DE60223278D1 - Nicotin- oder isonicotin benzothiazole derivaten - Google Patents

Nicotin- oder isonicotin benzothiazole derivaten

Info

Publication number
DE60223278D1
DE60223278D1 DE60223278T DE60223278T DE60223278D1 DE 60223278 D1 DE60223278 D1 DE 60223278D1 DE 60223278 T DE60223278 T DE 60223278T DE 60223278 T DE60223278 T DE 60223278T DE 60223278 D1 DE60223278 D1 DE 60223278D1
Authority
DE
Germany
Prior art keywords
isonicotin
nicotine
benzothiazole derivatives
benzothiazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60223278T
Other languages
English (en)
Other versions
DE60223278T2 (de
Inventor
Alexander Flohr
Roland Jakob-Roetne
Roger David Norcross
Claus Riemer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE60223278D1 publication Critical patent/DE60223278D1/de
Application granted granted Critical
Publication of DE60223278T2 publication Critical patent/DE60223278T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60223278T 2001-11-19 2002-11-11 Nicotin- oder isonicotin benzothiazole derivaten Expired - Lifetime DE60223278T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01127312 2001-11-19
EP01127312 2001-11-19
PCT/EP2002/012562 WO2003043636A1 (en) 2001-11-19 2002-11-11 Nicotin-or isonicotin benzothiazole derivatives

Publications (2)

Publication Number Publication Date
DE60223278D1 true DE60223278D1 (de) 2007-12-13
DE60223278T2 DE60223278T2 (de) 2008-08-14

Family

ID=8179263

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60223278T Expired - Lifetime DE60223278T2 (de) 2001-11-19 2002-11-11 Nicotin- oder isonicotin benzothiazole derivaten

Country Status (38)

Country Link
US (1) US6620811B2 (de)
EP (1) EP1448198B1 (de)
JP (1) JP4226474B2 (de)
KR (1) KR100577110B1 (de)
CN (1) CN100546580C (de)
AR (1) AR039367A1 (de)
AT (1) ATE376831T1 (de)
AU (1) AU2002351955B2 (de)
BR (1) BR0214245A (de)
CA (1) CA2467552C (de)
DE (1) DE60223278T2 (de)
DK (1) DK1448198T3 (de)
EA (1) EA007502B1 (de)
EC (1) ECSP045109A (de)
ES (1) ES2294187T3 (de)
GT (1) GT200200232A (de)
HR (1) HRP20040396A2 (de)
HU (1) HUP0402161A3 (de)
IL (2) IL161623A0 (de)
JO (1) JO2290B1 (de)
MA (1) MA27083A1 (de)
MX (1) MXPA04004684A (de)
MY (1) MY126176A (de)
NO (1) NO20042576L (de)
NZ (1) NZ532802A (de)
PA (1) PA8558001A1 (de)
PE (1) PE20030713A1 (de)
PL (1) PL369517A1 (de)
PT (1) PT1448198E (de)
RS (1) RS39904A (de)
RU (1) RU2294933C2 (de)
SI (1) SI1448198T1 (de)
TN (1) TNSN04087A1 (de)
TW (1) TW200407134A (de)
UA (1) UA77462C2 (de)
UY (1) UY27542A1 (de)
WO (1) WO2003043636A1 (de)
ZA (1) ZA200403817B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1303272B1 (de) * 2000-06-21 2008-02-13 F. Hoffmann-La Roche Ag Benzothiazolderivate zur behandlung von alzheimer und parkinson
US8309570B2 (en) * 2001-06-07 2012-11-13 Analgesic Neuropharmaceuticals, Llc Treatment of central neuropathic pain
US6734179B2 (en) * 2001-12-12 2004-05-11 Hoffmann-La Roche Inc. Benzothiazoles
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
US6872833B2 (en) * 2003-04-14 2005-03-29 Hoffmann-La Roche Inc. Adenosine receptor ligands
PL1651232T3 (pl) * 2003-07-23 2011-05-31 Synta Pharmaceuticals Corp Związki do zastosowań związanych z zapaleniami i odpornością
ES2375134T3 (es) 2003-07-30 2012-02-27 Xenon Pharmaceuticals Inc. Derivados de piperazina y su uso como agentes terapéuticos.
BRPI0414266A (pt) * 2003-09-19 2006-11-07 Hoffmann La Roche derivados de tiazolopiridina como ligandos receptores da adenosina
CA2543707A1 (en) 2003-10-31 2005-05-19 Takeda Pharmaceutical Company Limited Nitrogen-containing fused heterocyclic compounds
SI1700856T1 (sl) 2003-12-26 2016-02-29 Kyowa Hakko Kirin Co., Ltd., Tiazolni derivat
ATE537830T1 (de) * 2004-07-06 2012-01-15 Xenon Pharmaceuticals Inc Nicotinamid derivate und ihre verwendung als therapeutika
ATE457986T1 (de) * 2004-07-22 2010-03-15 Hoffmann La Roche Benzothiazolderivate
KR100823799B1 (ko) * 2004-07-22 2008-04-21 에프. 호프만-라 로슈 아게 벤조티아졸 유도체
MX2007000635A (es) * 2004-07-22 2007-03-07 Hoffmann La Roche Benzotiazoles sustituidos.
MX2007003318A (es) 2004-09-20 2007-05-18 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
JP5094398B2 (ja) * 2004-09-20 2012-12-12 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環式誘導体およびステアロイル−ＣｏＡデサチュラーゼのメディエータとしてのそれらの使用
WO2006034312A1 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coa-desaturase (scd)
CA2580857A1 (en) * 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
TW200626138A (en) * 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
WO2006034341A2 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
WO2006034441A1 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP2316457A1 (de) * 2004-09-20 2011-05-04 Xenon Pharmaceuticals Inc. Pyridin-Derivate zur Hemmung der menschlichen Stearoyl-Coa-Desaturase
WO2006034440A2 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
US7459563B2 (en) * 2004-11-05 2008-12-02 Hoffmann-La Roche Inc. Process for the preparation of isonicotinic acid derivatives
EP2457901A1 (de) * 2005-03-14 2012-05-30 High Point Pharmaceuticals, LLC Benzazolderivate, Zusammensetzungen und Verfahren zur Verwendung als b-Sekretase-Inhibitoren
AU2006343359A1 (en) * 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
KR20090064478A (ko) * 2006-11-13 2009-06-18 화이자 프로덕츠 인크. 디아릴, 디피리디닐 및 아릴-피리디닐 유도체, 및 이들의 용도
CA2758961A1 (en) 2009-04-27 2010-11-04 High Point Pharmaceuticals, Llc Substituted isoquinoline derivatives, pharmaceutical compositions, and methods of use as .beta.-secretase inhibitors
TWI548411B (zh) 2009-04-28 2016-09-11 Kyowa Hakko Kirin Co Ltd Exercise disorder treatment
UA113383C2 (xx) 2009-09-02 2017-01-25 Терапевтичний агент для лікування тривожних розладів
UA110097C2 (uk) 2009-09-02 2015-11-25 Терапевтичний агент для лікування розладів настрою
CA2792339A1 (en) * 2010-03-23 2011-09-29 High Point Pharmaceuticals, Llc Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as beta-secretase inhibitors
JP5248585B2 (ja) * 2010-12-15 2013-07-31 ゼノン・ファーマシューティカルズ・インコーポレイテッド 治療薬としてのニコチンアミド誘導体およびそれらの使用
DE102011005232A1 (de) 2011-03-08 2012-09-13 AristoCon GmbH & Co. KG Adenosin und seine Derivate zur Verwendung in der Schmerztherapie
NZ706635A (en) * 2012-10-02 2018-08-31 Gilead Sciences Inc Inhibitors of histone demethylases
CN111205244B (zh) * 2018-11-22 2023-08-18 上海科技大学 噻唑并环类化合物、其制备方法、中间体和应用
DE102019110904B4 (de) * 2019-04-26 2022-01-20 Helmholtz-Zentrum Dresden - Rossendorf E. V. N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-acetamid-Derivate und deren Verwendung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3374550D1 (en) 1982-12-21 1987-12-23 Johnsen Jorgensen Plastics Ltd Dispensing container
FI91859C (fi) 1987-06-17 1994-08-25 Eisai Co Ltd Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi
EP1303272B1 (de) * 2000-06-21 2008-02-13 F. Hoffmann-La Roche Ag Benzothiazolderivate zur behandlung von alzheimer und parkinson

Also Published As

Publication number Publication date
US20030134854A1 (en) 2003-07-17
RS39904A (en) 2006-10-27
EA200400598A1 (ru) 2005-02-24
TW200407134A (en) 2004-05-16
EP1448198A1 (de) 2004-08-25
RU2004118425A (ru) 2006-01-10
DK1448198T3 (da) 2008-01-07
TNSN04087A1 (en) 2006-06-01
CN1617722A (zh) 2005-05-18
MXPA04004684A (es) 2004-08-12
KR20050044535A (ko) 2005-05-12
PL369517A1 (en) 2005-04-18
PT1448198E (pt) 2007-12-11
MA27083A1 (fr) 2004-12-20
JO2290B1 (en) 2005-09-12
NO20042576L (no) 2004-06-18
IL161623A0 (en) 2004-09-27
CA2467552A1 (en) 2003-05-30
HRP20040396A2 (en) 2005-04-30
US6620811B2 (en) 2003-09-16
JP4226474B2 (ja) 2009-02-18
ZA200403817B (en) 2005-05-23
AR039367A1 (es) 2005-02-16
EA007502B1 (ru) 2006-10-27
SI1448198T1 (sl) 2008-02-29
HUP0402161A3 (en) 2010-06-28
AU2002351955B2 (en) 2007-03-15
HUP0402161A2 (hu) 2005-02-28
MY126176A (en) 2006-09-29
AU2002351955A1 (en) 2003-06-10
PE20030713A1 (es) 2003-08-23
DE60223278T2 (de) 2008-08-14
ATE376831T1 (de) 2007-11-15
CA2467552C (en) 2011-05-24
WO2003043636A1 (en) 2003-05-30
NZ532802A (en) 2005-07-29
UY27542A1 (es) 2003-05-30
EP1448198B1 (de) 2007-10-31
GT200200232A (es) 2003-06-17
RU2294933C2 (ru) 2007-03-10
ES2294187T3 (es) 2008-04-01
JP2005522413A (ja) 2005-07-28
PA8558001A1 (es) 2003-07-28
UA77462C2 (en) 2006-12-15
ECSP045109A (es) 2004-06-28
CN100546580C (zh) 2009-10-07
BR0214245A (pt) 2004-12-14
IL161623A (en) 2010-11-30
KR100577110B1 (ko) 2006-05-10

Similar Documents

Publication Publication Date Title
DK1448198T3 (da) Nicotin- eller isonicotin-benzothiazolderivater
NO20025978L (no) Benzotiazol-derivater
ATE391505T1 (de) Benzothiazole derivative
ATE319451T1 (de) Tetrahydrochinolin-derivate
ATE312827T1 (de) 3-substituierte-4-pyrimidonderivate
NO20034439D0 (no) Benzamidinderivater
DK1292604T3 (da) 2-Aminocarbonyl-9H-purinderivater
DK1458685T3 (da) Substituerede phenylderivater
ATE288437T1 (de) Tetrahydro-heterocycloazepinyl-pyrimidin-deriva e
DK1280809T3 (da) Antitumorecteinascidinderivater
EE200300447A (et) Asendatud bensofuraan-2-karboksamiidide derivaadid
ATE335729T1 (de) 3h-chinazoline -4-on derivaten
ATE423771T1 (de) Tetrahydrochinolinderivate
DE60223031D1 (de) Arylpiperazin gebundene tetrahydroindolonderivate
ATE403646T1 (de) Aminocyclohexan-derivate
DK1322593T3 (da) O-substituerede-6-methyl-tramadol-derivater
ATE330603T1 (de) Benzothiazolderivaten
NO20042980L (no) 3,4-dihydro-1H-isokinolin-2-yl-derivater
DK1246791T3 (da) Aminomethyl-phenyl-cyklohexanonderivater
ATE346045T1 (de) Heteroaryl-substituierte aminocyclohexan-derivate
DK1406859T3 (da) Substituerede 4-aminocyclohexannolderivater
DK1392670T3 (da) Substituerede C-furan-2-yl-methylamin- og C-thiophen-2-yl-methylamin-derivater
DE60202381D1 (de) Paroxetin-n-formyl-derivate
ATE374776T1 (de) Pyrrolotriazolopyrimidinonderivate
NO20024393D0 (no) 2-fenylpyran-4-on-derivater

Legal Events

Date Code Title Description
8364 No opposition during term of opposition