BR0305717A - Inibidores da protease do hiv 2-amino-benzotiazol sulfonamida de amplo espectro - Google Patents

Inibidores da protease do hiv 2-amino-benzotiazol sulfonamida de amplo espectro

Info

Publication number
BR0305717A
BR0305717A BR0305717-8A BR0305717A BR0305717A BR 0305717 A BR0305717 A BR 0305717A BR 0305717 A BR0305717 A BR 0305717A BR 0305717 A BR0305717 A BR 0305717A
Authority
BR
Brazil
Prior art keywords
alkyl
amino
protease inhibitors
hydrogen
broad
Prior art date
Application number
BR0305717-8A
Other languages
English (en)
Inventor
Dominique Louis Nest Surleraux
Piet Tom Bert Paul Wigerinck
Daniel P Getman
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of BR0305717A publication Critical patent/BR0305717A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"INIBIDORES DA PROTEASE DO HIV 2-AMINO-BENZOTIAZOL SULFONAMIDA DE AMPLO ESPECTRO". A presente invenção refere-se à aplicação de 2-amino-benzotiazóis, tendo a fórmula (I), em que R~ 1~ é hexahidrofuro[2,3-b]furanila, tetrahidrofuranila, oxozolila, tiazolila, piridinila, ou fenila, opcionalmente substituída com um ou mais substituintes selecionados de modo independente entre C~ 1-6 alquila, hidróxi, amino, halogênio, aminoC~ 1-4~ alquila e mono- ou di(C~ 1-4~ alquil)amino; R~ 2~ é hidrogênio OU C~ 1-6~ alquila; L é uma ligação direta, -O-, C~ 1-6~ alcanodiil-O- ou -O-C~ 1-6~ alcanodiila; R~ 3~ é fenilC~ 1-4~ alquila; R~ 4~ é C~ 1-6~ alquila; R~ 5~ é hidrogênio ou C~ 1-6~ alquila; R~ 6~ é hidrogênio ou C~ 1-6~ alquila; na fabricação de um medicamento útila para inibir a protease de HIV mutante em um mamífero infectado com a referida protease de HIV mutante. Além disso, refere-se a novos compostos de fórmula (I).
BR0305717-8A 2002-08-02 2003-08-04 Inibidores da protease do hiv 2-amino-benzotiazol sulfonamida de amplo espectro BR0305717A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02078231 2002-08-02
US42786202P 2002-11-20 2002-11-20
PCT/EP2003/050359 WO2004014371A1 (en) 2002-08-02 2003-08-04 Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors

Publications (1)

Publication Number Publication Date
BR0305717A true BR0305717A (pt) 2004-09-28

Family

ID=31716850

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0305717-8A BR0305717A (pt) 2002-08-02 2003-08-04 Inibidores da protease do hiv 2-amino-benzotiazol sulfonamida de amplo espectro

Country Status (16)

Country Link
US (2) US20050267156A1 (pt)
EP (1) EP1545518A1 (pt)
KR (1) KR20050025647A (pt)
CN (1) CN1671380B (pt)
AP (1) AP1878A (pt)
AU (1) AU2003262561B2 (pt)
BR (1) BR0305717A (pt)
CA (1) CA2492832C (pt)
EA (1) EA008594B1 (pt)
HR (1) HRP20050605A2 (pt)
IL (1) IL166257A (pt)
MX (1) MXPA05001275A (pt)
NO (1) NO20051089L (pt)
NZ (1) NZ538488A (pt)
PL (1) PL374948A1 (pt)
WO (1) WO2004014371A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5073480B2 (ja) * 2004-05-07 2012-11-14 セコイア、ファーマシューティカルズ、インコーポレイテッド 耐性防止レトロウイルスプロテアーゼ阻害薬
JO2841B1 (en) * 2006-06-23 2014-09-15 تيبوتيك فارماسيوتيكالز ليمتد 2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV)
US8267163B2 (en) * 2008-03-17 2012-09-18 Visteon Global Technologies, Inc. Radiator tube dimple pattern
WO2011061590A1 (en) 2009-11-17 2011-05-26 Hetero Research Foundation Novel carboxamide derivatives as hiv inhibitors
MX2012015293A (es) 2010-07-02 2013-05-30 Gilead Sciences Inc Derivados de acido 2-quinolinil-acetico como compuestos antivirales.
BR112013000043A2 (pt) 2010-07-02 2019-09-24 Gilead Sciences Inc derivados de ácido naft-2-ilacético para tratar aids
US9024038B2 (en) * 2010-12-27 2015-05-05 Purdue Research Foundation Compunds and methods for treating HIV
ES2707997T3 (es) 2011-04-21 2019-04-08 Gilead Sciences Inc Compuestos de benzotiazol y su uso farmacéutico
WO2013103724A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids
WO2013103738A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. Napthalene acetic acid derivatives against hiv infection
ES2571479T3 (es) 2012-04-20 2016-05-25 Gilead Sciences Inc Derivados del ácido benzotiazol-6-il acético y su uso para tratar una infección por VIH

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968942A (en) * 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
EP0715618B1 (en) * 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
CA2438304C (en) * 2001-02-14 2011-04-12 Dominique Louis Nestor Ghislain Surleraux Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors

Also Published As

Publication number Publication date
AP1878A (en) 2008-08-13
NO20051089L (no) 2005-05-02
US20050267156A1 (en) 2005-12-01
IL166257A0 (en) 2006-01-15
MXPA05001275A (es) 2005-04-28
CA2492832A1 (en) 2004-02-19
KR20050025647A (ko) 2005-03-14
HRP20050605A2 (en) 2006-02-28
AU2003262561A1 (en) 2004-02-25
PL374948A1 (en) 2005-11-14
CN1671380A (zh) 2005-09-21
IL166257A (en) 2013-04-30
EA200500298A1 (ru) 2005-08-25
EP1545518A1 (en) 2005-06-29
AP2005003242A0 (en) 2005-03-31
WO2004014371A1 (en) 2004-02-19
NZ538488A (en) 2007-10-26
CN1671380B (zh) 2010-05-26
CA2492832C (en) 2012-05-22
EA008594B1 (ru) 2007-06-29
AU2003262561B2 (en) 2008-10-16
US20090203742A1 (en) 2009-08-13

Similar Documents

Publication Publication Date Title
DK1585739T3 (da) Substituerede arylcyclopropylacetamider som glucokinaseaktivatorer
BE2018C008I2 (pt)
NO20063761L (no) Sulfonamidderivater for behandling av sykdommer
HRP20090162T1 (en) Quinolinone-carboxamide compounds as 5-ht4 receptor agonists
DK1996180T3 (da) Benzamid- og pyridylamidderivater som antibakterielle midler
DE60204674D1 (de) Retinoid x rezeptormodulatoren
DOP2005000006A (es) "derivados de sulfonamida para el tratamiento de enfermedades"
BR0314052A (pt) Imidazolpiridinas e métodos para sua fabricação e uso
SI1392642T1 (sl) Nove spojine kot protivnetna, imunomodulacijska in antiproliferativna sredstva
MA29261B1 (fr) Derives de (1,5-diphenyl-1h-pyrazol-3-yl)oxadiazole, leur preparation et leur application en therapeutique
NO20063275L (no) Anvendelse av substituerte 2-aminotetraliner for forebyggende behandling av Parkinsons sykdom
BR0305717A (pt) Inibidores da protease do hiv 2-amino-benzotiazol sulfonamida de amplo espectro
ATE540928T1 (de) Isochinolinverbindungen und ihre medizinische verwendung
HUP0300909A2 (hu) NHE-3 inhibitor hatású 2-guanidino-4-aril-kinazolin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
TNSN08414A1 (en) Terphenyl derivatives for treatment of alzheimer's disease
BRPI0607214B8 (pt) derivados de 2-(4-cianofenilamino)pirimidina inibidores de hiv, composição farmacêutica que os compreende e seus processos de preparação
ECSP024244A (es) Uso de (z)-2-cyano-3-hydroxy-but-2-enoic acid(4´-trifluoromethylphenyl)-amide para el tratamiento de la esclerosis múltiple
TW200640870A (en) Novel compounds
NO20060277L (no) Anvendelse av bisyklo [2.2.1] heptanderivater til fremstilling av nevrobeskyttende farmasoytiske sammensetninger
NO20081587L (no) Aerosolformulering for inhalering
HUP0402341A2 (hu) Szubsztituált tiazol-2-ilaminokat tartalmazó készítmények rák kezelésére
NO20022977D0 (no) Substituerte homopiperidinylbenzimidazolanaloger som fundiske relaksanter
AR029374A1 (es) Compuestos derivados de benceno, su utilizacion, un procedimiento para su preparacion y una composicion farmaceutica que los contiene
AR034313A1 (es) Utilizacion de derivados de piridoindolona para la preparacion de medicamentos
NO20075505L (no) 7-fluor-1,3-dihydro-indol-2-on oksazolidinoner som antibakterielle forbindelser

Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: TIBOTEC PHARMACEUTICALS LTD. (IE)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070001806/RJ DE 05/01/2007.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.