EA200500298A1 - 2-аминобензотиазолсульфонамидные ингибиторы протеазы вич широкого спектра действия - Google Patents

2-аминобензотиазолсульфонамидные ингибиторы протеазы вич широкого спектра действия

Info

Publication number
EA200500298A1
EA200500298A1 EA200500298A EA200500298A EA200500298A1 EA 200500298 A1 EA200500298 A1 EA 200500298A1 EA 200500298 A EA200500298 A EA 200500298A EA 200500298 A EA200500298 A EA 200500298A EA 200500298 A1 EA200500298 A1 EA 200500298A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
amino
hydrogen
hiv protease
aminobenzothiazolesulphonamide
Prior art date
Application number
EA200500298A
Other languages
English (en)
Other versions
EA008594B1 (ru
Inventor
Доминик Луи Нестор Гилэйн Сюрлеро
Пит Том Берт Пол Вигеринк
Дэниел П. Гетман
Original Assignee
Тиботек Фармасьютикалз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тиботек Фармасьютикалз Лтд. filed Critical Тиботек Фармасьютикалз Лтд.
Publication of EA200500298A1 publication Critical patent/EA200500298A1/ru
Publication of EA008594B1 publication Critical patent/EA008594B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к применению 2-аминобензотиазолов формулы (I), в которой Rозначает гексагидрофуро[2,3-b]-фуранил, тетрагидрофуранил, оксазолил, тиазолил, пиридинил или фенил, необязательно замещенный одним или несколькими заместителями, независимо выбираемыми из группы, включающей Cалкил, гидрокси, амино, галоген, амино-Cалкил и моно- или ди(Cалкил)амино; Rозначает водород или Cалкил; L означает прямую связь, -O-, Cалкандиил-O- или -O-Cалкандиил; Rозначает фенил-C-алкил; Rозначает Cалкил; Rозначает водород или Cалкил; Rозначает водород или Cалкил; при получении лекарственного средства, предназначенного для ингибирования мутантной протеазы ВИЧ у млекопитающего, инфицированного указанной мутантной протеазой ВИЧ. Данное изобретение относится также к новым соединениям формулы (I).Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500298A 2002-08-02 2003-08-04 2-аминобензотиазолсульфонамидные ингибиторы протеазы вич широкого спектра действия EA008594B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02078231 2002-08-02
US42786202P 2002-11-20 2002-11-20
PCT/EP2003/050359 WO2004014371A1 (en) 2002-08-02 2003-08-04 Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors

Publications (2)

Publication Number Publication Date
EA200500298A1 true EA200500298A1 (ru) 2005-08-25
EA008594B1 EA008594B1 (ru) 2007-06-29

Family

ID=31716850

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500298A EA008594B1 (ru) 2002-08-02 2003-08-04 2-аминобензотиазолсульфонамидные ингибиторы протеазы вич широкого спектра действия

Country Status (16)

Country Link
US (2) US20050267156A1 (ru)
EP (1) EP1545518A1 (ru)
KR (1) KR20050025647A (ru)
CN (1) CN1671380B (ru)
AP (1) AP1878A (ru)
AU (1) AU2003262561B2 (ru)
BR (1) BR0305717A (ru)
CA (1) CA2492832C (ru)
EA (1) EA008594B1 (ru)
HR (1) HRP20050605A2 (ru)
IL (1) IL166257A (ru)
MX (1) MXPA05001275A (ru)
NO (1) NO20051089L (ru)
NZ (1) NZ538488A (ru)
PL (1) PL374948A1 (ru)
WO (1) WO2004014371A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1997363B (zh) * 2004-05-07 2012-03-28 塞阔伊亚药品公司 抗耐药性反转录病毒蛋白酶抑制剂
JO2841B1 (en) * 2006-06-23 2014-09-15 تيبوتيك فارماسيوتيكالز ليمتد 2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV)
US8267163B2 (en) * 2008-03-17 2012-09-18 Visteon Global Technologies, Inc. Radiator tube dimple pattern
WO2011061590A1 (en) 2009-11-17 2011-05-26 Hetero Research Foundation Novel carboxamide derivatives as hiv inhibitors
ES2634490T3 (es) 2010-07-02 2017-09-28 Gilead Sciences, Inc. Derivados de ácido napht-2-ylacetico para tratar el sida
PE20130525A1 (es) 2010-07-02 2013-05-05 Gilead Sciences Inc Derivados de acido 2 quinolinil acetico como compuestos antivirales frente a vih
US9024038B2 (en) 2010-12-27 2015-05-05 Purdue Research Foundation Compunds and methods for treating HIV
AU2012245187B2 (en) * 2011-04-21 2016-06-30 Gilead Sciences, Inc. Benzothiazole compounds and their pharmaceutical use
WO2013103738A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. Napthalene acetic acid derivatives against hiv infection
WO2013103724A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids
CA2850881C (en) 2012-04-20 2021-02-16 Gilead Sciences, Inc. Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968942A (en) * 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
ATE174587T1 (de) * 1993-08-24 1999-01-15 Searle & Co Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
AU4828199A (en) * 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
CZ304273B6 (cs) * 2001-02-14 2014-02-12 Tibotec Pharmaceuticals Ltd. 2-(Substitovaná-amino)benzothiazolsulfonamidová sloučenina, způsob její přípravy a farmaceutická kompozice s jejím obsahem

Also Published As

Publication number Publication date
AU2003262561A1 (en) 2004-02-25
WO2004014371A1 (en) 2004-02-19
AU2003262561B2 (en) 2008-10-16
CN1671380A (zh) 2005-09-21
NZ538488A (en) 2007-10-26
BR0305717A (pt) 2004-09-28
CA2492832C (en) 2012-05-22
PL374948A1 (en) 2005-11-14
IL166257A0 (en) 2006-01-15
EA008594B1 (ru) 2007-06-29
EP1545518A1 (en) 2005-06-29
AP1878A (en) 2008-08-13
US20090203742A1 (en) 2009-08-13
NO20051089L (no) 2005-05-02
KR20050025647A (ko) 2005-03-14
AP2005003242A0 (en) 2005-03-31
CN1671380B (zh) 2010-05-26
US20050267156A1 (en) 2005-12-01
HRP20050605A2 (en) 2006-02-28
CA2492832A1 (en) 2004-02-19
MXPA05001275A (es) 2005-04-28
IL166257A (en) 2013-04-30

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KZ RU