MA53002A - Nouveaux composés de pyridine et de pyrazine en tant qu'inhibiteurs du récepteur cannabinoïde 2 - Google Patents

Nouveaux composés de pyridine et de pyrazine en tant qu'inhibiteurs du récepteur cannabinoïde 2

Info

Publication number
MA53002A
MA53002A MA053002A MA53002A MA53002A MA 53002 A MA53002 A MA 53002A MA 053002 A MA053002 A MA 053002A MA 53002 A MA53002 A MA 53002A MA 53002 A MA53002 A MA 53002A
Authority
MA
Morocco
Prior art keywords
cannabinoid
pyrazine
pyridine
new compounds
receptor inhibitors
Prior art date
Application number
MA053002A
Other languages
English (en)
Inventor
Simon M Ametamey
Luca Gobbi
Uwe Grether
Julian Kretz
Original Assignee
Eth Zuerich
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eth Zuerich, Hoffmann La Roche filed Critical Eth Zuerich
Publication of MA53002A publication Critical patent/MA53002A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
MA053002A 2018-06-27 2019-06-25 Nouveaux composés de pyridine et de pyrazine en tant qu'inhibiteurs du récepteur cannabinoïde 2 MA53002A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18180137 2018-06-27

Publications (1)

Publication Number Publication Date
MA53002A true MA53002A (fr) 2021-05-05

Family

ID=62814868

Family Applications (1)

Application Number Title Priority Date Filing Date
MA053002A MA53002A (fr) 2018-06-27 2019-06-25 Nouveaux composés de pyridine et de pyrazine en tant qu'inhibiteurs du récepteur cannabinoïde 2

Country Status (19)

Country Link
US (2) US12071420B2 (fr)
EP (1) EP3814329B1 (fr)
JP (1) JP7445610B2 (fr)
KR (1) KR102790077B1 (fr)
CN (2) CN112262132A (fr)
AU (2) AU2019294256B2 (fr)
BR (1) BR112020025013A2 (fr)
CA (1) CA3096777A1 (fr)
CL (1) CL2020003331A1 (fr)
CO (1) CO2020011855A2 (fr)
CR (1) CR20200643A (fr)
IL (1) IL279725B2 (fr)
MA (1) MA53002A (fr)
MX (1) MX2020012760A (fr)
PE (1) PE20210368A1 (fr)
PH (1) PH12020552152A1 (fr)
SG (1) SG11202009103WA (fr)
WO (1) WO2020002320A1 (fr)
ZA (1) ZA202005426B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006030671B4 (de) 2006-07-04 2008-10-02 Moeller Gmbh Schutzschalter-Kurzschließer-Kombination
CN110753690B (zh) 2017-06-20 2023-12-05 豪夫迈·罗氏有限公司 吡啶衍生物
EP3813888B1 (fr) 2018-06-27 2025-11-26 F. Hoffmann-La Roche AG Ligand du récepteur cannabinoïde 2 radiomarqué
JP7454512B2 (ja) 2018-06-27 2024-03-22 エフ. ホフマン-ラ ロシュ アーゲー 優先的カンナビノイド2アゴニストとしてのピリジン及びピラジン誘導体
MA53002A (fr) 2018-06-27 2021-05-05 Eth Zuerich Nouveaux composés de pyridine et de pyrazine en tant qu'inhibiteurs du récepteur cannabinoïde 2
WO2020002280A1 (fr) 2018-06-27 2020-01-02 F. Hoffmann-La Roche Ag Nouveaux composés de pyridine et de pyrazine substitués par azétidine en tant qu'inhibiteurs du récepteur cannabinoïde 2
JP2024541968A (ja) 2021-10-28 2024-11-13 ジェネンテック, インコーポレイテッド 治療的介入のためにmhc関連抗原を同定するためのシステムおよび方法

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ES2176251T3 (es) 1993-07-28 2002-12-01 Aventis Pharma Ltd Compuestos utilizados como inhibidores de pde iv y del factor de necrosis tumoral(tnf).
GB0222493D0 (en) * 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
JP2007523206A (ja) * 2004-02-24 2007-08-16 グラクソ グループ リミテッド Cb2受容体モジュレーターとしてのピリジン誘導体およびその使用
GB0418047D0 (en) 2004-08-12 2004-09-15 Syngenta Participations Ag Fungicidal compositions
US7776889B2 (en) 2005-03-31 2010-08-17 Schering Corporation Spirocyclic thrombin receptor antagonists
FR2887550A1 (fr) 2005-06-24 2006-12-29 Sanofi Aventis Sa Derives de 1-benzylpyrazole-3-acetamide, leur preparation et leur application en therapeutique
KR101347102B1 (ko) 2005-10-19 2014-01-03 그뤼넨탈 게엠베하 신규한 바닐로이드 수용체 리간드 및 약제를 제조하기 위한이의 용도
JP5064506B2 (ja) * 2006-10-04 2012-10-31 エフ.ホフマン−ラ ロシュ アーゲー Cb2受容体調節因子としてのピラジン−2−カルボキサミド誘導体
EP2311443A1 (fr) 2009-10-15 2011-04-20 Rheinische Friedrich-Wilhelms-Universität Composition pharmaceutique contenant des antagonistes de récepteur de cannabinoïde-2
US9321727B2 (en) * 2011-06-10 2016-04-26 Hoffmann-La Roche Inc. Pyridine derivatives as agonists of the CB2 receptor
WO2013028590A1 (fr) 2011-08-25 2013-02-28 Merck Sharp & Dohme Corp. Inhibiteurs pyrimidines de pde10
US9403808B2 (en) 2011-10-28 2016-08-02 Hoffmann-La Roche Inc. Pyrazine derivatives
CN104903466B (zh) 2012-11-05 2016-11-23 鲁比康基因组学公司 条形编码核酸
HRP20171459T1 (hr) 2012-12-07 2017-11-03 F. Hoffmann - La Roche Ag Piridin-2-amidi korisni kao agonisti cb2
JP6426619B2 (ja) 2012-12-07 2018-11-21 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Cb2アゴニストとして有用なピリジン−2−アミド
PL2928882T3 (pl) 2012-12-07 2017-07-31 F.Hoffmann-La Roche Ag Pochodne pirazyny jako agoniści receptora cb2
EP3357918A1 (fr) 2012-12-07 2018-08-08 F. Hoffmann-La Roche AG Nouveaux dérivés de pyridine
SI2978755T1 (en) 2013-03-26 2018-03-30 F. Hoffmann-La Roche Ag New pyridine derivatives
EP3126359A1 (fr) 2014-04-04 2017-02-08 F. Hoffmann-La Roche AG Pyridine-2-amides utiles comme agonistes de cb2
AU2015239537B2 (en) * 2014-04-04 2019-04-04 Eidgenoessische Technische Hochschule Zuerich 5,6-disubstituted pyridine-2-carboxamides as Cannabinoid receptor agonists
WO2016066534A1 (fr) 2014-10-27 2016-05-06 F. Hoffmann-La Roche Ag Ligands radiomarqués du récepteur cannabinoïde 2
JO3705B1 (ar) 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
BR112018011562B1 (pt) 2015-12-09 2023-05-02 F. Hoffmann-La Roche Ag Novos derivados de fenil
US11479807B2 (en) 2017-03-23 2022-10-25 University Of Washington Methods for targeted nucleic acid sequence enrichment with applications to error corrected nucleic acid sequencing
TW201906818A (zh) 2017-05-31 2019-02-16 美商511製藥公司 新穎氘取代之正子發射斷層掃描(pet)顯影劑及其藥理應用
CN110753690B (zh) 2017-06-20 2023-12-05 豪夫迈·罗氏有限公司 吡啶衍生物
EP3793547A4 (fr) 2018-05-15 2021-11-17 H. Lundbeck A/S Inhibiteurs de magl
JP7454512B2 (ja) 2018-06-27 2024-03-22 エフ. ホフマン-ラ ロシュ アーゲー 優先的カンナビノイド2アゴニストとしてのピリジン及びピラジン誘導体
MA53002A (fr) 2018-06-27 2021-05-05 Eth Zuerich Nouveaux composés de pyridine et de pyrazine en tant qu'inhibiteurs du récepteur cannabinoïde 2
EP3813888B1 (fr) 2018-06-27 2025-11-26 F. Hoffmann-La Roche AG Ligand du récepteur cannabinoïde 2 radiomarqué
WO2020002280A1 (fr) 2018-06-27 2020-01-02 F. Hoffmann-La Roche Ag Nouveaux composés de pyridine et de pyrazine substitués par azétidine en tant qu'inhibiteurs du récepteur cannabinoïde 2
TWI687701B (zh) 2018-12-05 2020-03-11 宏碁股份有限公司 判斷電量狀態的方法及其電子裝置

Also Published As

Publication number Publication date
IL279725B1 (en) 2023-12-01
EP3814329B1 (fr) 2024-01-17
BR112020025013A2 (pt) 2021-03-23
US20240383872A1 (en) 2024-11-21
ZA202005426B (en) 2025-06-25
SG11202009103WA (en) 2020-10-29
CR20200643A (es) 2021-05-11
US12071420B2 (en) 2024-08-27
PE20210368A1 (es) 2021-02-26
WO2020002320A1 (fr) 2020-01-02
AU2019294256B2 (en) 2024-06-20
IL279725B2 (en) 2024-04-01
MX2020012760A (es) 2021-03-25
CN112262132A (zh) 2021-01-22
EP3814329A1 (fr) 2021-05-05
PH12020552152A1 (en) 2021-07-05
EP3814329C0 (fr) 2024-01-17
CL2020003331A1 (es) 2021-05-07
CN119161323A (zh) 2024-12-20
JP7445610B2 (ja) 2024-03-07
US20210115011A1 (en) 2021-04-22
IL279725A (en) 2021-03-01
JP2021529157A (ja) 2021-10-28
KR102790077B1 (ko) 2025-04-03
CA3096777A1 (fr) 2020-02-02
KR20210028202A (ko) 2021-03-11
CO2020011855A2 (es) 2020-10-20
AU2019294256A1 (en) 2020-09-24
AU2024219640A1 (en) 2024-10-03

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