MA29634B1 - Heterocycles condenses avec la 1,4-dihydropyridine, procede pour preparer ceux-ci, utilisation et compositions contenant ceux-ci - Google Patents
Heterocycles condenses avec la 1,4-dihydropyridine, procede pour preparer ceux-ci, utilisation et compositions contenant ceux-ciInfo
- Publication number
- MA29634B1 MA29634B1 MA30580A MA30580A MA29634B1 MA 29634 B1 MA29634 B1 MA 29634B1 MA 30580 A MA30580 A MA 30580A MA 30580 A MA30580 A MA 30580A MA 29634 B1 MA29634 B1 MA 29634B1
- Authority
- MA
- Morocco
- Prior art keywords
- same
- dihydropyridine
- preparing
- compositions containing
- heterocycles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La présente invention concerne des hétérocycles condensés avec la 1,4-dihydropyridine, un procédé pour préparer ceux-ci, l'utilisation et des compositions contenant ceux-ci. L'invention concerne des hétérocycles condensés avec la dihydropyridine substitués utiles pour le traitement d'une maladie cancéreuse, en particulier pour empêcher des cellules cancéreuses de se diviser. Ces composés agissent en tant qu'inhibiteurs des kinases Aurora A et/ou B.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05291558A EP1746097B1 (fr) | 2005-07-20 | 2005-07-20 | Héterocyles à fusion1,4-dihydropyridineprocédé de préparation, utilisation et compositions de celles-ci |
Publications (1)
Publication Number | Publication Date |
---|---|
MA29634B1 true MA29634B1 (fr) | 2008-07-01 |
Family
ID=35510894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA30580A MA29634B1 (fr) | 2005-07-20 | 2008-01-16 | Heterocycles condenses avec la 1,4-dihydropyridine, procede pour preparer ceux-ci, utilisation et compositions contenant ceux-ci |
Country Status (37)
Country | Link |
---|---|
US (1) | US8163768B2 (fr) |
EP (2) | EP1746097B1 (fr) |
JP (2) | JP2009501778A (fr) |
KR (1) | KR101286796B1 (fr) |
CN (1) | CN101243087B (fr) |
AR (1) | AR054845A1 (fr) |
AT (2) | ATE455115T1 (fr) |
AU (1) | AU2006273692B8 (fr) |
BR (1) | BRPI0614002A2 (fr) |
CA (1) | CA2615700C (fr) |
CR (1) | CR9663A (fr) |
CY (1) | CY1109964T1 (fr) |
DE (1) | DE602005018911D1 (fr) |
DK (1) | DK1746097T3 (fr) |
DO (1) | DOP2006000175A (fr) |
EA (1) | EA016815B1 (fr) |
EC (1) | ECSP078062A (fr) |
ES (1) | ES2339676T3 (fr) |
HN (1) | HN2008000088A (fr) |
HR (1) | HRP20100195T1 (fr) |
IL (1) | IL188861A0 (fr) |
MA (1) | MA29634B1 (fr) |
MX (1) | MX2008000902A (fr) |
MY (1) | MY148617A (fr) |
NO (1) | NO20080831L (fr) |
NZ (1) | NZ592766A (fr) |
PE (2) | PE20100718A1 (fr) |
PL (1) | PL1746097T3 (fr) |
PT (1) | PT1746097E (fr) |
RS (1) | RS51351B (fr) |
SI (1) | SI1746097T1 (fr) |
TN (1) | TNSN08020A1 (fr) |
TW (1) | TWI386411B (fr) |
UA (1) | UA98928C2 (fr) |
UY (1) | UY29685A1 (fr) |
WO (1) | WO2007012972A2 (fr) |
ZA (1) | ZA200800542B (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2945535B1 (fr) | 2009-05-18 | 2011-06-10 | Sanofi Aventis | Compose anticancereux et composition pharmaceutique le contenant |
FR2967413A1 (fr) * | 2010-11-17 | 2012-05-18 | Sanofi Aventis | Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora. |
TR201807023T4 (tr) | 2012-05-15 | 2018-06-21 | Novartis Ag | Abl1, abl2 ve bcr- abl1 aktivitesinin inhibe edilmesi için benzamid türevleri. |
US9278981B2 (en) | 2012-05-15 | 2016-03-08 | Novartis Ag | Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 |
CN104302634B (zh) | 2012-05-15 | 2017-02-08 | 诺华股份有限公司 | 用于抑制abl1、abl2和bcr‑abl1的活性的苯甲酰胺衍生物 |
CN104334529B (zh) | 2012-05-15 | 2017-03-15 | 诺华股份有限公司 | 用于抑制abl1、abl2和bcr‑abl1的活性的化合物和组合物 |
SI2909204T1 (sl) * | 2012-10-12 | 2019-06-28 | The Broad Institute, Inc. | Inhibitorji GSK3 in postopki njihove uporabe |
JP2017537940A (ja) * | 2014-12-10 | 2017-12-21 | マサチューセッツ インスティテュート オブ テクノロジー | 増殖性疾患の処置に有用な融合1,3−アゾール誘導体 |
EP4212532A3 (fr) | 2015-04-30 | 2023-09-27 | Memorial Sloan Kettering Cancer Center | Analogues de la mitragynine et leurs utilisations |
RU2619932C1 (ru) * | 2015-11-25 | 2017-05-22 | федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ") | ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДО[3,4-е]ПИРИМИДИНЫ И ИХ ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗ |
US11180492B2 (en) | 2016-01-15 | 2021-11-23 | University Of Central Florida Research Foundation, Inc. | Anti-parasitic compounds and uses thereof |
CN109071456A (zh) | 2016-02-16 | 2018-12-21 | 麻省理工学院 | 作为myc调节剂的max结合剂及其用途 |
CA3058198A1 (fr) | 2017-04-05 | 2018-10-11 | The Broad Institute, Inc. | Composes tricycliques en tant qu'inhibiteurs de glycogene synthase kinase 3 (gsk3) et leurs utilisations |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2314355A1 (fr) * | 1997-12-13 | 1999-06-24 | Bristol-Myers Squibb Company | Utilisation de pyrazolo¢3,4-b!pyridine en tant qu'inhibiteurs de kinase dependant de la cycline |
WO2001036422A1 (fr) | 1999-11-19 | 2001-05-25 | Abbott Laboratories | Ouvreurs de canaux potassiques du type dihydropyrimidine tricyclique |
MXPA02008615A (es) | 2000-03-03 | 2003-04-14 | Abbott Lab | Abridores de canales de potasio de dihidropirazolona triciclica y dihidroisoxazolona triciclica. |
US6538004B2 (en) | 2000-03-03 | 2003-03-25 | Abbott Laboratories | Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers |
CA2437215A1 (fr) | 2001-02-02 | 2002-08-15 | Mitsubishi Pharma Corporation | Composes de dihydropyrazolopyridine et leur utilisation pharmaceutique |
FR2823854A1 (fr) | 2001-04-18 | 2002-10-25 | Centre Nat Rech Scient | Nouveau procede de criblage d'inhibiteurs de la liaison entre la proteine oxyde nitrique synthase neuronale et la proteine inhibitrice de l'oxyde nitrique synthase neuronale |
FR2825091B1 (fr) | 2001-05-23 | 2003-07-04 | Servier Lab | Nouveaux derives tricycliques de dihydro-quinnoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US7037902B2 (en) * | 2002-07-03 | 2006-05-02 | Receptron, Inc. | Affinity small molecules for the EPO receptor |
SE0301371D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | New Compounds |
KR20060070486A (ko) * | 2003-06-13 | 2006-06-23 | 젠타리스 게엠베하 | 포스파티딜이노시톨 3-키나제의 억제 활성을 갖는 화합물및 이의 사용 방법 |
-
2005
- 2005-07-20 DE DE602005018911T patent/DE602005018911D1/de active Active
- 2005-07-20 EP EP05291558A patent/EP1746097B1/fr active Active
- 2005-07-20 RS RSP-2010/0159A patent/RS51351B/en unknown
- 2005-07-20 ES ES05291558T patent/ES2339676T3/es active Active
- 2005-07-20 PL PL05291558T patent/PL1746097T3/pl unknown
- 2005-07-20 DK DK05291558.4T patent/DK1746097T3/da active
- 2005-07-20 SI SI200530964T patent/SI1746097T1/sl unknown
- 2005-07-20 PT PT05291558T patent/PT1746097E/pt unknown
- 2005-07-20 AT AT05291558T patent/ATE455115T1/de active
-
2006
- 2006-07-18 MX MX2008000902A patent/MX2008000902A/es active IP Right Grant
- 2006-07-18 NZ NZ592766A patent/NZ592766A/xx not_active IP Right Cessation
- 2006-07-18 ZA ZA200800542A patent/ZA200800542B/xx unknown
- 2006-07-18 AT AT06808922T patent/ATE521611T1/de not_active IP Right Cessation
- 2006-07-18 AU AU2006273692A patent/AU2006273692B8/en not_active Ceased
- 2006-07-18 AR ARP060103065A patent/AR054845A1/es not_active Application Discontinuation
- 2006-07-18 PE PE2010000153A patent/PE20100718A1/es not_active Application Discontinuation
- 2006-07-18 MY MYPI20063429A patent/MY148617A/en unknown
- 2006-07-18 UA UAA200802146A patent/UA98928C2/ru unknown
- 2006-07-18 EP EP06808922A patent/EP1910366B1/fr active Active
- 2006-07-18 JP JP2008522098A patent/JP2009501778A/ja not_active Withdrawn
- 2006-07-18 EA EA200800374A patent/EA016815B1/ru not_active IP Right Cessation
- 2006-07-18 WO PCT/IB2006/002734 patent/WO2007012972A2/fr active Application Filing
- 2006-07-18 CA CA2615700A patent/CA2615700C/fr not_active Expired - Fee Related
- 2006-07-18 CN CN2006800303826A patent/CN101243087B/zh not_active Expired - Fee Related
- 2006-07-18 PE PE2006000862A patent/PE20070212A1/es not_active Application Discontinuation
- 2006-07-18 KR KR1020087003945A patent/KR101286796B1/ko not_active IP Right Cessation
- 2006-07-18 BR BRPI0614002-5A patent/BRPI0614002A2/pt not_active IP Right Cessation
- 2006-07-19 TW TW095126453A patent/TWI386411B/zh not_active IP Right Cessation
- 2006-07-20 UY UY29685A patent/UY29685A1/es unknown
- 2006-07-20 DO DO2006000175A patent/DOP2006000175A/es unknown
-
2007
- 2007-12-27 EC EC2007008062A patent/ECSP078062A/es unknown
-
2008
- 2008-01-15 CR CR9663A patent/CR9663A/es unknown
- 2008-01-15 US US12/014,516 patent/US8163768B2/en active Active
- 2008-01-16 MA MA30580A patent/MA29634B1/fr unknown
- 2008-01-17 IL IL188861A patent/IL188861A0/en unknown
- 2008-01-18 TN TNP2008000020A patent/TNSN08020A1/en unknown
- 2008-01-21 HN HN2008000088A patent/HN2008000088A/es unknown
- 2008-02-15 NO NO20080831A patent/NO20080831L/no not_active Application Discontinuation
-
2010
- 2010-04-07 HR HR20100195T patent/HRP20100195T1/hr unknown
- 2010-04-09 CY CY20101100327T patent/CY1109964T1/el unknown
-
2012
- 2012-11-05 JP JP2012243375A patent/JP2013063987A/ja not_active Withdrawn
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