142177B1 (ko) | 2013-10-16 | 2020-08-07 | 에피자임, 인코포레이티드 | Ezh2 억제용 하이드로클로라이드 염 형태 |
-
2014
- 2014-10-15 KR KR1020167011534A patent/KR102142177B1/ko active IP Right Grant
- 2014-10-15 HU HUE14854272A patent/HUE063984T2/hu unknown
- 2014-10-15 MA MA38949A patent/MA38949A1/fr unknown
- 2014-10-15 AU AU2014337300A patent/AU2014337300B2/en active Active
- 2014-10-15 CA CA2925889A patent/CA2925889C/fr active Active
- 2014-10-15 CN CN201480056428.6A patent/CN105829302B/zh active Active
- 2014-10-15 MX MX2016004703A patent/MX2016004703A/es active IP Right Grant
- 2014-10-15 FI FIEP14854272.3T patent/FI3057962T3/fi active
- 2014-10-15 SG SG10201901977XA patent/SG10201901977XA/en unknown
- 2014-10-15 PE PE2016000506A patent/PE20161273A1/es unknown
- 2014-10-15 EP EP23203529.5A patent/EP4324525A2/fr active Pending
- 2014-10-15 WO PCT/US2014/060724 patent/WO2015057859A1/fr active Application Filing
- 2014-10-15 SG SG11201602269QA patent/SG11201602269QA/en unknown
- 2014-10-15 EP EP14854272.3A patent/EP3057962B1/fr active Active
- 2014-10-15 ES ES14854272T patent/ES2960953T3/es active Active
- 2014-10-15 PL PL14854272.3T patent/PL3057962T3/pl unknown
- 2014-10-15 LT LTEPPCT/US2014/060724T patent/LT3057962T/lt unknown
- 2014-10-15 JP JP2016519378A patent/JP6608812B2/ja active Active
- 2014-10-15 SI SI201432051T patent/SI3057962T1/sl unknown
- 2014-10-15 PT PT148542723T patent/PT3057962T/pt unknown
- 2014-10-15 EA EA201690650A patent/EA038869B1/ru unknown
- 2014-10-15 MY MYPI2016000542A patent/MY179802A/en unknown
- 2014-10-15 DK DK14854272.3T patent/DK3057962T3/da active
- 2014-10-15 US US15/029,848 patent/US10040782B2/en active Active
-
2016
- 2016-03-28 IL IL244787A patent/IL244787B/en unknown
- 2016-04-13 CL CL2016000866A patent/CL2016000866A1/es unknown
-
2018
- 2018-06-05 US US16/000,539 patent/US10710987B2/en active Active
- 2018-12-11 JP JP2018231817A patent/JP2019052181A/ja active Pending
-
2019
- 2019-04-02 AU AU2019202246A patent/AU2019202246A1/en not_active Abandoned
-
2020
- 2020-06-03 US US16/891,427 patent/US20210017163A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA38949A1 (fr) | Forme saline d'hydrochlorure pour inhibition d'ezh2 | |
MA45985B1 (fr) | Inhibiteurs de diacylglycérol acyltransférase 2 | |
MA38380A1 (fr) | Inhibiteurs quinazoline de l'activation des formes mutantes du récepteur de croissance épidermique (egfr) | |
MA40290A1 (fr) | Agents immunorégulateurs | |
MA39753B1 (fr) | Inhibiteurs de diacylglycérol acyltransférase pour le traitement de troubles métaboliques ou analogues | |
MX2014002459A (es) | Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodos de uso de los mismos. | |
MA42410B1 (fr) | Oxystérols et leurs méthodes d'utilisation | |
MA32393B1 (fr) | Composés et compositions servant d'inhibiteurs de kinases | |
TW201613919A (en) | Inhibitors of Bruton's tyrosine kinase | |
MX364378B (es) | Inhibidores de la quinurenina-3-monooxigenasa, sus composiciones farmaceuticas y metodos para uso. | |
EA201490163A1 (ru) | Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и способы их применения | |
MA38810B1 (fr) | Inhibiteurs de rorc2 méthodes d'utilisation associées | |
MA35945B1 (fr) | Inhibiteurs de la bêta-sécrétase | |
GEP20237541B (en) | Methods for treating and/or preventing graft-versus-host disease and/or diffuse alveolar hemorrhage and/or veno-occlusive disease associated with hematopoietic stem cell transplant | |
MA37763A1 (fr) | Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1 | |
MA38253A1 (fr) | Compositions comprenant de la vortioxétine et du donépézil | |
MA49839B1 (fr) | Inhibiteurs bicycliques de la histone déacétylase | |
MA39447A1 (fr) | (s)-pirlindole ou ses sels pharmaceutiquement acceptables pour une utilisation en médecine | |
MA39448B1 (fr) | (r)-pirlindole et ses sels pharmaceutiquement acceptables destinés à un usage médical | |
MX2016010892A (es) | Agente para suprimir el progreso de o para mejorar la enfermedad renal cronica. | |
UA109359C2 (xx) | Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном | |
MA38102A1 (fr) | Nouveaux composés utilisés comme inhibiteurs de diacylglycérol acyltransférase | |
PH12015501109A1 (en) | Novel compounds as diacylglycerol acyltransferase inhibitors | |
MA45990B1 (fr) | Combinaison d'agonistes inverses du récepteur de l'histamine-3 avec des inhibiteurs de l'acétylcholinestérase | |
MA46625B1 (fr) | Inhibiteurs de lsd1 et leurs utilisations médicales |