PA8558001A1 - Derivados de isonicotin y nicotinamida de benzotiazoles - Google Patents

Derivados de isonicotin y nicotinamida de benzotiazoles

Info

Publication number
PA8558001A1
PA8558001A1 PA20028558001A PA8558001A PA8558001A1 PA 8558001 A1 PA8558001 A1 PA 8558001A1 PA 20028558001 A PA20028558001 A PA 20028558001A PA 8558001 A PA8558001 A PA 8558001A PA 8558001 A1 PA8558001 A1 PA 8558001A1
Authority
PA
Panama
Prior art keywords
rent
lower rent
alcoxyl
replaced
morfolinilo
Prior art date
Application number
PA20028558001A
Other languages
English (en)
Inventor
Alexander Flohr
Roland Jakob-Roetne
Roger David Norcross
Claus Riemer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8558001A1 publication Critical patent/PA8558001A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A LOS COMPUESTOS DE FORMULA GENERAL EN DONDE R1 ES FENILO, PIPERIDIN-1-ILO O MORFOLINILO; A ES -O- Y R ES - (CH2) N-N(R' ') -C(O) -ALQUILO INFERIOR, -(C2)N-O-ALQUILO INFERIOR, -(CH2), N-O-(CH2)N-O-ALQUILO INFERIOR. ALQUILO INFERIOR, -(CH2)n-MORFOLINILO, -(CH2)n-FENILO, -(CH2)n- N (R' ') 2, -(CH2) N-PIRIDINILO, -(CH2)N-CF3, -(CH2)n-2-OXO-PIRROLIDINILO O C4-6-CICLOALQUILO; R' ' ES INDEPENDIENTEMENTE UNO DEL OTRO HIDROGENO O ALQUILO INFERIOR Y N ES 1 O 2; O A ES -N(R')-Y R ES ALQUILO INFERIOR, C4-6-CICLOALQUILO, -(CH2)N-O-ALQUILO INFERIOR, -(CH2)N-PIRIDINILO, -(CH2)N-PIPERIDINILO, -(CH2)N N-FENILO, -(CH2)N -N(R' ')-C(O)-ALQUILO INFERIOR, -(CH2)N-MORFOLINILO, 0-(CH2)N-N(R' ')2; R' Y R' ' SON INDEPENDIENTEMENTE UNO DEL OTRO HIDROGENO O ALQUILO INFERIOR Y N ES 1 O 2; O A ES -CH2- Y R ES -N(R' ')-(CH2)M-O-ALQUILO INFERIOR, -N(R' ')2, S-ALQUILO INFERIOR, O ES ACETIDINILO, PIRROLIDINILO O PIPERIDINILO, QUE ESTAN OPCIONALMENTE SUSTITUIDOS POR HIDROXILO O ALCOXILO INFERIOR O ES MORFOLINILO,- N(R'') -(CH2)M-C4-6-CICLOALQUILO, -N(R'')-(CH2)M-C(O)O-ALQUILO INFERIOR, -N(R'')-(CH2)M-C(O) OH, -2-OXO-PIRROLIDINILO, -N(R'')-C(O)O-ALQUILO INFERIOR, -O(CH2)M-O-ALQUILO INFERIOR O ALCOXILO; R'' ES INDEPENDIENTEMENTE UNO DEL OTRO HIDROGENO O ALQUILO INFERIOR Y M ES 1,2 Ó 3; O A ES-S-Y R ES ALQUILO INFERIOR; O A-R SON JUNTOS-PIPERAZINILO, SUSTITUIDO POR ALQUILO INFERIOR, -C(O)-ALQUILO INFERIOR O UN GRUPO OXO, O ES PIPERIDINILO, SUSTITUIDO POR ALCOXILO INFERIOR O HIDROXILO, O ES MORFOLINILO, SUSTITUIDO POR ALQUILO INFERIOR, O ES-C4-6-CICLOALQUILO, - AZETIDIN-1-ILO, OPCIONALMENTE SUSTITUIDO POR HIDROXILO O ALCOXILO INFERIOR, TIOMORFOLIN-1,1- POR DIOXO,- TETRAHIDOPIRANO O 2-OXA-5-AZA-BICICLO[2.2.1]HEPT-5-ILO; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. SE HA ENCONTRADO QUE LOS COMPUESTOS DE FORMULA GENERAL I SON LIGANDOS DEL RECEPTOR DE ADENOSINA. ESPECIFICAMENTE, LOS COMPUESTOS DE LA PRESENTE INVENCION TIENEN UNA BUENA AFINIDAD POR EL RECEPTOR A2A Y ESTOS SON POR LO TANTO UTILES EN EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON ESTE RECEPTOR.
PA20028558001A 2001-11-19 2002-11-14 Derivados de isonicotin y nicotinamida de benzotiazoles PA8558001A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01127312 2001-11-19

Publications (1)

Publication Number Publication Date
PA8558001A1 true PA8558001A1 (es) 2003-07-28

Family

ID=8179263

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20028558001A PA8558001A1 (es) 2001-11-19 2002-11-14 Derivados de isonicotin y nicotinamida de benzotiazoles

Country Status (38)

Country Link
US (1) US6620811B2 (es)
EP (1) EP1448198B1 (es)
JP (1) JP4226474B2 (es)
KR (1) KR100577110B1 (es)
CN (1) CN100546580C (es)
AR (1) AR039367A1 (es)
AT (1) ATE376831T1 (es)
AU (1) AU2002351955B2 (es)
BR (1) BR0214245A (es)
CA (1) CA2467552C (es)
DE (1) DE60223278T2 (es)
DK (1) DK1448198T3 (es)
EA (1) EA007502B1 (es)
EC (1) ECSP045109A (es)
ES (1) ES2294187T3 (es)
GT (1) GT200200232A (es)
HR (1) HRP20040396A2 (es)
HU (1) HUP0402161A3 (es)
IL (2) IL161623A0 (es)
JO (1) JO2290B1 (es)
MA (1) MA27083A1 (es)
MX (1) MXPA04004684A (es)
MY (1) MY126176A (es)
NO (1) NO20042576L (es)
NZ (1) NZ532802A (es)
PA (1) PA8558001A1 (es)
PE (1) PE20030713A1 (es)
PL (1) PL369517A1 (es)
PT (1) PT1448198E (es)
RS (1) RS39904A (es)
RU (1) RU2294933C2 (es)
SI (1) SI1448198T1 (es)
TN (1) TNSN04087A1 (es)
TW (1) TW200407134A (es)
UA (1) UA77462C2 (es)
UY (1) UY27542A1 (es)
WO (1) WO2003043636A1 (es)
ZA (1) ZA200403817B (es)

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US8541457B2 (en) * 2005-06-03 2013-09-24 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors
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TWI548411B (zh) 2009-04-28 2016-09-11 Kyowa Hakko Kirin Co Ltd Exercise disorder treatment
UA110097C2 (uk) 2009-09-02 2015-11-25 Терапевтичний агент для лікування розладів настрою
UA113383C2 (xx) 2009-09-02 2017-01-25 Терапевтичний агент для лікування тривожних розладів
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CA2467552A1 (en) 2003-05-30
JP4226474B2 (ja) 2009-02-18
AU2002351955A1 (en) 2003-06-10
EA007502B1 (ru) 2006-10-27
CN100546580C (zh) 2009-10-07
CN1617722A (zh) 2005-05-18
PL369517A1 (en) 2005-04-18
NZ532802A (en) 2005-07-29
HUP0402161A2 (hu) 2005-02-28
US20030134854A1 (en) 2003-07-17
IL161623A0 (en) 2004-09-27
DE60223278D1 (de) 2007-12-13
TW200407134A (en) 2004-05-16
TNSN04087A1 (en) 2006-06-01
HRP20040396A2 (en) 2005-04-30
IL161623A (en) 2010-11-30
NO20042576L (no) 2004-06-18
US6620811B2 (en) 2003-09-16
GT200200232A (es) 2003-06-17
RU2004118425A (ru) 2006-01-10
RU2294933C2 (ru) 2007-03-10
MA27083A1 (fr) 2004-12-20
EP1448198B1 (en) 2007-10-31
RS39904A (en) 2006-10-27
ES2294187T3 (es) 2008-04-01
AR039367A1 (es) 2005-02-16
DE60223278T2 (de) 2008-08-14
SI1448198T1 (sl) 2008-02-29
MY126176A (en) 2006-09-29
AU2002351955B2 (en) 2007-03-15
PE20030713A1 (es) 2003-08-23
KR20050044535A (ko) 2005-05-12
HUP0402161A3 (en) 2010-06-28
JO2290B1 (en) 2005-09-12
ZA200403817B (en) 2005-05-23
EA200400598A1 (ru) 2005-02-24
UY27542A1 (es) 2003-05-30
MXPA04004684A (es) 2004-08-12
BR0214245A (pt) 2004-12-14
ATE376831T1 (de) 2007-11-15
PT1448198E (pt) 2007-12-11
KR100577110B1 (ko) 2006-05-10
CA2467552C (en) 2011-05-24
WO2003043636A1 (en) 2003-05-30
EP1448198A1 (en) 2004-08-25
ECSP045109A (es) 2004-06-28
DK1448198T3 (da) 2008-01-07
JP2005522413A (ja) 2005-07-28
UA77462C2 (en) 2006-12-15

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