AR054845A1 - Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen - Google Patents

Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen

Info

Publication number
AR054845A1
AR054845A1 ARP060103065A ARP060103065A AR054845A1 AR 054845 A1 AR054845 A1 AR 054845A1 AR P060103065 A ARP060103065 A AR P060103065A AR P060103065 A ARP060103065 A AR P060103065A AR 054845 A1 AR054845 A1 AR 054845A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
heteroaryl
aryl
substituent selected
Prior art date
Application number
ARP060103065A
Other languages
English (en)
Inventor
Jacques Mauger
Anil Nair
Nina Ma
Kirsten Bjergarde
Odile Angouillant-Boniface
Serge Mignani
Bruno Filoche-Romme
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AR054845A1 publication Critical patent/AR054845A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Abstract

Se refiere a heterociclos dihidropiridina-condensados sustituidos utiles para el tratamiento de enfermedad de cáncer, especialmente para prevenir la division de células cancerígenas. Estos compuestos actuan como inhibidores de Aurora A y/o B quinasas. Reivindicacion 1: Compuesto correspondiente a la formula general (1) que se muestra a continuacion, en la que: R1 representa H, alquilo, arilo, heteroarilo, alquilo sustituido, arilo sustituido, o heteroarilo sustituido; R2 representa arilo sustituido o heteroarilo sustituido; R3 representa H o R4; X es NH o CR7; Y, Y' e Y''; i) cada uno representa independientemente un sustituyente seleccionado entre CH2, CHR5, CR5R6, C=O, O, S, NH y NR7; o ii) juntos representan un sustituyente seleccionado entre un resto de cadena -CH2-O-(C=O)-, -(CH2)4- y -(CH2)2-; cada uno de R4 y R7 representa independientemente un sustituyente seleccionado entre: R8, -COOR8, COR8 y CONHR8; cada uno de R5 y R6 representa independientemente R8; R8 representa H o uno de los siguientes opcionalmente sustituido: -alquilo, -alquil-alquileno, -alquileno, -heterocicloalquilo, -cicloalquilo, -arilo, -heteroarilo, -alquil-heterocicloalquilo, -alquil-cicloalquilo, -alquil-arilo, o -alquil- heteroarilo.
ARP060103065A 2005-07-20 2006-07-18 Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen AR054845A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05291558A EP1746097B1 (en) 2005-07-20 2005-07-20 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them

Publications (1)

Publication Number Publication Date
AR054845A1 true AR054845A1 (es) 2007-07-18

Family

ID=35510894

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103065A AR054845A1 (es) 2005-07-20 2006-07-18 Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen

Country Status (37)

Country Link
US (1) US8163768B2 (es)
EP (2) EP1746097B1 (es)
JP (2) JP2009501778A (es)
KR (1) KR101286796B1 (es)
CN (1) CN101243087B (es)
AR (1) AR054845A1 (es)
AT (2) ATE455115T1 (es)
AU (1) AU2006273692B8 (es)
BR (1) BRPI0614002A2 (es)
CA (1) CA2615700C (es)
CR (1) CR9663A (es)
CY (1) CY1109964T1 (es)
DE (1) DE602005018911D1 (es)
DK (1) DK1746097T3 (es)
DO (1) DOP2006000175A (es)
EA (1) EA016815B1 (es)
EC (1) ECSP078062A (es)
ES (1) ES2339676T3 (es)
HN (1) HN2008000088A (es)
HR (1) HRP20100195T1 (es)
IL (1) IL188861A0 (es)
MA (1) MA29634B1 (es)
MX (1) MX2008000902A (es)
MY (1) MY148617A (es)
NO (1) NO20080831L (es)
NZ (1) NZ592766A (es)
PE (2) PE20070212A1 (es)
PL (1) PL1746097T3 (es)
PT (1) PT1746097E (es)
RS (1) RS51351B (es)
SI (1) SI1746097T1 (es)
TN (1) TNSN08020A1 (es)
TW (1) TWI386411B (es)
UA (1) UA98928C2 (es)
UY (1) UY29685A1 (es)
WO (1) WO2007012972A2 (es)
ZA (1) ZA200800542B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2945535B1 (fr) * 2009-05-18 2011-06-10 Sanofi Aventis Compose anticancereux et composition pharmaceutique le contenant
FR2967413A1 (fr) * 2010-11-17 2012-05-18 Sanofi Aventis Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora.
CA2868958C (en) 2012-05-15 2020-09-01 Novartis Ag Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
MX2014013373A (es) 2012-05-15 2015-08-14 Novartis Ag Derivados de benzamida para inhibir la actividad de abl1, abl2 y bcr-abl1.
BR112014027584B1 (pt) 2012-05-15 2023-01-24 Novartis Ag Uso de inibidores da atividade de abl1, abl2 e bcr-abl1, e composição farmacêutica
BR112014027244A2 (pt) 2012-05-15 2017-06-27 Novartis Ag derivados de benzamida para inibição da atividade de abl1, abl2 e bcr-abl1
JP6321662B2 (ja) 2012-10-12 2018-05-09 ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. Ｇｓｋ３阻害剤およびその使用の方法
WO2016094688A1 (en) 2014-12-10 2016-06-16 Massachusetts Institute Of Technology Fused 1,3-azole derivatives useful for the treatment of proliferative diseases
US11046692B2 (en) 2015-04-30 2021-06-29 Memorial Sloan-Kettering Cancer Center Mitragynine analogs and uses thereof
RU2619932C1 (ru) * 2015-11-25 2017-05-22 федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ") ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДО[3,4-е]ПИРИМИДИНЫ И ИХ ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗ
WO2017124087A1 (en) 2016-01-15 2017-07-20 Memorial Sloan-Kettering Cancer Center Anti-parasitic compounds and uses thereof
EP3416950A1 (en) 2016-02-16 2018-12-26 Massachusetts Institute of Technology Max binders as myc modulators and uses thereof
EA201992359A1 (ru) 2017-04-05 2020-03-12 Дзе Брод Инститьют Инк. Трициклические соединения в качестве ингибиторов киназы гликогенсинтазы-3 (gsk3) и их применение

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69837282T2 (de) * 1997-12-13 2007-11-08 Bristol-Myers Squibb Co. VERWENDUNG VON PYRAZOLO Ä 3,4-bÜ PYRIDIN ALS CYCLIN-ABHÄNGIGE KINASE HEMMER
EP1242422A1 (en) 1999-11-19 2002-09-25 Abbott Laboratories Tricyclic dihydropyrimidine potassium channel openers
US6538004B2 (en) 2000-03-03 2003-03-25 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
MXPA02008615A (es) 2000-03-03 2003-04-14 Abbott Lab Abridores de canales de potasio de dihidropirazolona triciclica y dihidroisoxazolona triciclica.
CA2437215A1 (en) 2001-02-02 2002-08-15 Mitsubishi Pharma Corporation Dihydropyrazolopyridine compounds and pharmaceutical use thereof
FR2823854A1 (fr) 2001-04-18 2002-10-25 Centre Nat Rech Scient Nouveau procede de criblage d'inhibiteurs de la liaison entre la proteine oxyde nitrique synthase neuronale et la proteine inhibitrice de l'oxyde nitrique synthase neuronale
FR2825091B1 (fr) 2001-05-23 2003-07-04 Servier Lab Nouveaux derives tricycliques de dihydro-quinnoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7037902B2 (en) * 2002-07-03 2006-05-02 Receptron, Inc. Affinity small molecules for the EPO receptor
SE0301371D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab New Compounds
JP2007500249A (ja) * 2003-06-13 2007-01-11 ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ホスファチジルイノシトール３−キナーゼ阻害活性を有する化合物及びその使用方法

Also Published As

Publication number Publication date
DK1746097T3 (da) 2010-05-25
BRPI0614002A2 (pt) 2011-03-01
IL188861A0 (en) 2008-04-13
PL1746097T3 (pl) 2010-06-30
RS51351B (en) 2011-02-28
US8163768B2 (en) 2012-04-24
CA2615700A1 (en) 2007-02-01
ATE455115T1 (de) 2010-01-15
KR101286796B1 (ko) 2013-07-17
CN101243087B (zh) 2013-07-24
CA2615700C (en) 2013-06-18
CY1109964T1 (el) 2014-09-10
ATE521611T1 (de) 2011-09-15
KR20080026658A (ko) 2008-03-25
PE20100718A1 (es) 2010-10-20
TNSN08020A1 (en) 2009-07-14
PE20070212A1 (es) 2007-03-21
UA98928C2 (ru) 2012-07-10
US20080261969A1 (en) 2008-10-23
JP2009501778A (ja) 2009-01-22
ECSP078062A (es) 2008-01-23
WO2007012972A3 (en) 2007-04-05
TW200740812A (en) 2007-11-01
NO20080831L (no) 2008-04-03
AU2006273692A1 (en) 2007-02-01
HRP20100195T1 (hr) 2010-05-31
ZA200800542B (en) 2010-02-24
MA29634B1 (fr) 2008-07-01
JP2013063987A (ja) 2013-04-11
CN101243087A (zh) 2008-08-13
EP1746097B1 (en) 2010-01-13
MX2008000902A (es) 2008-03-26
EA016815B1 (ru) 2012-07-30
AU2006273692A8 (en) 2012-12-13
PT1746097E (pt) 2010-04-15
EP1746097A1 (en) 2007-01-24
MY148617A (en) 2013-05-15
AU2006273692B2 (en) 2012-11-22
UY29685A1 (es) 2007-02-28
DOP2006000175A (es) 2007-03-31
EP1910366B1 (en) 2011-08-24
ES2339676T3 (es) 2010-05-24
CR9663A (es) 2008-02-21
SI1746097T1 (sl) 2010-05-31
WO2007012972A2 (en) 2007-02-01
NZ592766A (en) 2012-12-21
EA200800374A1 (ru) 2008-08-29
TWI386411B (zh) 2013-02-21
DE602005018911D1 (de) 2010-03-04
EP1910366A2 (en) 2008-04-16
HN2008000088A (es) 2011-05-31
AU2006273692B8 (en) 2012-12-13

Similar Documents

Publication Publication Date Title
AR054845A1 (es) Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen
PE20190656A1 (es) Compuestos de tiazolo-piridina sustituida como inhibidores de malt1
ES2528451T3 (es) Inhibidores de esfingosina cinasa
AR078157A1 (es) Derivados de pirazol-[4,5-d]pirrolo[2,3-b]piridina inhibidores de tirosinquinasas jak 2, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer
AR074343A1 (es) Derivados de piridina y pirimidina como inhibidores de la fosfodiesterasa 10
AR053120A1 (es) Aminopiridinas como inhibidores de beta secretasa
AR041739A1 (es) Compuestos derivados -3,4-dihidro-1h-pirimido[4,5-d]pirimidin-2-ona y con actividad antiproliferativa.
PE20080266A1 (es) 4-amino-pirido[3,2-e]pirazinas, su uso como inhibidores de fosfodiesterasa 10 y procesos para su preparacion
AR097431A1 (es) Compuestos de carboxamida de furo y tienopiridina útiles como inhibidores de quinasas pim
AR074435A1 (es) Derivados de 1,3-benzotiazol, medicamentos que los contienen y uso de los mismos en el tratamiento del cancer.
AR091023A1 (es) Inhibidores del nampt
AR055592A1 (es) Derivados de 2-amino-5-cicloalquil-hidantoina como moduladores y/o inhibidores de la beta-secretasa(bace)
AR041133A1 (es) Pirazolopirimidinas como inhibidores de la quinasa dependientes de la ciclina
ECSP055535A (es) Derivados de 1-heterociclialquil-3-sulfonilazaindol o azaindol como ligandos de 5-hidroxitriptamina-6
AR047531A1 (es) Derivados 1h-tieno(2,3-c)pirazol utiles como inhibidores de quinasa
AR051795A1 (es) Derivados de hidantoina inhibidores de metaloproteinasas
WO2006136837A3 (en) Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators
CU20090064A7 (es) Nuevos derivados de benzamida como antagonistas de la bradiquinina
ECSP088805A (es) 2-(piridin-2-il)-pirimidinas como fungicidas
CU23921B1 (es) Nuevos derivados dihidroindolonas
CO6362013A2 (es) Derivados de rifamicina
AR041864A1 (es) Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
AR073043A1 (es) Compuestos de azetidinas polisustituidos, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de los mismos en el tratamiento de enfermedades respiratorias, metabolicas y del sistema nervioso central, entre otras.
AR054109A1 (es) Derivados de 2-metil-4-fenil-5-oxo-1,4,5,6,7,8-hexahidroquinolina, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento de la infertilidad
NO20080937L (no) Substituerte-3-sulfonylindazolderivater som 5-hydroksytryptamin-6-ligander

Legal Events

Date Code Title Description
FA Abandonment or withdrawal