JOP20200222A1 - أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون - Google Patents
أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتونInfo
- Publication number
- JOP20200222A1 JOP20200222A1 JOP/2020/0222A JOP20200222A JOP20200222A1 JO P20200222 A1 JOP20200222 A1 JO P20200222A1 JO P20200222 A JOP20200222 A JO P20200222A JO P20200222 A1 JOP20200222 A1 JO P20200222A1
- Authority
- JO
- Jordan
- Prior art keywords
- bruton
- tyrosine kinase
- crystalline forms
- conditions
- kinase inhibitor
- Prior art date
Links
- 229940125814 BTK kinase inhibitor Drugs 0.000 title abstract 2
- 229940124291 BTK inhibitor Drugs 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- -1 crystalline forms Chemical compound 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- XYFPWWZEPKGCCK-GOSISDBHSA-N ibrutinib Chemical compound C1=2C(N)=NC=NC=2N([C@H]2CN(CCC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XYFPWWZEPKGCCK-GOSISDBHSA-N 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract
يتعلق الاختراع الحالي عن مثبط إنزيم تيروسين كيناز لبروتون (Btk) 1- ((R)- 3- (4-فينوكسي فينيل)-1H- بيرازولول [3، 4-d] بيريميدين-1-يل)بيريميدين-1-يل)بيبريدين-1-يل)بروب-2- ين-1- أون، بما في ذلك صورة البلورية، وذواباته، وأملاحه المقبولة صيدلانياً. كما يتم الكشف عن تركيبات صيدلانية تشتمل على مثط Btk، وكذلك طرق لاستخدام مثبط Btk، سواء بمفرده أو بالاشتراك مع عوامل علاجية أخلى، في علاج أمراض أو حالات مناعة ذاتية، أو أمراض أو حالات مناعة غير متجانسة، أو سرطان، مثل الأورام الليمفاوية، وأمراض أو حالات التهابية.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261655381P | 2012-06-04 | 2012-06-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
JOP20200222A1 true JOP20200222A1 (ar) | 2022-10-30 |
Family
ID=49712527
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2013/0168A JO3754B1 (ar) | 2012-06-04 | 2013-06-03 | أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون |
JOP/2020/0222A JOP20200222A1 (ar) | 2012-06-04 | 2020-09-09 | أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2013/0168A JO3754B1 (ar) | 2012-06-04 | 2013-06-03 | أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون |
Country Status (32)
Country | Link |
---|---|
US (25) | US9540382B2 (ar) |
EP (1) | EP2854859A4 (ar) |
JP (8) | JP6236071B2 (ar) |
KR (7) | KR20220093389A (ar) |
CN (2) | CN110354132A (ar) |
AR (2) | AR092844A1 (ar) |
AU (6) | AU2013271918C1 (ar) |
BR (1) | BR112014030424A8 (ar) |
CA (4) | CA2991994C (ar) |
CL (3) | CL2014003306A1 (ar) |
CO (1) | CO7240408A2 (ar) |
CR (1) | CR20140558A (ar) |
DO (3) | DOP2014000274A (ar) |
EA (1) | EA201492082A1 (ar) |
EC (2) | ECSP14033163A (ar) |
GT (1) | GT201400281A (ar) |
HK (1) | HK1208803A1 (ar) |
IL (3) | IL235894B (ar) |
JO (2) | JO3754B1 (ar) |
MA (2) | MA37711A1 (ar) |
MX (2) | MX348290B (ar) |
MY (2) | MY194911A (ar) |
NZ (4) | NZ731932A (ar) |
PE (2) | PE20190390A1 (ar) |
PH (2) | PH12014502681A1 (ar) |
SG (2) | SG11201408067YA (ar) |
TN (1) | TN2014000492A1 (ar) |
TW (3) | TWI662963B (ar) |
UA (2) | UA114421C2 (ar) |
UY (2) | UY34848A (ar) |
WO (1) | WO2013184572A1 (ar) |
ZA (3) | ZA202105175B (ar) |
Families Citing this family (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE531263T1 (de) | 2006-09-22 | 2011-11-15 | Pharmacyclics Inc | Hemmer der bruton-tyrosinkinase |
US20120101113A1 (en) | 2007-03-28 | 2012-04-26 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
JP5369183B2 (ja) | 2008-07-16 | 2013-12-18 | ファーマサイクリックス,インク. | 固形腫瘍の治療用のブルートンのチロシンキナーゼの阻害剤 |
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BR122023020985A2 (pt) | 2015-03-03 | 2023-12-26 | Pharmacyclics Llc | Formulação de comprimido sólido de um inibidor de tirosina quinase de bruton |
WO2016139588A1 (en) | 2015-03-03 | 2016-09-09 | Dr. Reddy's Laboratories Limited | Polymorphs of ibrutinib |
MA41828A (fr) | 2015-03-27 | 2018-01-30 | Pharmacyclics Llc | Co-cristaux d'un inhibiteur de la tyrosine kinase de bruton |
MA41827A (fr) | 2015-03-27 | 2018-01-30 | Pharmacyclics Llc | Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton |
JP6705833B2 (ja) | 2015-04-02 | 2020-06-03 | ラティオファルム ゲー・エム・ベー・ハー | イブルチニブとカルボン酸との共結晶 |
DK3892302T3 (da) | 2015-04-06 | 2023-11-13 | Janssen Pharmaceutica Nv | Sammensætninger indeholdende ibrutinib |
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