MA47079A - Composés amino-triazolopyidines et leur utilisation pour traiter le cancer - Google Patents
Composés amino-triazolopyidines et leur utilisation pour traiter le cancerInfo
- Publication number
- MA47079A MA47079A MA047079A MA47079A MA47079A MA 47079 A MA47079 A MA 47079A MA 047079 A MA047079 A MA 047079A MA 47079 A MA47079 A MA 47079A MA 47079 A MA47079 A MA 47079A
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- salts
- triazolopyidine
- amino
- treat cancer
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 6
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne d'une manière générale des composés de formule (i) et des sels pharmaceutiquement acceptables de ceux-ci. Dans la formule (i), r1 et r2 peuvent prendre une quelconque des significations définies dans la description. L'invention concerne également l'utilisation de ces composés et de leurs sels pour traiter ou prévenir une maladie induite par dna-pk, y compris le cancer. L'invention concerne en outre, des compositions pharmaceutiques et des kits comprenant lesdits composés et sels ; des procédés de fabrication desdits composés et sels ; des intermédiaires utiles dans la fabrication desdits composés et sels ; et des procédés de traitement de maladies induites par dna-pk, y compris le cancer, par l'utilisation desdits composés et sels.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662436619P | 2016-12-20 | 2016-12-20 | |
| PCT/EP2017/083625 WO2018114999A1 (fr) | 2016-12-20 | 2017-12-19 | Composés amino-triazolopyridine et leur utilisation dans le traitement du cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA47079A true MA47079A (fr) | 2019-10-30 |
| MA47079B1 MA47079B1 (fr) | 2021-05-31 |
Family
ID=60937727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA47079A MA47079B1 (fr) | 2016-12-20 | 2017-12-19 | Composés amino-triazolopyidines et leur utilisation pour traiter le cancer |
Country Status (39)
| Country | Link |
|---|---|
| US (4) | US10407446B2 (fr) |
| EP (1) | EP3558997B1 (fr) |
| JP (1) | JP6883653B2 (fr) |
| KR (1) | KR102220971B1 (fr) |
| CN (1) | CN110177791B (fr) |
| AR (1) | AR110400A1 (fr) |
| AU (1) | AU2017384388B2 (fr) |
| BR (1) | BR112019012217B1 (fr) |
| CA (1) | CA3046339C (fr) |
| CL (1) | CL2019001714A1 (fr) |
| CO (1) | CO2019007810A2 (fr) |
| CR (1) | CR20190301A (fr) |
| CY (1) | CY1124239T1 (fr) |
| DK (1) | DK3558997T3 (fr) |
| DO (1) | DOP2019000168A (fr) |
| EA (1) | EA037745B1 (fr) |
| EC (1) | ECSP19044159A (fr) |
| ES (1) | ES2867274T3 (fr) |
| HR (1) | HRP20210548T1 (fr) |
| HU (1) | HUE054548T2 (fr) |
| IL (1) | IL267158B (fr) |
| JO (1) | JOP20190151B1 (fr) |
| LT (1) | LT3558997T (fr) |
| MA (1) | MA47079B1 (fr) |
| MX (1) | MX390535B (fr) |
| MY (1) | MY183036A (fr) |
| NI (1) | NI201900062A (fr) |
| NZ (1) | NZ755222A (fr) |
| PE (1) | PE20191474A1 (fr) |
| PH (1) | PH12019501350B1 (fr) |
| PL (1) | PL3558997T3 (fr) |
| PT (1) | PT3558997T (fr) |
| RS (1) | RS61701B1 (fr) |
| SI (1) | SI3558997T1 (fr) |
| SM (1) | SMT202100225T1 (fr) |
| TW (1) | TWI776835B (fr) |
| UA (1) | UA123032C2 (fr) |
| WO (1) | WO2018114999A1 (fr) |
| ZA (1) | ZA201904695B (fr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102220971B1 (ko) | 2016-12-20 | 2021-02-25 | 아스트라제네카 아베 | 아미노-트리아졸로피리딘 화합물 및 암 치료에서의 이의 용도 |
| TWI820146B (zh) * | 2018-06-15 | 2023-11-01 | 瑞典商阿斯特捷利康公司 | 嘌呤酮化合物及其在治療癌症中之用途 |
| WO2020186211A1 (fr) * | 2019-03-13 | 2020-09-17 | The Uab Research Foundation | Procédés et compositions pour le traitement d'une infection par le polyomavirus |
| JP7696834B2 (ja) * | 2019-05-27 | 2025-06-23 | ディザル(ジァンスー)ファーマシューティカル・カンパニー・リミテッド | Dna依存性タンパク質キナーゼ阻害剤 |
| EP3983545A1 (fr) | 2019-06-17 | 2022-04-20 | Vertex Pharmaceuticals Incorporated | Compositions et procédés pour l'édition de bêta-globine pour le traitement d'hémoglobinopathies |
| US20230055321A1 (en) * | 2019-11-22 | 2023-02-23 | Medshine Discovery Inc. | Pyrimidopyrrole spiro compounds and derivatives thereof as dna-pk inhibitors |
| TWI807228B (zh) * | 2019-11-25 | 2023-07-01 | 大陸商南京明德新藥研發有限公司 | 作為dna-pk抑制劑的嘧啶并吡咯類化合物 |
| CA3163093A1 (fr) * | 2019-11-26 | 2021-06-03 | Primmune Therapeutics, Inc. | Agonistes de tlr7 |
| CN113121573A (zh) * | 2019-12-31 | 2021-07-16 | 成都百裕制药股份有限公司 | 嘌呤衍生物及其在医药上的应用 |
| WO2021136462A1 (fr) * | 2019-12-31 | 2021-07-08 | 成都百裕制药股份有限公司 | Dérivés furane et leur application en médecine |
| KR102786205B1 (ko) * | 2019-12-31 | 2025-03-31 | 청두 바이위 파머수티컬 씨오., 엘티디 | 퓨린 유도체 및 의학에서의 그의 용도 |
| CN113493471B (zh) * | 2020-04-03 | 2024-06-11 | 山东轩竹医药科技有限公司 | 杂芳环类激酶抑制剂 |
| WO2021209055A1 (fr) * | 2020-04-17 | 2021-10-21 | 成都百裕制药股份有限公司 | Dérivé d'imidazolinone et son utilisation en médecine |
| WO2021213460A1 (fr) * | 2020-04-23 | 2021-10-28 | 山东轩竹医药科技有限公司 | Inhibiteur de kinase tricyclique |
| BR112022021676A2 (pt) | 2020-04-28 | 2023-01-31 | Intellia Therapeutics Inc | Métodos de distribuição de célula in vitro |
| WO2021260583A1 (fr) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Association d'un conjugué anticorps-médicament et d'un inhibiteur de la dna-pk |
| WO2022017368A1 (fr) * | 2020-07-20 | 2022-01-27 | 首药控股(北京)股份有限公司 | Inhibiteur sélectif de dna-pk, son procédé de préparation et son utilisation |
| US12280049B2 (en) * | 2020-08-04 | 2025-04-22 | Astrazeneca Ab | Methods of delaying pain progression and treating prostate cancer |
| CN114249753A (zh) * | 2020-09-22 | 2022-03-29 | 山东轩竹医药科技有限公司 | 三唑并吡啶类激酶抑制剂 |
| CN116669725A (zh) * | 2020-09-24 | 2023-08-29 | 奥克兰联合服务有限公司 | 新型氨基吡啶及其在治疗癌症中的用途 |
| CN114573605A (zh) * | 2020-12-01 | 2022-06-03 | 武汉光谷亚太医药研究院有限公司 | Dna依赖蛋白激酶抑制剂及其应用 |
| CN114634522A (zh) * | 2020-12-15 | 2022-06-17 | 江苏恒瑞医药股份有限公司 | 嘌呤酮衍生物、其制备方法及其在医药上的应用 |
| US12497614B2 (en) | 2020-12-17 | 2025-12-16 | Vertex Pharmaceuticals Incorporated | Compositions and methods for editing beta-globin for treatment of hemaglobinopathies |
| CN116685323A (zh) * | 2020-12-21 | 2023-09-01 | 江苏恒瑞医药股份有限公司 | 嘌呤酮衍生物、其制备方法及其在医药上的应用 |
| CN114656487B (zh) * | 2020-12-22 | 2023-11-14 | 江苏恒瑞医药股份有限公司 | 稠合嘧啶类化合物、其制备方法及其在医药上的应用 |
| WO2022135555A1 (fr) * | 2020-12-24 | 2022-06-30 | 江苏恒瑞医药股份有限公司 | Composé de purinone, son procédé de préparation et son application pharmaceutique |
| WO2022199547A1 (fr) * | 2021-03-22 | 2022-09-29 | 成都赜灵生物医药科技有限公司 | Dérivé de 7,9-dihydropurine et son usage pharmaceutique |
| JP2024516376A (ja) | 2021-04-17 | 2024-04-15 | インテリア セラピューティクス,インコーポレーテッド | Dna依存性プロテインキナーゼの阻害剤ならびにその組成物及び使用 |
| JP2024521565A (ja) * | 2021-05-19 | 2024-06-03 | ザイ ラボ (シャンハイ) カンパニー、リミテッド. | 複素環置換のプリノン誘導体の塩の形及び結晶 |
| CN117377676A (zh) * | 2021-06-29 | 2024-01-09 | 成都百裕制药股份有限公司 | 嘌呤衍生物的晶型及其药物组合物 |
| CN116023394B (zh) * | 2021-10-25 | 2025-08-12 | 山东轩竹医药科技有限公司 | 三环类激酶抑制剂的晶型 |
| CN116023395B (zh) * | 2021-10-25 | 2025-07-15 | 山东轩竹医药科技有限公司 | 三环类激酶抑制剂的晶型 |
| CN116023393B (zh) * | 2021-10-25 | 2025-08-12 | 山东轩竹医药科技有限公司 | 三环类激酶抑制剂的晶型 |
| WO2023220418A2 (fr) * | 2022-05-13 | 2023-11-16 | The Board Of Trustees Of The Leland Stanford Junior University | Amélioration de l'efficacité de ciblage génique dans des cellules humaines au moyen d'un traitement par inhibiteur d'adn-pk |
| JP2025540239A (ja) | 2022-12-06 | 2025-12-11 | アストラゼネカ・アクチエボラーグ | Polq阻害剤 |
| WO2025023957A1 (fr) * | 2023-07-21 | 2025-01-30 | Wei Zhong | Composés de 2-amino-9-(3,3-difluoropipéridin-4-yl)-7,9-dihydro-8h-purin-8-one substitués et leur utilisation dans le traitement du cancer |
| WO2025049481A1 (fr) | 2023-08-28 | 2025-03-06 | Intellia Therapeutics, Inc. | Procédés d'édition in vitro d'un gène hla-a |
| WO2025181336A1 (fr) | 2024-03-01 | 2025-09-04 | Cellectis Sa | Compositions et procédés d'édition de hbb dans hspc |
| WO2025248119A1 (fr) | 2024-05-31 | 2025-12-04 | Astrazeneca Ab | Dérivés de 6-(cyclo)alcoxypurine utiles en tant qu'inhibiteurs de polq |
| WO2025248117A1 (fr) | 2024-05-31 | 2025-12-04 | Astrazeneca Ab | Dérivés de 6-aminopurine utiles en tant qu'inhibiteurs de polq |
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| KR102220971B1 (ko) | 2016-12-20 | 2021-02-25 | 아스트라제네카 아베 | 아미노-트리아졸로피리딘 화합물 및 암 치료에서의 이의 용도 |
-
2017
- 2017-12-19 KR KR1020197021026A patent/KR102220971B1/ko active Active
- 2017-12-19 MY MYPI2019003492A patent/MY183036A/en unknown
- 2017-12-19 UA UAA201907754A patent/UA123032C2/uk unknown
- 2017-12-19 US US15/846,679 patent/US10407446B2/en active Active
- 2017-12-19 PL PL17825829T patent/PL3558997T3/pl unknown
- 2017-12-19 MA MA47079A patent/MA47079B1/fr unknown
- 2017-12-19 HU HUE17825829A patent/HUE054548T2/hu unknown
- 2017-12-19 PT PT178258299T patent/PT3558997T/pt unknown
- 2017-12-19 PH PH1/2019/501350A patent/PH12019501350B1/en unknown
- 2017-12-19 SM SM20210225T patent/SMT202100225T1/it unknown
- 2017-12-19 JP JP2019533052A patent/JP6883653B2/ja active Active
- 2017-12-19 HR HRP20210548TT patent/HRP20210548T1/hr unknown
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2021
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2023
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