SG11201407576YA - Difluoro-hexahydro-cyclopentaoxazinyls and difluoro-hexahydro-benzooxazinyls as bace1 inhibitors - Google Patents
Difluoro-hexahydro-cyclopentaoxazinyls and difluoro-hexahydro-benzooxazinyls as bace1 inhibitorsInfo
- Publication number
- SG11201407576YA SG11201407576YA SG11201407576YA SG11201407576YA SG11201407576YA SG 11201407576Y A SG11201407576Y A SG 11201407576YA SG 11201407576Y A SG11201407576Y A SG 11201407576YA SG 11201407576Y A SG11201407576Y A SG 11201407576YA SG 11201407576Y A SG11201407576Y A SG 11201407576YA
- Authority
- SG
- Singapore
- Prior art keywords
- hexahydro
- difluoro
- cyclopentaoxazinyls
- benzooxazinyls
- bace1 inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12173690 | 2012-06-26 | ||
| PCT/EP2013/063086 WO2014001228A1 (fr) | 2012-06-26 | 2013-06-24 | Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201407576YA true SG11201407576YA (en) | 2015-03-30 |
Family
ID=48672630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201407576YA SG11201407576YA (en) | 2012-06-26 | 2013-06-24 | Difluoro-hexahydro-cyclopentaoxazinyls and difluoro-hexahydro-benzooxazinyls as bace1 inhibitors |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9181232B2 (fr) |
| EP (1) | EP2864324B1 (fr) |
| JP (1) | JP6251257B2 (fr) |
| KR (1) | KR20150023450A (fr) |
| CN (1) | CN104470915B (fr) |
| AU (1) | AU2013283524B2 (fr) |
| BR (1) | BR112014029742A2 (fr) |
| CA (1) | CA2872181A1 (fr) |
| CL (1) | CL2014003325A1 (fr) |
| CO (1) | CO7151509A2 (fr) |
| CR (1) | CR20140528A (fr) |
| EA (1) | EA025273B1 (fr) |
| HK (1) | HK1206344A1 (fr) |
| IL (1) | IL236138A (fr) |
| MA (1) | MA37763B1 (fr) |
| MX (1) | MX2014014937A (fr) |
| NZ (1) | NZ702253A (fr) |
| PE (1) | PE20142450A1 (fr) |
| PH (1) | PH12014502623A1 (fr) |
| SG (1) | SG11201407576YA (fr) |
| UA (1) | UA113309C2 (fr) |
| WO (1) | WO2014001228A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2727859C (fr) | 2008-06-13 | 2016-11-01 | Shionogi & Co., Ltd. | DERIVE HETEROCYCLIQUE CONTENANT DU SOUFRE AYANT UNE ACTIVITE INHIBANT LA ß-SECRETASE |
| ES2590038T5 (es) † | 2009-12-11 | 2021-10-19 | Shionogi & Co | Derivado de oxazina |
| US9540359B2 (en) | 2012-10-24 | 2017-01-10 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity |
| CA2902212C (fr) | 2013-03-01 | 2020-10-13 | Amgen Inc. | Composes perfluores 5,6-dihydro-4h-1,3-oxazine-2-amine substitues en tant qu'inhibiteurs de la beta-secretase et procedes d'utilisation correspondants |
| JP6374889B2 (ja) | 2013-03-08 | 2018-08-15 | アムジエン・インコーポレーテツド | β−セクレターゼ阻害剤としての過フッ素化シクロプロピル縮合１，３−オキサジン−２−アミン化合物、及び使用方法 |
| TW201623295A (zh) | 2014-04-11 | 2016-07-01 | 塩野義製藥股份有限公司 | 具有ｂａｃｅ１抑制活性之二氫噻及二氫衍生物 |
| CN106795147B (zh) | 2014-08-08 | 2020-09-22 | 美国安进公司 | 作为β-分泌酶抑制剂的环丙基稠合噻嗪-2-胺化合物和使用方法 |
| WO2016150785A1 (fr) | 2015-03-20 | 2016-09-29 | F. Hoffmann-La Roche Ag | Inhibiteurs de bace1 |
| AU2019258575A1 (en) * | 2018-04-27 | 2020-10-29 | Shionogi & Co., Ltd. | Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2010047372A1 (ja) | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Ｂａｃｅ１阻害活性を有する２−アミノピリミジン−４−オンおよび２−アミノピリジン誘導体 |
| GB0912778D0 (en) * | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
| ES2590038T5 (es) * | 2009-12-11 | 2021-10-19 | Shionogi & Co | Derivado de oxazina |
| UA103272C2 (uk) * | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
-
2013
- 2013-06-24 US US14/406,289 patent/US9181232B2/en not_active Expired - Fee Related
- 2013-06-24 SG SG11201407576YA patent/SG11201407576YA/en unknown
- 2013-06-24 BR BR112014029742A patent/BR112014029742A2/pt not_active IP Right Cessation
- 2013-06-24 EP EP13730887.0A patent/EP2864324B1/fr not_active Not-in-force
- 2013-06-24 CN CN201380033783.7A patent/CN104470915B/zh not_active Expired - Fee Related
- 2013-06-24 UA UAA201500578A patent/UA113309C2/uk unknown
- 2013-06-24 NZ NZ702253A patent/NZ702253A/en not_active IP Right Cessation
- 2013-06-24 EA EA201590066A patent/EA025273B1/ru not_active IP Right Cessation
- 2013-06-24 MA MA37763A patent/MA37763B1/fr unknown
- 2013-06-24 AU AU2013283524A patent/AU2013283524B2/en not_active Expired - Fee Related
- 2013-06-24 MX MX2014014937A patent/MX2014014937A/es unknown
- 2013-06-24 WO PCT/EP2013/063086 patent/WO2014001228A1/fr active Application Filing
- 2013-06-24 PE PE2014002406A patent/PE20142450A1/es not_active Application Discontinuation
- 2013-06-24 JP JP2015519008A patent/JP6251257B2/ja not_active Expired - Fee Related
- 2013-06-24 KR KR20147036016A patent/KR20150023450A/ko not_active Application Discontinuation
- 2013-06-24 CA CA2872181A patent/CA2872181A1/fr not_active Abandoned
-
2014
- 2014-11-18 CR CR20140528A patent/CR20140528A/es unknown
- 2014-11-24 PH PH12014502623A patent/PH12014502623A1/en unknown
- 2014-12-05 CL CL2014003325A patent/CL2014003325A1/es unknown
- 2014-12-08 IL IL236138A patent/IL236138A/en not_active IP Right Cessation
- 2014-12-10 CO CO14271199A patent/CO7151509A2/es unknown
-
2015
- 2015-07-21 HK HK15106931.2A patent/HK1206344A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL236138A0 (en) | 2015-02-01 |
| MX2014014937A (es) | 2015-03-09 |
| PH12014502623B1 (en) | 2015-01-21 |
| AU2013283524A1 (en) | 2014-11-13 |
| CA2872181A1 (fr) | 2014-01-03 |
| NZ702253A (en) | 2016-06-24 |
| HK1206344A1 (en) | 2016-01-08 |
| KR20150023450A (ko) | 2015-03-05 |
| JP2015521640A (ja) | 2015-07-30 |
| PH12014502623A1 (en) | 2015-01-21 |
| UA113309C2 (xx) | 2017-01-10 |
| JP6251257B2 (ja) | 2017-12-20 |
| PE20142450A1 (es) | 2015-01-28 |
| MA37763B1 (fr) | 2017-05-31 |
| EA025273B1 (ru) | 2016-12-30 |
| US9181232B2 (en) | 2015-11-10 |
| IL236138A (en) | 2016-10-31 |
| MA37763A1 (fr) | 2016-08-31 |
| WO2014001228A1 (fr) | 2014-01-03 |
| AU2013283524B2 (en) | 2017-03-30 |
| CN104470915A (zh) | 2015-03-25 |
| CO7151509A2 (es) | 2014-12-29 |
| CR20140528A (es) | 2015-01-12 |
| CN104470915B (zh) | 2019-07-26 |
| EA201590066A1 (ru) | 2015-04-30 |
| BR112014029742A2 (pt) | 2017-06-27 |
| CL2014003325A1 (es) | 2015-04-24 |
| US20150133440A1 (en) | 2015-05-14 |
| EP2864324A1 (fr) | 2015-04-29 |
| EP2864324B1 (fr) | 2018-03-28 |
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