PL2168966T3 - Pochodna bicykloaniliny - Google Patents
Pochodna bicykloanilinyInfo
- Publication number
- PL2168966T3 PL2168966T3 PL08777358T PL08777358T PL2168966T3 PL 2168966 T3 PL2168966 T3 PL 2168966T3 PL 08777358 T PL08777358 T PL 08777358T PL 08777358 T PL08777358 T PL 08777358T PL 2168966 T3 PL2168966 T3 PL 2168966T3
- Authority
- PL
- Poland
- Prior art keywords
- bicycloaniline
- derivative
- bicycloaniline derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007159217 | 2007-06-15 | ||
US96591807P | 2007-08-23 | 2007-08-23 | |
EP08777358.6A EP2168966B1 (en) | 2007-06-15 | 2008-06-12 | Bicycloaniline derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2168966T3 true PL2168966T3 (pl) | 2017-06-30 |
Family
ID=40129803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL08777358T PL2168966T3 (pl) | 2007-06-15 | 2008-06-12 | Pochodna bicykloaniliny |
Country Status (22)
Country | Link |
---|---|
US (1) | US8436004B2 (pl) |
EP (1) | EP2168966B1 (pl) |
JP (1) | JP5129812B2 (pl) |
KR (1) | KR20100024932A (pl) |
CN (1) | CN101784551A (pl) |
AU (1) | AU2008262837B2 (pl) |
CA (1) | CA2689429C (pl) |
CY (1) | CY1118448T1 (pl) |
DK (1) | DK2168966T3 (pl) |
ES (1) | ES2608940T3 (pl) |
HR (1) | HRP20161536T1 (pl) |
HU (1) | HUE032403T2 (pl) |
IL (1) | IL202262A0 (pl) |
LT (1) | LT2168966T (pl) |
MX (1) | MX2009013728A (pl) |
NZ (1) | NZ581936A (pl) |
PL (1) | PL2168966T3 (pl) |
PT (1) | PT2168966T (pl) |
RU (1) | RU2010101052A (pl) |
SI (1) | SI2168966T1 (pl) |
WO (1) | WO2008153207A1 (pl) |
ZA (1) | ZA200908298B (pl) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2719376A1 (en) * | 2008-04-07 | 2009-10-15 | Gilead Sciences, Inc. | 2h-benzo[b][1,4]oxazin-3(4h)-one derivatives for use as stearoyl coa desaturase inhibitors |
EP2303885B1 (en) * | 2008-06-12 | 2013-07-03 | Merck Sharp & Dohme Corp. | Process for producing bicycloaniline derivatives |
JP2012511501A (ja) * | 2008-12-12 | 2012-05-24 | Msd株式会社 | ジヒドロピリミドピリミジン誘導体 |
EP2376493B1 (en) | 2008-12-12 | 2016-10-05 | Msd K.K. | Dihydropyrimidopyrimidine derivative |
CA2750716A1 (en) | 2009-02-25 | 2010-09-02 | Msd K.K. | Pyrimidopyrimidoindazole derivative |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
WO2013013031A1 (en) | 2011-07-19 | 2013-01-24 | Abbvie Inc. | Pyridazino [4, 5 -d] pyrimidin- (6h) -one inhibitors of wee - 1 kinase |
US9345705B2 (en) | 2011-09-15 | 2016-05-24 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer |
CN107652289B (zh) | 2012-06-13 | 2020-07-21 | 因塞特控股公司 | 作为fgfr抑制剂的取代的三环化合物 |
CN103113311A (zh) * | 2012-07-19 | 2013-05-22 | 南京邮电大学 | 一类2-芳基喹唑啉或2-杂环芳基喹唑啉衍生物及其制备方法 |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
PL2925888T3 (pl) * | 2012-11-28 | 2018-03-30 | Merck Sharp & Dohme Corp. | Kompozycje i sposoby do stosowania w leczeniu nowotworów |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
EA036160B1 (ru) | 2013-03-15 | 2020-10-08 | Селджен Кар Ллс | Гетероарильные соединения и их применение |
AR095464A1 (es) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y usos de los mismos |
KR102350704B1 (ko) | 2013-03-15 | 2022-01-13 | 셀젠 카르 엘엘씨 | 헤테로아릴 화합물 및 이의 용도 |
JP6449244B2 (ja) | 2013-04-19 | 2019-01-09 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Fgfr抑制剤としての二環式複素環 |
GB201322602D0 (en) | 2013-12-19 | 2014-02-05 | Almac Discovery Ltd | Pharmaceutical compounds |
CN104725333A (zh) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | 一种新的氮杂环庚烷衍生物的制备方法 |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
WO2016134320A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
WO2017031116A1 (en) * | 2015-08-18 | 2017-02-23 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of ku70/80 and uses thereof |
US20180353464A1 (en) * | 2015-11-24 | 2018-12-13 | Indiana University Research And Technology Corporation | Composition for blocking angiogenesis |
CN110177791B (zh) | 2016-12-20 | 2022-07-12 | 阿斯利康(瑞典)有限公司 | 氨基-三唑并吡啶化合物及其在治疗癌症中的用途 |
WO2018183891A1 (en) | 2017-03-31 | 2018-10-04 | Cascadian Therapeutics | Combinations of chk1- and wee1 - inhibitors |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
WO2019074979A1 (en) | 2017-10-09 | 2019-04-18 | Girafpharma, Llc | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
AU2018347307A1 (en) * | 2017-10-09 | 2020-04-23 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
WO2019096322A1 (zh) * | 2017-11-20 | 2019-05-23 | 上海医药集团股份有限公司 | 一种吡唑酮并嘧啶类化合物、其制备方法及应用 |
SG11202010882XA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Salts of an fgfr inhibitor |
DK3788047T3 (da) | 2018-05-04 | 2024-09-16 | Incyte Corp | Faste former af en FGFR-inhibitor og fremgangsmåder til fremstilling deraf |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
EP3952879A4 (en) * | 2019-04-09 | 2023-01-04 | Nuvation Bio Inc. | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
EP3952878A4 (en) * | 2019-04-09 | 2023-01-04 | Nuvation Bio Inc. | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
MX2021012418A (es) | 2019-04-09 | 2021-11-12 | Nuvation Bio Inc | Compuestos heterociclicos y sus usos. |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
CN112442049A (zh) * | 2019-09-03 | 2021-03-05 | 微境生物医药科技(上海)有限公司 | 作为Wee1抑制剂的嘧啶衍生物 |
MX2022004513A (es) | 2019-10-14 | 2022-07-19 | Incyte Corp | Heterociclos biciclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr). |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
WO2021078925A1 (en) | 2019-10-25 | 2021-04-29 | Astrazeneca Ab | Methods of treating cancer |
BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Fgfr阻害剤としての三環式複素環 |
US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
US20240182447A1 (en) * | 2021-02-19 | 2024-06-06 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | Fused ring compound as wee-1 inhibitor |
EP4323405A1 (en) | 2021-04-12 | 2024-02-21 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
MX2023012852A (es) | 2021-04-29 | 2024-01-15 | Novartis Ag | Quimeras que tienen como diana la desubiquitinasa y metodos relacionados. |
CN117222648A (zh) * | 2021-04-30 | 2023-12-12 | 微境生物医药科技(上海)有限公司 | 作为Wee-1抑制剂的稠环化合物及其制备方法和用途 |
CA3220274A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
AU2023232376A1 (en) | 2022-03-07 | 2024-10-10 | Debiopharm International S.A. | Methods of treating small cell lung cancer |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9911590A (pt) * | 1998-05-26 | 2001-02-13 | Warner Lambert Co | Pirimidinas bicìclicas e 3,4-diidropirimidinas bicìclicas como inibidores da proliferação celular |
AP2002002643A0 (en) * | 2000-03-06 | 2002-12-31 | Warner Lambert Co | 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors |
DE10228103A1 (de) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungizide Wirkstoffkombinationen |
PA8577501A1 (es) * | 2002-07-25 | 2004-02-07 | Warner Lambert Co | Inhibidores de quinasas |
TW200413381A (en) * | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
PT1562426E (pt) * | 2002-11-15 | 2007-02-28 | Basf Ag | Misturas fungicidas para o combate a agentes patogenicos do arroz |
US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
TW200530235A (en) * | 2003-12-24 | 2005-09-16 | Renovis Inc | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
EP1769092A4 (en) | 2004-06-29 | 2008-08-06 | Europ Nickel Plc | IMPROVED LIXIVIATION OF BASE METALS |
FR2873118B1 (fr) | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | Derives de pyrido-pyrimidine, leur application en therapeutique |
CN101014600A (zh) * | 2004-09-21 | 2007-08-08 | 霍夫曼-拉罗奇有限公司 | 用作蛋白激酶抑制剂的6-(2-烷基-苯基)-吡啶并[2,3-d]嘧啶类 |
ATE498358T1 (de) | 2005-06-29 | 2011-03-15 | Compumedics Ltd | Sensoranordnung mit leitfähiger brücke |
DE602007008837D1 (de) * | 2006-02-14 | 2010-10-14 | Vertex Pharma | Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine |
-
2008
- 2008-06-12 RU RU2010101052/04A patent/RU2010101052A/ru not_active Application Discontinuation
- 2008-06-12 DK DK08777358.6T patent/DK2168966T3/en active
- 2008-06-12 KR KR1020097026035A patent/KR20100024932A/ko not_active Application Discontinuation
- 2008-06-12 JP JP2009519343A patent/JP5129812B2/ja active Active
- 2008-06-12 PL PL08777358T patent/PL2168966T3/pl unknown
- 2008-06-12 EP EP08777358.6A patent/EP2168966B1/en active Active
- 2008-06-12 MX MX2009013728A patent/MX2009013728A/es not_active Application Discontinuation
- 2008-06-12 US US12/663,729 patent/US8436004B2/en active Active
- 2008-06-12 LT LTEP08777358.6T patent/LT2168966T/lt unknown
- 2008-06-12 NZ NZ581936A patent/NZ581936A/en unknown
- 2008-06-12 HU HUE08777358A patent/HUE032403T2/en unknown
- 2008-06-12 WO PCT/JP2008/061182 patent/WO2008153207A1/ja active Application Filing
- 2008-06-12 PT PT87773586T patent/PT2168966T/pt unknown
- 2008-06-12 AU AU2008262837A patent/AU2008262837B2/en active Active
- 2008-06-12 ES ES08777358.6T patent/ES2608940T3/es active Active
- 2008-06-12 CN CN200880103594A patent/CN101784551A/zh active Pending
- 2008-06-12 CA CA2689429A patent/CA2689429C/en active Active
- 2008-06-12 SI SI200831719A patent/SI2168966T1/sl unknown
-
2009
- 2009-11-22 IL IL202262A patent/IL202262A0/en unknown
- 2009-11-24 ZA ZA200908298A patent/ZA200908298B/xx unknown
-
2016
- 2016-11-21 HR HRP20161536TT patent/HRP20161536T1/hr unknown
- 2016-12-27 CY CY20161101346T patent/CY1118448T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20110135601A1 (en) | 2011-06-09 |
HUE032403T2 (en) | 2017-09-28 |
CA2689429C (en) | 2012-08-21 |
CA2689429A1 (en) | 2008-12-18 |
ZA200908298B (en) | 2010-08-25 |
LT2168966T (lt) | 2017-01-10 |
HRP20161536T1 (hr) | 2016-12-30 |
ES2608940T3 (es) | 2017-04-17 |
NZ581936A (en) | 2011-08-26 |
AU2008262837A1 (en) | 2008-12-18 |
RU2010101052A (ru) | 2011-07-20 |
EP2168966A4 (en) | 2011-02-16 |
PT2168966T (pt) | 2017-01-02 |
EP2168966B1 (en) | 2016-09-28 |
IL202262A0 (en) | 2010-06-16 |
US8436004B2 (en) | 2013-05-07 |
AU2008262837B2 (en) | 2013-05-23 |
WO2008153207A1 (ja) | 2008-12-18 |
EP2168966A1 (en) | 2010-03-31 |
JP5129812B2 (ja) | 2013-01-30 |
DK2168966T3 (en) | 2017-01-23 |
MX2009013728A (es) | 2010-01-25 |
JPWO2008153207A1 (ja) | 2010-08-26 |
SI2168966T1 (sl) | 2017-03-31 |
CY1118448T1 (el) | 2017-06-28 |
CN101784551A (zh) | 2010-07-21 |
KR20100024932A (ko) | 2010-03-08 |
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