IL202262A0 - Bicycloaniline derivative - Google Patents
Bicycloaniline derivativeInfo
- Publication number
- IL202262A0 IL202262A0 IL202262A IL20226209A IL202262A0 IL 202262 A0 IL202262 A0 IL 202262A0 IL 202262 A IL202262 A IL 202262A IL 20226209 A IL20226209 A IL 20226209A IL 202262 A0 IL202262 A0 IL 202262A0
- Authority
- IL
- Israel
- Prior art keywords
- bicycloaniline
- derivative
- bicycloaniline derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007159217 | 2007-06-15 | ||
| US96591807P | 2007-08-23 | 2007-08-23 | |
| PCT/JP2008/061182 WO2008153207A1 (en) | 2007-06-15 | 2008-06-12 | Bicycloaniline derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL202262A0 true IL202262A0 (en) | 2010-06-16 |
Family
ID=40129803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL202262A IL202262A0 (en) | 2007-06-15 | 2009-11-22 | Bicycloaniline derivative |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8436004B2 (en) |
| EP (1) | EP2168966B1 (en) |
| JP (1) | JP5129812B2 (en) |
| KR (1) | KR20100024932A (en) |
| CN (1) | CN101784551A (en) |
| AU (1) | AU2008262837B2 (en) |
| CA (1) | CA2689429C (en) |
| CY (1) | CY1118448T1 (en) |
| DK (1) | DK2168966T3 (en) |
| ES (1) | ES2608940T3 (en) |
| HR (1) | HRP20161536T1 (en) |
| HU (1) | HUE032403T2 (en) |
| IL (1) | IL202262A0 (en) |
| LT (1) | LT2168966T (en) |
| MX (1) | MX2009013728A (en) |
| NZ (1) | NZ581936A (en) |
| PL (1) | PL2168966T3 (en) |
| PT (1) | PT2168966T (en) |
| RU (1) | RU2010101052A (en) |
| SI (1) | SI2168966T1 (en) |
| WO (1) | WO2008153207A1 (en) |
| ZA (1) | ZA200908298B (en) |
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| EP2278976A1 (en) * | 2008-04-07 | 2011-02-02 | Gilead Sciences, Inc. | 2h-benzo[b][1,4]oxazin-3(4h)-one derivatives for use as stearoyl coa desaturase inhibitors |
| WO2009151997A1 (en) * | 2008-06-12 | 2009-12-17 | Merck & Co., Inc. | Process for producing bicycloaniline derivatives |
| CA2745959A1 (en) | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivatives |
| WO2010067886A1 (en) | 2008-12-12 | 2010-06-17 | Banyu Pharmaceutical Co.,Ltd. | Dihydropyrimidopyrimidine derivative |
| CA2750716A1 (en) * | 2009-02-25 | 2010-09-02 | Msd K.K. | Pyrimidopyrimidoindazole derivative |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| WO2013013031A1 (en) * | 2011-07-19 | 2013-01-24 | Abbvie Inc. | Pyridazino [4, 5 -d] pyrimidin- (6h) -one inhibitors of wee - 1 kinase |
| WO2013039854A1 (en) | 2011-09-15 | 2013-03-21 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer |
| BR112014030812B1 (en) | 2012-06-13 | 2022-11-08 | Incyte Holdings Corporation | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS, THEIR USES, PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITING A FGFR ENZYME |
| CN103113311A (en) * | 2012-07-19 | 2013-05-22 | 南京邮电大学 | 2-aryl quinazoline or 2-heterocyclic aryl quinazoline derivative and preparation method thereof |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| RU2660349C2 (en) | 2012-11-28 | 2018-07-05 | Мерк Шарп И Доум Корп. | Compositions and methods for treatment of malignant tumour |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| US9321786B2 (en) | 2013-03-15 | 2016-04-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| KR102350704B1 (en) | 2013-03-15 | 2022-01-13 | 셀젠 카르 엘엘씨 | Heteroaryl compounds and uses thereof |
| EP2968337B1 (en) | 2013-03-15 | 2021-07-21 | Celgene CAR LLC | Heteroaryl compounds and uses thereof |
| SG10201708520YA (en) | 2013-04-19 | 2017-12-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| GB201322602D0 (en) | 2013-12-19 | 2014-02-05 | Almac Discovery Ltd | Pharmaceutical compounds |
| CN104725333A (en) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | Preparation method of novel azacycloheptane derivative |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| AU2016219822B2 (en) | 2015-02-20 | 2020-07-09 | Incyte Holdings Corporation | Bicyclic heterocycles as FGFR inhibitors |
| MA41551A (en) | 2015-02-20 | 2017-12-26 | Incyte Corp | BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| US10308656B2 (en) * | 2015-08-18 | 2019-06-04 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of Ku70/80 and uses thereof |
| EP3380194B1 (en) * | 2015-11-24 | 2023-11-01 | Indiana University Research & Technology Corporation | Composition for blocking angiogenesis |
| MX2019007189A (en) | 2016-12-20 | 2019-10-09 | Astrazeneca Ab | Amino-triazolopyridine compounds and their use in treating cancer. |
| AU2018243667A1 (en) | 2017-03-31 | 2019-10-17 | Seagen Inc. | Combinations of Chk1- and Wee1 - inhibitors |
| AR111960A1 (en) | 2017-05-26 | 2019-09-04 | Incyte Corp | CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION |
| AU2018347307A1 (en) * | 2017-10-09 | 2020-04-23 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| US11299493B2 (en) | 2017-10-09 | 2022-04-12 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| CN109810111B (en) * | 2017-11-20 | 2023-10-27 | 上海医药集团股份有限公司 | Pyrazolopyrimidine compound, and preparation method and application thereof |
| KR20210018265A (en) | 2018-05-04 | 2021-02-17 | 인사이트 코포레이션 | Solid form of FGFR inhibitor and method for preparing same |
| SG11202010882XA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Salts of an fgfr inhibitor |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| JP2022526831A (en) | 2019-04-09 | 2022-05-26 | ニューベイション・バイオ・インコーポレイテッド | Heterocyclic compounds and their use |
| EP3952879A4 (en) * | 2019-04-09 | 2023-01-04 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| EP3952878A4 (en) * | 2019-04-09 | 2023-01-04 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CN112442049A (en) * | 2019-09-03 | 2021-03-05 | 微境生物医药科技(上海)有限公司 | Pyrimidine derivatives as Wee1 inhibitors |
| JP2022552324A (en) | 2019-10-14 | 2022-12-15 | インサイト・コーポレイション | Bicyclic heterocycles as FGFR inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US20220387468A1 (en) | 2019-10-25 | 2022-12-08 | Astrazeneca Ab | Methods of treating cancer |
| EP4069695A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Derivatives of an fgfr inhibitor |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| CN116888107A (en) * | 2021-02-19 | 2023-10-13 | 微境生物医药科技(上海)有限公司 | Fused ring compounds as Wee-1 inhibitors |
| BR112023022315A2 (en) | 2021-04-29 | 2024-02-20 | Novartis Ag | CHIMERAS TARGETING DESUBIQUITINASE AND RELATED METHODS |
| JP2024515318A (en) * | 2021-04-30 | 2024-04-08 | ウィゲン・バイオメディシン・テクノロジー・（シャンハイ）・カンパニー・リミテッド | Fused ring compounds as wee-1 inhibitors, methods for their preparation and their use - Patents.com |
| AR126102A1 (en) | 2021-06-09 | 2023-09-13 | Incyte Corp | TRICYCLIC HETEROCYCLES AS FGFR INHIBITORS |
| TW202337469A (en) | 2022-03-07 | 2023-10-01 | 瑞士商德彪製藥國際公司 | Methods of treating small cell lung cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999061444A2 (en) * | 1998-05-26 | 1999-12-02 | Warner-Lambert Company | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
| BR0109056A (en) * | 2000-03-06 | 2003-06-03 | Warner Lambert Co | 5-alkylpyrido [2,3-d] pyrimidines tyrosine kinase inhibitors |
| DE10228103A1 (en) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungicidal active ingredient combinations |
| US7196090B2 (en) * | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
| TW200413381A (en) | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
| WO2004045283A2 (en) * | 2002-11-15 | 2004-06-03 | Basf Aktiengesellschaft | Fungicidal mixtures for controlling rice pathogens |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| TW200530235A (en) * | 2003-12-24 | 2005-09-16 | Renovis Inc | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
| RU2346996C2 (en) | 2004-06-29 | 2009-02-20 | ЮРОПИЭН НИКЕЛЬ ПиЭлСи | Improved leaching of base metals |
| FR2873118B1 (en) | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | PYRIDO-PYRIMIDINE DERIVATIVES, THEIR APPLICATION IN THERAPEUTICS |
| US7550589B2 (en) * | 2004-09-21 | 2009-06-23 | Hoffman-La Roche Inc. | 6-(2-alkyl-phenyl)-pyrido[2,3-D]pyrimidines useful as protein kinase inhibitors |
| NZ563639A (en) | 2005-06-29 | 2009-12-24 | Compumedics Ltd | Sensor assembly with conductive bridge |
| DE602007008837D1 (en) | 2006-02-14 | 2010-10-14 | Vertex Pharma | AS PROTEIN KINASE INHIBITORS USEFUL DYHYDRODIAZEPINE |
-
2008
- 2008-06-12 CA CA2689429A patent/CA2689429C/en active Active
- 2008-06-12 DK DK08777358.6T patent/DK2168966T3/en active
- 2008-06-12 WO PCT/JP2008/061182 patent/WO2008153207A1/en active Application Filing
- 2008-06-12 LT LTEP08777358.6T patent/LT2168966T/en unknown
- 2008-06-12 JP JP2009519343A patent/JP5129812B2/en active Active
- 2008-06-12 MX MX2009013728A patent/MX2009013728A/en not_active Application Discontinuation
- 2008-06-12 HU HUE08777358A patent/HUE032403T2/en unknown
- 2008-06-12 AU AU2008262837A patent/AU2008262837B2/en active Active
- 2008-06-12 CN CN200880103594A patent/CN101784551A/en active Pending
- 2008-06-12 ES ES08777358.6T patent/ES2608940T3/en active Active
- 2008-06-12 NZ NZ581936A patent/NZ581936A/en unknown
- 2008-06-12 PL PL08777358T patent/PL2168966T3/en unknown
- 2008-06-12 US US12/663,729 patent/US8436004B2/en active Active
- 2008-06-12 RU RU2010101052/04A patent/RU2010101052A/en not_active Application Discontinuation
- 2008-06-12 PT PT87773586T patent/PT2168966T/en unknown
- 2008-06-12 KR KR1020097026035A patent/KR20100024932A/en not_active Application Discontinuation
- 2008-06-12 EP EP08777358.6A patent/EP2168966B1/en active Active
- 2008-06-12 SI SI200831719A patent/SI2168966T1/en unknown
-
2009
- 2009-11-22 IL IL202262A patent/IL202262A0/en unknown
- 2009-11-24 ZA ZA200908298A patent/ZA200908298B/en unknown
-
2016
- 2016-11-21 HR HRP20161536TT patent/HRP20161536T1/en unknown
- 2016-12-27 CY CY20161101346T patent/CY1118448T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2168966T3 (en) | 2017-01-23 |
| JP5129812B2 (en) | 2013-01-30 |
| PT2168966T (en) | 2017-01-02 |
| US20110135601A1 (en) | 2011-06-09 |
| HRP20161536T1 (en) | 2016-12-30 |
| US8436004B2 (en) | 2013-05-07 |
| PL2168966T3 (en) | 2017-06-30 |
| EP2168966A4 (en) | 2011-02-16 |
| EP2168966B1 (en) | 2016-09-28 |
| LT2168966T (en) | 2017-01-10 |
| RU2010101052A (en) | 2011-07-20 |
| CA2689429C (en) | 2012-08-21 |
| CN101784551A (en) | 2010-07-21 |
| ES2608940T3 (en) | 2017-04-17 |
| CY1118448T1 (en) | 2017-06-28 |
| JPWO2008153207A1 (en) | 2010-08-26 |
| AU2008262837B2 (en) | 2013-05-23 |
| EP2168966A1 (en) | 2010-03-31 |
| SI2168966T1 (en) | 2017-03-31 |
| AU2008262837A1 (en) | 2008-12-18 |
| ZA200908298B (en) | 2010-08-25 |
| NZ581936A (en) | 2011-08-26 |
| HUE032403T2 (en) | 2017-09-28 |
| WO2008153207A1 (en) | 2008-12-18 |
| MX2009013728A (en) | 2010-01-25 |
| KR20100024932A (en) | 2010-03-08 |
| CA2689429A1 (en) | 2008-12-18 |
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