BR0214245A - Derivados de nicotin- ou isonicotin-benzotiazol - Google Patents

Derivados de nicotin- ou isonicotin-benzotiazol

Info

Publication number
BR0214245A
BR0214245A BR0214245-7A BR0214245A BR0214245A BR 0214245 A BR0214245 A BR 0214245A BR 0214245 A BR0214245 A BR 0214245A BR 0214245 A BR0214245 A BR 0214245A
Authority
BR
Brazil
Prior art keywords
lower alkyl
morpholinyl
substituted
alkoxy
pyrrolidinyl
Prior art date
Application number
BR0214245-7A
Other languages
English (en)
Inventor
Alexander Flohr
Roland Jakob-Roetne
Roger David Norcross
Claus Riemer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0214245A publication Critical patent/BR0214245A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE NICOTIN- OU ISONICOTIN-BENZOTIAZOL". A presente invenção refere-se a compostos de fórmula geral (I): onde: R^ 1^ é fenila, piperidin-1-ila ou morfolinila; A é -O- e R é (CH~ 2~)~ n~-N(R")-C(O)-alquila inferior, -(CH~ 2~)~ n~-O-alquila inferior, -(CH~ 2~,)~ n~-O-(CH~ 2~)~ n~-O-alquila inferior, alquila inferior, -(CH~ 2~)~ n~,-morfolinila, -(CH~ 2~)~ n~-fenila, -(CH~ 2~,)~ n~-N(R")~ 2<39>~-(CH~ 2~)~ n~piridinila, -(CH~ 2~)~ n~-CF~ 3~, -(CH~ 2~)~ n~-2-oxo-pirrolidinila ou C~ 4-6~-cicloalquila; R" é independentemente hidrogênio ou alquila inferior; e n é 1 ou 2; ou A é -N(R<39>)-, e R é alquila inferior, C~ 4-6~-cicloalquila, -(CH~ 2~)~ n~-O-alquila inferior, -(CH~ 2~)~ n~-piridinila, -(CH~ 2~)~ n~-piperidinila, -(CH~ 2~)~ n~-fenila, -(CH~ 2~)~ n~-N(R")-C(O)-alquila inferior, -(CH~ 2~)~ n~morfolinila ou -(CH~ 2~)~ n~-N(R")~ 2~; R<39> e R" são independentemente entre si hidrogênio ou alquila inferior; e n é 1 ou 2; ou A é -CH~ 2~-, e R é -N(R")-(CH~ 2~)~ m~-O-alquila inferior, -N(R")~ 2~, S-alquila inferior ou é acetidinila, pirrolidinila ou piperidinila, os quais são opcionalmente substituídos por hidróxi ou alcóxi inferior ou é morfolinila, -N(R") -(CH~ 2~)~ m~-C(O)OH, -2-oxo-pirrolidinila, -N(R")-C(O)O-alquila inferior, -O-(CH~ 2~)~ m~-O-alquila ou alcóxi inferior; R" é independentemente hidrogênio ou alquila inferior; e m é 1, 2 ou 3; ou A é -S-, e R é alquila inferior; ou A-R são juntos: piperazinila, substituído por alquila inferior, -C(O)-alquila inferior ou um grupo oxo ou é piperidinila, substituído por alcóxi inferior ou hidróxi, ou é morfolinila, substituído por alquila inferior, ou é C~ 4-6~-cicloalquila, -azetidin-1-ila, opcionalmente substituído por hidróxi ou alcóxi inferior, tiomorfolina-1,1-dioxo, -tetraidropirano ou 2-oxa-5-aza-biciclo[2.2.1]hept-5-ila; e sais de adição de ácido farmaceuticamente aceitáveis dos mesmos. Foi descoberto que os compostos de fórmula geral I são ligantes do receptor de adenosina. Especificamente, os compostos da presente invenção apresentam uma satisfatória afinidade ao receptor A~ 2A~, sendo, portanto, de utilidade no tratamento de doenças correlacionadas a esse receptor.
BR0214245-7A 2001-11-19 2002-11-11 Derivados de nicotin- ou isonicotin-benzotiazol BR0214245A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01127312 2001-11-19
PCT/EP2002/012562 WO2003043636A1 (en) 2001-11-19 2002-11-11 Nicotin-or isonicotin benzothiazole derivatives

Publications (1)

Publication Number Publication Date
BR0214245A true BR0214245A (pt) 2004-12-14

Family

ID=8179263

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0214245-7A BR0214245A (pt) 2001-11-19 2002-11-11 Derivados de nicotin- ou isonicotin-benzotiazol

Country Status (38)

Country Link
US (1) US6620811B2 (pt)
EP (1) EP1448198B1 (pt)
JP (1) JP4226474B2 (pt)
KR (1) KR100577110B1 (pt)
CN (1) CN100546580C (pt)
AR (1) AR039367A1 (pt)
AT (1) ATE376831T1 (pt)
AU (1) AU2002351955B2 (pt)
BR (1) BR0214245A (pt)
CA (1) CA2467552C (pt)
DE (1) DE60223278T2 (pt)
DK (1) DK1448198T3 (pt)
EA (1) EA007502B1 (pt)
EC (1) ECSP045109A (pt)
ES (1) ES2294187T3 (pt)
GT (1) GT200200232A (pt)
HR (1) HRP20040396A2 (pt)
HU (1) HUP0402161A3 (pt)
IL (2) IL161623A0 (pt)
JO (1) JO2290B1 (pt)
MA (1) MA27083A1 (pt)
MX (1) MXPA04004684A (pt)
MY (1) MY126176A (pt)
NO (1) NO20042576L (pt)
NZ (1) NZ532802A (pt)
PA (1) PA8558001A1 (pt)
PE (1) PE20030713A1 (pt)
PL (1) PL369517A1 (pt)
PT (1) PT1448198E (pt)
RS (1) RS39904A (pt)
RU (1) RU2294933C2 (pt)
SI (1) SI1448198T1 (pt)
TN (1) TNSN04087A1 (pt)
TW (1) TW200407134A (pt)
UA (1) UA77462C2 (pt)
UY (1) UY27542A1 (pt)
WO (1) WO2003043636A1 (pt)
ZA (1) ZA200403817B (pt)

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CA2543707A1 (en) 2003-10-31 2005-05-19 Takeda Pharmaceutical Company Limited Nitrogen-containing fused heterocyclic compounds
SI1700856T1 (sl) 2003-12-26 2016-02-29 Kyowa Hakko Kirin Co., Ltd., Tiazolni derivat
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KR20090064478A (ko) * 2006-11-13 2009-06-18 화이자 프로덕츠 인크. 디아릴, 디피리디닐 및 아릴-피리디닐 유도체, 및 이들의 용도
CA2758961A1 (en) 2009-04-27 2010-11-04 High Point Pharmaceuticals, Llc Substituted isoquinoline derivatives, pharmaceutical compositions, and methods of use as .beta.-secretase inhibitors
TWI548411B (zh) 2009-04-28 2016-09-11 Kyowa Hakko Kirin Co Ltd Exercise disorder treatment
UA113383C2 (xx) 2009-09-02 2017-01-25 Терапевтичний агент для лікування тривожних розладів
UA110097C2 (uk) 2009-09-02 2015-11-25 Терапевтичний агент для лікування розладів настрою
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EP1303272B1 (en) * 2000-06-21 2008-02-13 F. Hoffmann-La Roche Ag Benzothiazole derivatives for the treatment of alzheimer's disease and parkinson's disease

Also Published As

Publication number Publication date
US20030134854A1 (en) 2003-07-17
RS39904A (en) 2006-10-27
EA200400598A1 (ru) 2005-02-24
TW200407134A (en) 2004-05-16
EP1448198A1 (en) 2004-08-25
RU2004118425A (ru) 2006-01-10
DK1448198T3 (da) 2008-01-07
TNSN04087A1 (en) 2006-06-01
CN1617722A (zh) 2005-05-18
MXPA04004684A (es) 2004-08-12
KR20050044535A (ko) 2005-05-12
PL369517A1 (en) 2005-04-18
PT1448198E (pt) 2007-12-11
MA27083A1 (fr) 2004-12-20
JO2290B1 (en) 2005-09-12
NO20042576L (no) 2004-06-18
IL161623A0 (en) 2004-09-27
CA2467552A1 (en) 2003-05-30
HRP20040396A2 (en) 2005-04-30
US6620811B2 (en) 2003-09-16
JP4226474B2 (ja) 2009-02-18
ZA200403817B (en) 2005-05-23
AR039367A1 (es) 2005-02-16
EA007502B1 (ru) 2006-10-27
SI1448198T1 (sl) 2008-02-29
HUP0402161A3 (en) 2010-06-28
AU2002351955B2 (en) 2007-03-15
HUP0402161A2 (hu) 2005-02-28
MY126176A (en) 2006-09-29
AU2002351955A1 (en) 2003-06-10
DE60223278D1 (de) 2007-12-13
PE20030713A1 (es) 2003-08-23
DE60223278T2 (de) 2008-08-14
ATE376831T1 (de) 2007-11-15
CA2467552C (en) 2011-05-24
WO2003043636A1 (en) 2003-05-30
NZ532802A (en) 2005-07-29
UY27542A1 (es) 2003-05-30
EP1448198B1 (en) 2007-10-31
GT200200232A (es) 2003-06-17
RU2294933C2 (ru) 2007-03-10
ES2294187T3 (es) 2008-04-01
JP2005522413A (ja) 2005-07-28
PA8558001A1 (es) 2003-07-28
UA77462C2 (en) 2006-12-15
ECSP045109A (es) 2004-06-28
CN100546580C (zh) 2009-10-07
IL161623A (en) 2010-11-30
KR100577110B1 (ko) 2006-05-10

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