MA41654B2 - Formes cristallines d'un inhibiteur de tyrosine kinase de bruton - Google Patents

Formes cristallines d'un inhibiteur de tyrosine kinase de bruton

Info

Publication number
MA41654B2
MA41654B2 MA41654A MA41654A MA41654B2 MA 41654 B2 MA41654 B2 MA 41654B2 MA 41654 A MA41654 A MA 41654A MA 41654 A MA41654 A MA 41654A MA 41654 B2 MA41654 B2 MA 41654B2
Authority
MA
Morocco
Prior art keywords
tyrosine kinase
kinase inhibitor
conditions
crystal forms
diseases
Prior art date
Application number
MA41654A
Other languages
English (en)
Other versions
MA41654A1 (fr
Inventor
Mark Smyth
Erick Goldman
David D Wirth
Norbert Purro
Original Assignee
Pharmacyclics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49712527&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA41654(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacyclics Inc filed Critical Pharmacyclics Inc
Publication of MA41654A1 publication Critical patent/MA41654A1/fr
Publication of MA41654B2 publication Critical patent/MA41654B2/fr

Links

Classifications

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Composite Materials (AREA)
  • Mechanical Engineering (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)

Abstract

La présente invention concerne l'inhibiteur de tyrosine kinase de bruton (btk) 1-((r)-3-(4-amino-3-(4-phénoxyphényl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)pipéridin-1-yl)prop-2-èn-1-one, celui-ci comprenant des formes cristallines, des solvates et des sels de qualité pharmaceutique de celui-ci. L'invention concerne également des compositions pharmaceutiques qui comprennent l'inhibiteur de btk, ainsi que des procédés d'utilisation de l'inhibiteur de btk, seul ou en combinaison avec d'autres agents thérapeutiques, pour le traitement de maladies ou d'états auto-immuns, de maladies ou d'états hétéro-immuns, du cancer, y compris un lymphome, et de maladies ou d'états inflammatoires.
MA41654A 2012-06-04 2013-06-03 Formes cristallines d'un inhibiteur de tyrosine kinase de bruton MA41654B2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261655381P 2012-06-04 2012-06-04
PCT/US2013/043888 WO2013184572A1 (fr) 2012-06-04 2013-06-03 Formes cristallines d'un inhibiteur de tyrosine kinase de bruton

Publications (2)

Publication Number Publication Date
MA41654A1 MA41654A1 (fr) 2018-07-31
MA41654B2 true MA41654B2 (fr) 2020-12-31

Family

ID=49712527

Family Applications (2)

Application Number Title Priority Date Filing Date
MA37711A MA37711A1 (fr) 2012-06-04 2013-06-03 Formes cristallines d'un inhibiteur de tyrosine kinase de bruton
MA41654A MA41654B2 (fr) 2012-06-04 2013-06-03 Formes cristallines d'un inhibiteur de tyrosine kinase de bruton

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA37711A MA37711A1 (fr) 2012-06-04 2013-06-03 Formes cristallines d'un inhibiteur de tyrosine kinase de bruton

Country Status (32)

Country Link
US (27) US9296753B2 (fr)
EP (1) EP2854859B1 (fr)
JP (10) JP6236071B2 (fr)
KR (8) KR20250151610A (fr)
CN (2) CN110354132A (fr)
AR (2) AR092844A1 (fr)
AU (7) AU2013271918C1 (fr)
BR (1) BR112014030424A8 (fr)
CA (4) CA3218491A1 (fr)
CL (3) CL2014003306A1 (fr)
CO (1) CO7240408A2 (fr)
CR (1) CR20140558A (fr)
DO (3) DOP2014000274A (fr)
EA (1) EA201492082A1 (fr)
EC (2) ECSP14033163A (fr)
GT (1) GT201400281A (fr)
HK (1) HK1208803A1 (fr)
IL (4) IL315394A (fr)
JO (2) JO3754B1 (fr)
MA (2) MA37711A1 (fr)
MX (3) MX348290B (fr)
MY (2) MY194911A (fr)
NZ (4) NZ731932A (fr)
PE (3) PE20241581A1 (fr)
PH (3) PH12021552282A1 (fr)
SG (2) SG11201408067YA (fr)
TN (1) TN2014000492A1 (fr)
TW (3) TWI662963B (fr)
UA (2) UA126959C2 (fr)
UY (2) UY39740A (fr)
WO (1) WO2013184572A1 (fr)
ZA (4) ZA202105175B (fr)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA018573B1 (ru) 2006-09-22 2013-09-30 Фармасайкликс, Инк. Ингибиторы тирозинкиназы брутона
US8809273B2 (en) 2007-03-28 2014-08-19 Pharmacyclics, Inc. Inhibitors of Bruton's tyrosine kinase
CN105362277A (zh) 2008-07-16 2016-03-02 药品循环有限公司 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂
US8491927B2 (en) * 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
CA3007787C (fr) 2010-06-03 2020-03-10 Pharmacyclics Llc Utilisation d'inhibiteurs de la tyrosine kinase de bruton (btk)
AU2012205601B2 (en) 2011-01-11 2016-03-24 Novartis Ag Combination
BR112014000653A2 (pt) 2011-07-13 2017-02-14 Pharmacyclics Inc inibidores de tirosina quinase de bruton
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