ES2176251T3 - Compuestos utilizados como inhibidores de pde iv y del factor de necrosis tumoral(tnf). - Google Patents
Compuestos utilizados como inhibidores de pde iv y del factor de necrosis tumoral(tnf).Info
- Publication number
- ES2176251T3 ES2176251T3 ES94922940T ES94922940T ES2176251T3 ES 2176251 T3 ES2176251 T3 ES 2176251T3 ES 94922940 T ES94922940 T ES 94922940T ES 94922940 T ES94922940 T ES 94922940T ES 2176251 T3 ES2176251 T3 ES 2176251T3
- Authority
- ES
- Spain
- Prior art keywords
- tnf
- cyclic amp
- amp phosphodiesterase
- inhibiting
- necrosis factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
- C07C2603/64—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings having a tricyclo[2.2.1.0(2,6)]heptstructure
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/66—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings
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Abstract
ESTA INVENCION VA DIRIGIDA A UN COMPUESTO [DI(ETER O TIOETER) ETEROARIL O ARIL FLUORO SUSTITUIDO] O UN OXIDO-N DEL MISMO O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, UTIL PARA INHIBIR LA PRODUCCION DE EFECTOS FISIOLOGICOS DE TNF EN EL TRATAMIENTO DE UN PACIENTE AFECTADO DE UNA ENFERMEDAD ASOCIADA CON UN EXCESO FISIOLOGICAMENTE DETRIMENTAL DE UN FACTOR DE NECROSIS TUMORAL (TMF). LOS COMPUESTOS DENTRO DEL AMBITO DE LA PRESENTE INVENCION TAMBIEN INHIBEN LA FOSFODIESTERASA AMP CICLICA, Y SON UTILES EN EL TRATAMIENTO DE UN ESTADO DE ENFERMEDAD ASOCIADO CON CONDICIONES PATOLOGICAS MODULADAS MEDIANTE LA INHIBICION DE LA FOSFODIESTERASA AMP CICLICA, INCLUYENDO TALES ESTADOS DE ENFERMEDAD, ENFERMEDADES INFLAMATORIAS Y AUTOINMUNES, EN PARTICULAR DEL TIPO IV DE FOSFODIESTERASA AMP CICLICA. LA PRESENTE INVENCION VA POR TANTO DIRIGIDA A SUS USOS FARMACOLOGICOS PARA INHIBIR LA FOSFODIESTERASA AMP CICLICA Y/O TNF, COMPOSICIONES FARMACOLOGICAS QUE INCLUYEN LOS COMPUESTOS Y METODOS PARA SU PREPARACION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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GB939315581A GB9315581D0 (en) | 1993-07-28 | 1993-07-28 | Novel compositions of matter |
GB939315632A GB9315632D0 (en) | 1993-07-28 | 1993-07-28 | New compositions of matter |
Publications (1)
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ES2176251T3 true ES2176251T3 (es) | 2002-12-01 |
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ES94922940T Expired - Lifetime ES2176251T3 (es) | 1993-07-28 | 1994-07-28 | Compuestos utilizados como inhibidores de pde iv y del factor de necrosis tumoral(tnf). |
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US (6) | US6472412B1 (es) |
EP (1) | EP0711282B1 (es) |
JP (3) | JP3775685B2 (es) |
AT (1) | ATE218549T1 (es) |
AU (1) | AU7267094A (es) |
CA (1) | CA2160928C (es) |
DE (1) | DE69430747T2 (es) |
DK (1) | DK0711282T3 (es) |
ES (1) | ES2176251T3 (es) |
IL (1) | IL110492A0 (es) |
PT (1) | PT711282E (es) |
WO (1) | WO1995004045A1 (es) |
ZA (1) | ZA945609B (es) |
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-
1994
- 1994-07-28 IL IL11049294A patent/IL110492A0/xx unknown
- 1994-07-28 ES ES94922940T patent/ES2176251T3/es not_active Expired - Lifetime
- 1994-07-28 ZA ZA945609A patent/ZA945609B/xx unknown
- 1994-07-28 WO PCT/GB1994/001630 patent/WO1995004045A1/en active IP Right Grant
- 1994-07-28 CA CA002160928A patent/CA2160928C/en not_active Expired - Lifetime
- 1994-07-28 AU AU72670/94A patent/AU7267094A/en not_active Abandoned
- 1994-07-28 PT PT94922940T patent/PT711282E/pt unknown
- 1994-07-28 AT AT94922940T patent/ATE218549T1/de active
- 1994-07-28 DK DK94922940T patent/DK0711282T3/da active
- 1994-07-28 DE DE69430747T patent/DE69430747T2/de not_active Expired - Lifetime
- 1994-07-28 JP JP50565795A patent/JP3775685B2/ja not_active Expired - Lifetime
- 1994-07-28 EP EP94922940A patent/EP0711282B1/en not_active Expired - Lifetime
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1996
- 1996-01-26 US US08/592,817 patent/US6472412B1/en not_active Expired - Lifetime
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2002
- 2002-07-29 US US10/207,493 patent/US20030013713A1/en not_active Abandoned
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2004
- 2004-03-03 US US10/792,579 patent/US7045660B2/en not_active Expired - Fee Related
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2005
- 2005-01-06 JP JP2005001859A patent/JP4521283B2/ja not_active Expired - Lifetime
- 2005-11-30 US US11/290,322 patent/US20060084809A1/en not_active Abandoned
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2007
- 2007-06-18 US US11/764,317 patent/US7652144B2/en not_active Expired - Fee Related
-
2010
- 2010-01-26 US US12/693,791 patent/US8129537B2/en not_active Expired - Fee Related
- 2010-03-08 JP JP2010050508A patent/JP2010195787A/ja active Pending
Also Published As
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ATE218549T1 (de) | 2002-06-15 |
US20030013713A1 (en) | 2003-01-16 |
US6472412B1 (en) | 2002-10-29 |
JP4521283B2 (ja) | 2010-08-11 |
EP0711282B1 (en) | 2002-06-05 |
DE69430747T2 (de) | 2003-03-06 |
IL110492A0 (en) | 1994-10-21 |
US20040171618A1 (en) | 2004-09-02 |
DE69430747D1 (de) | 2002-07-11 |
US7652144B2 (en) | 2010-01-26 |
US20060084809A1 (en) | 2006-04-20 |
US8129537B2 (en) | 2012-03-06 |
DK0711282T3 (da) | 2002-09-16 |
JP3775685B2 (ja) | 2006-05-17 |
JP2005225868A (ja) | 2005-08-25 |
PT711282E (pt) | 2002-11-29 |
CA2160928A1 (en) | 1995-02-09 |
US20100240677A1 (en) | 2010-09-23 |
EP0711282A1 (en) | 1996-05-15 |
US7045660B2 (en) | 2006-05-16 |
ZA945609B (en) | 1995-05-12 |
CA2160928C (en) | 2005-07-05 |
US20080132706A1 (en) | 2008-06-05 |
WO1995004045A1 (en) | 1995-02-09 |
JP2010195787A (ja) | 2010-09-09 |
AU7267094A (en) | 1995-02-28 |
JPH09501155A (ja) | 1997-02-04 |
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