MA45990B1 - Combinaison d'agonistes inverses du récepteur de l'histamine-3 avec des inhibiteurs de l'acétylcholinestérase - Google Patents
Combinaison d'agonistes inverses du récepteur de l'histamine-3 avec des inhibiteurs de l'acétylcholinestéraseInfo
- Publication number
- MA45990B1 MA45990B1 MA45990A MA45990A MA45990B1 MA 45990 B1 MA45990 B1 MA 45990B1 MA 45990 A MA45990 A MA 45990A MA 45990 A MA45990 A MA 45990A MA 45990 B1 MA45990 B1 MA 45990B1
- Authority
- MA
- Morocco
- Prior art keywords
- combination
- histamine
- inverse agonists
- receptor inverse
- acetylcholinesterase inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne la combinaison d'un agoniste inverse du récepteur de l'histamine-3 et d'un inhibiteur de l'acétylcholinestérase. L'invention concerne également un agoniste inverse du récepteur d'histamine-3 (h3r) ou un/des sel(s) pharmaceutiquement acceptable(s) de celui-ci, en combinaison avec, ou comme adjuvant à, un inhibiteur de l'acétylcholinestérase, ainsi que leur utilisation dans le traitement des troubles cognitifs. L'invention concerne encore la composition pharmaceutique contenant ladite combinaison.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201641028166 | 2016-08-18 | ||
| PCT/IB2017/054938 WO2018033847A1 (fr) | 2016-08-18 | 2017-08-14 | Combinaison d'agonistes inverses du récepteur de l'histamine-3 avec des inhibiteurs de l'acétylcholinestérase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA45990A MA45990A (fr) | 2019-06-26 |
| MA45990B1 true MA45990B1 (fr) | 2020-08-31 |
Family
ID=59887325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA45990A MA45990B1 (fr) | 2016-08-18 | 2017-08-14 | Combinaison d'agonistes inverses du récepteur de l'histamine-3 avec des inhibiteurs de l'acétylcholinestérase |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US10603323B2 (fr) |
| EP (1) | EP3500253B1 (fr) |
| JP (1) | JP6734470B2 (fr) |
| KR (1) | KR102039585B1 (fr) |
| CN (1) | CN109640975B (fr) |
| AU (1) | AU2017313427B2 (fr) |
| BR (1) | BR112019002645A2 (fr) |
| CA (1) | CA3033039C (fr) |
| CY (1) | CY1123238T1 (fr) |
| DK (1) | DK3500253T3 (fr) |
| EA (1) | EA032957B1 (fr) |
| ES (1) | ES2810983T3 (fr) |
| HR (1) | HRP20201262T1 (fr) |
| HU (1) | HUE052003T2 (fr) |
| IL (1) | IL264406B (fr) |
| LT (1) | LT3500253T (fr) |
| MA (1) | MA45990B1 (fr) |
| MD (1) | MD3500253T2 (fr) |
| ME (1) | ME03812B (fr) |
| MX (1) | MX2019001696A (fr) |
| NZ (1) | NZ750150A (fr) |
| PL (1) | PL3500253T3 (fr) |
| PT (1) | PT3500253T (fr) |
| RS (1) | RS60669B1 (fr) |
| SG (1) | SG11201900681SA (fr) |
| SI (1) | SI3500253T1 (fr) |
| WO (1) | WO2018033847A1 (fr) |
| ZA (1) | ZA201900467B (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112367998B (zh) * | 2018-05-31 | 2024-05-28 | 苏文生命科学有限公司 | 用组胺-3受体反向激动剂进行治疗的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102803268A (zh) * | 2009-06-10 | 2012-11-28 | 桑诺维恩药品公司 | 组胺h3反相激动剂和拮抗剂及其使用方法 |
| PL2694492T3 (pl) * | 2011-02-23 | 2015-12-31 | Suven Life Sciences Ltd | Nowe związki jako ligandy receptorów histaminowych H<sub>3 </sub> |
| FR2974729B1 (fr) * | 2011-05-02 | 2013-04-19 | Servier Lab | Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide et un inhibiteur de l'acetylcholinesterase et les compositions pharmaceutiques qui la contiennent |
| HUP1300139A2 (en) * | 2013-03-06 | 2014-09-29 | Richter Gedeon Nyrt | Phenoxypiperidine h3 antagonists |
| KR20160048930A (ko) | 2013-09-09 | 2016-05-04 | 사노피 | 알츠하이머 질환의 치료에 사용하기 위해 콜린에스테라제 저해제와 조합된 h3 수용체 길항제 |
-
2017
- 2017-08-14 MA MA45990A patent/MA45990B1/fr unknown
- 2017-08-14 NZ NZ750150A patent/NZ750150A/en unknown
- 2017-08-14 CA CA3033039A patent/CA3033039C/fr active Active
- 2017-08-14 EP EP17768234.1A patent/EP3500253B1/fr active Active
- 2017-08-14 SG SG11201900681SA patent/SG11201900681SA/en unknown
- 2017-08-14 DK DK17768234.1T patent/DK3500253T3/da active
- 2017-08-14 ES ES17768234T patent/ES2810983T3/es active Active
- 2017-08-14 RS RS20200949A patent/RS60669B1/sr unknown
- 2017-08-14 SI SI201730360T patent/SI3500253T1/sl unknown
- 2017-08-14 PL PL17768234T patent/PL3500253T3/pl unknown
- 2017-08-14 PT PT177682341T patent/PT3500253T/pt unknown
- 2017-08-14 HU HUE17768234A patent/HUE052003T2/hu unknown
- 2017-08-14 EA EA201990480A patent/EA032957B1/ru unknown
- 2017-08-14 CN CN201780049311.9A patent/CN109640975B/zh active Active
- 2017-08-14 AU AU2017313427A patent/AU2017313427B2/en active Active
- 2017-08-14 ME MEP-2020-167A patent/ME03812B/fr unknown
- 2017-08-14 LT LTEP17768234.1T patent/LT3500253T/lt unknown
- 2017-08-14 US US16/320,949 patent/US10603323B2/en active Active
- 2017-08-14 WO PCT/IB2017/054938 patent/WO2018033847A1/fr active Search and Examination
- 2017-08-14 MX MX2019001696A patent/MX2019001696A/es active IP Right Grant
- 2017-08-14 MD MDE20190714T patent/MD3500253T2/ro unknown
- 2017-08-14 JP JP2019506640A patent/JP6734470B2/ja active Active
- 2017-08-14 KR KR1020197007056A patent/KR102039585B1/ko active IP Right Grant
- 2017-08-14 BR BR112019002645A patent/BR112019002645A2/pt active Search and Examination
-
2019
- 2019-01-22 IL IL264406A patent/IL264406B/en active IP Right Grant
- 2019-01-23 ZA ZA2019/00467A patent/ZA201900467B/en unknown
-
2020
- 2020-08-05 CY CY20201100725T patent/CY1123238T1/el unknown
- 2020-08-11 HR HRP20201262TT patent/HRP20201262T1/hr unknown
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