PE20161273A1 - Forma salina de hidrocloruro para la inhibicion de ezh2 - Google Patents

Forma salina de hidrocloruro para la inhibicion de ezh2

Info

Publication number
PE20161273A1
PE20161273A1 PE2016000506A PE2016000506A PE20161273A1 PE 20161273 A1 PE20161273 A1 PE 20161273A1 PE 2016000506 A PE2016000506 A PE 2016000506A PE 2016000506 A PE2016000506 A PE 2016000506A PE 20161273 A1 PE20161273 A1 PE 20161273A1
Authority
PE
Peru
Prior art keywords
hydrochloride
methyl
treatment
polymorph
ezh2
Prior art date
Application number
PE2016000506A
Other languages
English (en)
Inventor
Arani Chanda
Hyeong-Wook Choi
Kristen Sanders
Steven Mathieu
Kevin W Kuntz
Original Assignee
Epizyme Inc
Eisai Randd Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme Inc, Eisai Randd Management Co Ltd filed Critical Epizyme Inc
Publication of PE20161273A1 publication Critical patent/PE20161273A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a un polimorfo C de monohidrocloruro de N-((4,6-dimetil-2-oxo-1,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2H-piran-4-il)amino)-4-metil-4’-(morfolinometil)-[1,1’-bifenil]-3-carboxamida donde el polimorfo exhibe un patron de difraccion de rayos X del polvo que tiene al menos diez picos caracteristicos expresados en grados 2-theta (+/- 0.2), seleccionados de 10.08, 10.94, 16.58, 17.12, 17.53, 18.34, 18.66, 20.50, 21.14, 21.92, 22.22, 23.46, 26.22, 26.60, 27.72 y 30.30. Tambien se refiere a un metodo de preparacion, tratamiento y una composicion. Dicho compuesto inhibe la actividad como histona metiltransferasa de EZH2 siendo util en el tratamiento de cancer de mama, linfoma no hodgkiniano o linfoma de celulas B
PE2016000506A 2013-10-16 2014-10-15 Forma salina de hidrocloruro para la inhibicion de ezh2 PE20161273A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361891786P 2013-10-16 2013-10-16

Publications (1)

Publication Number Publication Date
PE20161273A1 true PE20161273A1 (es) 2016-12-18

Family

ID=52828660

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016000506A PE20161273A1 (es) 2013-10-16 2014-10-15 Forma salina de hidrocloruro para la inhibicion de ezh2

Country Status (24)

Country Link
US (3) US10040782B2 (es)
EP (2) EP4324525A2 (es)
JP (2) JP6608812B2 (es)
KR (1) KR102142177B1 (es)
CN (1) CN105829302B (es)
AU (2) AU2014337300B2 (es)
CA (1) CA2925889C (es)
CL (1) CL2016000866A1 (es)
DK (1) DK3057962T3 (es)
EA (1) EA038869B1 (es)
ES (1) ES2960953T3 (es)
FI (1) FI3057962T3 (es)
HU (1) HUE063984T2 (es)
IL (1) IL244787B (es)
LT (1) LT3057962T (es)
MA (1) MA38949A1 (es)
MX (1) MX2016004703A (es)
MY (1) MY179802A (es)
PE (1) PE20161273A1 (es)
PL (1) PL3057962T3 (es)
PT (1) PT3057962T (es)
SG (2) SG11201602269QA (es)
SI (1) SI3057962T1 (es)
WO (1) WO2015057859A1 (es)

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Also Published As

Publication number Publication date
KR20160082993A (ko) 2016-07-11
DK3057962T3 (da) 2023-11-06
EP3057962A4 (en) 2017-05-24
US20180282312A1 (en) 2018-10-04
SG11201602269QA (en) 2016-04-28
PT3057962T (pt) 2023-11-07
SG10201901977XA (en) 2019-04-29
AU2014337300B2 (en) 2019-01-03
JP2016533349A (ja) 2016-10-27
MY179802A (en) 2020-11-16
EA201690650A1 (ru) 2016-10-31
AU2014337300A1 (en) 2016-04-14
CA2925889A1 (en) 2015-04-23
CN105829302B (zh) 2020-09-08
PL3057962T3 (pl) 2024-01-29
SI3057962T1 (sl) 2024-01-31
US20210017163A1 (en) 2021-01-21
EP3057962B1 (en) 2023-10-18
FI3057962T3 (fi) 2023-11-03
MX2016004703A (es) 2017-02-28
CN105829302A (zh) 2016-08-03
JP6608812B2 (ja) 2019-11-20
IL244787B (en) 2022-04-01
CA2925889C (en) 2020-09-29
LT3057962T (lt) 2023-12-11
HUE063984T2 (hu) 2024-02-28
MA38949A1 (fr) 2017-07-31
US20160237068A1 (en) 2016-08-18
NZ718201A (en) 2021-09-24
IL244787A0 (en) 2016-04-21
KR102142177B1 (ko) 2020-08-07
EA038869B1 (ru) 2021-10-29
US10040782B2 (en) 2018-08-07
CL2016000866A1 (es) 2016-12-23
US10710987B2 (en) 2020-07-14
JP2019052181A (ja) 2019-04-04
EP4324525A2 (en) 2024-02-21
AU2019202246A1 (en) 2019-04-18
WO2015057859A1 (en) 2015-04-23
EP3057962A1 (en) 2016-08-24
ES2960953T3 (es) 2024-03-07

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