MX2023012852A - Quimeras que tienen como diana la desubiquitinasa y metodos relacionados. - Google Patents
Quimeras que tienen como diana la desubiquitinasa y metodos relacionados.Info
- Publication number
- MX2023012852A MX2023012852A MX2023012852A MX2023012852A MX2023012852A MX 2023012852 A MX2023012852 A MX 2023012852A MX 2023012852 A MX2023012852 A MX 2023012852A MX 2023012852 A MX2023012852 A MX 2023012852A MX 2023012852 A MX2023012852 A MX 2023012852A
- Authority
- MX
- Mexico
- Prior art keywords
- deubiquitinase
- related methods
- targeting chimeras
- well
- target protein
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000001477 Deubiquitinating Enzymes Human genes 0.000 abstract 1
- 108010093668 Deubiquitinating Enzymes Proteins 0.000 abstract 1
- 230000001588 bifunctional effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
En el presente documento se describen compuestos bifuncionales, así como sales, hidratos, solvatos, profármacos, estereoisómeros o tautómeros farmacéuticamente aceptables de estos, que actúan reclutando ciertas desubiquitinasas a una proteína diana para la modulación (p. ej., estabilización) de la proteína diana, así como métodos de uso de estos.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163181796P | 2021-04-29 | 2021-04-29 | |
US202163186739P | 2021-05-10 | 2021-05-10 | |
US202163273118P | 2021-10-28 | 2021-10-28 | |
US202263311781P | 2022-02-18 | 2022-02-18 | |
PCT/US2022/027120 WO2022232634A1 (en) | 2021-04-29 | 2022-04-29 | Deubiquitinase-targeting chimeras and related methods |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023012852A true MX2023012852A (es) | 2024-01-15 |
Family
ID=81748638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023012852A MX2023012852A (es) | 2021-04-29 | 2022-04-29 | Quimeras que tienen como diana la desubiquitinasa y metodos relacionados. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP4329815A1 (es) |
JP (1) | JP2024515828A (es) |
KR (1) | KR20240004584A (es) |
AU (1) | AU2022265718A1 (es) |
BR (1) | BR112023022315A2 (es) |
CA (1) | CA3216614A1 (es) |
IL (1) | IL307863A (es) |
MX (1) | MX2023012852A (es) |
WO (1) | WO2022232634A1 (es) |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007021982A2 (en) | 2005-08-11 | 2007-02-22 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
JP5409010B2 (ja) | 2005-12-28 | 2014-02-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | N−[2,4−ビス(1,1−ジメチルエチル)−5−ヒドロキシフェニル]−1,4−ジヒドロ−4−オキソキノリン−3−カルボキサミドの固体形態 |
AR060635A1 (es) | 2006-04-27 | 2008-07-02 | Banyu Pharma Co Ltd | Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer |
CA2689429C (en) | 2007-06-15 | 2012-08-21 | Banyu Pharmaceutical Co., Ltd. | Bicycloaniline derivatives |
WO2009108245A2 (en) | 2007-12-21 | 2009-09-03 | University Of Virginia Patent Foundation | System, method and computer program product for protecting software via continuous anti-t ampering and obfuscation transforms |
ES2430053T3 (es) | 2008-06-12 | 2013-11-18 | Merck Sharp & Dohme Corp. | Procedimiento para producir derivados de bicicloanilina |
CZ2009620A3 (cs) | 2009-09-22 | 2011-04-06 | Ústav makromolekulární chemie AV CR, v.v.i. | Surovina pro výrobu polyurethanu a zpusob její výroby z odpadního polyurethanu |
US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
AU2011242454A1 (en) | 2010-04-22 | 2012-11-08 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions and administrations thereof |
EA201591177A1 (ru) | 2012-12-19 | 2015-11-30 | Новартис Аг | Трициклические соединения для ингибирования канала cftr |
WO2014097147A1 (en) | 2012-12-19 | 2014-06-26 | Novartis Ag | Tricyclic compounds as cftr inhibitors |
WO2018037350A1 (en) | 2016-08-23 | 2018-03-01 | Laurus Labs Limited | Solid forms of lumacaftor, process for its preparation and pharmaceutical compositions thereof |
KR20210020107A (ko) * | 2018-06-13 | 2021-02-23 | 암피스타 테라퓨틱스 엘티디 | UchL5 표적화를 위한 이중작용성 분자 |
KR20210130195A (ko) * | 2019-02-21 | 2021-10-29 | 로키 테라퓨틱스 리미티드 | 생존-표적화 키메라 (surtac) 분자 |
WO2021146390A1 (en) * | 2020-01-14 | 2021-07-22 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for targeted protein stabilization by redirecting endogenous deubiquitinases |
-
2022
- 2022-04-29 WO PCT/US2022/027120 patent/WO2022232634A1/en active Application Filing
- 2022-04-29 IL IL307863A patent/IL307863A/en unknown
- 2022-04-29 JP JP2023566513A patent/JP2024515828A/ja active Pending
- 2022-04-29 EP EP22724358.1A patent/EP4329815A1/en active Pending
- 2022-04-29 BR BR112023022315A patent/BR112023022315A2/pt unknown
- 2022-04-29 MX MX2023012852A patent/MX2023012852A/es unknown
- 2022-04-29 CA CA3216614A patent/CA3216614A1/en active Pending
- 2022-04-29 KR KR1020237040245A patent/KR20240004584A/ko unknown
- 2022-04-29 AU AU2022265718A patent/AU2022265718A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20240004584A (ko) | 2024-01-11 |
CA3216614A1 (en) | 2022-11-03 |
BR112023022315A2 (pt) | 2024-02-20 |
EP4329815A1 (en) | 2024-03-06 |
IL307863A (en) | 2023-12-01 |
WO2022232634A1 (en) | 2022-11-03 |
AU2022265718A1 (en) | 2023-11-02 |
JP2024515828A (ja) | 2024-04-10 |
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