PA8558201A1 - Derivados de benzotiazol - Google Patents

Derivados de benzotiazol

Info

Publication number
PA8558201A1
PA8558201A1 PA20028558201A PA8558201A PA8558201A1 PA 8558201 A1 PA8558201 A1 PA 8558201A1 PA 20028558201 A PA20028558201 A PA 20028558201A PA 8558201 A PA8558201 A PA 8558201A PA 8558201 A1 PA8558201 A1 PA 8558201A1
Authority
PA
Panama
Prior art keywords
optionally replaced
ilo
phenyl
rent
benzo
Prior art date
Application number
PA20028558201A
Other languages
English (en)
Inventor
Alexander Flohr
Claus Riemer
Roland Jakob-Roetne
Roger David Norcross
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8558201A1 publication Critical patent/PA8558201A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA GENERAL EN DONDE R ES HIDROGENO, - (CH2)N-FENILO, OPCIONALMENTE SUSTITUIDO POR HALOGENO, ALQUILO INFERIOR, ALCOXILO INFERIOR, TRIFLUOROMETILO O -N(R´)-C(O)-ALQUILO INFERIOR,-(CH2)N-PIRIDINILO, OPCIONALMENTE SUSTITUIDO POR ALQUILO INFERIOR,-(CH2)N-C3-6-CICLOALQUILO, OPCIONALMENTE SUSTITUIDO POR HIDROXILO,-(CH2)N-N(R´) -C3-6-CICLOALQUILO,-(CH2)N-BENZO [1,3]-DIOXILO,-(CR´2)-TIOFENILO, OPCIONALMENTE SUSTITUIDO POR ALQUILO INFERIOR,-(CR´2)N-TIAZOLILO, OPCIONALMENTE SUSTITUIDO POR ALQUILO INFERIOR,-(CH2)N-C(O)-TIOFENILO, OPCIONALMENTE SUSTITUIDO POR HALOGENO,-(CH2)N-FURANILO, OPCIONALMENTE SUSTITUIDO POR ALQUILO INFERIOR,-(CH2)N-C(O)-(CH2)N-TIOFENILO,-(CHR´)N-BENZOFURAN-2-ILO,-(CH2)N-BENZO[B]TIOFENILO,OPCIONALMENTE SUSTITUIDO POR ALQUILO INFERIOR, -(CH2)N-N(R´)-C(O)-FENILO, OPCIONALMENTE SUSTITUIDO POR HALOGENO O ALCOXILO INFERIOR, -(CH2)N-C(O)-FENILO, OPCIONALMENTE SUSTITUIDO POR ALCOXILO INFERIOR, -(CH2)N-C(O)-2, 3-DIHIDRO-BENZO[1,4]DIOXIN-6-ILO, -(CH2)N-N(R´)-C(O)-PIRIDINILO,-(CH2)N-TETRAHIDROFURANILO,-CH-BI-FENILO,-CH(FENIL)-PIRIDINILO, -(CH2)N-1-OXO-1-OXO-1, 3-DIHIDRO-ISOINDOL-2-ILO, -(CH2)N-1, 3-DIOXO-1,3-DIHIDRO-ISOINDOL -2-ILO, -(CH2)N-CH(FENIL)-TETRAHIDROPIRANILO, -(CH2)N-1-OXO-1,2,3,4-TETRAHIDRO-ISOQUINOLIN-3-IL O -(CH2)N-S-[1,3,4]TIAZOL-2-ILO, OPCIONALMENTE SUSTITUIDO POR AMINO; ES HIDROGENO O ALQUILO INFERIOR, INDEPENDIENTEMENTE UNO DEL OTRO EN EL CASO DE R´2; Y N ES 0,1,2,3 O 4; Y LAS SALES DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. LOS COMPUESTOS DE FORMULA I TIENEN UNA BUENA AFINIDAD POR EL RECEPTOR A2A Y ESTOS SON POR LO TANTO UTILES EN EL TRATAMIENTO DE ENFERMEDADES, RELACIONADAS CON ESTE RECEPTOR.
PA20028558201A 2001-11-27 2002-11-22 Derivados de benzotiazol PA8558201A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01127442 2001-11-27

Publications (1)

Publication Number Publication Date
PA8558201A1 true PA8558201A1 (es) 2003-09-05

Family

ID=8179277

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20028558201A PA8558201A1 (es) 2001-11-27 2002-11-22 Derivados de benzotiazol

Country Status (21)

Country Link
US (1) US6596718B1 (es)
EP (1) EP1450796B1 (es)
JP (1) JP4216193B2 (es)
KR (1) KR100613197B1 (es)
CN (1) CN1325052C (es)
AR (1) AR037418A1 (es)
AT (1) ATE391505T1 (es)
AU (1) AU2002352045B2 (es)
BR (1) BR0214455A (es)
CA (1) CA2467825A1 (es)
DE (1) DE60226063T2 (es)
ES (1) ES2303558T3 (es)
GT (1) GT200200240A (es)
MX (1) MXPA04004982A (es)
PA (1) PA8558201A1 (es)
PE (1) PE20030735A1 (es)
PL (1) PL370978A1 (es)
RU (1) RU2293083C2 (es)
TW (1) TW200408391A (es)
UY (1) UY27551A1 (es)
WO (1) WO2003045385A1 (es)

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US20090286791A1 (en) * 2001-11-27 2009-11-19 Takeda Pharmaceutical Company Limited Amide Compounds
US6678828B1 (en) * 2002-07-22 2004-01-13 Vormetric, Inc. Secure network file access control system
KR100859886B1 (ko) 2003-05-19 2008-09-23 에프. 호프만-라 로슈 아게 아데노신 수용체 리간드로서의 벤조싸이아졸 유도체
JP4795022B2 (ja) * 2003-09-30 2011-10-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環化合物を含有する新規な抗真菌剤
JP4842829B2 (ja) 2003-10-31 2011-12-21 武田薬品工業株式会社 含窒素縮合複素環化合物
EP1710233A4 (en) * 2004-01-28 2009-07-15 Kissei Pharmaceutical NEW BENZO FURANDERIVATE, THIS MEDICAL COMPOSITION AND APPLICATIONS THEREOF
EP1730596B1 (en) * 2004-03-30 2011-02-16 Carl Zeiss SMT AG Projection objective and projection exposure apparatus
BRPI0513510A (pt) * 2004-07-22 2008-05-06 Hoffmann La Roche benzotiazóis substituìdos
US20090227799A1 (en) * 2004-08-09 2009-09-10 Kazutaka Nakamoto Novel Antimalarial Agent Containing Heterocyclic Compound
JP4874958B2 (ja) 2005-03-30 2012-02-15 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピリジン誘導体を含有する抗真菌剤
JPWO2006115134A1 (ja) * 2005-04-22 2008-12-18 キッセイ薬品工業株式会社 新規なベンゾフラン誘導体、それを含有する医薬組成物およびそれらの用途
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WO2008035726A1 (fr) * 2006-09-21 2008-03-27 Eisai R & D Management Co., Ltd. Dérivé de pyridine substitué par un cycle hétéroaryle, et agent antifongique le comprenant
AU2007328995B2 (en) 2006-12-07 2012-04-26 F. Hoffmann-La Roche Ag Spiro-piperidine derivatives as VIa receptor antagonists
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CA2674518A1 (en) 2006-12-22 2008-07-03 F.Hoffmann-La Roche Ag Spiro-piperidine derivatives
TW200841879A (en) 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
CA2685194A1 (en) * 2007-04-27 2008-11-13 Eisai R&D Management Co., Ltd. Heterocycle-substituted pyridine derivatives salt or crystal thereof
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US8188119B2 (en) * 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
MX2013015274A (es) 2011-06-24 2014-03-31 Amgen Inc Anatagonista trpm8 y su uso en tratamientos.
CA2839703A1 (en) 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
WO2013042137A1 (en) * 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
US8940742B2 (en) * 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
EA201690713A1 (ru) 2013-10-04 2016-08-31 Инфинити Фармасьютикалз, Инк. Гетероциклические соединения и их применения
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
DK3119397T3 (da) 2014-03-19 2022-03-28 Infinity Pharmaceuticals Inc Heterocykliske forbindelser til anvendelse i behandling af PI3K-gamma-medierede lidelser
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
AU2016322552B2 (en) 2015-09-14 2021-03-25 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
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KR20190078646A (ko) * 2016-11-18 2019-07-04 머크 샤프 앤드 돔 코포레이션 디아실글리세리드 o-아실트랜스퍼라제 2의 억제제로서 유용한 인다졸 유도체
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Also Published As

Publication number Publication date
GT200200240A (es) 2003-07-30
BR0214455A (pt) 2004-11-03
AU2002352045B2 (en) 2006-08-17
PL370978A1 (en) 2005-06-13
CA2467825A1 (en) 2003-06-05
KR20040062968A (ko) 2004-07-09
JP4216193B2 (ja) 2009-01-28
MXPA04004982A (es) 2004-08-11
ES2303558T3 (es) 2008-08-16
RU2004119438A (ru) 2006-01-10
CN1731999A (zh) 2006-02-08
KR100613197B1 (ko) 2006-08-21
US6596718B1 (en) 2003-07-22
PE20030735A1 (es) 2003-08-29
TW200408391A (en) 2004-06-01
EP1450796B1 (en) 2008-04-09
AU2002352045A1 (en) 2003-06-10
CN1325052C (zh) 2007-07-11
UY27551A1 (es) 2003-06-30
AR037418A1 (es) 2004-11-10
DE60226063D1 (en) 2008-05-21
WO2003045385A1 (en) 2003-06-05
EP1450796A1 (en) 2004-09-01
ATE391505T1 (de) 2008-04-15
RU2293083C2 (ru) 2007-02-10
JP2005526007A (ja) 2005-09-02
DE60226063T2 (de) 2009-05-20

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