MX348290B - Formas cristalinas de un inhibidor de tirosina quinasa de bruton. - Google Patents

Formas cristalinas de un inhibidor de tirosina quinasa de bruton.

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Publication number
MX348290B
MX348290B MX2014014848A MX2014014848A MX348290B MX 348290 B MX348290 B MX 348290B MX 2014014848 A MX2014014848 A MX 2014014848A MX 2014014848 A MX2014014848 A MX 2014014848A MX 348290 B MX348290 B MX 348290B
Authority
MX
Mexico
Prior art keywords
tyrosine kinase
crystalline forms
bruton
inhibitor
kinase inhibitor
Prior art date
Application number
MX2014014848A
Other languages
English (en)
Other versions
MX2014014848A (es
Inventor
Smyth Mark
Goldman Erick
D Wirth David
Purro Norbert
Original Assignee
Pharmacyclics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49712527&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX348290(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacyclics Llc filed Critical Pharmacyclics Llc
Publication of MX2014014848A publication Critical patent/MX2014014848A/es
Publication of MX348290B publication Critical patent/MX348290B/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

La presente invención se refiere al inhibidor de tirosina quinasa (Btk) de Bruton 1-((R)-3-(4-amino-3-(4-fenoxifenil)-1H-pirazolo [3,4-d] pirimidin-1-il) piperidin-1-il) prop-2-en-1-ona, incluyendo las formas cristalinas, solvatos y sus sales aceptables en el campo farmacéutico. Se describe también composiciones farmacéuticas que incluyen al inhibidor Btk, así como métodos para usar a dicho inhibidor solo o en combinación con otros agentes terapéuticos, para el tratamiento de enfermedades o condiciones autoinmunes, enfermedades o condiciones heteroinmunes, cáncer, incluyendo linfoma, así como enfermedades o condiciones inflamatorias.
MX2014014848A 2012-06-04 2013-06-03 Formas cristalinas de un inhibidor de tirosina quinasa de bruton. MX348290B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261655381P 2012-06-04 2012-06-04
PCT/US2013/043888 WO2013184572A1 (en) 2012-06-04 2013-06-03 Crystalline forms of a bruton's tyrosine kinase inhibitor

Publications (2)

Publication Number Publication Date
MX2014014848A MX2014014848A (es) 2015-07-06
MX348290B true MX348290B (es) 2017-06-05

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Application Number Title Priority Date Filing Date
MX2014014848A MX348290B (es) 2012-06-04 2013-06-03 Formas cristalinas de un inhibidor de tirosina quinasa de bruton.
MX2017006815A MX387669B (es) 2012-06-04 2013-06-03 Formas cristalinas de un inhibidor de tirosina quinasa de bruton.
MX2021012478A MX2021012478A (es) 2012-06-04 2014-12-04 Formas cristalinas de un inhibidor de tirosina quinasa de bruton.

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MX2017006815A MX387669B (es) 2012-06-04 2013-06-03 Formas cristalinas de un inhibidor de tirosina quinasa de bruton.
MX2021012478A MX2021012478A (es) 2012-06-04 2014-12-04 Formas cristalinas de un inhibidor de tirosina quinasa de bruton.

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US (27) US9540382B2 (es)
EP (2) EP4729054A1 (es)
JP (10) JP6236071B2 (es)
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MX (3) MX348290B (es)
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NZ (4) NZ713828A (es)
PE (3) PE20150174A1 (es)
PH (3) PH12021552282A1 (es)
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Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0622054B8 (pt) 2006-09-22 2021-05-25 Oxford Amherst Llc composto e composição farmacêutica
US20120101114A1 (en) 2007-03-28 2012-04-26 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
ES2660418T3 (es) 2008-07-16 2018-03-22 Pharmacyclics Llc Inhibidores de la tirosina quinasa de Bruton para el tratamiento de tumores sólidos
US8491927B2 (en) * 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
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