PE20100718A1 - Derivados triciclicos de 1, 4-dihidropiridina [b, e]-condensados como inhibidores de aurora quinasas - Google Patents
Derivados triciclicos de 1, 4-dihidropiridina [b, e]-condensados como inhibidores de aurora quinasasInfo
- Publication number
- PE20100718A1 PE20100718A1 PE2010000153A PE2010000153A PE20100718A1 PE 20100718 A1 PE20100718 A1 PE 20100718A1 PE 2010000153 A PE2010000153 A PE 2010000153A PE 2010000153 A PE2010000153 A PE 2010000153A PE 20100718 A1 PE20100718 A1 PE 20100718A1
- Authority
- PE
- Peru
- Prior art keywords
- naphthyridin
- ona
- hexahydro
- phenyl
- dihydropyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE R1 ES H O METILO; R2 ES ARILO O HETEROARILO SUSTITUIDOS; R3 ES H O R4; X ES N O CR7, DONDE R4 Y R7 SON CADA UNO R8, -COOR8, COR8 O CONHR8, EN DONDE R8 ES H, ALQUILO, CICLOALQUILO, ARILO, ENTRE OTROS; Y, Y' E Y'' SON CADA UNO CH2, C=O, O, S, NH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-(4-HIDROXI-3-METIL-FENIL)-2,4,6,7,8,9-HEXAHIDRO-PIRAZOLO[3,4-b]-1,7-NAFTIRIDIN-5-ONA, 4-[5-(4-CLORO-FENIL)-FURAN-2-IL]-2,4,6,7,8,9-HEXAHIDRO-PIRAZOLO[3,4-b]-1,7-NAFTIRIDIN-5-ONA, 4-[3-(4-CLORO-FENOXI)-FENIL]-2,4,6,7,8,9-HEXAHIDRO-PIRAZOLO[3,4-b]-1,7-NAFTIRIDIN-5-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LAS QUINASAS AURORA A Y B SIENDO UTILES EN EL TRATAMIENTO DE CANCER DE MAMA, CANCER DE COLON, MELANOMA, LEUCEMIA MIELOIDE AGUDA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05291558A EP1746097B1 (en) | 2005-07-20 | 2005-07-20 | 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20100718A1 true PE20100718A1 (es) | 2010-10-20 |
Family
ID=35510894
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2010000153A PE20100718A1 (es) | 2005-07-20 | 2006-07-18 | Derivados triciclicos de 1, 4-dihidropiridina [b, e]-condensados como inhibidores de aurora quinasas |
PE2006000862A PE20070212A1 (es) | 2005-07-20 | 2006-07-18 | Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000862A PE20070212A1 (es) | 2005-07-20 | 2006-07-18 | Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen |
Country Status (37)
Country | Link |
---|---|
US (1) | US8163768B2 (es) |
EP (2) | EP1746097B1 (es) |
JP (2) | JP2009501778A (es) |
KR (1) | KR101286796B1 (es) |
CN (1) | CN101243087B (es) |
AR (1) | AR054845A1 (es) |
AT (2) | ATE455115T1 (es) |
AU (1) | AU2006273692B8 (es) |
BR (1) | BRPI0614002A2 (es) |
CA (1) | CA2615700C (es) |
CR (1) | CR9663A (es) |
CY (1) | CY1109964T1 (es) |
DE (1) | DE602005018911D1 (es) |
DK (1) | DK1746097T3 (es) |
DO (1) | DOP2006000175A (es) |
EA (1) | EA016815B1 (es) |
EC (1) | ECSP078062A (es) |
ES (1) | ES2339676T3 (es) |
HN (1) | HN2008000088A (es) |
HR (1) | HRP20100195T1 (es) |
IL (1) | IL188861A0 (es) |
MA (1) | MA29634B1 (es) |
MX (1) | MX2008000902A (es) |
MY (1) | MY148617A (es) |
NO (1) | NO20080831L (es) |
NZ (1) | NZ592766A (es) |
PE (2) | PE20100718A1 (es) |
PL (1) | PL1746097T3 (es) |
PT (1) | PT1746097E (es) |
RS (1) | RS51351B (es) |
SI (1) | SI1746097T1 (es) |
TN (1) | TNSN08020A1 (es) |
TW (1) | TWI386411B (es) |
UA (1) | UA98928C2 (es) |
UY (1) | UY29685A1 (es) |
WO (1) | WO2007012972A2 (es) |
ZA (1) | ZA200800542B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2945535B1 (fr) * | 2009-05-18 | 2011-06-10 | Sanofi Aventis | Compose anticancereux et composition pharmaceutique le contenant |
FR2967413A1 (fr) * | 2010-11-17 | 2012-05-18 | Sanofi Aventis | Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora. |
CA2871715A1 (en) | 2012-05-15 | 2013-11-21 | Novartis Ag | Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1 |
CA2871332A1 (en) | 2012-05-15 | 2013-11-21 | Novartis Ag | Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1 |
US9315489B2 (en) | 2012-05-15 | 2016-04-19 | Novartis Ag | Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 |
DK2861579T5 (da) | 2012-05-15 | 2022-10-24 | Novartis Ag | Benzamidderivater til at hæmme aktiviteten af ABL1, ABL2 og BCR-ABL1 |
JP6321662B2 (ja) | 2012-10-12 | 2018-05-09 | ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. | Gsk3阻害剤およびその使用の方法 |
AU2015360416A1 (en) | 2014-12-10 | 2017-06-08 | Massachusetts Institute Of Technology | Fused 1,3-azole derivatives useful for the treatment of proliferative diseases |
EP4212532A3 (en) | 2015-04-30 | 2023-09-27 | Memorial Sloan Kettering Cancer Center | Mitragynine analogs and uses thereof |
RU2619932C1 (ru) * | 2015-11-25 | 2017-05-22 | федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ") | ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДО[3,4-е]ПИРИМИДИНЫ И ИХ ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗ |
US11180492B2 (en) | 2016-01-15 | 2021-11-23 | University Of Central Florida Research Foundation, Inc. | Anti-parasitic compounds and uses thereof |
EP3416950A1 (en) | 2016-02-16 | 2018-12-26 | Massachusetts Institute of Technology | Max binders as myc modulators and uses thereof |
JP7157075B2 (ja) | 2017-04-05 | 2022-10-19 | ザ ブロード インスティテュート,インコーポレーテッド | グリコーゲンシンターゼキナーゼ3(gsk3)インヒビターとしての三環式化合物およびそれらの使用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE355841T1 (de) * | 1997-12-13 | 2007-03-15 | Bristol Myers Squibb Co | Verwendung von pyrazolo ( 3,4-b) pyridin als cyclin-abhängige kinase hemmer |
CA2391291A1 (en) | 1999-11-19 | 2001-05-25 | Abbott Laboratories | Tricyclic dihydropyrimidine potassium channel openers |
MXPA02008615A (es) | 2000-03-03 | 2003-04-14 | Abbott Lab | Abridores de canales de potasio de dihidropirazolona triciclica y dihidroisoxazolona triciclica. |
US6538004B2 (en) | 2000-03-03 | 2003-03-25 | Abbott Laboratories | Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers |
KR20030076650A (ko) | 2001-02-02 | 2003-09-26 | 미쯔비시 웰 파마 가부시키가이샤 | 디하이드로피라졸로피리딘 화합물 및 그의 약학적 용도 |
FR2823854A1 (fr) | 2001-04-18 | 2002-10-25 | Centre Nat Rech Scient | Nouveau procede de criblage d'inhibiteurs de la liaison entre la proteine oxyde nitrique synthase neuronale et la proteine inhibitrice de l'oxyde nitrique synthase neuronale |
FR2825091B1 (fr) * | 2001-05-23 | 2003-07-04 | Servier Lab | Nouveaux derives tricycliques de dihydro-quinnoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US7037902B2 (en) * | 2002-07-03 | 2006-05-02 | Receptron, Inc. | Affinity small molecules for the EPO receptor |
SE0301371D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | New Compounds |
JP2007500249A (ja) * | 2003-06-13 | 2007-01-11 | ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング | ホスファチジルイノシトール3−キナーゼ阻害活性を有する化合物及びその使用方法 |
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2005
- 2005-07-20 EP EP05291558A patent/EP1746097B1/en active Active
- 2005-07-20 AT AT05291558T patent/ATE455115T1/de active
- 2005-07-20 RS RSP-2010/0159A patent/RS51351B/en unknown
- 2005-07-20 SI SI200530964T patent/SI1746097T1/sl unknown
- 2005-07-20 PL PL05291558T patent/PL1746097T3/pl unknown
- 2005-07-20 ES ES05291558T patent/ES2339676T3/es active Active
- 2005-07-20 PT PT05291558T patent/PT1746097E/pt unknown
- 2005-07-20 DE DE602005018911T patent/DE602005018911D1/de active Active
- 2005-07-20 DK DK05291558.4T patent/DK1746097T3/da active
-
2006
- 2006-07-18 KR KR1020087003945A patent/KR101286796B1/ko not_active IP Right Cessation
- 2006-07-18 NZ NZ592766A patent/NZ592766A/xx not_active IP Right Cessation
- 2006-07-18 EP EP06808922A patent/EP1910366B1/en active Active
- 2006-07-18 BR BRPI0614002-5A patent/BRPI0614002A2/pt not_active IP Right Cessation
- 2006-07-18 AT AT06808922T patent/ATE521611T1/de not_active IP Right Cessation
- 2006-07-18 CN CN2006800303826A patent/CN101243087B/zh not_active Expired - Fee Related
- 2006-07-18 MX MX2008000902A patent/MX2008000902A/es active IP Right Grant
- 2006-07-18 ZA ZA200800542A patent/ZA200800542B/xx unknown
- 2006-07-18 JP JP2008522098A patent/JP2009501778A/ja not_active Withdrawn
- 2006-07-18 AR ARP060103065A patent/AR054845A1/es not_active Application Discontinuation
- 2006-07-18 UA UAA200802146A patent/UA98928C2/ru unknown
- 2006-07-18 MY MYPI20063429A patent/MY148617A/en unknown
- 2006-07-18 WO PCT/IB2006/002734 patent/WO2007012972A2/en active Application Filing
- 2006-07-18 EA EA200800374A patent/EA016815B1/ru not_active IP Right Cessation
- 2006-07-18 PE PE2010000153A patent/PE20100718A1/es not_active Application Discontinuation
- 2006-07-18 AU AU2006273692A patent/AU2006273692B8/en not_active Ceased
- 2006-07-18 CA CA2615700A patent/CA2615700C/en not_active Expired - Fee Related
- 2006-07-18 PE PE2006000862A patent/PE20070212A1/es not_active Application Discontinuation
- 2006-07-19 TW TW095126453A patent/TWI386411B/zh not_active IP Right Cessation
- 2006-07-20 DO DO2006000175A patent/DOP2006000175A/es unknown
- 2006-07-20 UY UY29685A patent/UY29685A1/es unknown
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2007
- 2007-12-27 EC EC2007008062A patent/ECSP078062A/es unknown
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2008
- 2008-01-15 US US12/014,516 patent/US8163768B2/en active Active
- 2008-01-15 CR CR9663A patent/CR9663A/es unknown
- 2008-01-16 MA MA30580A patent/MA29634B1/fr unknown
- 2008-01-17 IL IL188861A patent/IL188861A0/en unknown
- 2008-01-18 TN TNP2008000020A patent/TNSN08020A1/en unknown
- 2008-01-21 HN HN2008000088A patent/HN2008000088A/es unknown
- 2008-02-15 NO NO20080831A patent/NO20080831L/no not_active Application Discontinuation
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2010
- 2010-04-07 HR HR20100195T patent/HRP20100195T1/hr unknown
- 2010-04-09 CY CY20101100327T patent/CY1109964T1/el unknown
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2012
- 2012-11-05 JP JP2012243375A patent/JP2013063987A/ja not_active Withdrawn
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