NO20073926L - Pyrazolforbindelser som modulerer aktivitet av CDK-, GSK- og aurorakinaser - Google Patents

Pyrazolforbindelser som modulerer aktivitet av CDK-, GSK- og aurorakinaser

Info

Publication number
NO20073926L
NO20073926L NO20073926A NO20073926A NO20073926L NO 20073926 L NO20073926 L NO 20073926L NO 20073926 A NO20073926 A NO 20073926A NO 20073926 A NO20073926 A NO 20073926A NO 20073926 L NO20073926 L NO 20073926L
Authority
NO
Norway
Prior art keywords
gsk
cdk
aurorakinases
compounds
pyrazole compounds
Prior art date
Application number
NO20073926A
Other languages
English (en)
Inventor
Valerio Berdini
Maria Grazia Carr
Adrian Liam Gill
Paul Graham Wyatt
Steven Howard
Eva Figueroa Navarro
Gary Rewartha
David Charles Rees
Mladen Vinkovic
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0428554A external-priority patent/GB0428554D0/en
Priority claimed from GB0428552A external-priority patent/GB0428552D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of NO20073926L publication Critical patent/NO20073926L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer en forbindelse med formel (I): eller et salt, solvat, tautomer eller N-oksid derav, hvori M er valgt fra en gruppe D1 og en gruppe D2: og R1, E, A og X er som definert i kravene. Også tilveiebrakt er farmasøytiske sammensetninger som inneholder forbindelsene, fremgangsmåter for fremstilling av forbindelsene og anvendelse av forbindelsene ved profylakse eller behandling av en sykdomstilstand mediert av en CDK kinase, GSK-3 kinase eller Aurora kinase.
NO20073926A 2004-12-30 2007-07-26 Pyrazolforbindelser som modulerer aktivitet av CDK-, GSK- og aurorakinaser NO20073926L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64059704P 2004-12-30 2004-12-30
US64047504P 2004-12-30 2004-12-30
GB0428554A GB0428554D0 (en) 2004-12-30 2004-12-30 Pharmaceutical compounds
GB0428552A GB0428552D0 (en) 2004-12-30 2004-12-30 Pharmaceutical compounds
PCT/GB2005/005097 WO2006070195A1 (en) 2004-12-30 2005-12-30 Pyrazole compounds that modulate the activity of cdk, gsk and aurora kinases

Publications (1)

Publication Number Publication Date
NO20073926L true NO20073926L (no) 2007-10-01

Family

ID=39495737

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073926A NO20073926L (no) 2004-12-30 2007-07-26 Pyrazolforbindelser som modulerer aktivitet av CDK-, GSK- og aurorakinaser

Country Status (14)

Country Link
US (2) US8110573B2 (no)
EP (2) EP2395000A1 (no)
JP (1) JP5507049B2 (no)
KR (1) KR101334511B1 (no)
AU (1) AU2005321091B2 (no)
BR (1) BRPI0519759A2 (no)
CA (1) CA2593993C (no)
IL (1) IL183751A0 (no)
MX (1) MX2007008008A (no)
NO (1) NO20073926L (no)
NZ (1) NZ555982A (no)
RU (1) RU2416610C2 (no)
TW (1) TWI427077B (no)
WO (1) WO2006070195A1 (no)

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CA2593993C (en) 2014-07-29
US20080132495A1 (en) 2008-06-05
TW200635918A (en) 2006-10-16
US20120190673A1 (en) 2012-07-26
KR101334511B1 (ko) 2013-11-29
US8778936B2 (en) 2014-07-15
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RU2007128959A (ru) 2009-02-10
IL183751A0 (en) 2007-09-20
RU2416610C2 (ru) 2011-04-20
EP2395000A1 (en) 2011-12-14
AU2005321091B2 (en) 2012-04-12
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WO2006070195A8 (en) 2006-08-24
US8110573B2 (en) 2012-02-07
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JP2008526722A (ja) 2008-07-24
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MX2007008008A (es) 2007-11-12
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