AR037418A1 - Derivados de benzotiazol - Google Patents

Derivados de benzotiazol

Info

Publication number
AR037418A1
AR037418A1 ARP020104516A ARP020104516A AR037418A1 AR 037418 A1 AR037418 A1 AR 037418A1 AR P020104516 A ARP020104516 A AR P020104516A AR P020104516 A ARP020104516 A AR P020104516A AR 037418 A1 AR037418 A1 AR 037418A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
lower alkyl
phenyl
thiophenyl
pyridinyl
Prior art date
Application number
ARP020104516A
Other languages
English (en)
Inventor
Alexander Flohr
Roland Jakob-Roetne
Roger David Norcross
Claus Riemer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR037418A1 publication Critical patent/AR037418A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compuestos de fórmula general (1) en donde: R es hidrógeno, -(CH2)n-fenilo, opcionalmente sustituido por halógeno, alquilo inferior, alcoxilo inferior, trifluorometilo ó -N(R')-C(O)-alquilo inferior, -(CH2)n-piridinilo, opcionalmente sustituido por alquilo inferior, -(CH2)n-cicloalquilo C3-6, opcionalmente sustituido por hidroxilo, -(CH2)n-N(R')-cicloalquilo C3-6, -(CH2)n-benzo[1,3]-dioxolilo, -(CH'2)n-tiofenilo, opcionalmente sustituido por alquilo inferior, -(CH'2)n-tiazolilo, opcionalmente sustituido por alquilo inferior, -(CH2)n-C(O)-tiofenilo, opcionalmente sustituido por halógeno, -(CH2)n-furanilo, opcionalmente sustituido por alquilo inferior, -(CH2)n-C(O)-(CH2)-tiofenilo, -(CHR')n-benzofuran-2-ilo, -(CH2)n-benzo[b]tiofenilo, opcionalmente sustituido por alquilo inferior, -(CH2)n-N(R')-C(O)-fenilo, opcionalmente sustituido por halógeno o alcoxilo inferior, -(CH2)n-C(O)-fenilo, opcionalmente sustituido por alcoxilo inferior, -(CH2)n-C(O)-2,3-dihidro-benzo[1,4]dioxin-6-ilo, -(CH2)n-N(R')-C(O)-piridinilo, -(CH2)n-tetrahidrofuranilo, -CH-bi-fenilo, -CH(fenil)-piridinilo, -(CH2)n-1-oxo-1,3-dihidro-isoindol-2-ilo, -(CH2)n-1,3-dioxo-1,3-dihidro-isoindol-2-ilo, -(CH2)n-CH(fenil)-tetrahidropiranilo, -(CH2)n-1-oxo-1,2,3,4-tetrahidro-isoquinolin-3-il ó -(CH2)n-S-[1,3,4]tiazol-2-ilo, opcionalmente sustituido por amino; R' es hidrógeno ó alquilo inferior, independientemente uno del otro en el caso de R'2; y n es 0, 1, 2, 3 ó 4; y las sales de adición ácida farmacéuticamente aceptables de los mismos. Los compuestos de fórmula (1) tienen una buena afinidad por el receptor A2A y éstos son por lo tanto útiles en el tratamiento de enfermedades, relacionadas con este receptor.
ARP020104516A 2001-11-27 2002-11-25 Derivados de benzotiazol AR037418A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01127442 2001-11-27

Publications (1)

Publication Number Publication Date
AR037418A1 true AR037418A1 (es) 2004-11-10

Family

ID=8179277

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020104516A AR037418A1 (es) 2001-11-27 2002-11-25 Derivados de benzotiazol

Country Status (21)

Country Link
US (1) US6596718B1 (es)
EP (1) EP1450796B1 (es)
JP (1) JP4216193B2 (es)
KR (1) KR100613197B1 (es)
CN (1) CN1325052C (es)
AR (1) AR037418A1 (es)
AT (1) ATE391505T1 (es)
AU (1) AU2002352045B2 (es)
BR (1) BR0214455A (es)
CA (1) CA2467825A1 (es)
DE (1) DE60226063T2 (es)
ES (1) ES2303558T3 (es)
GT (1) GT200200240A (es)
MX (1) MXPA04004982A (es)
PA (1) PA8558201A1 (es)
PE (1) PE20030735A1 (es)
PL (1) PL370978A1 (es)
RU (1) RU2293083C2 (es)
TW (1) TW200408391A (es)
UY (1) UY27551A1 (es)
WO (1) WO2003045385A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6678828B1 (en) * 2002-07-22 2004-01-13 Vormetric, Inc. Secure network file access control system
DK1636223T3 (da) * 2003-05-19 2008-06-23 Hoffmann La Roche Benzothiazolderivater som adenosinreceptorligander
EP1669348A4 (en) * 2003-09-30 2009-03-11 Eisai R&D Man Co Ltd NEW ANTIPILIC AGENT CONTAINING A HETEROCYCLIC COMPOUND
WO2005044793A2 (en) 2003-10-31 2005-05-19 Takeda Pharmaceutical Company Limited Nitrogen-containing fused heterocyclic compounds
EP1710233A4 (en) * 2004-01-28 2009-07-15 Kissei Pharmaceutical NEW BENZO FURANDERIVATE, THIS MEDICAL COMPOSITION AND APPLICATIONS THEREOF
WO2005096098A2 (en) * 2004-03-30 2005-10-13 Carl Zeiss Smt Ag Projection objective, projection exposure apparatus and reflective reticle for microlithography
MX2007000635A (es) * 2004-07-22 2007-03-07 Hoffmann La Roche Benzotiazoles sustituidos.
US20090227799A1 (en) * 2004-08-09 2009-09-10 Kazutaka Nakamoto Novel Antimalarial Agent Containing Heterocyclic Compound
US7829585B2 (en) 2005-03-30 2010-11-09 Eisai R&D Management Co., Ltd. Antifungal agent containing pyridine derivative
JPWO2006115134A1 (ja) * 2005-04-22 2008-12-18 キッセイ薬品工業株式会社 新規なベンゾフラン誘導体、それを含有する医薬組成物およびそれらの用途
TWI385169B (zh) * 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
EP2044055A4 (en) * 2006-07-21 2011-03-23 Takeda Pharmaceutical amide compounds
WO2008035726A1 (fr) * 2006-09-21 2008-03-27 Eisai R & D Management Co., Ltd. Dérivé de pyridine substitué par un cycle hétéroaryle, et agent antifongique le comprenant
JP2010511661A (ja) 2006-12-07 2010-04-15 エフ．ホフマン−ラ ロシュ アーゲー Ｖ１ａ受容体アンタゴニストとしてのスピロ−ピペリジン誘導体
US7501432B2 (en) 2006-12-22 2009-03-10 Hoffman-La Roche Inc. Spiro-piperidine derivatives
WO2008077810A2 (en) 2006-12-22 2008-07-03 F. Hoffmann-La Roche Ag Spiro-piperidine derivatives
TW200841879A (en) 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
CA2685194A1 (en) * 2007-04-27 2008-11-13 Eisai R&D Management Co., Ltd. Heterocycle-substituted pyridine derivatives salt or crystal thereof
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
US8188119B2 (en) * 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
CA2839703A1 (en) 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
EA201490152A1 (ru) 2011-06-24 2014-05-30 Эмджен Инк. Антагонисты trpm8 и их применение при лечении
WO2013042137A1 (en) * 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
MY175778A (en) 2013-10-04 2020-07-08 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
SG11201607705XA (en) 2014-03-19 2016-10-28 Infinity Pharmaceuticals Inc Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR20180058741A (ko) 2015-09-14 2018-06-01 인피니티 파마슈티칼스, 인코포레이티드 이소퀴놀리논의 고체형, 그의 제조 방법, 이를 포함하는 조성물 및 이를 사용하는 방법
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2019005786A (es) * 2016-11-18 2019-08-26 Merck Sharp & Dohme Derivados de indazol utiles como inhibidores de diacilglicerido o-aciltransferasa 2.
CN112638908A (zh) * 2018-09-04 2021-04-09 豪夫迈·罗氏有限公司 用于治疗自身免疫性疾病的苯并噻唑类化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0112395A (pt) 2000-06-21 2003-07-08 Hoffmann La Roche Derivados de benzotiazol

Also Published As

Publication number Publication date
US6596718B1 (en) 2003-07-22
TW200408391A (en) 2004-06-01
ES2303558T3 (es) 2008-08-16
KR100613197B1 (ko) 2006-08-21
CN1731999A (zh) 2006-02-08
DE60226063D1 (en) 2008-05-21
CN1325052C (zh) 2007-07-11
RU2004119438A (ru) 2006-01-10
RU2293083C2 (ru) 2007-02-10
EP1450796B1 (en) 2008-04-09
BR0214455A (pt) 2004-11-03
AU2002352045A1 (en) 2003-06-10
PL370978A1 (en) 2005-06-13
KR20040062968A (ko) 2004-07-09
UY27551A1 (es) 2003-06-30
ATE391505T1 (de) 2008-04-15
JP4216193B2 (ja) 2009-01-28
JP2005526007A (ja) 2005-09-02
WO2003045385A1 (en) 2003-06-05
PA8558201A1 (es) 2003-09-05
EP1450796A1 (en) 2004-09-01
AU2002352045B2 (en) 2006-08-17
PE20030735A1 (es) 2003-08-29
MXPA04004982A (es) 2004-08-11
GT200200240A (es) 2003-07-30
CA2467825A1 (en) 2003-06-05
DE60226063T2 (de) 2009-05-20

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