MA37763A1 - Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1 - Google Patents
Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1Info
- Publication number
- MA37763A1 MA37763A1 MA37763A MA37763A MA37763A1 MA 37763 A1 MA37763 A1 MA 37763A1 MA 37763 A MA37763 A MA 37763A MA 37763 A MA37763 A MA 37763A MA 37763 A1 MA37763 A1 MA 37763A1
- Authority
- MA
- Morocco
- Prior art keywords
- hexahydro
- difluoro
- benzooxazinyls
- cyclopentaoxazinyl
- bace1 inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Abstract
La présente invention concerne des difluorocyclopentaoxazinyles et des difluorobenzooxazinyles de formule (i), présentant une activité inhibitrice de bace1, leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en tant que substances actives sur le plan thérapeutique. Les composés actifs de la présente invention sont utiles dans le traitement thérapeutique et/ou prophylactique de, par exemple, la maladie d'alzheimer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12173690 | 2012-06-26 | ||
PCT/EP2013/063086 WO2014001228A1 (fr) | 2012-06-26 | 2013-06-24 | Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1 |
Publications (2)
Publication Number | Publication Date |
---|---|
MA37763A1 true MA37763A1 (fr) | 2016-08-31 |
MA37763B1 MA37763B1 (fr) | 2017-05-31 |
Family
ID=48672630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA37763A MA37763B1 (fr) | 2012-06-26 | 2013-06-24 | Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1 |
Country Status (22)
Country | Link |
---|---|
US (1) | US9181232B2 (fr) |
EP (1) | EP2864324B1 (fr) |
JP (1) | JP6251257B2 (fr) |
KR (1) | KR20150023450A (fr) |
CN (1) | CN104470915B (fr) |
AU (1) | AU2013283524B2 (fr) |
BR (1) | BR112014029742A2 (fr) |
CA (1) | CA2872181A1 (fr) |
CL (1) | CL2014003325A1 (fr) |
CO (1) | CO7151509A2 (fr) |
CR (1) | CR20140528A (fr) |
EA (1) | EA025273B1 (fr) |
HK (1) | HK1206344A1 (fr) |
IL (1) | IL236138A (fr) |
MA (1) | MA37763B1 (fr) |
MX (1) | MX2014014937A (fr) |
NZ (1) | NZ702253A (fr) |
PE (1) | PE20142450A1 (fr) |
PH (1) | PH12014502623B1 (fr) |
SG (1) | SG11201407576YA (fr) |
UA (1) | UA113309C2 (fr) |
WO (1) | WO2014001228A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8637504B2 (en) | 2008-06-13 | 2014-01-28 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
BR112012013854A2 (pt) | 2009-12-11 | 2019-09-24 | Shionogi & Co | derivados de oxazina. |
WO2014065434A1 (fr) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dérivés de dihydrooxazine ou d'oxazépine ayant une activité inhibitrice de bace1 |
WO2014134341A1 (fr) | 2013-03-01 | 2014-09-04 | Amgen Inc. | Composés perfluorés 5,6-dihydro-4h-1,3-oxazine-2-amine substitués en tant qu'inhibiteurs de la bêta-sécrétase et procédés d'utilisation correspondants |
EP2964644B1 (fr) | 2013-03-08 | 2018-12-26 | Amgen, Inc. | Composés perfluorés à base de 1,3-oxazin-2-amine condensée avec un cyclopropyle en tant qu'inhibiteurs de la bêta-secrétase et leurs procédés d'utilisation |
TW201623295A (zh) | 2014-04-11 | 2016-07-01 | 塩野義製藥股份有限公司 | 具有bace1抑制活性之二氫噻及二氫衍生物 |
WO2016022724A1 (fr) | 2014-08-08 | 2016-02-11 | Amgen Inc. | Composés thiazin-2-amine fusionnée à un groupement cyclopropyle utilisés en tant qu'inhibiteurs de la bêta-secrétase et leurs procédés d'utilisation |
SG11201707050VA (en) | 2015-03-20 | 2017-10-30 | Hoffmann La Roche | Bace1 inhibitors |
KR20210003872A (ko) | 2018-04-27 | 2021-01-12 | 시오노기 앤드 컴파니, 리미티드 | 선택적 bace1 억제 활성을 갖는 테트라하이드로피라노옥사진 유도체 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2010047372A1 (ja) | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体 |
GB0912778D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
UA103272C2 (uk) * | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
BR112012013854A2 (pt) | 2009-12-11 | 2019-09-24 | Shionogi & Co | derivados de oxazina. |
-
2013
- 2013-06-24 CN CN201380033783.7A patent/CN104470915B/zh not_active Expired - Fee Related
- 2013-06-24 MA MA37763A patent/MA37763B1/fr unknown
- 2013-06-24 BR BR112014029742A patent/BR112014029742A2/pt not_active IP Right Cessation
- 2013-06-24 JP JP2015519008A patent/JP6251257B2/ja not_active Expired - Fee Related
- 2013-06-24 EA EA201590066A patent/EA025273B1/ru not_active IP Right Cessation
- 2013-06-24 US US14/406,289 patent/US9181232B2/en not_active Expired - Fee Related
- 2013-06-24 MX MX2014014937A patent/MX2014014937A/es unknown
- 2013-06-24 UA UAA201500578A patent/UA113309C2/uk unknown
- 2013-06-24 KR KR20147036016A patent/KR20150023450A/ko not_active Application Discontinuation
- 2013-06-24 SG SG11201407576YA patent/SG11201407576YA/en unknown
- 2013-06-24 EP EP13730887.0A patent/EP2864324B1/fr not_active Not-in-force
- 2013-06-24 PE PE2014002406A patent/PE20142450A1/es not_active Application Discontinuation
- 2013-06-24 CA CA2872181A patent/CA2872181A1/fr not_active Abandoned
- 2013-06-24 WO PCT/EP2013/063086 patent/WO2014001228A1/fr active Application Filing
- 2013-06-24 NZ NZ702253A patent/NZ702253A/en not_active IP Right Cessation
- 2013-06-24 AU AU2013283524A patent/AU2013283524B2/en not_active Expired - Fee Related
-
2014
- 2014-11-18 CR CR20140528A patent/CR20140528A/es unknown
- 2014-11-24 PH PH12014502623A patent/PH12014502623B1/en unknown
- 2014-12-05 CL CL2014003325A patent/CL2014003325A1/es unknown
- 2014-12-08 IL IL236138A patent/IL236138A/en not_active IP Right Cessation
- 2014-12-10 CO CO14271199A patent/CO7151509A2/es unknown
-
2015
- 2015-07-21 HK HK15106931.2A patent/HK1206344A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP2864324A1 (fr) | 2015-04-29 |
JP2015521640A (ja) | 2015-07-30 |
EA025273B1 (ru) | 2016-12-30 |
NZ702253A (en) | 2016-06-24 |
UA113309C2 (xx) | 2017-01-10 |
AU2013283524A1 (en) | 2014-11-13 |
JP6251257B2 (ja) | 2017-12-20 |
CR20140528A (es) | 2015-01-12 |
AU2013283524B2 (en) | 2017-03-30 |
IL236138A0 (en) | 2015-02-01 |
US20150133440A1 (en) | 2015-05-14 |
EA201590066A1 (ru) | 2015-04-30 |
PH12014502623A1 (en) | 2015-01-21 |
PE20142450A1 (es) | 2015-01-28 |
WO2014001228A1 (fr) | 2014-01-03 |
CO7151509A2 (es) | 2014-12-29 |
MX2014014937A (es) | 2015-03-09 |
CN104470915B (zh) | 2019-07-26 |
PH12014502623B1 (en) | 2015-01-21 |
BR112014029742A2 (pt) | 2017-06-27 |
EP2864324B1 (fr) | 2018-03-28 |
IL236138A (en) | 2016-10-31 |
CL2014003325A1 (es) | 2015-04-24 |
US9181232B2 (en) | 2015-11-10 |
HK1206344A1 (en) | 2016-01-08 |
CN104470915A (zh) | 2015-03-25 |
KR20150023450A (ko) | 2015-03-05 |
MA37763B1 (fr) | 2017-05-31 |
SG11201407576YA (en) | 2015-03-30 |
CA2872181A1 (fr) | 2014-01-03 |
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