MXPA05001275A - 2-amino-benzotiazolsulfonhamida como inhibidores de proteasa de virus de inmunodeficiencia humana de amplio espectro. - Google Patents

2-amino-benzotiazolsulfonhamida como inhibidores de proteasa de virus de inmunodeficiencia humana de amplio espectro.

Info

Publication number
MXPA05001275A
MXPA05001275A MXPA05001275A MXPA05001275A MXPA05001275A MX PA05001275 A MXPA05001275 A MX PA05001275A MX PA05001275 A MXPA05001275 A MX PA05001275A MX PA05001275 A MXPA05001275 A MX PA05001275A MX PA05001275 A MXPA05001275 A MX PA05001275A
Authority
MX
Mexico
Prior art keywords
amino
hiv protease
6alkyl
hydrogen
broadspectrum
Prior art date
Application number
MXPA05001275A
Other languages
English (en)
Inventor
Daniel P Getman
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of MXPA05001275A publication Critical patent/MXPA05001275A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Abstract

La presente invencion se refiere al uso de 2-amino-benzotiazoles, que tienen la formula en donde R1 es hexahidrofuro[2,3-b]furanilo, tetrahidrofuranilo, oxazolilo, tiazolilo, piridinilo o fenilo opcionalmente sustituido con uno o mas sustituyentes independientemente seleccionados de alquilo de C1-6, hidroxi, amino, halogeno, amino-alquilo de C1-4 y mono-o di(alquilo de C1-4)amino; R2 es hidrogeno o alquilo de C1-6 L es un enlace directo, -O-, alcanodiilo de C1-6-O- o -0-alcanodiilo de C1-6 R3 es fenilo-alquilo de C1-4 R4 es alquilo de C1-6 R5 es hidrogeno o alquilo de C1-6 R6 es hidrogeno o alquilo de C1-6 en la fabricacion de un medicamento util para inhibir proteasa de VIH mutante en un mamifero infectado con proteasa de VIH mutante; tambien se refiere a compuestos novedosos de la formula (1).
MXPA05001275A 2002-08-02 2003-08-04 2-amino-benzotiazolsulfonhamida como inhibidores de proteasa de virus de inmunodeficiencia humana de amplio espectro. MXPA05001275A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02078231 2002-08-02
US42786202P 2002-11-20 2002-11-20
PCT/EP2003/050359 WO2004014371A1 (en) 2002-08-02 2003-08-04 Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors

Publications (1)

Publication Number Publication Date
MXPA05001275A true MXPA05001275A (es) 2005-04-28

Family

ID=31716850

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05001275A MXPA05001275A (es) 2002-08-02 2003-08-04 2-amino-benzotiazolsulfonhamida como inhibidores de proteasa de virus de inmunodeficiencia humana de amplio espectro.

Country Status (16)

Country Link
US (2) US20050267156A1 (es)
EP (1) EP1545518A1 (es)
KR (1) KR20050025647A (es)
CN (1) CN1671380B (es)
AP (1) AP1878A (es)
AU (1) AU2003262561B2 (es)
BR (1) BR0305717A (es)
CA (1) CA2492832C (es)
EA (1) EA008594B1 (es)
HR (1) HRP20050605A2 (es)
IL (1) IL166257A (es)
MX (1) MXPA05001275A (es)
NO (1) NO20051089L (es)
NZ (1) NZ538488A (es)
PL (1) PL374948A1 (es)
WO (1) WO2004014371A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1750696B1 (en) * 2004-05-07 2013-06-26 Sequoia Pharmaceuticals Inc RETROVIRAL PROTEASE INHIBITORS RESISTING THEIR RESISTANCE
JO2841B1 (en) * 2006-06-23 2014-09-15 تيبوتيك فارماسيوتيكالز ليمتد 2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV)
US8267163B2 (en) * 2008-03-17 2012-09-18 Visteon Global Technologies, Inc. Radiator tube dimple pattern
WO2011061590A1 (en) 2009-11-17 2011-05-26 Hetero Research Foundation Novel carboxamide derivatives as hiv inhibitors
KR20130135826A (ko) 2010-07-02 2013-12-11 길리애드 사이언시즈, 인코포레이티드 Ａｉｄｓ를 치료하기 위한 나프트-2-일아세트산 유도체
NZ604716A (en) 2010-07-02 2014-12-24 Gilead Sciences Inc 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds
US9024038B2 (en) * 2010-12-27 2015-05-05 Purdue Research Foundation Compunds and methods for treating HIV
ES2707997T3 (es) * 2011-04-21 2019-04-08 Gilead Sciences Inc Compuestos de benzotiazol y su uso farmacéutico
US9376392B2 (en) 2012-01-04 2016-06-28 Gilead Sciences, Inc. 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS
US9284323B2 (en) 2012-01-04 2016-03-15 Gilead Sciences, Inc. Naphthalene acetic acid derivatives against HIV infection
NZ622769A (en) 2012-04-20 2017-06-30 Gilead Sciences Inc Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968942A (en) * 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
DK0715618T3 (da) * 1993-08-24 1999-08-23 Searle & Co Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
AU4828199A (en) * 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
AU2002302363B2 (en) * 2001-02-14 2008-05-01 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors

Also Published As

Publication number Publication date
EP1545518A1 (en) 2005-06-29
CA2492832C (en) 2012-05-22
CN1671380B (zh) 2010-05-26
IL166257A (en) 2013-04-30
AP1878A (en) 2008-08-13
US20090203742A1 (en) 2009-08-13
KR20050025647A (ko) 2005-03-14
EA008594B1 (ru) 2007-06-29
BR0305717A (pt) 2004-09-28
PL374948A1 (en) 2005-11-14
IL166257A0 (en) 2006-01-15
NZ538488A (en) 2007-10-26
US20050267156A1 (en) 2005-12-01
WO2004014371A1 (en) 2004-02-19
HRP20050605A2 (en) 2006-02-28
NO20051089L (no) 2005-05-02
AU2003262561A1 (en) 2004-02-25
AP2005003242A0 (en) 2005-03-31
CA2492832A1 (en) 2004-02-19
AU2003262561B2 (en) 2008-10-16
CN1671380A (zh) 2005-09-21
EA200500298A1 (ru) 2005-08-25

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